Reading Comprehension 4 Level 12

Directions: Read the passage. Then answer the questions below.

Autism spectrum disorders (ASD) are a range of psychological conditions characterized by

abnormalities in social interaction, behavior, interests, and communication. The five forms

of ASD include classical autism, Asperger syndrome, Pervasive Developmental Disorder,

Rett syndrome, and Childhood Disintegrative Disorder. Although the number of reported

cases of ASD has experienced a dramatic increase in the past 25 years, the majority of

doctors agree that this increase is due to changes in diagnostic practices and advances in

the understanding of psychiatric health. While there is no general consensus among

medical professionals about the underlying causes of ASD, theories range from genetic

inheritance to environmental factors. One of the most controversial theories to have

emerged in recent times is the hypothesis that ASD could be caused by the MMR vaccine,

which is an immunization against measles, mumps, and rubella that was first developed in

the 1960’s. The vaccine is a mixture of three live viruses and is administered via injection

to children when they are one year old. By the late 1990’s, this vaccination had led to the

near-eradication of measles in countries that employed widespread inoculation. However,

a combination of spurious scientific data and alarmist media attention led to an entirely

preventable resurgence in measles cases in the early 21st century.

The first claims of a connection between the MMR vaccine and autism were made in 1998,

when an article in The Lancet, a respected British medical journal, reported on eight cases

of autism that could possibly be traced back to the administration of an MMR vaccine. The

parents of the children in this study contended that the symptoms of autism in their

children developed within days of vaccination. During a press conference, Andrew

Wakefield, one of the authors of the article, called on British doctors to stop giving
combined MMR vaccines, instead advocating for individual inoculations against measles,

mumps, and rubella.

Following the publication of this article, Wakefield published several follow-up papers that

further questioned the safety of the MMR vaccine. An onslaught of media coverage then

began. Parents appeared on television sharing anecdotal evidence linking their child’s

inoculation to the onset of ASD. The popular press quickly seized upon this story; in 2002,

over 1200 articles were written about the link between MMR vaccines and ASD. Less than

30% of these articles mentioned that an overwhelming amount of scientific evidence

suggested that these vaccinations were completely safe.

Since the initial panic, fears that MMR vaccines cause ASD have generally subsided. A

survey completed in 2004 showed that only 2% of people in the United Kingdom thought

that there was a legitimate link between MMR vaccines and ASD. Fears were most likely

allayed when, in 2004, an investigative reporter discovered that Andrew Wakefield had

received a large sum of money from lawyers seeking evidence to use in cases against

vaccine manufacturers. It was then discovered that Wakefield had applied for patents on

an alternate MMR vaccine. These severe conflicts of interest damaged the credibility of

Wakefield’s study beyond repair. In 2010, Wakefield was tried by Britain’s General Medical

Council under allegations that he had falsified data and manipulated test results. The

Council found that Wakefield had acted “dishonestly and irresponsibly,” and consequently

The Lancet officially retracted Wakefield’s 1998 article.

The anti-MMR vaccine panic that arose immediately after Wakefield’s article was

published had a significant negative effect on the health of thousands of children. Once the

controversy began, the number of parents in the United Kingdom who inoculated their

children with the MMR vaccine experienced a sharp decline. Not surprisingly, the number

of reported cases of measles increased; while there were only 56 confirmed cases of

measles in the UK in 1998; in 2008 there were over 1300. Between 2002 and 2008, there
were outbreaks of measles throughout Europe and North America. These outbreaks cost

millions of dollars in health care and resulted in the deaths of dozens of children and adults

with compromised immune systems.

Who is to blame for these deaths? It is easy to hold Andrew Wakefield accountable, but

the media must also bear some of the responsibility. The media’s appetite for a

sensational medical story overshadowed the fact that there was very little scientific

evidence behind Wakefield’s claim. Although Wakefield is certainly not the first person to

publish fraudulent scientific findings in a respected medical journal, the magnitude of this

event was anomalous, as most medical hoaxes are discredited before they can reach the

popular media. While The Lancet should not have published Wakefield’s article without

checking it thoroughly, the popular media should not have blown the study out of

proportion without fully considering the consequences.

Questions
1) The primary purpose of the passage is to

A. warn parents about the dangers of not vaccinating their children against measles
B. criticize The Lancet for publishing Wakefield’s article without vetting it more thoroughly
C. provide an overview of the MMR vaccine controversy, including its consequences and
responsible parties
D. inform readers about the history of the MMR vaccine, especially in the U.S. and the UK
E. blame parents who believed alarmist media reports for the measles outbreaks

2) As used in paragraph 1, which is the best antonym for spurious?

A. reassuring
B. safe
C. clear
D. necessary
E. legitimate

3) Which of the following statements most accurately summarizes the author’s explanation for the
increase in reported cases of ASD over the past 25 years?

A. Over the past 25 years, parents have been more likely to have their young children inoculated
against MMR.
B. Since the results of Wakefield’s study were published, parents have been less likely to have their
young children inoculated against MMR.
C. In the past 25 years, doctors have developed a better understanding of genetics, which is
thought to be the leading factor in whether or not a child will develop ASD.
D. The drastic changes in our environment that have occurred over the past 25 years have most
significantly contributed to an increase in cases of ASD.
E. The increase in reported cases of ASD is mainly the result of an increased understanding of how
to recognize ASD.

4) Which of the following pieces of evidence from paragraphs 2 and 3 support(s) the author’s claim
that popular media is partially responsible for creating unnecessary panic?

I. “An article published in The Lancet, a respected British medical journal, reported on eight cases
of autism that could possibly be traced back to the administration of an MMR vaccine.”
II. “In 2002, over 1200 articles were written about the link between MMR vaccines and ASD. Less
than 30% of these articles mentioned that an overwhelming amount of scientific evidence
suggested that these vaccinations were completely safe.”
III. “Parents appeared on television sharing anecdotal evidence regarding the links between their
child’s inoculation and the onset of ASD.”

A. l only
B. II only
C. I and II only
D. II and III only
E. I, II, and III

5) In paragraph 4, the author cites all of the following as ways that Wakefield’s study was
discredited except

A. investigators discovered that the parents of children in Wakefield’s study were litigants in a
lawsuit against the pharmaceutical company that made the MMR vaccine
B. The Lancet eventually retracted Wakefield’s original article
C. it was discovered that Wakefield accepted money from lawyers who were filing a suit against the
pharmaceutical companies responsible for making the MMR vaccine
D. an investigation into Wakefield’s research found that he had falsified data in his initial study
E. Wakefield himself had apparently been working on an alternate vaccine to compete with MMR

6) Based on its use in paragraph 4, it can be inferred that the phrase “conflicts of interest” means
situations in which people

A. unethically accept large sums of money

7) As used in paragraph 6, which is the best synonym for anomalous?

A. timely
B. calamitous
C. abnormal
D. unacceptable
E. coincidental
8) Which of the following pieces of evidence, if true, would best strengthen the author’s argument in
paragraph 6?

A. An estimated 1.4 million measles deaths are averted each year due to MMR immunization.
B. 90% of parents in the UK who decided not to immunize their children against measles reported
that they did so against their doctors’ wishes.
C. Measles outbreaks in Japan can be traced back to Japanese exchange students who were
studying in the UK.
D. In the United States, over 60% of children who are not immunized against MMR never exhibit
any symptoms of the measles.
E. Andrew Wakefield sued the investigative reporter who accused him of fraud.