Scribd Logo
Upload

Welcome to Scribd!

  • 83 views

    Drug Study

    Uploaded by

    gwendee ealdama
    The document details an order for the amino acid isoleucine to be administered via NGT to a patient twice daily to treat hepatic encephalopathy, listing the generic and brand names, date ordered, dosage, and classification. It then provides information on the mechanism of action of isoleucine and branched-chain amino acids, noting their roles in muscle catabolism, energy production, and metabolic pathways. Potential side effects, contraindications, and nursing considerations are not specified.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Drug Study

    Uploaded by

    gwendee ealdama
    83 views2 pages
    The document details an order for the amino acid isoleucine to be administered via NGT to a patient twice daily to treat hepatic encephalopathy, listing the generic and brand names, date ordered, dosage, and classification. It then provides information on the mechanism of action of isoleucine and branched-chain amino acids, noting their roles in muscle catabolism, energy production, and metabolic pathways. Potential side effects, contraindications, and nursing considerations are not specified.

    Original Description:

    drug study

    Original Title

    Drug-Study

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document details an order for the amino acid isoleucine to be administered via NGT to a patient twice daily to treat hepatic encephalopathy, listing the generic and brand names, date ordered, dosage, and classification. It then provides information on the mechanism of action of isoleucine and branched-chain amino acids, noting their roles in muscle catabolism, energy production, and metabolic pathways. Potential side effects, contraindications, and nursing considerations are not specified.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    83 views2 pages

    Drug Study

    Uploaded by

    gwendee ealdama
    The document details an order for the amino acid isoleucine to be administered via NGT to a patient twice daily to treat hepatic encephalopathy, listing the generic and brand names, date ordered, dosage, and classification. It then provides information on the mechanism of action of isoleucine and branched-chain amino acids, noting their roles in muscle catabolism, energy production, and metabolic pathways. Potential side effects, contraindications, and nursing considerations are not specified.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Dela Torre, Erica D.

    Brand Name Vencin


    Generic Name Isoleucine
    Date Ordered 10/1/22
    Rationale for the  is an amino acid commonly found as a component of total parenteral
    Drug Order nutrition.
    Classification Amino acid
    Actual Dose/ 1 sachet 5ml water b.I.d via NGT
    Frequency/ Route
    The branched-chain amino acids may have antihepatic encephalopathy
    Indication activity in some. They may also have anticatabolic and antitardive
    dyskinesia activity.
    (Applies to Valine, Leucine and Isoleucine) This group of essential
    amino acids are identified as the branched-chain amino acids, BCAAs.
    Because this arrangement of carbon atoms cannot be made by humans,
    these amino acids are an essential element in the diet. The catabolism of
    all three compounds initiates in muscle and yields NADH and FADH2
    which can be utilized for ATP generation. The catabolism of all three of
    these amino acids uses the same enzymes in the first two steps. The first
    step in each case is a transamination using a single BCAA
    aminotransferase, with a-ketoglutarate as amine acceptor. As a result,
    three different a-keto acids are produced and are oxidized using a
    common branched-chain a-keto acid dehydrogenase, yielding the three
    different CoA derivatives. Subsequently the metabolic pathways
    diverge, producing many intermediates. The principal product from
    Mechanism of
    valine is propionylCoA, the glucogenic precursor of succinyl-CoA.
    Action Isoleucine catabolism terminates with production of acetylCoA and
    propionylCoA; thus isoleucine is both glucogenic and ketogenic.
    Leucine gives rise to acetylCoA and acetoacetylCoA, and is thus
    classified as strictly ketogenic. There are a number of genetic diseases
    associated with faulty catabolism of the BCAAs. The most common
    defect is in the branched-chain a-keto acid dehydrogenase. Since there
    is only one dehydrogenase enzyme for all three amino acids, all three a-
    keto acids accumulate and are excreted in the urine. The disease is
    known as Maple syrup urine disease because of the characteristic odor
    of the urine in afflicted individuals. Mental retardation in these cases is
    extensive. Unfortunately, since these are essential amino acids, they
    cannot be heavily restricted in the diet; ultimately, the life of afflicted
    individuals is short and development is abnormal The main
    neurological problems are due to poor formation of myelin in the CNS.
    Contraindication

    Side Effects

    Adverse
    Reactions
    Nursing
    Considerations/
    Responsibilities

    You might also like