Dyspnoea Ddx/Associated Features Body System/key Qs Acute
Dyspnoea Ddx/Associated Features Body System/key Qs Acute
Dyspnoea Ddx/Associated Features Body System/key Qs Acute
DDx/ASSOCIATED FEATURES
Body system/key qs
ACUTE Pulmonary causes:
Pneumothorax: abrupt, sharp CP, tachypnoea, diminished breath sounds
PE: sharp chest pain, tachypnoea, tachycardia, RFs for PE
Asthma, bronchospasm or reactive airway disease: wheezing, trigger present
Foreign body inhalation: sudden onset of cough or stridor in a patient without URTI or
constitutional Sx
Pneumonia: fever, productive cough, pleuritic chest pain
COPD exacerbation: cough, accessory muscle use or pursed lip breathing
Cardiac causes:
AMI: substernal chest pressure which may radiate to arm/jaw, CVD RF present
Angina or IHD: substernal chest pressure which may radiate to arm/jaw, provoked by physical
exertion, presence of CVD RFs
Papillary muscle dysfunction/rupture: new/loud holosystolic murmur, signs of HF, recent MI
HF (APO): crackles, S3 gallop, elevated JVP, peripheral oedema
Arrhythmia
Pericardial effusion or tamponade: muffled heart sounds
Other
Anxiety disorder: situational dyspnoea accompanied by psychomotor agitation and
paraesthesia in the fingers or around the mouth
Anaphylaxis: PMHx, medication use, swelling/facial oedema
Metabolic acidosis: e.g. DKA
Cardiac causes:
HF
Stable angina
Other:
Anaemia: dyspnoea on exertion progressing to dyspnoea at rest, sometimes systolic flow
murmur, syncope, fatigue, heavy periods, ↓exercise tolerance
OTHER
BODY SYSTEM DDx
Cardiovascular:
o IHD
o CCF (+ acute exacerbation)
infection, ischaemia/infarction, anaemia, arrhythmia, fluid overload (non-compliance to fluid
restriction), non-compliance to medications, Na+ retaining drugs e.g. (aspirin or steroids)
o Cardiac tamponade
o Aortic dissection
o Pericarditis
Respiratory:
o PE
o Pneumothorax
o Acute asthma attack
o IECOPD
o Lung/pleural malignancy
o Pneumonia
o Diffuse lung disease
o IPF, asbestosis, sarcoidosis, drugs (e.g. methotrexate, nitrofurantoin, amiodarone, isoniazid)
o RTI
Haematological:
o Anaemia
o Haematological (or any) malignancy
Others:
o DKA
o Allergy/anaphylaxis
o Sepsis
o GORD
o MND/GBS/MG
o Anxiety and panic disorders
o Hyperthyroidism (triggering AF)
Investigations
Bedside/Bloods
o FBE: Hb (anaemia), WCC (infection, leukaemia), CRP (inflammatory)
o Random blood glucose (DKA)
o Cardiac enzymes/ECG: troponin, CK (AMI)
o Sputum M/C/S (microscopy, culture, sensitivity), nasopharyngeal swab
Blood cultures (?pneumonia)
Imaging
o CXR (pneumonia, pneumothorax)
o CT pulmonary angiogram (PE)
o CT chest (malignancy)
o Echo (CCF)
Other
o Pulmonary function tests (asthma, COPD, IPF)
OTHER NOTES
Well’s Score
Measures risk of PE:
Signs and symptoms of DVT (3)
PE is the most likely diagnosis (3)
Tachycardia >100bpm (1.5)
Immobilisation > 3 days of surgery in last 4 weeks (1.5)
Previously diagnoses DVT or PE (1.5)
Haemoptysis (1)
Malignancy diagnosed within past 6 months (1)
PE/DVT: pleuritic chest pain, unilateral leg swelling/tenderness (RFs of DVT), clotting Hx
Pneumothorax: young skinny male, sudden onset
Pneumonia/malignancy: cough, sputum, haemoptysis, fevers, night sweats, fatigue
Asthma/COPD: wheeze, pursed-lip breathing, fever (if infective)
RTI: coryzal symptoms (sore throat, runny nose, cough etc.)
Asthma/COPD Hx
Vaccinations (Infection/COPD exacerbation)
Smoking (COPD)
Cancer
GORD
Allergies/atopy (Anaphylaxis)
OTHER/RED Severe chest pain – AMI, PE Clinical pearls:
FLAGS/CLINICL Haemoptysis – lung malignancy, PE Pneumonia and normal CXR? → LATERAL
A PEARLS Night sweats – TB CXR b.c can’t see behind the heart
Splenomegaly – leukaemia
Fever, tachycardia, hypotension – sepsis Bilateral symmetrical findings: CHF/APO
Hypotension and rash – sepsis
Weight loss – malignancy
EXAMINATION Cardiovascular examination
Respiratory examination
Haematological examination
Percussion note
o Dull – solid organ or fluid
o Resonant – normal aerated lung
o Hyper-resonant – air (hyperinflated lung or air in pleural space)
Breath sounds
o Quality
Normal/vesicular (inspiratory > expiratory without interposed gap)
Bronchial breathing (prolonged during expiration, harsher – filled alveoli)
o Intensity
↓/muffled breath sounds (pleural effusion, pneumonia, COPD, pneumothorax, mass)
o Added sounds
Polyphonic wheeze (EXPIRATORY, asthma, COPD – airway narrowing)
Monophonic wheeze (EXPIRATORY, SOL - fixed obstruction)
Stridor (INSPIRATORY, upper airway obstruction)
Crackles (opening of small airways)
Early inspiratory – COPD
Later/pan-inspiratory – alveolar disease
Fine crackles/Velcro – IPF
Medium crackles – LV failure
Coarse crackles – bronchiectasis (retained secretions)
Pleural rub (pleuritis - inflamed pleura rub against each other, 2ndary to pneumonia, infarct)
Vocal resonance/vocal fremitus
o ↑vocal resonance = ↑ tissue density
o ↓vocal resonance = ↑air present/fluid in pleural space