Dyspnoea Ddx/Associated Features Body System/key Qs Acute

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DYSPNOEA

DDx/ASSOCIATED FEATURES

Body system/key qs
ACUTE Pulmonary causes:
 Pneumothorax: abrupt, sharp CP, tachypnoea, diminished breath sounds
 PE: sharp chest pain, tachypnoea, tachycardia, RFs for PE
 Asthma, bronchospasm or reactive airway disease: wheezing, trigger present
 Foreign body inhalation: sudden onset of cough or stridor in a patient without URTI or
constitutional Sx
 Pneumonia: fever, productive cough, pleuritic chest pain
 COPD exacerbation: cough, accessory muscle use or pursed lip breathing

Cardiac causes:
 AMI: substernal chest pressure which may radiate to arm/jaw, CVD RF present
 Angina or IHD: substernal chest pressure which may radiate to arm/jaw, provoked by physical
exertion, presence of CVD RFs
 Papillary muscle dysfunction/rupture: new/loud holosystolic murmur, signs of HF, recent MI
 HF (APO): crackles, S3 gallop, elevated JVP, peripheral oedema
 Arrhythmia
 Pericardial effusion or tamponade: muffled heart sounds

Other
 Anxiety disorder: situational dyspnoea accompanied by psychomotor agitation and
paraesthesia in the fingers or around the mouth
 Anaphylaxis: PMHx, medication use, swelling/facial oedema
 Metabolic acidosis: e.g. DKA

CHRONIC Pulmonary causes:


 Obstructive lung disease
 Restrictive lung disease: progressive dyspnoea in patients with known occupational exposure
of neurologic condition
 ILD: fine crackles, dry cough
 Pleural effusion: pleuritic chest pain, Hx of cancer, HF, RA, SLE or acute pneumonia
 TB: signs of infection, travel to/from TB endemic country

Cardiac causes:
 HF
 Stable angina

Other:
 Anaemia: dyspnoea on exertion progressing to dyspnoea at rest, sometimes systolic flow
murmur, syncope, fatigue, heavy periods, ↓exercise tolerance

OTHER
BODY SYSTEM DDx
 Cardiovascular:
o IHD
o CCF (+ acute exacerbation)
 infection, ischaemia/infarction, anaemia, arrhythmia, fluid overload (non-compliance to fluid
restriction), non-compliance to medications, Na+ retaining drugs e.g. (aspirin or steroids)
o Cardiac tamponade
o Aortic dissection
o Pericarditis
 Respiratory:
o PE
o Pneumothorax
o Acute asthma attack
o IECOPD
o Lung/pleural malignancy
o Pneumonia
o Diffuse lung disease
o IPF, asbestosis, sarcoidosis, drugs (e.g. methotrexate, nitrofurantoin, amiodarone, isoniazid)
o RTI
 Haematological:
o Anaemia
o Haematological (or any) malignancy
 Others:
o DKA
o Allergy/anaphylaxis
o Sepsis
o GORD
o MND/GBS/MG
o Anxiety and panic disorders
o Hyperthyroidism (triggering AF)

Investigations
 Bedside/Bloods
o FBE: Hb (anaemia), WCC (infection, leukaemia), CRP (inflammatory)
o Random blood glucose (DKA)
o Cardiac enzymes/ECG: troponin, CK (AMI)
o Sputum M/C/S (microscopy, culture, sensitivity), nasopharyngeal swab
 Blood cultures (?pneumonia)
 Imaging
o CXR (pneumonia, pneumothorax)
o CT pulmonary angiogram (PE)
o CT chest (malignancy)
o Echo (CCF)
 Other
o Pulmonary function tests (asthma, COPD, IPF)

OTHER NOTES
Well’s Score
Measures risk of PE:
 Signs and symptoms of DVT (3)
 PE is the most likely diagnosis (3)
 Tachycardia >100bpm (1.5)
 Immobilisation > 3 days of surgery in last 4 weeks (1.5)
 Previously diagnoses DVT or PE (1.5)
 Haemoptysis (1)
 Malignancy diagnosed within past 6 months (1)

Cardinal Features of Dyspnoea


Feature Note/Significance
Site -
Quality Are you having trouble getting air in or out? Wheeze/tightness?
Severity Are you short of breath normally/at rest?
Impact on daily activities?
How far can you walk?
How many flights of steps?
Orthopnoea/PND? How many pillows? CHF severity, OSA
Time course Duration? Onset/offset? Fluctuations/progression? Past episodes?
Context Lung/heart problems? (Asthma, COPD, HF)
Sick contacts/travel? (Infection, TB endemic countries)
Chest trauma? (Pneumothorax)
Surgery/immobility/flight/clotting disorders? (DVT/PE)
Swallowed down wrong way? (Obstruction/aspiration pneumonia)
Diabetes? (Silent MI)
Exposure to asbestos or harsh chemicals? (Asbestosis)
Relieving Puffer?
factors Rest?
Aggravating Lying flat? Exertion?
factors Asthma triggers?
Associated  AMI: central crushing CP, sweaty, N/V, palpitations, syncope, intermittent claudication
features  CCF: chest pain, peripheral oedema, orthopnoea, PND
 Aortic dissection: dizzy/lightheaded, CT disorders

 PE/DVT: pleuritic chest pain, unilateral leg swelling/tenderness (RFs of DVT), clotting Hx
 Pneumothorax: young skinny male, sudden onset
 Pneumonia/malignancy: cough, sputum, haemoptysis, fevers, night sweats, fatigue
 Asthma/COPD: wheeze, pursed-lip breathing, fever (if infective)
 RTI: coryzal symptoms (sore throat, runny nose, cough etc.)

 Anaemia: fatigue, dizziness upon standing, palpitations, syncope


 GORD: reflux
 Stress and anxiety
PMHx CVD (and RFs)
Coagulopathies, OCP (PE)

Asthma/COPD Hx
Vaccinations (Infection/COPD exacerbation)
Smoking (COPD)

Cancer
GORD
Allergies/atopy (Anaphylaxis)
OTHER/RED  Severe chest pain – AMI, PE Clinical pearls:
FLAGS/CLINICL  Haemoptysis – lung malignancy, PE Pneumonia and normal CXR? → LATERAL
A PEARLS  Night sweats – TB CXR b.c can’t see behind the heart
 Splenomegaly – leukaemia
 Fever, tachycardia, hypotension – sepsis Bilateral symmetrical findings: CHF/APO
 Hypotension and rash – sepsis
 Weight loss – malignancy
EXAMINATION Cardiovascular examination
Respiratory examination
Haematological examination

Respiratory exam findings

 Percussion note
o Dull – solid organ or fluid
o Resonant – normal aerated lung
o Hyper-resonant – air (hyperinflated lung or air in pleural space)
 Breath sounds
o Quality
 Normal/vesicular (inspiratory > expiratory without interposed gap)
 Bronchial breathing (prolonged during expiration, harsher – filled alveoli)
o Intensity
 ↓/muffled breath sounds (pleural effusion, pneumonia, COPD, pneumothorax, mass)
o Added sounds
 Polyphonic wheeze (EXPIRATORY, asthma, COPD – airway narrowing)
 Monophonic wheeze (EXPIRATORY, SOL - fixed obstruction)
 Stridor (INSPIRATORY, upper airway obstruction)
 Crackles (opening of small airways)
 Early inspiratory – COPD
 Later/pan-inspiratory – alveolar disease
 Fine crackles/Velcro – IPF
 Medium crackles – LV failure
 Coarse crackles – bronchiectasis (retained secretions)
 Pleural rub (pleuritis - inflamed pleura rub against each other, 2ndary to pneumonia, infarct)
 Vocal resonance/vocal fremitus
o ↑vocal resonance = ↑ tissue density
o ↓vocal resonance = ↑air present/fluid in pleural space

Condition Percussion note Breath sounds Vocal resonance


Pneumonia/APO Dull Bronchial breath sounds ↑
Pleural effusion Dull ↓breath sounds ↓
Pneumothorax Hyperresonant ↓breath sounds ↓
COPD Hyperresonant Polyphonic wheeze, early ↓
inspiratory crackles

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