01 Drug File MHN
01 Drug File MHN
01 Drug File MHN
SESSION 2019-2020
PSYCHIATRIC NURSING
DRUG BOOK
PSYCHOTROPIC DRUGS
TRYHEXIPHENIDYL
TRYHEXIPHENIDYL
MAOI
MAOISS
LONG ACTING VERY SHORT ACTING
LITHIUM
DIPHENILBUTYLE
DIPHENILBUTYLE PIPERIDINES
PIPERIDINES SHORT ACTING
SHORT ACTING
SODIUM CARBAMAZEPINE
VALPROATE
DIBENZOXAZEPINES
ATYPICAL
ATYPICAL ANTIPSYCHOTICS
ANTIPSYCHOTICS
CLASSIFICATION OF ANTIPSYCHOTICS
A. B. C. D. E. F. G.
Benzisoxazole Butyrophenones Thioxanthenes Dibenzoxazepine Dihydroindolone Dibenzodiazepine
Phenothiazines
1.Aliphatics
a. Chlorpromazi
ne -Risperidone -Droperidol (Inapsine) -Chlorprothixene -Loxapine (Loxitane) -Molindoe (Moban) -Clozapine (Clozaril)
(Thorazine)
(Risperdal) (Taractan)
b. Promazine
(Sparine) -Haloperidol (Haldol)
c. Triflupromaz
-Thiothixene
ine (Vesprin)
(Navane)
2.Piperidines
a. Mesoridazine
(Serentil)
b. Thioridazine
(Mellaril)
3.Piperazines
a. Fluphenazine
(Prolixin,
Permitil)
b. Perphenazine
(Trilafon)
c. Trifluoperazi
ne (Stelazine)
CLASSIFICATION OF ANTIDEPRESSANTS
Benzodiazepines Barbiturates Nonbenzodiaze Quinazoli Acetylinic Piperidinedio Chloral Azaspirode Historical anxiolytics
pines, ne alcohol ne derivatives derivative canediones
nonbarbiturate s
propanediols
-Alprazolam (Xanax) -Amobarbital -Meprobramate - Ethchlorvy -Glutethimide -Chloral -Buspirone -Ethanol (generic)
Chlordiazepoxide (Amytal) (Equanil, Methaqual nol (Doriden) hydrate (BuSpar) -Ethchlorvynol
(Librium) Miltown) one (Placidyl) (Noctec) (Placidyl)
-Clorazepate -Butabarbital (Quaalude -Methyprylon -Chloral hydrate
(Tranxene) (Butisol) -Tybamate ) (Noludar) -Chloral (generic)
-Diazepam (Valium) (Solacen) betaine -Paraldehyde (generic)
-Estazolam (ProSom) Pentobarbital (Beta- -Meprobamate(Equanil,
-Flurazepam (Nembutal) Chlor) Miltown)
(Dalmane) -Tybamate(Tybatran,
-Halazepam Phenobarbita -Triclofos Solacen)
(Paxipam) l (Luminal) (Triclos) -Secobarbital (Seconal)
-Lorazepam (Ativan) -Glutethimide (Doriden)
-Oxazepam (Serax) -Secobarbital -Methyprylon (Noludar)
-Prazepam (Centrax) (Seconal) -Methaqualone
-Temazepam (Quaalude, Sopor)
(Restoril) -Hydroxyzine(Atarax,
-Triazolam (Halcion) Vistaril)
-Promethazine
(Phenergan)
Antimanic agents and mood stabilizers Alternative antimanic agents and mood stabilizers
1. Amantadine (Symmetrel)
1. Benztropine (Cogentin) 1.Diphenhydramine (Benadryl) 2. Benzodiazepines (Lorazepam,
2. Trihexyphenidyl (Artane) Diazepam, and Clonazepam)
3. Procyclidine (Kemadrin) 3. Propranolol (Inderal)
4. Biperiden (Akineton) 4. Clonidine (Catapres)
5. Nifedipine (Procardia)
6. Verapamil (Calan)
7. Dantrolene (Dantrium)
ANTIPSYCHOTIC DRUGS
DEFINITION:-
Antipsychotics are those psychotropic drugs, which are used for the treatment of
psychotic symptoms.
These are also known as neuroleptics as they produce neurological side-effects, major
tranquilizers, D2-receptor blockers and anti-schizophrenic drugs.
Classification of antipsychotic drugs:-
Phenothiazines:-
Chlorpromazine
Triflupromazine
Thioridazine
Trifluoperazine
Fluphenazine decanoate
Thioxanthenes:-
Flupenthizole
Atypical antipsychotics:-
Clozapine
Resperidone
Ziprasidone
Reserpine
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
NO (mg/da OF ACTION S DRUG
. y) REACTION
1. Heloperdole 0.5-5 Oral Block post Schizophrenia, Angle closure Hypotension, Instruct the patient to:-
synaptic mania, glaucoma, Dizziness, = sips of water frequently
Trade name:- 5-100 IM/IV dopamine Depression with CNS depression, Syncope, = fiber diet,
Serenace, mg/ml receptors, psychotic Myelosuppression, Dry mouth, = move slowly,
Triperidol, Interrupts symptoms, Parkinson disease, Blurred
Haldol nerve impulses Delirium, Severe cardiac or vision, Observe the pt. for
movement, Dementia, hepatic disease. Lethargy, irregular movement.
increase Tourette’s Constipation, Take all seizures
turnover of syndrome, Nasal precautions.
dopamine. Huntington’s congestion, Avoid driving.
disease. Urine To use sunscreen
retention, measures.
EPS- Teach about drug.d
akasthesia, Monitor TLC, DLC.
Acute
dystonia,
Nausea
vomiting,
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
o. y) REACTION
2. Chlorpromazine 300- Oral D2 receptore Delirium, Circulatory disorders, Weight gain, Instruct the patient to:-
1500 block in the Dementia, CNS depression, Sedation, = sips of water frequently
Megatil mesolimbic Delirium Coma, Acute = fiber diet,
Largactil 50-100 IV/ IM and tremens, Drug intoxication, movement = move slowly,
Tranchlor mesofrontal Schizophrenia, Bone marrow disorders,
system. Paranoid suppression, Parkinsonism Observe the pt. for
disorders, Phaeochromocytoma , irregular movement.
Alpha Mania, , Hypotension Take all seizures
adrenergic Major Hepatic failure, with precautions.
blocker. depression with Active liver disease, dizziness. Avoid driving.
psychotic Jaundice, To use sunscreen
symptoms, Agranulocytosis, measures.
Attention deficit Epilepsy, Teach about drug.d
hyperactivity Parkinson disease, Monitor TLC, DLC.
disorders, Myasthenia gravis,
Autism, Hypoparathyroidism,
Enuresis, BPH.
Conduct
disorders,
Anorexia
nervosa,
Intractable OCD,
Huntington’s
chorea,
Hiccough,
Nausea
vomiting,
Tic disorder,
Eclampsia,
Heat stroke,
Tetanus.
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
O. y) REACTION
3. Fluphenazine 1-30 Oral Dopamine Schizophrenia, Angle closure Hypotension, - Assess pt.
Hydrochloride neurotransmet Mania with glaucoma, Dizziness, behavior &
er antagonist psychotic Myelosuppression, Syncope, emotional status,
by blocking symptoms, Severe cardiac and Dry mouth, - Avoid skin
Trade nazme:- post synaptic Organinc brain hepatic disease, Blurred contact,
Permitil, 25mg/ IM/IV dopaminergixc syndrome, Severe hypertension vision, - Monitor vital
Prolixin, ml 2-4 receptors in Chronic or hypotension, Lethargy, signs,
Decanoate, wk the brain. schizophrenia. Constipation, - Observe EPS
Nasal symptoms,
congestion, - Pt. shd be avoid
Urine riding and driving.
retention, - Teach about drug.
EPS- - Administered
akasthesia, large injection in
Acute deep muscle.
dystonia,
Nausea
vomiting,
Antidepressants:-
Antidepressants are those drugs, which are used for the treatment of depressive illness.
Classification:- TCAs
SSRIS
Dopaminergic antidepressants
Atypical antidepressants
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
O. y) REACTION
4. Imipramine 75-300 oral Blocking the Depressive Cardiac disorders, Dry mouth, . perform CBC, blood
reuptake or episode, acute recovery constipation, serum chemistry test.
Trade name:- norepinephrine depression with period after MI, use urinary . ECG
Antidep, (NE) and psychotic within 14 days of retention, Avoid drug younger then 6
Topranel serotonin (5- symptoms, MAOIs mydriasis, years.
HT) at the dysthymia, orthostatic Avoid large dose.
nerve terminal, reactive hypotension, Give oral fluid.
thus increasing depression, impotence, Monitor vital signs.
NE & 5-HT level secondary delirium, Monitor daily living
of receptor depression due blurred activity of patients.
site. to vision. Monitor intake output of
Regulation of hypothyroidism, Sedation, pt.
beta cushing’s tremers, Do not crush the coated
adrenergic syndrome , withdrawal tablets.
receptors. abnormal grif symptoms, Avoid driving and riding to
reaction. seizures. the pt.
Childhood Tachycardia
psychiatric Arrhythemias
disorders ,
enuresis, Direct
phobia, myocardial
seppression depression.
anxiety, Agranulocyto
somnambulism, sis,
night terrors. Jaundice,
Aggression, post Wt gain,
traumatic stress tiredness,
disorder, drowsiness,
depesonalizatio insomnia,
n. acute organic
syndrome
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
O. y) REACTION
5. Clomipramine 150- Oral Reuptake of NR OCD Cardiac disorders, Dry mouth, perform CBC, blood serum
250 & serotonin. Depression acute recovery constipation, chemistry test.
Trade name:- Panic disorders period after MI, use urinary . ECG
Anafranil Phobias within 14 days of retention, Avoid drug younger then 6
Pain disorders MAOIs mydriasis, years.
Pregnancy orthostatic Avoid large dose.
Hepatic failure hypotension, Give oral fluid.
Renal failure impotence, Monitor vital signs.
delirium, Monitor daily living
blurred activity of patients.
vision. Monitor intake output of
Sedation, pt.
tremers, Do not crush the coated
withdrawal tablets.
symptoms, Avoid driving and riding to
seizures. the pt.
Tachycardia
Arrhythemias
,
Direct
myocardial
depression.
Agranulocyto
sis,
Jaundice,
Wt gain,
tiredness,
drowsiness,
insomnia,
acute organic
syndrome
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
O. y) REACTION
6. Amitryptiline 30-100 Oral Blocking the Depression Cardiac disorders, Dry mouth, perform CBC, blood serum
Hydrochloride reuptake or Bulimia nervosa, Use within 14 days of constipation, chemistry test.
norepinephrine Post MAOI. urinary . ECG
Trade name:- (NE) and therapeutic retention, Avoid drug younger then 6
Elavil, serotonin (5- neuralgia, mydriasis, years.
Endep, HT) at the orthostatic Avoid large dose.
Levate. nerve terminal, hypotension, Give oral fluid.
thus increasing impotence, Monitor vital signs.
NE & 5-HT level delirium, Monitor daily living
of receptor blurred activity of patients.
site. vision. Monitor intake output of
Regulation of Sedation, pt.
beta tremers, Do not crush the coated
adrenergic withdrawal tablets.
receptors. symptoms, Avoid driving and riding to
seizures. the pt.
Tachycardia
Arrhythemias
,
Direct
myocardial
depression.
Agranulocyto
sis,
Jaundice,
Wt gain,
tiredness,
drowsiness,
insomnia,
acute organic
syndrome
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
O. y) REACTION
7. Flupoxetine 20-80 Oral Selective Depression Hypersensitivity, Sedation, perform CBC, blood serum
Hydrochloride inhibit OCD, Severe hepatic renal tremers, chemistry test.
serotonin Panic disorders, impairment, withdrawal . ECG
Trade name:- reuptake in Anxiety Pregnancy, symptoms, Avoid drug younger then 6
Auscap CNS , disorders, Lactation, seizures. years.
Fluohexal enhancing Bulimia nervosa, History of seizures. Tachycardia Avoid large dose.
Lovan serotonergic Premenstrual Arrhythemias Give oral fluid.
Prozac function. dysphoric , Monitor vital signs.
disorders, Direct Monitor daily living
Treatment of myocardial activity of patients.
hot flashes. depression. Monitor intake output of
Agranulocyto pt.
sis, Do not crush the coated
Jaundice, tablets.
Wt gain, Avoid driving and riding to
tiredness, the pt.
drowsiness,
insomnia,
Sexual
dysfunction,
Dyspepsia,
Seixures.
ANXIOLYTICS AND HYPNOSEDATIVES
These are also called as minor tranquilizes. Most of them belong to the benzodiazepine group of drugs.
Examples:-
Barbiturates
lorazepam
alprazolam
oxazepam
midazolam
triazolam
chlordiazepoxide
alzolam
clonazepam nitrazepam
diphenhydramine
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
O. y) REACTION
8. Sertraline 50-200 Oral Selective Depression Hypersensitivity, Sedation, perform CBC, blood serum
Hydrochloride inhibit OCD, Severe hepatic renal tremers, chemistry test.
serotonin Panic disorders, impairment, withdrawal . ECG
Trade name:- reuptake in Anxiety Pregnancy, symptoms, Avoid drug younger then 6
zoloft CNS , disorders, Lactation, seizures. years.
enhancing Bulimia nervosa, History of seizures. Tachycardia Avoid large dose.
serotonergic Premenstrual Arrhythemias Give oral fluid.
function. dysphoric , Monitor vital signs.
disorders, Direct Monitor daily living
Treatment of myocardial activity of patients.
hot flashes. depression. Monitor intake output of
Agranulocyto pt.
sis, Do not crush the coated
Jaundice, tablets.
Wt gain, Avoid driving and riding to
tiredness, the pt.
drowsiness,
insomnia,
Sexual
dysfunction,
Dyspepsia,
Seixures.
S. NAME OF DOSE ROUT MECHANISM INDICATIONS CONTRAINDICA ADVERSE DRUG NURSES’ RESPONSIBILITY
N DRUG (mg/day) E OF ACTION TIONS REACTION
O.
9. Alprazolamn 0.25-0.5 Oral Increase the Anxiety Acute alcohol Ataxia, Health education:-
inhibiting disorders, intoxication, Light headache, Not consume other CNS
Trade name:- 2-3 times effect of Panic Acute angle Transient mild depressants (including alcohol).
Alprax, GABA. disorders, closure somnolence, ● Not take nonprescription
Apo-alpraz, Premenstrual glaucoma, Slurred speech, medication without approval from
Novo- syndrome, Myasthenia Confusion, the physician.
alprazol. Insomnia, gravis, Depression, ● Rise slowly from sitting or lying
Irritable bowel Severe COPD, Blurred vision, position to prevent sudden drop in
syndrome. Hypersensitivity, Constipation, blood pressure.
Pregnancy, Dry mouth, ● Immediately report symptoms
lactation. Nausea. of sore throat, fever, malaise, easy
Irritability, bruising, unusual bleeding, or
Insomnia, motor restlessness to physician.
Abdominal ● Be aware of risks of taking this
cramps, drug during pregnancy.
Confusion, ● Be aware of possible side
Coma. effects. The client should refer to
written materials furnished by
healthcare providers regarding the
correct method of self-
administration.
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
O. y) REACTION
10 Diazepam 2-10 Oral Potentiate Anxiety, Angle closure Ataxia, Health education:-
. GABA, Skeletal msl glaucoma, Light Not consume other CNS depressants
Trade name:- IM/IV relaxation, Pre-existing CNS headache, (including alcohol).
Valium, PAM, depression, Transient ● Not take nonprescription
Valpam. Alcohol Severe uncontrolled mild medication without approval from
withdrawal, pain. somnolence, the physician.
Status Slurred ● Rise slowly from sitting or lying
epilepticus, speech, position to prevent sudden drop in
Seizures, Confusion, blood pressure.
Treatment of Depression, ● Immediately report symptoms of
panic disorders, Blurred sore throat, fever, malaise, easy
Tension, vision, bruising, unusual bleeding, or motor
Headache, Constipation, restlessness to physician.
Tremors, Dry mouth, ● Be aware of risks of taking this drug
Nausea. during pregnancy.
Irritability, ● Be aware of possible side effects.
Insomnia, The client should refer to written
Abdominal materials furnished by healthcare
cramps, providers regarding the correct
Confusion, method of self-administration.
Coma.
MOOD STABILIZING DRUGS
Lithium
Carbamazepine
Sodium valproate
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
O. y) REACTION
11 Lithium 900- Oral Accelerates Acute mania, Cardiac, renal, Tremors, Assess lithium toxicity
. 2100 presynaptic Unipolar and thyroid, neurological Seizures, symptoms.
reuptake bipolar mood dysfunctions. Polyuria, Vital signs.
inhibition. disorders, Pregnancy and Nephritic Blood biochemistry and
Schizoaffective lactation. syndrome, serum level of lithium.
Destruction of disorders, Pt. of serious lithium T-wave
catecholamine. Cyclothymia, toxicity. depression.
Impulsivity and Nausea ,
Decrease post aggression, Vomiting,
synaptic Bulimia nervosa, Goiter,
serotonin Trichotilomania, Weight gain,
receptor Cluster Acneiform,
sensitivity. headache.
Lithium
Inhibites the toxicity when
release of serum
catecholamine lithium level
at the synapse. above 2.0
mEq/L
S. NAME OF DRUG DOSE ROUTE MECHANISM INDICATIONS CONTRAINDICATION ADVERSE NURSES’ RESPONSIBILITY
N (mg/da OF ACTION S DRUG
O. y) REACTION
12 Carbamazepine 600- Oral Anticonvulsant Seizures:- Drowsiness, Drowsiness, Avoid driving and riding.
. 1800 action by complex partial, Confusion, Confusion, Regular follow up.
Trade name:- decreasing GTCS, Headache, Headache, Monitor vital signs.
Tegretol synaptic Bipolar Ataxia Ataxia Blood investigation.
Mazetol, transmission in disorders, Hypertension, Hypertension
Zeptol, CNS. Acute Arrhythmias, ,
Zenretard. depression, Skin rashes, Arrhythmias,
Psychosis with Skin rashes,
epilepsy,
Borderline
personality
disorders,
Cocaine
withdrawal
symptoms.
Trigeminal
neuralgia.
BIBLIOGRAPHY
1. R SREEVANI, A GUIDE TO MENTAL HEALTH AND PSYCHIATRC NURSING, THIRF EDITION, jaypee publications Ltd. Page no. 95-105.
2. Neeraj Ahuja, a short text book of psychiatric, 7th edition, jaypee [publications. Page no.:- 213-225.
3. Sheila L. Videbeck, psychiatric mental health nursing, 5th edition, wolter kluwer & Lippincott Williams & wikins, page no. 235-268.
4. Marry C. Townsend, essentials of psychiatric mental health nursing, 5 th edition, dewis plus , page no. 330-338.
5. www.medhub.net./
6. www.psychiatric.encyclopedia./