This document discusses essential fatty acids and their roles and sources. It notes that alpha-linolenic acid and linoleic acid are the only two fatty acids essential for humans. Essential fatty acids serve multiple functions in the body, including forming eicosanoids and affecting inflammation, mood, and behavior. The document also discusses reference intake values, conjugated linoleic acid and its uses, and polyunsaturated fatty acids.
This document discusses essential fatty acids and their roles and sources. It notes that alpha-linolenic acid and linoleic acid are the only two fatty acids essential for humans. Essential fatty acids serve multiple functions in the body, including forming eicosanoids and affecting inflammation, mood, and behavior. The document also discusses reference intake values, conjugated linoleic acid and its uses, and polyunsaturated fatty acids.
This document discusses essential fatty acids and their roles and sources. It notes that alpha-linolenic acid and linoleic acid are the only two fatty acids essential for humans. Essential fatty acids serve multiple functions in the body, including forming eicosanoids and affecting inflammation, mood, and behavior. The document also discusses reference intake values, conjugated linoleic acid and its uses, and polyunsaturated fatty acids.
This document discusses essential fatty acids and their roles and sources. It notes that alpha-linolenic acid and linoleic acid are the only two fatty acids essential for humans. Essential fatty acids serve multiple functions in the body, including forming eicosanoids and affecting inflammation, mood, and behavior. The document also discusses reference intake values, conjugated linoleic acid and its uses, and polyunsaturated fatty acids.
• Essential fatty acids (EFA) are fatty acids that humans and other
animals must ingest because the body requires them for good health but cannot synthesize them. • The term "essential fatty acid" refers to fatty acids required for biological processes but does not include the fats that only act as fuel • Only two fatty acids are known to be essential for humans: alpha-linolenic acid (an omega-3 fatty acid) and linoleic acid (an omega-6 fatty acid). • Mammals lack the ability to introduce double bonds in fatty acids beyond carbon 9 and 10, hence ω-6 linoleic acid (18:2,9,12), abbreviated LA (18:2n-6), and the ω-3 linolenic acid(18:3,9,12,15), abbreviated ALA (18:3n-3), are essential for humans in the diet. • In humans, arachidonic acid (20:4,5,8,11,14, abbreviated 20:4n-6) can be synthesized from LA by alternative desaturation and chain elongation. Roles of essential fatty acid
In the body, essential fatty acids serve multiple functions. The balance between dietary ω-3 and ω-6 strongly affects function. • They are modified to make
- the classic eicosanoids (affecting inflammation and many other cellular
functions) – the endocannabinoids (affecting mood, behavior and inflammation) – the lipoxins which are a group of eicosanoid derivatives formed via the lipoxygenase pathway from ω-6 EFAs and resolvins from ω-3 (in the presence of acetylsalicylic acid, downregulating inflammation) – the isofurans, neurofurans, isoprostanes, hepoxilins, epoxyeicosatrienoic acids (EETs) and Neuroprotectin D • They form lipid rafts (affecting cellular signaling) • They act on DNA (activating or inhibiting transcription factors such as NF-κB, which is linked to pro-inflammatory cytokine production) Reference intake values
Reference intake values for as published by the Panel on Dietetic
Products, Nutrition and Allergies of the European Food Safety Authority (EFSA) Conjugated linoleic acid • Conjugated fatty acids are polyunsaturated fatty acids in which at least one pair of double bonds is separated by only one single bond. Example: conjugated linoleic acid. • Dairy products and beef are the major sources of conjugated linoleic acid in the diet. • An average diet supplies 15-174 mg of conjugated linoleic acid daily. • Conjugated linoleic acid is commonly taken by mouth for weight loss. • It is also often used for bodybuilding and fitness, but there is limited scientific evidence to support these uses.
How does it work?
Conjugated linoleic acid might help reduce body fat deposits
and improve immune function. Polyunsaturated fatty acids
• Polyunsaturated fatty acids (PUFAs) are fatty acids that contain
more than one double bond in their backbone. • This class includes many important compounds, such as essential fatty acids and those that give drying oils their characteristic property • Polyunsaturated fats — along with monounsaturated fats — are considered healthy fats, as they may reduce your risk of heart disease, especially when substituted for saturated fats • the two major classes of polyunsaturated fats are omega-3 and omega-6 fatty acids • Both are essential fatty acids that your body needs for brain function and cell growth. • Your body cannot make essential fatty acids, so you must get them from your diet • Polyunsaturated fatty acids in culinary oils undergo oxidative deterioration at temperatures of 150 °C (302 °F). • The heating causes a free radical chain reaction, which oxidizes the PUFAs into hydroperoxide, which further decomposes into a complex mixture of secondary products.