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    Osteomyelitis: Farmakoterapi Infeksi Tulang

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    Karmila
    Osteomyelitis is a bone infection most often caused by Staphylococcus aureus and other pathogens that can be acute or chronic. It is classified based on the route of infection (hematogenous spread from blood or contiguous spread from nearby tissue) and duration of disease (acute or chronic). Treatment involves eradicating the infection with a 4-6 week course of antimicrobial therapy targeting the likely causative pathogen, with intravenous administration for 1-2 weeks followed by oral therapy. For chronic osteomyelitis, surgical intervention is also typically required to treat bone necrosis in addition to antimicrobial therapy.

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    Osteomyelitis: Farmakoterapi Infeksi Tulang

    Uploaded by

    Karmila
    21 views39 pages
    Osteomyelitis is a bone infection most often caused by Staphylococcus aureus and other pathogens that can be acute or chronic. It is classified based on the route of infection (hematogenous spread from blood or contiguous spread from nearby tissue) and duration of disease (acute or chronic). Treatment involves eradicating the infection with a 4-6 week course of antimicrobial therapy targeting the likely causative pathogen, with intravenous administration for 1-2 weeks followed by oral therapy. For chronic osteomyelitis, surgical intervention is also typically required to treat bone necrosis in addition to antimicrobial therapy.

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    Infeksi tulang

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    3-Fater2-InfeksiTulang

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    Osteomyelitis is a bone infection most often caused by Staphylococcus aureus and other pathogens that can be acute or chronic. It is classified based on the route of infection (hematogenous spread from blood or contiguous spread from nearby tissue) and duration of disease (acute or chronic). Treatment involves eradicating the infection with a 4-6 week course of antimicrobial therapy targeting the likely causative pathogen, with intravenous administration for 1-2 weeks followed by oral therapy. For chronic osteomyelitis, surgical intervention is also typically required to treat bone necrosis in addition to antimicrobial therapy.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    21 views39 pages

    Osteomyelitis: Farmakoterapi Infeksi Tulang

    Uploaded by

    Karmila
    Osteomyelitis is a bone infection most often caused by Staphylococcus aureus and other pathogens that can be acute or chronic. It is classified based on the route of infection (hematogenous spread from blood or contiguous spread from nearby tissue) and duration of disease (acute or chronic). Treatment involves eradicating the infection with a 4-6 week course of antimicrobial therapy targeting the likely causative pathogen, with intravenous administration for 1-2 weeks followed by oral therapy. For chronic osteomyelitis, surgical intervention is also typically required to treat bone necrosis in addition to antimicrobial therapy.

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    of 39

    Osteomyelitis

    Farmakoterapi
    Infeksi Tulang

    Wahyu Hendrarti
    Osteomyelitis
     Infeksi yang terjadi pada tulang yang disebabkan oleh
    Staphylococcus aureus dan beberapa patogen lainnya
    yang dapat bersifat Akut dan Kronis.
     Tanda dan gejala osteomyelitis: Nyeri lokal dan
    beberapa keadaan yg berefek pada tulang [inflamasi,
    erythema, edema, dan keterbatasan dalam bergerak].
    Pasien acute hematogenous osteomyelitis biasa juga
    disertai demam, panas-dingin, dan malaise.
     The gold standard for diagnosis: bone biopsy dengan
    mengisolasi microorganism(s) dari kultur dan melihat
    keberadaan sel-sel inflamasi dan osteonecrosis pada uji
    histologi.
    Klasifikasi Osteomyelitis
     Osteomyelitis paling sering diklasifikasikan berdasarkan:
    [1] Rute Infeksi [route of infection]
    [2] Lama penyakit [duration of disease]

    1
    Menyebar a
    dari aliran b
    darah ke Menyebar
    tulang dari
    jaringan
    terdekat

    FIGURE 78–1. Classification by Route of Infection .


    PATHOGENESIS
    OF Osteomyelitis

    1
    Route of
    Infection

    Jaringan yang
    nekrotik dan
    terisolasi
    Osteomyelitis is most often classified by

    2
    1
    2
    Duration of
    Disease

    2
    Osteomyelitis
     The treatment goals for acute and
    chronic osteomyelitis are to:
    1) eradicate the infection and
    2) prevent recurrence.
     Therefore, in chronic osteomyelitis, a
    common treatment goal for many
    patients is to prevent complications
    such as amputation.
    Osteomyelitis
     Treatment of osteomyelitis is dependent
    on the extent of bone necrosis.
    1. For acute osteomyelitis with
    minimal bone destruction, an
    extended course of antimicrobial
    therapy should effectively treat the
    infection;
    2. however, in chronic osteomyelitis
    surgical intervention is also typically
    required.
    Osteomyelitis
     Empiric antimicrobial therapy should target
    likely causative pathogen(s) based on patient-
    specific risk factors and route of infection.
     The total duration of antimicrobial therapy is
    typically 4 to 6 weeks. Therapy is often
    administered intravenously for 1 or 2 weeks and
    then switched to the oral route.
     Patients should be monitored for clinical
    response, development of adverse drug reactions,
    and potential drug-drug interactions.
    TABLE 78–1. Empiric
    Antimicrobial Therapy for
    Osteomyelitis

    Ingat
    Obatnya
    !!!
    TABLE 78–1. Empiric Antimicrobial Therapy for Osteomyelitis

    Ingat
    Obatnya
    !!!
    TABLE 78–1. Empiric Antimicrobial Therapy for Osteomyelitis

    elderly
    TABLE 78–1. Empiric Antimicrobial Therapy for
    Osteomyelitis
    Methicillin Sensitive
    Staphylococcus aureus
    Methicillin Resistant
    Staphylococcus aureus
    Belum pernah dilaporkan
    interaksi obatnya
    Belum pernah dilaporkan interaksi obatnya
    Sumber
    Terima
    Kasih
    Wahyu Hendrarti

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