Plasma Kinins
Plasma Kinins
Plasma Kinins
By
Dr. Fazlullah Khan
Introduction
The term plasma kinins was introduced in 1958.
Poly peptides which have marked biological effects and are
derived from plasma.
Liberated from protein precursors in plasma (kininogens) by
the action of kinnogenases.
These enzymes are found in exocrine glands and their
secretions .
Also in plasma and snake & wasp venoms and human urine.
Plasma kinins
A). Bradykinin
B). Kallidin
They are potent vasodilator peptides.
Renal autacoids
Bradykinin
• Bradykinin receptor
• The B1 receptor (also called bradykinin
receptor B1) is expressed only as a result of
tissue injury, and is presumed to play a role in
chronic pain. This receptor has been also
described to play a role in inflammation. It
was shown that the kinin B1 receptor
recruits neutrophil via the
chemokine CXCL5 production.
• The B2 receptor is constitutively expressed and
participates in bradykinin's vasodilatory role.