Infectious Disease Outbreak RRM PDF

MOH / K / EPI / 39.
03 (HB)
INFECTIOUS DISEASES OUTBREAK
RAPID RESPONSE
MANUAL
Coordinated by:
Disease Control Division

MINISTRY OF HEALTH MALAYSIA
1st Edition
June 2003
1
EDITORIAL BOARD
ADVISOR: Dr. Shafie Ooyub

Director of Disease Control
Disease Control Division, MOH.
MEMBERS: Prof. Dr. Victor Lim

Director of Infectious Disease Research Centre,
Institute for Medical Research (IMR).
Dr. Lee Cheow Pheng

Public Health Specialist,
Dr. Cheng Hoei Hon

Deputy Director of Disease Control (Surveillance),
Dr. Zainudin Abdul Wahab

Principal Assistant Director
Communicable Disease Surveillance Section, MOH.
Dr. K. Devan
Communicable Disease Control Section, MOH.
Dr. Amal Nasir Mustafa

Epidemiologist
Epidemiology and Biostatistic Division, IMR.
Dr. Fadzilah Kamaludin

Datin Dr. Salbiah Hj Nawi

Pathologist
National Public Health Laboratory.
Dr. Leela Anthony

Epidemiology Officer
National Public Health Laboratory.
Dr. Rohani Jahis

Assistant Director,
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CONTENT PAGE
1.0 Introduction. 7
2.0 Outbreak Preparedness 9
3.0 Surveillance and Alert 28
4.0 Outbreak Management. 40
5.0 Risk Communication 49
6.0 Occupational Health And Safety For Health Care Workers 49
7.0 Criteria For Recommending The Invoking Of ‘Arahan’ 20 49

National Security Council
8.0 Training 51
9.0 Funding 53
10.0 Reference 54
11.0 Appendices 55
12.0 Acknowledgement 73
LIST OF APPENDICES PAGE
1. List of notifiable communicable diseases 55
2. Microbiological services available at the Reference Laboratories. 58
3. Directory Of Laboratory Services 59
4. Contact number of reference laboratories 66
5. Standard operating procedure for setting up of an operations room 67
6. Protocols and guidelines available at ministry of health 70
7. Format for writing a final report on an outbreak/epidemic 71
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LIST OF TABLES PAGE
1. Existing and future regional reference laboratories 17
2. International laboratory resources. 19
3. Stockpiles of critical materials 24
4. List of Personal Protective Equipment 27
5. List of zoonotic diseases with public health importance 33
6. Proxy indicators of existing surveillance system 39
LIST OF FIGURES PAGE
1. Surveillance mechanism in Malaysia 30
2. Laboratory based surveillance flow chart 31
3. Syndromic surveillance flow chart 32
4. Flow of surveillance data and information dissemination 36
5. Outbreak management framework 40
6. Outbreak management flow chart 41
7. Line of communication (outbreak information and support request) 43
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FOREWORD
Many new infectious diseases have been identified in the world in the
last few decades. Over the last 2 decades alone 30 new infectious
diseases have been described. The Severe Acute Respiratory
Syndrome (SARS) is the latest of such diseases. The SARS outbreak
demonstrated most clearly the need for preparedness and rapid
response. Any lack of preparedness and delay in response can lead to
catastrophic impacts on human lives and the economy.
The Director General of World Health Organisation (WHO), Dr.

Brundtland had stressed that crucial hours lost in early days of a
disease outbreak can mean the difference between a handful of cases
and a major epidemic. Rapid detection, identification and response are
key to saving lives and controlling infectious disease; whether caused
by an incident of bioterrorism or naturally occurring. Strategies to
enhance preparedness against both of these threats depend on an
effective and efficient health infrastructure.
As detection and response to infectious disease outbreaks require

multi-sectoral, multi-agency and multidisciplinary cooperation and
collaboration, this document was prepared with contributions from a
multidisciplinary group of health professionals at a workshop held in
September 2002. It is hoped that this document will be of practical
use; and through the same spirit of cooperation and collaboration,
infectious disease outbreaks will be overcome in a more coordinated
and well organised manner.
TAN SRI DATU DR MOHAMAD TAHA BIN ARIF

DIRECTOR GENERAL OF HEALTH
16 June 2003
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ABBREVIATION
APW Alkaline peptone water CSF Cerebro-spinal fluid
CDSS Communicable Disease DCD Disease Control Division

Surveillance Section
FOMEMA Foreign Workers Medical GIS Geographical Information System

Examination Monitoring Agency
HFMD Hand-foot-mouth disease HKL Kuala Lumpur Hospital
HUKM Hopsital Universiti HUSM Hospital Universiti Sains Malaysia

Kebangsaan Malaysia
ID Infectious Diseases IMR Institute for Medical Research
MAb Monoclonal antibody MOH Medical Officer of Health

(District Health Officer)
NPHL National Public Health PCID Prevention And Control of

Laboratory Infectious Diseases Act
PHI Public Health Inspector PHL Public Health Laboratory
PPE Personnel Protective Equipment RAT Rapid Assessment Team
RRT Rapid Response Team Scl-F Salenite-F
SHD State Health Department UMMC University Malaya Medical Centre
UNIMAS University Malaysia Sarawak USM, PP University Sains Malaysia, Pulau

Pinang.
VRI Veterinary Research Institute VTM Viral transport media
WHO World Health Organisation
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1. INTRODUCTION
The purpose of this document is to provide guidelines for effective management

of infectious disease outbreaks.
An epidemic or a disease outbreak is the occurrence of the disease at an unusual

(unexpected) frequency. Under the Prevention and Control of Infectious Diseases Act
(PCID) 1988, the person authorised to declare an outbreak is the Minister of Health.
Early investigation and verification to an infectious disease outbreak and institution of
control measures must preceed such declaration of an outbreak.
1.1 BACKGROUND
The last few years have witnessed the occurrence of several infectious diseases outbreaks
which resulted in the loss of lives, property and money. These included the ssfollowing:
¾ 1996 -A major cholera outbreak occurred in Penang with subsequent spread to

the other Peninsular States resulting in a total of 1,182 reported cases and
231 detected carriers. Even though there were no fatalities, the direct and
indirect costs as a result of the outbreak had adverse implications in
several sectors.
¾ 1997 - The Hand, foot and mouth disease (HFMD) outbreak in Sarawak,
mainly during the months of June and July, generated a lot of attention because
of the 31 paediatric deaths.
¾ 1999 - A Nipah Encephalitis outbreak which occurred in 3 defined localities in

Peninsular Malaysia resulted in 283 cases including 109 deaths. This was the first
report of such infection in the world.
¾ 2001 - An anthrax scare with a total of136 reported incidents occurred nationwide
following a bioterrorist attack in United States of America.
As a result of the above outbreaks, there is an urgent need to address the following issues:
i. to provide guidelines for the management of infectious disease outbreaks at

district, state and national levels.
ii. to anticipate and identify possible disease outbreaks by strengthening the

surveillance system.
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iii. to identify who should initiate the first response in the affected areas and
who should be responsible for taking measures to manage the outbreak
rapidly, effectively and efficiently.
iv. to define the role of the various relevant agencies in the management of
outbreaks.
v. to determine the resources necessary to manage the outbreaks in terms of the

expertise, drugs, vaccines, laboratory services, equipment and other facilities.
vi. to prepare uniform and standard operating procedures for the activation of Rapid
Response Teams (RRT) in outbreak management.
vii. to develop linkages and lines of communication with other relevant agencies in
managing the outbreaks.
vii. to undertake training and capacity building to enhance the nations capability in
managing future outbreaks.
1.3 OBJECTIVE
1.3.1 General Objective
To provide prompt and effective response to infectious disease outbreaks and to

reduce morbidity and mortality to a minimum by being constantly and adequately
prepared in managing the outbreak.
1.3.2 Specific Objectives
a) To prevent, control and contain infectious disease outbreaks.
b) To reduce morbidity and mortality due to infectious disease outbreaks.
c) To strengthen public health infectious disease surveillance.
d) To provide general guidelines and develop a mechanism for effective

implementation of outbreak management.
e) To enhance effective emergency and risk communication.
f) To collaborate and coordinate activities with other relevant agencies, both within
and outside the country in managing the outbreak.
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1.4 GENERAL PRINCIPLE OF OUTBREAK PREVENTION IN MINISTRY OF
HEALTH MALAYSIA.
There are several outbreak prevention strategies. There are:
1.4.1 Outbreak management planning
Health organisations at district, state and national levels should undertake surveillance on
infectious diseases. Regular surveillance will enable the organisations to forecast possible
outbreaks (early warning signals) and develop plans to prevent such occurrences. Such
planning helps the organisations to take action before an outbreak occurs.
1.4.2. Organising training and simulation exercises.
Appropriate training must be provided to the people in an organisation for people who
would be involved in outbreak investigation. Various categories of people should know
what is expected of them when a certain type of outbreak occurs. This training can take
the form of simulation, seminars and exercises.
1.4.3 Learning from previous crisis situations
Learning and reflecting on lessons from previous outbreak management which the
organisation had experienced would help avert future outbreaks or better manage new
outbreaks when they occur.
2.0 OUTBREAK PREPAREDNESS
2.1 RAPID RESPONSE TEAMS
2.1.1 Definition of Rapid Response Team (RRT)
A RRT is a predetermined team identified based on individual expertise and experience

and assembled by matching expertise and incident needs in order to provide rapid
response in managing disease outbreak effectively.
RRTs should be formed at district, state and national levels.
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2.1.2 General roles and functions
1. To analyse and act on surveillance information concerning infectious diseases.
2. To plan control and response strategies for managing outbreaks.
3. To identify additional resources needed for rapid response.
4. To investigate and manage the outbreak including communication with the general
public and the media.
5. To collaborate and coordinate with other relevant agencies in managing the outbreak.
6. To evaluate the effectiveness of the response and intervention measures adopted

during the outbreak.
7. To produce a detailed report on the outbreak investigation and control activities

including recommendations.
8. To predict and plan for the management of future outbreaks.
2.1.3 District Level RRT
2.1.3.1 Membership
The district level RRT may comprise the following:
• District Medical Officer of Health (MOH) / Epidemiologist – as team leader.

• Hospital Director / Physician / Medical and Health Officer
Senior Health Inspector
• Health Inspectors (Disease Control / Vector Borne Disease Control).
• Health Matron / Health Sister.
• Health Education Officer / Health Education Co-ordinator.
• Other co-opted members from relevant agencies as and when needed.
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2.1.3.2 Roles and Functions of District RRT
i. Outbreak Preparedness
• Surveillance of infectious diseases and risk analysis.

• Establishing clear lines of responsibility for planned actions.
• Identification of teams leaders and members (e.g. Rapid Assessment Team
(RAT), Investigation Teams, Control Teams etc).
• Regular meetings to review data and evaluate the effectiveness of the
implemented measures.
• Predicting and planning for potential future outbreaks.
• Determining additional resources needed for rapid response.
• Ensuring availability of personnel and training.
• Maintaining an inventory of resources for rapid response.
• Conducting regular simulation exercises.
• Making recommendations for improvements of outbreak preparedness plan.
ii. Rapid Assessment
• Formation of RAT. The RAT may comprise MOH / District Epidemiologist /

Public Health Inspector (PHI).
• The RAT shall verify the occurrence of the outbreak.
• The RAT shall undertake risk analysis and needs assessment if necessary.
iii. Outbreak Investigation
• Field Investigation (Epidemiological, Environment & Laboratory)
iv. Control activities
• Implement prevention and control measures.

• Risk communication
v. Report and recommendations
• Produce report of the outbreak.

• Evaluate response / intervention measures undertaken during the outbreak.
• Disseminate report to the relevant parties.
• Maintaining an archive of outbreak management reports
2.1.3.3 Criteria for Activation of District Level RRT
a) Unusual occurrence of notifiable infectious diseases in the

district (refer to list of notifiable diseases Appendix 1)
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b) Unusual occurrences of other infectious diseases in the district
c) Unusual occurrences / clusters of diseases / deaths in the district.
d) Upon directive from a higher authority.
2.1.3.4 Flow Chart for mobilization of District RRT
ACTIVITIES RESPONSIBILITY
Receive / obtain outbreak information from: District Medical Officer of Health

• Media
• Community
• District / State / national
surveillance system (on single
district outbreak)
Mobilise RAT District Medical Officer of Health
Verify the outbreak District RAT
Outbreak? District RRT

No
Yes
END District RRT

Field investigation
Control measures
Inform state and national levels
Report and recommendation, dissemination District RRT
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2.1.4 State level RRT
2.1.4.1 Membership
The state level RRT may comprise the following:
• State Director of Health – as team leader.

• State Deputy Director of Health (Public Health)
• State Deputy Director of Health (Medical)
• State Deputy Director of Health (Pharmacy)
• State Deputy Director of Health (Administration)
• State Epidemiology Officer
• State Chief Health Inspector
• State Health Matron
• State Medical Officer of Health (Vector)
• State Entomologist
• State Health Education Officer
• State Physician / Infectious Disease Physician
• State Paediatrician
• State Pathologist
• State Food Technologist
2.1.4.2 Roles and Functions of State RRT
• Surveillance of infectious diseases and risk analysis in the state.

• Identification of teams’ leaders and members (e.g. Rapid Assessment Team
(RAT), Investigation Teams, Control Teams etc).
• Conducting regular meetings to review data and evaluate the effectiveness of the
implemented measures in the state.
• Predicting and planning for potential future outbreaks in the state.
• Ensuring availability of personnel and training.
• Maintaining an inventory of resources for rapid response.
• Conducting regular simulation exercises and training in the state.
• Making recommendations for improvements of outbreak preparedness plan.
• Coordinating & deployment of resources
– Inter-district collaboration
– Communication with Ministry of Health Head Quarters and other states.
– Communication with National Security Council (state level).
• Maintaining an archive of outbreak management reports
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2.1.4.3 Criteria for activation of State RRT
• Unusual occurrences of notifiable infectious diseases in more than one district in

the state (refer to list of notifiable diseases: Appendix 1)
• Unusual occurrences of other infectious diseases in more than one district in the
state.
• Unusual occurrences / clusters of diseases / deaths in more than one district in the
state.
• Request for assistance from a District Health Office.
• The nature of the outbreak requires the involvement of the state (e.g. in highly
contagious and fatal infectious diseases).
• Upon directive from a higher authority.
2.1.2.4 Flow chart for mobilisation of State RRT
Receive / obtain outbreak information from: State Epidemiology Officer
• State / National Surveillance system
(multi districts within state)
• National level or District Health
Office
• International agencies.
• Media
Verify the outbreak State Epidemiology Officer
No Yes
State Deputy Director of Health

END Inform District State Epidemiology Officer
to investigate
Requires state involvement?
No Yes
END
Activate State RRT State Director of Health
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2.1.5 National RRT
2.1.5.1 Membership
The national level RRT may comprise the following:

• Deputy Director General of Health (Public Health) – as team leader.
• Deputy Director General of Health (Medical).
• Director of Pharmacy Services.
• Head of Pathology Services.
• Chief Physician, MOH.
• Chief Infectious Disease (ID) Physician, MOH.
• Chief Paediatrician,MOH.
• Director of Disease Control Division, MOH.
• Director of Institute for Medical Research.
• Deputy Directors for Disease Control.
• Director of National Public Health Laboratory.
• Director of Infectious Disease Research Centre.
• Director of Health Education and Communication Centre.
• Director of Public Health Institute.
2.1.5.2 Functions
• Surveillance of infectious diseases and risk analysis in the country.

• Providing the expert resources for management of outbreaks when necessary.
• Conducting regular meetings to evaluate the national preparedness for the
management of outbreaks and make recommendations for improvements.
• Predicting and planning for potential future outbreaks.
• Ensuring availability of trained personnel.
• Maintaining an inventory of expert resources (local and international).
• Conducting regular training and simulation exercises.
• Ensuring adequate resource allocation and deployment of resources at national
and state levels.
• Coordinating & collaboration in managing outbreaks
– Inter-state / district levels.
– Inter-ministerial and agencies (National Task Force).
– Communication with relevant international agencies e.g. WHO.
– Communication with National Security Council (national level).
Preparing National Policy and legislation on infectious diseases
• Providing risk communication.
• Maintaining an archive of outbreak management reports.
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2.1.5.3 Criteria for activation at National Level
• Unusual occurrence of notifiable infectious diseases in more than one state (refer
to list of notifiable diseases: Appendix 1)
• Unusual occurrences of other infectious diseases in more than one state.
• Unusual occurrences / clusters of diseases / deaths in more than one state.
• Request for assistance from State / District Health Office.
• The nature of the outbreak requires the involvement at national level (e.g. in
highly contagious and fatal infectious diseases, transboundary spread, bioterrorist
attack).
• Upon directive from a higher authority.
• An international alert.
• Systems breakdown and natural disasters that may affect health e.g. disruption of
water supplies, civil disturbances etc.
2.1.5.4 Flow Chart for mobilisation National RRT
Request from state / district

Request by higher authority
International alert
Mobilisation of Expertise to Director of Disease Control

verify and investigate
Assess the situation Expert Team
Further action?
No Yes
END
Activate National RRT National RRT Team Leader
Further action
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2.2 LABORATORY PREPAREDNESS
Laboratory support is an essential component in outbreak management and involves the

rapid detection, identification and epidemiological typing of the aetiological agent in
order to determine the source and mode of transmission. In the case of bacterial agents,
susceptibility testing is required to guide clinicians in the treatment and prophylaxis.
2.2.1 Inventory of laboratory resources
An inventory of laboratory resources will be maintained and up-dated by the Director of

IDRC. The inventory of resources is a list of laboratories, experts and tests available and
should be up-dated on an annual basis and made available to the relevant parties.
The current inventory of microbiological services is shown in Appendix 2. A Directory of
Laboratory Tests provided by laboratories in Malaysia is shown in Appendix 3.
2.2.2 Regional reference laboratories
A system of regional reference laboratories will be established. The regional reference

laboratories will offer an expanded repertoire of diagnostic tests including virus isolation
and tests based on molecular technique. Table 1 shows the existing and future
laboratories that has been identified and planned to be the regional reference laboratories.
The contact numbers of existing reference laboratories are as in Appendix 4.
Table 1: Existing and future regional reference laboratories
REGION LAB
North Region (Perlis, P.Pinang, Kedah, • Public Health Laboratory (PHL) Ipoh*
North Perak) • Veterinary Research Institute (VRI) Ipoh*
• Pulau Pinang Hospital
Central Region (Selangor, W. Persekutuan, • Kuala Lumpur Hospital *

N. Sembilan, Malacca, Pahang & South • Natinal PHL (NPHL)*, Sg. Buloh
Perak)
South Region (Johore, Malacca, N. • PHL Johor Bahru*

Sembilan) • Sultanah Aminah Hospital, Johor Bahru
East Region (Kelantan, Terengganu, • Kota Bharu Hospital

Pahang) • Kuala Terengganu Hospital
• Universiti Sains Malaysia* Hospital
(HUSM), Kubang Kerian
• PHL Kota Bharu (Future)
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REGION LAB
Sabah • Queen Elizabeth Hospital, Kota Kinabalu

• PHL (Future)
• Universiti Malaysia Sabah
• Tawau Hospital
• Sandakan Hospital
Sarawak • Universiti Malaysia Sarawak* (UNIMAS)

Kota Samarahan
• Sarawak General Hospital, Kuching
• PHL (Future)
* viral isolation facilities

Laboratories in italics are functioning as regional reference laboratory.
2.2.3 National reference laboratories
National reference laboratories will provide specialised tests that require expensive
equipment and the appropriate containment facilities. In principle the specialised tests
should not be duplicated between these laboratories. The national reference laboratories
will also be responsible for liaising with other international reference laboratories when
the need arises. The following laboratories have been identified to function as national
reference laboratories.
The NPHL will co-ordinate the activity of national reference laboratories;

which are:
• Institute for Medical Research, Kuala Lumpur

• Hospital Universiti Kebangsaan Malaysia, (HUKM) Kuala Lumpur
• University Malaya Medical Centre, (UMMC) Kuala Lumpur
• University Malaysia Sarawak, Kota Samarahan
• National Public Health Laboratory, Sg. Buloh, Selangor
• Veterinary Research Institute, Ipoh, Perak
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2.2.4 International Specialised laboratory resources.
When the need arises the national Reference Laboratories will liaise with overseas’
specialised laboratory resources as identified in table 2 below.
Table 2: International laboratory resources
INTERNATIONAL LABORATORY RESOURCES LIAISONING AGENCY
CDC Atlanta IMR & UMMC & NPHL
WHO:
Victoria Infectious Disease Centre-Enterovirus
IMR & UMMC
WHO Collaborating Centre for Ref. & Research on Influenza
CDC Fort Collins US IMR & UMMC & NPHL
Australian animal health laboratory (CSIRO), Geelong, Australia VRI & UMMC
Nagasaki Institute For Tropical Medicine – Arbovirus IMR & UMMC
Central Public Health Laboratory, Colindale UK IMR
2.2.4 Stockpile of critical laboratories material.
Certain laboratory materials should be stockpiled and kept by the regional stockpile
centres which will ensure that the materials are within the expiry date and stored
appropriately. These materials must be distributed in a timely manner to the requesting
laboratories during an outbreak.
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2.2.4.1 Materials to be stockpiled
No Item Amount and Center to stock Comments

types
1 Specimen containers/ Transport Sufficient to Stockpiles Networking is
Media/ Media/ reagents process 500 centre important
• Sterile containers specimens
• Swabs Order in stages
• VTM
• APW To exchange before
• Scl-F expiry
• Cary Blair Media
• Secondary and tertiary
Containers for packaging &
transport
• Boxes for exporting
specimen
• Amies Transport Media
• Reagents: diagnostic kits,
Cell-Lines, MAb (IMR &
NHPL)
2 Containers for hazardous Materials Metal Cylinder/ Stockpiles Disease Control
(WHO Standard) capsule centre Division (DCD),
30/centre MOH to purchase
centrally and
Boxes (IMR) Export distribute to
30/centre Purposes: IMR reference laboratory
Licensed person
(5 from IMR and 3
from PHL) for export
of hazardous
materials.
Training for
packaging and export
of infectious
materials every 2
years.
IMR to function as
export centre during
an outbreak
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2.2.4.2 Stockpile centres
The following have been identified as the regional stockpile centres for laboratory
materials.
STATE LABORATORY
EAST COAST
Kelantan Kota Bharu Hospital
Terengganu Kuala Terengganu Hopsital
Pahang Tengku Ampuan Afzan Hospital, Kuantan
Mentakab Hospital
CENTRAL
WPKL National Public Health Laboratory (NPHL)
Selangor Institute for Medical Research (IMR)
Malacca
N. Sembilan
SOUTH
Johore Public Health Laboratory Johor Bahru
NORTH
Penang P. Pinang Hospital
Perak Public Health Laboratory
Perlis
Kedah
SABAH Hospital Queen Elizabeth, Kota Kinabalu
SandakanHospital
Tawau Hospital
SARAWAK Miri Hospital

Sibu Hospital
Kuching General Hospital
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2.3 CLINICAL RESOURCES
Early clinical diagnosis, timely isolation and appropriate treatment of cases are essential
components in the management of an outbreak.
2.3.1 Inventory of clinical resources
i. Existing general Clinical Services are available at

- Health Centers
- District Hospitals
- State Hospitals
- Tertiary / University Hospitals
- Army hospitals
- General practitioners and private hospitals.
ii. Identified hospitals with specialised ID services

Hospitals with specialised ID services should have
• Adult / Paediatric ID physician
• Specialists in respiratory medicine, gastroenterology and neurology.
• Pathologist (Microbiology)
•
The following hospitals have been identified to provide the specialised ID
services:
• Kuala Lumpur Hospital*.
• Penang Hospital*.
• Sungai Buloh Hospital (when news hospital ready*)
• Tengku Ampuan Afzan Hospital, Kuantan.
• Sultanah Aminah Hospital, Johor Bahru.
• Sarawak General Hospital, Kuching
• Queen Elizabeth Hospital, Kota Kinabalu, Sabah.
• University Malaya Medical Centre, Kuala Lumpur*
* Hospital with existing specialised 10 services and/or specialists
2.3.2 Isolation and high containment facilities
2.3.2.1 Isolation facilities in Hospitals
All hospitals with specialised ID services should have isolation facilities. The minimal
requirements for an isolation facility are the following:
( a single room with an anteroom.
( hand-washing facilities in the anteroom.
( attached bathroom.
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( inlet / outlet pass.
( negative pressure (droplet transmission cases).
( air lock.
Eventually all state hospitals will also have isolation facilities as shown in table below.
For all new hospitals, it is proposed that ID wards with designated isolation rooms and
negative pressure rooms be made available.
Minimum number of Minimum number of

isolation rooms isolation rooms with
negative pressure
Hospital with specialised
ID Physician 8 rooms 4 rooms
State hospital 4 rooms 2 rooms
Patients suspected to be infected with Risk Group 4 pathogens (e.g. Ebola, Marburg,
Lassa etc) should be sent to a high containment facility. Sungai Buloh Hospital has been
identified as a high containment hospital.
Transportation of patients with highly contagious diseases should be done in a special

transporter or special ambulances. The interior of these ambulances should be easily
dismantled and the surfaces easily decontaminated.
2.3.3 Decontamination facilities
2.3.3.1 Onsite decontamination facilities
These facilities are meant for the victims and emergency response personnel (medical /
non-medical e.g. army, HAZMAT etc). The sites of facilities should be selected based on
risk analysis and risk assessment.
The onsite decontamination facilities are vehicle mounted mobile self-contained cabin.
Such vehicles are to be located in hospitals with ID specialists as identified. They are
proposed for:
Kuala Lumpur Hospital*.
P. Pinang Hospital*.
Sungai Buloh Hospital (when new hospital ready*)
Tengku Ampuan Afzan Hospital, Kuantan.
Sultanah Aminah Hospital, Johor Bahru.
Sarawak General Hospital, Kuching
Queen Elizabeth Hospital, Kota Kinabalu, Sabah.
University Malaya Medical Centre, Kuala Lumpur*
* Hospital with existing specialised 10 services and/or specialists
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2.3.3.2 Hospital decontamination facilities
i. Location
The identified hospitals with ID Specialised services should have decontamination

facilities.
ii. Requirements of the hospital decontamination facility
The facility shall comprise designated room(s) or space which should

• Have separate doors (entrance / exit)
• Be away from crowded areas
• Have separate ventilation system (negative pressure)
• Have a system where the waste water should be self-contained and to be
disposed properly
• Have separate shower for patient and personnel
2.4 STOCKPILES OF CRITICAL MATERIALS
2.4.1 Vaccines, antibiotics and other essential items
There should be a four month buffer stock for vaccines and antibiotics. The vaccines and
antibiotics and other essential items are as shown in table 3.
Table 3: Stockpiles of critical materials.
ITEM HOW MUCH STORED AT
Vaccines: Rabies To be worked To be worked

Mumps-Measles-Rubella out with out with
Diphteria-Pertussis-Tetanus Pharmacy Pharmacy
Diphteria- Tetanus Division. Division.
Smallpox
Meninggococcal
Haemophilus influenzae b
Yellow fever
Chicken Pox
Anthrax,
Influenza
Immunoglobulin Rabies
Antitoxin Botulinum antitoxin
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ITEM HOW MUCH STORED AT
Antibiotics doxycycline, rifampicin,

ciprofloxacin
Decontamination sodium hypochloride Regional

solutions Hibiscrub pharmacies
- surfaces
- equipment chlorine 1:10 solution for
- personnel disinfecting excreta,
cadavers and spills of
infectious fluids
chlorine to make a 1:100

solution for disinfecting
gloved hands, bare hands &
skin, floors, clothing,
equipment,bedding
Household bleach 5%
active chlorine
Calcium hypochloride
powder or granules 70%
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2.4.2 Flow Chart for distribution of critical material (Vaccine & drugs)
DISEASE CONTROL
DIVISION,
Public Health Department
Proposal for new drugs / vaccines for
infectious disease
NATIONAL DRUG
COMMITTEE
Decide
Disagree Agree
END PURCHASING
DIVISION
Put in contract list
PHARMANIAGA
Infectious disease
outbreak
No Yes
STOCKPILE FOR 3 MOBILISATION

MONTHS FOR USE
26
The following Personal Protective Equipment (PPE) items (table 4) should also be
kept as emergency stockpiles.
Table 4: List of Personal protective equipment
ITEM AMOUNT STORE AT
TYVEK DUPONT To be worked out with 6 regional centres which are

Disposable Suit The Medical Division • Head Quarters MOH
Safety boot Nitrle Chemical • Johor State Health
Resistant Department (SHD)
Fumigation Heat Chamber • Penang SHD
Class A Biohazard Suit • Pahang SHD
Spare cylinder • Sarawak SHD
Fumigation mask • Sabah SHD
HEPA/Charcoal/HEPA
Cartridge
Apron Chemical Spray
Portable fire extinguisher
Gum Boot without toe cap
Respirator with full mask
complete with battery
charger
FR2 Tychem Hood with full 6 regional centres which are
face piece • Head Quarters MOH
Level A test kit for safety • Johor State Health
suit Department (SHD)
Knapsack disinfectant • Penang SHD
sprayer • Pahang SHD
Biohazard Bag Autoclavable • Sarawak SHD
Cabinet • Sabah SHD
Decontamination packs
Full Body Containment suits
Face mask respirator with
filter
27
2.4.4 Epidemic Kits.
Epidemic Kits are tools that are necessary for the Rapid Response Team to take along
whenever they go to investigate an outbreak. The suggested epidemic kits should
comprise of the following:
• Digital Camera
• Hand held Global Positioning System (GPS) device
• Notebook computer (with downloaded resource materials, guidelines,
questionnaire etc).
• Portable printer
• Mobile phone with internet access
• Relevant laboratory materials including transport media
• Personnel Protective Equipment
• Other relevant materials.
3.0 SURVEILLANCE AND ALERT
3.1 DEFINITION
Surveillance is the ongoing systematic collection, analysis, and interpretation of

communicable disease data essential to the planning, implementation, and
evaluation of public health practice, closely integrated with the timely
dissemination of these data to those who need to know, so as to take the
appropriate action. The final link in the surveillance chain is the application of
these data to prevention and control.
3.2 OBJECTIVES
Surveillance systems are distinguished from health information systems by their

direct application to epidemiological investigation, and disease prevention and
control actions. To support these actions, each surveillance system will need to
achieve the following objectives:
• identifying cases of infectious disease that require immediate public health

control measures
• monitoring infectious disease incidence and distribution, and alert health
workers to changes in disease activity in their area,
• identifying infectious disease outbreaks and support their effective
management,
• assessing infectious disease impact and help set priorities for prevention
and control activities,
• identifying risk factors for infectious disease to support development of
effective prevention measures,
28
• evaluating prevention and control activities,
• identifying and predicting emerging and re-emerging infectious diseases,
• monitoring changes in infectious disease agents through laboratory testing,
• generating and evaluating hypotheses about infectious disease occurrence,
• fulfilling statutory and international reporting requirements, e.g.
surveillance of yellow fever, cholera and plague.
3.3 INFECTIOUS DISEASE (ID) SURVEILLANCE SYSTEMS IN MALAYSIA
There are several surveillance systems for infectious diseases in Malaysia and the flow of
surveillance data and information is as shown. (Figure 1).
3.3.1 Mandatory notifiable diseases surveillance
The mandatory notificable disease surveillance system requires the mandatory

notification of presently 26 infectious diseases under the schedule 1 and 2 of the
Prevention and Control of Infectious Disease Act 1988 (PCID) as shown in Appendix I.
This list is reviewed from time to time.
The present system involves manual reporting of ID using a prescribed notification form
as provided for under the Act. However, an electronic Communicable Disease Control
Information System (CDCIS) was implemented nationally since 2001. (Refer to CDCIS
Manual)
29
Figure 1: Surveillance mechanisms in Malaysia
Laboratory Mandatory notification Clinical based Comm. based Other

Surveillance Disease Surveillance surveillance (Sentinel surveillance agencies
(Notification Disease /National /
(Notifiable Diseases) Syndromic)
Public:
Health Centres Sentinel selected clinics Community / media / Dept of
Microbiology Hospitals National (hospitals) international sources Veterinary
Private: Syndromic A&E/wards/clinics Services
GP Clinics (Zoonotic
Hospitals Diseases)
Notification
FOMEMA
of micro- Sdn. Bhd
organism
District Health
Office
Notification
of micro-
organism Isolates and
notification of State Health
micro- Department
organism
Results National: Div.

IMR/ PHL Disease Control,
MOH
30
3.3.2 Laboratory based surveillance
Laboratory based surveillance system which monitor the ID agents was introduced in
August 2002. This system also complements the mandatory notifiable disease
surveillance system.
This system entails the reporting of micro-organisms isolated in all public/private

laboratories in Malaysia to the relevant health authorities. Presently, 6 types of bacteria
viz. V.cholerae, H. influenzae B, Salmonella spp., S. typhi/paratyhpi, N. meningitides,
and Leptospira are being prioritized to be monitored by the participating microbiology
laboratories from the Ministry of Health (MOH).
This system is being piloted in all MOH government microbiology laboratories and will
be extended to the other laboratories in the public and private sectors in the country after
evaluation of the pilot project. The number of microorganisms which is to be monitored
will be reviewed from time to time. Figure 2 shows the laboratory based surveillance
flow chart.
For details, refer to the Field Guidelines for Laboratory based surveillance.
Figure 2: Laboratory based surveillance flowchart
Microbiology laboratories of
Isolates with laboratory IMR / PHL and other
public and private hospitals
and private laboratories reference laboratories
Notification Form
(Confirmation, typing etc)
Notification
Result
District Health Office
Notification
State Health Office
Result
Communicable Disease Surveillance
Section, MOH
Data Notification
Information feedback
31
3.3.3 Clinical based surveillance
Clinical based surveillance is limited to specific infections either on a national basis

(acute flaccid paralysis and acute gastroenteritis) or on a sentinel site basis e.g. hand, foot
and mouth disease. A more comprehensive syndromic based surveillance (acute jaundice
syndrome, acute neurological syndrome, acute respiratory syndrome, acute
dermatological syndrome and acute haemorrhagic fever syndrome) has been introduced
in 2003.
Figure 3 shows the syndromic surveillance flow chart. For the detailed refer to the
Syndromic Notification and Laboratory Investigation Manual.
Figure 3: Syndromic Surveillance Flowchart
Diagnosis of syndrome by Emergency Department /

Accident & Emergency Unit / Hospital wards
Notification
District Health Office
State Health Department

Notification
Communicable Disease
Surveillance Section,
MOH
Data / Notification
Information / feedback
32
3.3.4 Disease surveillance by other agencies
Other agencies such as the Department of Veterinary Services and FOMENA Sdn. Bhd.
also contribute to the surveillance of certain infectious diseases.
Surveillance of certain ID in foreign workers in Malaysia is being done by FOMENA and

reported to the Disease Control Division.
The Department of Veterinary Services currently undertakes zoonotic disease

surveillance. Any unusual occurrence of zoonotic diseases in animals (as listed in table 5
below) should be reported to the Communicable Disease Surveillance Section (CDSS),
MOH as agreed by the Inter-ministry Committee for the Control of Zoonotic Diseases
Table 5: List of zoonotic diseases with public health importance
NO DISEASE
1 Rabies
2 Nipah Virus infection
3 Avian influenza
4 Japanese Encephalitis
5 Vancomycin resistant Enterococcus
6 Bovine Tuberculosis
7 Bovine Spongiform Encephalopathy
8 Brucellosis
9 Anthrax infection
10 Toxoplasmosis
11 Leptospirosis
3.3.5 Community based surveillance
In addition to the above systems, community based surveillance including monitoring of

rumours / reports on ID from the community and media (print/electronic) both nationally
and internationally, is essential and should become an activity which should be
formalised.
CDSS, (MOH), all State Health Offices and District Health Offices, including entry
points should play a proactive role in monitoring rumours, local press and media reports
and take prompt action to verify these reports in their areas of jurisdiction.
CDSS, MOH, has assigned an officer to perform this task, in particular the monitoring of
international ID trends using the Internet and reports from international organization like
the WHO.
33
3.3.6 Surveillance activities at various levels
Surveillance activities as shown in the table below must be undertaken routinely at all
levels of the Ministry of Health. The extent and degree of the surveillance activities will
depend in the type of infectious diseases as specified by the respective ID prevention and
control programmes.
Collection
Compilation
Analysis Compilation
Surveillance
Process Interpretation Analysis
Information and Interpretation

Dissemination
For Action
Action
Evaluation
3.3.6.1 Surveillance at the District Level
The District Health Office is responsible for the surveillance of infectious diseases in the
district and must establish a system to routinely collect data from
• Health Clinics
• General Practitioners’ Clinics
• Hospitals (both government and private)
• Microbiology laboratories
This data must be submitted on a weekly basis to the State Health Office in a timely
manner.
34
The Medical Officer of Health (MOH) will be responsible for collating, analyzing,
interpreting the trends of data or for patterns that would suggest that an outbreak is
occurring in the district. The information then should be distributed for action by relevant
personnel in the district.
3.3.6.2 Surveillance at the State Level
The State Health Office is responsible for collecting surveillance data from the District
Health Offices and must collate, analyse and interpret the data for trends and patterns that
would suggest that an outbreak is occurring in more than one district in the state. The
State Health Office must submit the State data on a weekly basis and in a timely manner
to the CDSS.
The State Epidemiology Officer will be responsible for all surveillance activity in the
state.
3.3.6.3 Surveillance at the National Level (Communicable Disease, Surveillance

Section, Disease Control Division)
CDSS, Disease Control Division is responsible for the collection of data from all State
Health Offices, directly from laboratories under the Laboratory Based Surveillance
system and directly from reporting physician under the Syndromic Surveillance System.
CDSS will collate, integrate, analyse and interpret the data from the various sources to
detect trends and patterns of disease outbreak on a national level. The section will employ
appropriate tools and techniques for this purpose e.g. Geographical Information System
(GIS). The section will also be responsible for monitoring press and other media reports
both nationally and internationally and take the appropriate action when necessary.
3.3.7 Dissemination and flow of data
There must be efficient and timely flow of data from the District level to the State and to
the Surveillance Section, Disease Control Division and vice-versa. Under normal
circumstances weekly reports must be made by all District Health Offices to the State
Health Office and by all State Health Offices to the Surveillance Section, Disease Control
Division. Where the situation warrants it, immediate reporting by phone may be
necessary.
The dissemination of information to all who need to know is equally important. Such
information should be sent to the relevant personnel on a regular basis through bulletins
and newsletters, at a minimum, on a quarterly basis. Urgent information should be
transmitted immediately by phone, fax or e-mail.
The District Health Office is responsible for the feedback of district surveillance
information to relevant personnel in the district.
35
The State Health Office is responsible for the feedback of state surveillance information
to relevant personnel in the state.
CDSS, Disease Control Division is responsible for the feedback of national surveillance
information to all relevant personnel in the country.
At present the bulk of data and information is still transmitted in paper form and this has
caused undue delay in the analysis and interpretation of the data, hence a delay in
response. All effort must be made to upgrade the dissemination of data and information
using the latest in information technology in order that the flow is seamless and in real
time. The flow of data and information is summarized in figure 4.
Figure 4: Flow of surveillance data and information dissemination
Reporting physician:
3.3.8 Dissemination and flow of data
Reporting physician:
Public sector
Public sector
Private sector
Private sector
There must be efficientCase
andof timely flow of data from the District level to the State and to
infectious
the CDSS, Disease Control
disease
Division and vice-versa. Under normal circumstances weekly
reports must be made by all District Health Offices to the State Health Office and by all
State Health Offices to the CDSS, Disease Control Division. Where the situation warrants
it, immediate reporting by phone may be necessary.
The dissemination of information to all who need to know is equally important. Such
information should be sentcaseto the relevant personnel on a regular basis through bulletins
Conduct
Laboratory
and newsletters, at investigation
a minimum, on a quarterly basis.
District Medical
District Medical
Officer ofUrgent information
Officer of
Laboratory should be
- District Lab.
and initiate Health - District Lab.
transmitted immediately by phone, fax or e-mail. Health - State Lab.
control - State Lab.
- IMR
measures - IMR
- Other Labs.
The District Health Office is responsible for the feedback of district
- Other Labs.surveillance
information to relevant personnel in the district.
State Health Office
The State Health OfficeConduct

is responsible for the feedback of state surveillance information
follow-up on
to relevant personnel in the state.
certain
infectious Communicable Disease
Communicable Disease
CDSS,Data
Disease Controldisease
Division is responsible
Control for the
Control Section,
Section, feedback of national surveillance
Public
Public
Health Department,
information to all relevant personnel in the country.
Health Department,
Ministry of Health
Information Ministry of Health
At present the bulk of data and information is still transmitted in paper form and this has
caused undue delayWHO WHO
and other
inrelevant
the analysis and interpretation of the data, hence a delay in
and other
response. All effort must be
relevant
international made to upgrade the dissemination of data and information
international
using the latest in information
agencies technology in order that the flow is seamless and in real
agencies
time. The flow of data and in information is summarized in figure 4.
36
3.4 ALERT MECHANISM AND INITIAL EVALUATION OF POTENTIAL
OUTBREAKS
3.4.1 Mechanism of collection, integration and analysis of all surveillance

information at district, state and national levels.
• Data from the various surveillance systems need to be integrated using

information technology and appropriate statistical software (e.g. Epi-Info) for
meaningful analysis.
• Analysis of surveillance shall be undertaken at District, State and National
levels (see 2.1.2).
• At the District Level the MOH will be responsible for all surveillance
activities in the district.
• At the State Level the State Epidemiologist will be responsible for all
surveillance activities in the state.
• Appropriate training shall be given to all health personnel undertaking
surveillance activities.
3.4.2 Alerting other relevant parties when an outbreak is suspected
3.4.2.1 District Level
When an outbreak or impending outbreak is suspected based on surveillance activities,

the district shall immediately alert:
• The State Health Office by telephone to be followed by a written report within

24 hours to confirm the outbreak or otherwise
• The District Hospital and Microbiology Laboratory by phone to be on standby
• Other relevant governmental agencies in the district to be on standby
depending on the nature of the outbreak
• The MOHs of neighbouring districts depending on the nature of the outbreak
3.4.2.2 State Level
When an outbreak or impending outbreak is suspected in more than one district in the
state the State Health Director shall immediately alert:
• The Communicable Disease Surveillance Section, Disease Control Division

by telephone to be followed by a written report within 24 hours to confirm the
outbreak or otherwise.
• The State Hospital and Microbiology Laboratory by phone to be on standby
• Other relevant governmental agencies in the state to be on standby depending
on the nature of the outbreak.
• The MOHs of the unaffected districts depending on the nature of the outbreak.
37
• The State Directors of neighbouring states depending on the nature of the
outbreak.
3.4.2.3 National Level
When an outbreak or an impending outbreak is reported from more than one state, the
Director of Disease Control Division will immediately alert:
• Deputy Director General of Health (Public Health)

• The relevant Control and Prevention Programme Heads.
• The Chief ID Consultant Physician.
• IMR, NPHL and other relevant laboratory resources.
• Any other relevant agencies when the need arise.
3.5 OUTBREAK DETECTION
3.5.1 Alert indicators
Indicators of impending outbreaks will include:
1. Action thresholds.
These thresholds will be established at district, state and national levels together
with the relevant programmes taking into account:
• Epidemiological trend in the district, state or country.

• Baseline incidence levels of infections.
• The magnitude of the present problem compared with the baseline.
• The nature of the infection (for rare or very virulent infections, even one case
can constitute an outbreak).
2. The occurrence of a cluster of disease or deaths related in person, place or time.
3. Alerts generated by other surveillance system e.g. vector density, GIS,

epidemiological typing etc.
4. Surveillance-related information from

• Vaccine coverage data
• Food Laboratory results
• Other agencies e.g. Department of Veterinary Services
5. Proxy indicators as in table 6:
38
Table 6: Proxy indicators of existing surveillance system
Proxy Disease/problem
Acute Gastroenteritis Food and water borne diseases
Acute Flaccid Paralysis Poliomyelitis
HFMD Enteroviruses
Acute Respiratory Infection Pneumonia, Influenza virus
The defined syndromes under the Emerging or unknown infections

syndromic notification system
Unexplained / ill defined death Emerging or unknown infections

of infectious origin
Refer to S.O.P. for surveillance of infectious diseases.
3.5.2 Outbreak Verification
The purpose of outbreak verification is to confirm the occurrence of an outbreak and

represents the first important measure in outbreak response. A multidisciplinary approach
is required and will include one or a combination of the following:
• Review of the epidemiological data and trend.

• Clinical examination of cases.
• Review of medical records.
• Review of laboratory results.
The task of the outbreak verification shall be performed by the Rapid Assessment Team
which is composed of relevant members of RRT.
3.5.2 Evaluation of severity of outbreak
Upon verification of an outbreak the Rapid Assessment Team should also undertake a
brief evaluation of the severity of the outbreak. To assess the severity of an outbreak the
Rapid Assessment Team will take into account the following:
• Increasing mortality and morbidity.

• High case-fatality rate.
• High rate of severe presentation of disease.
• High rate of anti-microbial resistance.
• Involvement of vulnerable and other high risk group.
39
3.5.3 Literature search, retrospective review, consultation with experts
Where the need arisen the Rapid Response Team should also undertake an initial
literature search, conduct a retrospective review or consult with experts in the field as to
the possible nature of the outbreak. This will greatly facilitate subsequent investigation
and control activities.
4.0 MANAGEMENT OF OUTBREAK
4.1 OUTBREAK MANAGEMENT FRAMEWORK
Outbreak preparedness is the first essential step in the whole management framework. An
efficient surveillance system allows for the early detection of outbreaks which should
then trigger off a whole series of activities including alert, verification, investigation,
control and documentation. Systematic evaluation of every outbreak response will further
enhance outbreak preparedness thus completing the cycle (Figure 5).
Figure 5: Outbreak management framework
Preparation
Surveillance/Notification
Outbreak Investigation Outbreak Response
Confirmation & Assessment Outbreak Control
Outbreak Description
Outbreak Communication
Full Investigation
Analytic
Outbreak Documentation
Environment
Lab
souce: ESR-NZ Disease Outbreak Manual
40
4.2 INITIATION OF OUTBREAK INVESTIGATION AND CONTROL
ACTIVITIES
Once an outbreak has been verified by the Rapid Assessment Team, depending on the
nature of the outbreak, the MOH of the district or State Director of Health or the Deputy
Director General of Health (Public Health) will initiate activities designed to investigate,
control and contain the outbreak (Figure 6).
Figure 6: Outbreak Management Flow Chart
VERIFICATION OF OUTBREAK
SET-UP INVESTIGATE THE CONTROL

OPERATION OUTBREAK MEASURES
ROOM
CESSATION OF
DATA OUTBREAK
CESSATION OF ANALYSIS
OUTBREAK
CLOSE
OPERATION
ROOM
DOCUMENTATION
& FINAL REPORT
RECOMMENDATIONS PUBLICATION AND

AND FOLLOW-UP ARCHIVING
41
4.2.1 Outbreak definition
For each outbreak there should be a case definition.

• For known diseases: Refer to Disease Control Division, MOH Case Definition
for Infection disease in Malaysia.
• For unknown diseases, consider epidemiological linkages (time, place, person,
clinical presentation)
The case definition should contain the following:

9 The name of the disease (or as “…like” until more precise data is
available)
9 The most frequently occurring signs and symptoms
9 Epidemiological circumstances
9 Confirmatory laboratory tests, if any
9 Criteria of the level of certainty: ‘‘confirmed”, “probable” and “suspect”.
4.2.2 Standard Operating Procedure for initiation of outbreak investigation and

control activities in the District
Activity Person Responsible Timeline

1 Detection of possible outbreak District MOH On-going
through surveillance mechanisms
2 Assemble Rapid Assessment Team District MOH Immediate
3 Alert State Health Office by phone District MOH Immediate
4 Alert other relevant parties if District MOH Immediate
necessary
5 Outbreak verification Rapid Assessment * Within 24 - 48
Team hours of alert
6 Report outcome of verification Rapid Assessment As soon as
exercise to MOH District Team verification is made
7 If outbreak verified, mobilise the District MOH Immediately upon
members of Rapid Response Team verification of
outbreak
8 Inform State Health Office of District MOH Immediately upon
verification by phone verification of
outbreak
9 Inform other relevant parties where District MOH Immediately upon
necessary by phone verification of
outbreak
10 Meeting of Rapid Response Team Rapid Response Within 24 hours of
to initiate investigation and control Team verification
of outbreak activities
42
Activity Person Responsible Timeline
11 Inform State Health Office via a District MOH Within 24 hours of

written preliminary report and the verification
District MKN by fax or e-mail.
• depending on the nature of the outbreak, a longer period of time for
verification may be necessary.
The flow of processes is as summarised in figure 7.
Figure 7: Line of Communication

(Outbreak information and support request)
Key: Outbreak detected at the district

Outbreak detected at the ministry / state level
Disease Control Division, Other states, IMR, PHL,
National
MOH Alert Other relevant authorities
MKN
State MKN Phone, followed by prelim. report

Within 24 Hours
State Director Neighbouring State Director

Alert of Health
District MKN
Phone, followed by prelim. report
Within 24 Hours
District Hospital District PKD Neighbouring District PKD

Local PHL Alert Alert
MKN: ‘Majlis Keselamatan Negara’ (National Security Council)
43
4.2.3 Outbreak Operation Room.
Refer appendix 5. For details on how to set up and close an Operation Room,
refer to standard Operating Procedure (S.O.P) for Operations Room in infectious
disease outbreak.
4.2.4 Field data collection and analysis
The Rapid Response Team will collect the relevant data in the field. Important
data needed are name, age, sex, race, date of onset, exposure, address, symptoms
of disease and laboratory results. Case line listing and the epidemic curve should
be updated on a daily basis. For diseases with very short incubation period the
data should be up-dated more frequently.
All data should be entered into a computer using the EPI-Info software. This
application will also be used to analyse and document the outbreak.
4.2.5 Control activities
4.2.5.1 Public Health control activities
General public health control activities should be implemented immediately.

Specific public health control measures will be applied when the nature of the
outbreak becomes clearer or is established.
Where relevant MOH guidelines for the control of specific infectious diseases are
available and should be adhered to (Appendix 6).
4.2.5.2 Infection control activities in hospitals and clinics during ID outbreak
General Control activities should be implemented immediately. Specific control

measures will be applied when the nature of the outbreak becomes clearer or is
established.
For details, refer to the Standard Operating Procedures (S.O.P) for infection
control during outbreak
4.2.6 Meetings of the Rapid Response Team, Progress Reports and Request for
Additional Resources
The Rapid Response Team should meet daily to discuss the progress of
investigation and management of the outbreak.
44
For district outbreaks, the MOH of the District should submit written daily
progress reports to the State Health Office. For state outbreaks the State Director
of Health should submit written daily progress reports to the Director of Disease
Control Division.
Where additional resources are required to manage an outbreak, the District MOH
shall make such requests to the State Director of Health and in the case of a state
level outbreak; the State Director should make the request to the Director of
Disease Control Division.
The State Director of Health or the Director of Disease Control Division as the
case may be will coordinate all activities arising from such requests including
obtaining experts and material resources from the Ministry of Health or other
agencies.
4.2.7 Cessation of outbreak
• For known diseases, the cessation of an outbreak is defined as “when no new

epidemiologically linked cases are detected over a period of double-the-
incubation period of the infectious disease”.
• For unknown diseases, the cessation of an outbreak will be determined by the
RRT based on their judgment.
• For a District level outbreak the decision will be made by the District RRT
with the agreement of the State Health Director
• For a State level outbreak the decision will be made by the State RRT and to
inform the Disease Control Division
• For a National level Outbreak the decision will be made by the Director
General of Health.
4.2.8 Final report of the outbreak
4.2.8.1 Person responsible for writing the outbreak report
A final report must be produced for every outbreak. The person responsible for
writing the report is as follows:
• District Medical Officer of Health at the district level
• State Epidemiologist at state level
• Director of Disease Control Division, MOH at national level.
45
4.2.8.2 Format for report
The report should be based on the standardised format (Appendix 7) consisting of:
• Title
• Summary
• Introduction
• Objectives
• Methodology
• Results
• Discussion
• Conclusion and recommendation
• References
4.2.8.3 Dissemination of report
i. District Level outbreak

The report should be sent to:
• State Director of Health of the involved state.

• Director of Disease Control Division, Ministry of Health.
• Executive summary with recommendations to the relevant district
authorities (e.g. Education Department, Local Authority etc)
ii. State Level Outbreak

• Director of Disease Control Division, Ministry of Health.

• Executive summary with recommendations to the relevant state
authorities (e.g.: Education Department, Local Authority etc)
iii. National Level outbreak

• Director General of Health.

• Deputy Directors General of Health.
• Executive summary with recommendations to the relevant national
authorities (e.g.: Education Department, Local Authority etc)
4.2.8.4 Tabling of the report
The report should also be tabled for discussion at
• District/State/National RRTs (depending on the nature of the

outbreak)
46
• State Epidemiologists Meeting (all relevant parties should be
invited)
• National outbreak management conference (to be organised by
Disease Control Division; and where all relevant parties should be
invited including clinicians and laboratory personnel).
4.2.9 Publication
The outbreak report may be published in local or international journals / bulletins,

etc with the permission of the Director General of Health.
4.2.10 Recommendations for policy changes
Recommendations for policy changes from district and state health offices should
be directed to the Director of Disease Control Division for his consideration and
action.
4.2.11 Archiving of the reports
Hard copies of the reports are to be kept at the district, state and national levels
depending on the site of the outbreak. Access to these reports should be restricted
to Ministry of Health personnel only. Bona-fide researchers who want to see and
photocopy the report should be allowed to do so only with the written permission
of the Director General of Health.
The Disease Control Division will set-up a national outbreak report repository
with a cataloging system for use as reference material.
4.3 THE ROLE OF HEALTH CENTRES AND HOSPITALS IN AN

OUTBREAK
4.3.1 Alert systems
Hospital and health centres may be alerted to the possibility of an outbreak from
the following:
• An alert from district/state/national RRT.

• When the hospital/health centre encounters
- an unusual cluster of ID cases.

- an unusual cluster of patients presenting with similar signs and
symptoms (refer to Syndromic Notification and Laboratory
Investigation Manual).
47
- unexplained deaths suspected to be infectious in origin.
• When the laboratory reports an unusual number of isolates of specific

microorganisms or even single report of highly virulent and contagious
pathogens.
• Unusual number of referrals from general practitioners of patients with
similar signs and symptoms.
4.3.2 Preparation in health centres and hospitals
Depending on the nature of the outbreak, the hospitals should make adequate
preparation for the following:
• protocol for admission of cases and contacts.

• diagnosis of cases
¾ clinical
¾ laboratory
• isolation facilities for cases and contacts.
• decontamination and barrier precautions to prevent transmission to
staff and other patients.
• treatment.
• referral and transfer of cases.
• discharge and follow-up.
3.3.3 Triage for Infectious Disease Outbreaks with high mortality or due to
deliberate release of biological agents
This protocol is meant for infectious diseases with high fatality rate like SARS,
Ebola, Lassa, pulmonary Anthrax, Marburg, Plague, Yellow Fever, Hanta
Pulmonary Syndrome and other newly emerging diseases or outbreak due to
deliberate release of biological agents.
The patient is categorised
• by level of exposure/contamination
• by clinical condition either
i) critical / highly exposed/contaminated
ii) semicritical / low risk exposure
iii) non critical / no exposure
The need for decontamination, to isolate and to manage cases should be assessed
accordingly.
48
5.0 RISK COMMUNICATION
Risk communication is very important in outbreak management. It is not only to inform

the public about the outbreak with regard to the control and prevention, but to alleviate
anxiety and panic among the public. The information given to the public must be truthful
and transparent. A spokesperson should be appointed to communicate with the public
especially the media. The following will act as spokesperson
• at the national level, the Director General of Health or his representative

shall be the spokesperson.
• the state level or his representative, the State Director of Health shall be
the spokesperson.
• the district level, the District Medical Officer of Health shall be the
spokesperson.
• any other person authorised by the Director General of Health.
6.0 OCCUPATIONAL HEALTH AND SAFETY FOR HEALTH CARE

WORKERS
Personal protective equipment should be used according to the suspected aetiological

agent. Vaccination and chemoprophylaxis should be given as appropriate to known
etiologic agents. There should be a mechanism to ensure compliance to the Occupational
Safety and Health Act 1994.
For known infectious pathogen (Risk Group 1 and 2), the standard precautions should be
adopted. However for unknown aetiological agents, maximum possible protective
measures should be observed. Decontamination procedures for exposed health care
workers are as outlined in the Annex 9.
Exposed health care workers should also be given counseling and advice on stress
management. They must also be provided with post exposure prophylaxis and treatment
with follow up if appropriate.
7.0 CRITERIA FOR RECOMMENDING THE INVOKING OF ‘ARAHAN’ 20

NATIONAL SECURITY COUNCIL.
7.1 Criteria for recommending the invoking of ‘arahan’ 20 in the event of

infectious diseases outbreak
7.1.1 Objective of ‘Arahan’ 20
‘Arahan’ 20 outlines the policy on disaster management and disaster relief in Malaysia
according to the level of the crisis. It puts in place a mechanism for determining the roles
and responsibilities of the various agencies involved in the handling the disaster that
49
occurs. Certain outbreaks of infectious diseases can be considered to be a disaster that
warrants the invoking of the ‘Arahan’ 20.
7.1.2 Definition of disaster under ‘Arahan’ 20
A disaster is defined as an incident that occurs without warning, complex in nature and
results in loss of lives, property and damage to the environment. It also disrupts services
and local community activities. Management of this incident requires extensive resources
(man, money and material) and effective multi agency co-ordination and participation.
7.1.3 The criteria for recommending the invoking of ‘Arahan’ 20
The criteria for recommending the invoking of ‘Arahan’ 20 in the event of infectious
diseases outbreaks are:
i. Magnitude of the outbreak in terms of

a. number of cases.
b. number of deaths.
c. large geographical areas involved.
ii. The nature of the confirmed or suspected pathogen

a. an imported known highly virulent pathogen e.g. Marburg, Lassa,
Yellow Fever, Ebola etc.
b. a newly emerging pathogen that is associated with high mortality rate.
c. a highly contagious air-borne pathogen.
iii. the outbreak is the result of confirmed or suspected deliberate release of

biological agents.
iv. any outbreak or perceived outbreak that result in mass panic and hysteria.
v. any other outbreaks which in the judgment of Ministry of Health requires

invoking of ‘Arahan’ 20.
7.2 Procedure for recommending the invoking of ‘Arahan’ 20
When the National Rapid Response Team, based on the above criteria in 7.1.3, is of the
opinion that the outbreak is of such a nature that would require the involvement of the
National Security Council, the National RRT will inform the Director General of Health
of its opinion.
If the Director General of Health is satisfied that a case has been made, he shall
recommend to the National Security Council that ‘Arahan’ 20 be invoked.
50
8.0 TRAINING
Fund should be allocated for training, either locally or internationally. Training should
include infectious disease management, disaster control and emergency response. Table
top simulation and hands-on exercises should be held regularly.
8.1 Epidemic Intelligence Programme (EIP).
An EIP has been started by the MOH. This field training programme is designed to
provide relevant health personnel with the knowledge and skill essential for the
management of infectious diseases outbreak. This programme is suitable for public health
practioners, clinicians, microbiologists, public health inspectors, nurses and other
relevant health care practitioners.
In the event of an outbreak occurring, the EIP fellows under training should play an
active role in the management of the outbreak.
8.2 Training for Epi-Info software.
All Medical Officers of Health and Health Inspectors should be trained on the use of the
Epi-info package. Epi-info software is chosen because it is public domain and can be
assessed freely.
8.3 Training in risk communication
Risk communication is an important aspect of an outbreak management. All relevant

health personnel should receive training in risk communication conducted by the Public
Health Institute.
8.4 Training in the use of Infectious Disease Outbreak: Rapid Response Manual
and Syndromic Notification and Laboratory Investigation Manual
All relevant medical and health personnel likely to be involved in outbreak management
should be given appropriate training in the use of the manuals. This includes briefings
and simulation exercises. “Train the trainers” session will be conducted by the Disease
Control Division and Institute for Medical Research. Echo training will be conducted at
state and district level.
8.5 Training in the use of PPE and decontamination procedure
Front-line personnel who may need to use PPE and perform the decontamination
procedure either on themselves or on cases and contacts e.g. field investigators; front-line
doctors should be trained in the use of the equipment and decontamination procedures.
51
8.6 Training on isolation, barrier nursing, disinfection and sterilisation
procedures.
Medical personnel who manage patients with infectious diseases should be given
appropriate training on isolation procedures, barrier nursing including use of PPE,
disinfection and sterilisation procedures and the safe disposal of infectious waste.
8.7 Training of Laboratory Personnel in handling risk group 3 & 4 pathogens.
As outbreaks may involve risk group 3 & 4 pathogens like the causative agents of Lassa,
Nipah, Ebola, Anthrax, plague etc. laboratory personnel who handle infectious materials
should also receive training including safe laboratory work procedures and proper
disposal of laboratory waste in normal laboratories as well as BSL 3 laboratories. As
these agents are rarely encountered in routine practice selected personnel should receive
special training in the identification of these pathogens.
Training of selected laboratory personnel from all national reference laboratories is

required for the packing and sending materials overseas. Similar training is required for
personnel from regional laboratories in sending similar materials to national reference
laboratories. These personnel should also be familiar with the Prevention and Control of
Infectious Diseases Regulation 2001 – pertaining to the import and export of cadavers,
human tissues and pathogenic organisms and other materials.
8.8 Training in psychological management and counselling
Selected medical and health personnel should receive training in psychological

management and counselling in order to adequately manage any cases, their family
members and contacts who suffer psychological stress during outbreaks.
8.9 Training in risk management
All Medical Officers of Health (MOHs) are required to undergo training in risk
management. This training will enable them to undertake risk and hazard analysis in their
respective districts, implement measures to mitigate and communicate such risks to those
who need to know including the public in order to take appropriate action.
The MOHs are also required to undergo training in risk communication during outbreaks.
8.10 Training in legal aspects
All health managers as well as those involved in field investigation should receive
training in legal aspects of outbreak management including Prevention and Control of
Infectious Disease Act 1988 and Destruction of Disease Bearing Insect Act (DDBIA)
amended 2001 and other relevant legislation. In cases of bioterrorism health personnel
are also required to be familiar with the Criminal Procedure Code.
52
8.11 Training in postmortem procedures
Training in postmortem procedures for deaths resulting from confirmed or suspected

infectious diseases case is required for pathologists and other mortuary workers. Such
training should include the use of PPE, the autopsy techniques, specimen collection,
storage and transport, and the safe disposal of the remains. For details see the Guidelines
/ Protocol on Post-mortem.
8.12 Trainers
Suitable trainers should be identified at district, state and national levels. Training the
trainers will be conducted at the national level and echo training by the state and district
level trainers. All trainers should attend refresher courses to update and keep abreast with
the latest technology in the management of infectious diseases.
For certain specialised training foreign expertise may be required.
8.13 Training methods
A variety of training methods will be employed. These will include didactic sessions,
interactive workshops, use of demonstration and other multi-media kits, simulation
exercises and mock drills. Trainees will be assessed on their knowledge and skill.
All aspect of the training programme will be evaluated from time to time for their
effectiveness by the Disease Control Division and changes made as appropriate. Specific
outcome indicators for effective outbreak management will be identified, measured and
monitored; and the appropriate remedial measures should be taken.
9.0 FUNDING
Funding for the management of the outbreak should be derived from the operating
budget. In the event that the operating budget allocated is insufficient, additional funds
can be applied for from the Director of Disease Control Division, Ministry of Health.
In an emergency situation e.g. large outbreak, the total allocated operating budget for the
state can be used to manage the situation and reimbursement for these expenditures can
be obtained from the Ministry of Health in due course. However, prior notification for
such usage must be made to Director of Disease Control Division.
53
10.0 REFERENCE
ESR- NZ, 2002. Disease Outbreak Manual, April 2002
WHO-CDC. 2001. Technical Guideline for integrated disease surveillance and response
in Africa Region. July 2001
CDSS, MOH. 2002. Syndromic Notification and Laboratory Investigation Manual. July
2002.
CDSS, MOH. 2002 Field Guildelines for Laboratory based Surveillance. August 2002.
CDSS, MOH. 2002. Case Definition for infections di
54
APPENDIX 1
List of notifiable communicable diseases
DISEASES Notification by Written Lab Notification by Diagnostic Status

phone within notification confirmation
24 hours within 1 week Clinical diagnosis Labaratory diagnosis
AIDS • REQUIRED X
HIV INFECTION • REQUIRED X
CHANCROID • REQUIRED X
CHOLERA REQUIRED X X
DENGUE FEVER, DHF, REQUIRED X X

DSS
DIPHTERIA REQUIRED X X
DYSENTRY • REQUIRED X X
EBOLA-MARBURG REQUIRED X X
DISEASE
FOOD POISONING NOT X

REQUIRED
GONOCOCCAL • REQUIRED X
INFECTIONS
LEPROSY • REQUIRED X
VIRAL HEPATITIS • REQUIRED X X
55
24 hours within 1 week Clinical diagnosis Clinical diagnosis
HEPATITIS A • REQUIRED X
HEPATITIS B • REQUIRED X
ACUTE VIRAL • REQUIRED X

HEPATITIS C, D& E
JAPANESE • REQUIRED X
ENCEPHALITIS
MALARIA • REQUIRED X
MEASLES • NOT X X
REQUIRED
PERTUSSIS • REQUIRED X X
PLAGUE REQUIRED X X
POLIOMYELITIS (AC) REQUIRED X X
RABIES REQUIRED X X
RELAPSING FEVER • REQUIRED X X
SALMONELLOSIS • REQUIRED X
SYPHILIS • REQUIRED X
56
24 hours within 1 week Clinical diagnosis Clinical diagnosis
TETANUS • NOT X
REQUIRED
TUBERCULOSIS • REQUIRED X
TYPHOID/ • REQUIRED X
PARATYPHOID
TYPHUS • REQUIRED X X
YELLOW FEVER REQUIRED X X
45
APPENDIX 2
Microbiological services available at the Reference Laboratories.

MICROBIOLOGICAL SERVICES
BACTERIOLOGY VIROLOGY PARA MYCOLOGY POISONS BSL 3 MOLECULAR EM

SITE SITO AND FACILITY DIAGNOSTIC
LOGY TOXINS
Basic Specialised Serology specialised General Basic Specialised Electron
/reference (commerciall including / reference microscopy
y available isolation
diagnostic
kits)
HKL X X X X* X* X X*
State Hospital X X X
District Hosp X X X
University
PPUM X X X X X X X X X X
HUKM X X X X X X X X X*
HUSM X X X X X X X
Unimas X X X X
VRI X X X X X X X (Toxin) X X X
IMR X X X X X X X X X X
NPHL
X (Food lab)
X X X X X X X* X X*
(Toxin)
PHL Ipoh
X X X X X X X
PHL Johor
Bahru X X X X X X X
USM PP X X
Jab Kimia X X
UPM X X
Note: (*) –under development
46
APPENDIX 3
Directory Of Laboratory Services
DISEASE/PATHOGEN SERVICE SPECIMEN REQUIRED TESTING LABORATORY
Microscopic examinationBlood smear: Thick and thin State hospitals and district hospital with
microbiologists.
Virus isolation Blood,Cerebrospinal fluid IMR (Virology Division), NPHL, university hospital
laboratories
Bacterial and viral antigen Serum, tissue, CSF State hospitals and district hospital with
Acute haemorrhagic syndrome detection microbiologists.
Viral genome detection Serum, tissue, CSF IMR (Virology Division), NPHL, university hospital
laboratories
Antibody levels Serum, CSF State hospitals
Antigen detection, antibody Serum, tissue State hospitals

levels,
Microscopic examination Blood smear: Thick and thin State hospitals and district hospital with
smear microbiologists.
Acute jaundice syndrome Bacterial isolation Blood, tissue State hospitals
Viral isolation Blood, tissue
IMR (Virology Division), NPHL, university hospital
Virus serotyping, genome Serum, tissue laboratories
detection
Bacterial isolation, Throat swab/washing/gargle, State hospitals and district hospital with
identification and tissue and other body fluids microbiologists and Public Health Laboratories
Acute neurological syndrome susceptibility testing
* IMR and NPHL are the coordinating agencies for virology. These laboratories will collaborate with other laboratories within and outside the countries if
needed.
45
Virus isolation Faeces, throat IMR(Virology Division), NPHL, university hospital

swab/washing/gargle, tissue laboratories
and other body fluids
Acute neurological syndrome Serology Serum State hospitals and district hospital with
microbiologists, IMR (Virology division).
Acute respiratory syndrome Bacterial isolation, Blood culture, throat swab/ State hospitals and district hospital with
identification and gargle, sputum, microbiologists.
susceptibility testing nasopharyngeal swab /
aspirate, bronchoalveolar
lavage / tracheal aspirate,
pleural fluid
Acute respiratory syndrome Virus isolation, antigen Throat swab/ gargle, IMR (Virology Division), NPHL, university hospital
testing nasopharyngeal swab / laboratories
aspirate, bronchoalveolar
lavage / tracheal aspirate,
pleural fluid
Adenovirus Isolation Throat swab, stool Virology division(IMR)
Amoebic dysentery Microscopy State hospitals and district hospital with
Stool microbiologists
Antigen detection State hospital, Parasitology division (IMR)
Microscopic examination Blood, sputum, skin or ulcer State hospitals and district hospital with
Anthrax
of clinical specimen tissue microbiologists
46
Isolation and identification Blood, sputum, skin or ulcer BSL 3 laboratories ( VRI, IMR)
Anthrax tissue
Identification of pure Pure, actively growing IMR (Bacteriology division),PHLs, university hospital
Bacterial culture identification isolates determined to be of culture on suitable agar slant laboratories
clinical significance
Bacterial typing, Pulsed Field To determine if isolates Pure isolates on agar slants IMR (Bacteriology division), PHLs, university
Gel Electrophoresis from different sources are hospital laboratories
the same
Bordetella pertussis and other Isolation Sputum, nasopharyngeal State hospitals and district hospital with
bordetellae aspirate microbiologists
Identification susceptibility Pure culture State hospitals

testing of bordetella isolates
Antigen detection (IF) Nasopharyngeal swab State hospitals
Bordetella pertussis and other
bordetellae Bordetella pertussis Serum State hospitals, Public Health Laboratories, university
serology hospital laboratories
Characterisation of Pure culture IMR (bacteriology division), Public Health
bordetella isolates Laboratories, university hospital laboratories
Brucellosis Culture and susceptibility Blood, bone marrow, abscess, State hospitals and district hospital with
testing liver or spleen biopsy microbiologists. Primary specimens for isolation and
identification are acceptable with prior consultation
47
Chlamydia pneumoniae Antigen detection Brochoalveolar lavage State hospitals
Serology Serum State hospitals
Corynebacterium diptheriae Isolation and identification Swab from inflamed areas of State hospitals and district hospital with
the membranes in throat and microbiologists
nasopharynx, skin lesion and
materials removed from
wounds by swab or aspiration
In-vitro toxin testing Pure culture IMR (bacteriology division), PHLs
Clostridium perfringes Culture and susceptibility Stool State hospitals

testing
Enteric pathogens (Salmonella, Culture, identification and Stool, rectal swab State hospitals and district hospital with
Shigella, Yersinia, E. coli susceptibility testing microbiologists
0157:H7, Campylobacter,
Vibrio, Aeromonas,
Pleisomonas
Antigen detection (IF) State hospitals
Enterovirus
Stool, throat swab, CSF,
infections(Coxsackieviruses,
Isolation and strain typing vesicle fluid and tissue
echoviruses, poliovirus) IMR(Virology Division)
48
Enterovirus Genome detection Stool, throat swab, CSF, IMR(Virology Division), NPHL, university hospital
infections(Coxsackieviruses, vesicle fluid and tissue laboratories*
echoviruses, poliovirus)
EIA for mumps, measles Serum State hospitals and Public Health Laboratories, IMR
and rubella (Virology Division)
Exanthematous viral infections
IFA Vesicular fluid, lesion swab State hospitals and Public Health Laboratories
Haemophilus ducreyi Isolation, identification and Genital ulcer swab, aspirated State hospitals and district hospital with
susceptibility testing pus microbiologists, Public Health Laboratories
HIV Screening and confirmation Serum State hospitals and district hospital with
microbiologists, Public Health Laboratories
Antigen test State hospitals, Public Health Laboratories.
Throat swab, nasopharyngeal Note: Need to confirm positives with conventional
swab, bronchial wash or other virus isolation and subtyping by Virology Division,
respiratory specimen IMR. Specimens tested negative are not reported until
conventional culture results are r
Influenzae virus/ parainfluenza
Isolation and typing of State hospitals.
virus Throat swab, nasopharyngeal
influenza virus by shell Note: Specimens tested negative are not reported until
Influenzae virus/ parainfluenza swab, bronchial wash or other
vials conventional culture results are reported.
virus respiratory specimen
Isolation and typing by Virology Division, IMR
Throat swab, nasopharyngeal
conventional culture
swab, bronchial wash or other
respiratory specimen
49
Isolation and identification Lung tissue, pleural fluid, State hospitals, Public Health Laboratories
of Legionella pneumophila transtracheal aspirate and
serogroup 1 lower respiratory secretions
Legionellosis Speciation and Pure culture Bacteriology Division, IMR

serogrouping of other
legionella
Isolation, identification and Blood and CSF (1st 10 days State hospitals, Public Health Laboratories
susceptibility testing of illness), urine (2nd week -
30 days)
Antigen detection Urine State hospitals, Public Health Laboratories
Leptospirosis EIA - screening Serum State hospitals, Public Health Laboratories
MAT- confirmatory Bacteriology Division, IMR
Meningococcal disease Bacterial culture, CSF, blood State hospitals and district hospital with
identification, susceptibility microbiologists.
testing and antigen testing
Culture and susceptibility Endocervical swab, urethral State hospitals and district hospital with
testing swab, eye swab in Amies microbiologists and Public Health Laboratories
transport media. Preferably
swab from suspected site of
Neisseria gonorhoea infection is streaked on to
selective media e.g. Thayer
Martin
50
Neisseria gonorhoea Strain typing Pure culture IMR (Bacteriology Division)

Isolation only Sputum, blood, CSF, gastric State hospitals and district hospital with
lavage, skin lesion material, microbiologists
tissue, stool, urine
Isolation, genus Sputum, blood, CSF, gastric State hospitals with automated Tb culture system and
identification and lavage, skin lesion material, Public Health Laboratories
susceptibility testing tissue, stool, urine
Tuberculosis
Species identification and Pure, actively growing Institute Of Respiratory Medicine, HKL and National
susceptibility testing (gold culture on LJ agar slant Public Health Laboratory
standard method of testing)
Molecular strain typing Pure culture National PHL
(RFLP)
Rickettsial diseases Indirect Immunoperoxidase Serum State hospitals
Isolation, identification and Blood, pus, throat swab State hospitals and district hospital with
Streptococcal infections susceptibility testing microbiologists and Public Health Laboratories
Strain typing Pure culture IMR (Bacteriology Division)
Syphilis Serology Serum, CSF State hospitals and district hospital with
microbiologists.
Serology (latex Stool State hospitals
agglutination, EIA)
Viral gastroenteritis
Electron microscopic Stool IMR(Virology Division)
examination
51
APPENDIX 4
CONTACT NUMBER OF REFERENCE LABORATORIES
LABORATORY PHONE / FAX NUMBER
Institute of Medical Research 03 - 26988876 (phone)

Jalan Pahang, KL. 03 - 26939335 (fax)
National Public Health Lab 03 - 61565109 (phone)

Sungai Buloh, Selangor. 03 - 61571036 (phone)
03 - 61402249 (fax)
Ipoh Public Health Lab 05 - 5287829 (phone)

Jalan Jelapang, 30020 Ipoh 05 - 5287836 (fax)
Johor Bharu Public Health Lab 07 - 2387162 (phone)

Jalan Persiaran 1 Tampoi 07 - 2387215 (fax)
81200 Johor Bharu, Johor.
University Malaya Medical Centre 03 - 79677022 (phone)

Lembah Pantai 03 - 79594767 (fax)
59100 Kuala Lumpur
Universiti Kebangsaan Malaysia 03 - 91733333 (phone)

Jalan Yaacob Latif 03 - 9702531 (phone)
Bandar Tun Razak 03 - 9702548 (phone)
56000 Cheras, Kuala Lumpur 03 - 91737149 (fax)
Universiti Malaysia Sarawak 082 - 671000 (phone)

94300 Kota Samarahan 082 - 67111903 (fax)
Sarawak 082 - 672275 (fax)
Universiti Sains Malaysia 09 - 7651711 (phone)

Jalan Raja Perempuan Zainab II 09 - 7651700 (phone)
16150 Kubang Kerian, Kelantan. 09 - 7652198 (fax)
Veterinary Research Institute 05 – 5457166 / 87 (phone)

No. 59, Jalan Sultan Azlan Shah, 05 - 5452863 (phone)
31400 Ipoh, Perak Darul Ridzuan. 05 - 5463368 (fax)
Penang Poison Centre 04 - 6570099 (phone)

University Science Malaysia 04 - 6568417 (fax)
11800 Pulau Pinang
Jabatan Kimia Malaysia 03 - 79573611 (phone)

Jalan Sultan 03 - 79853000 (phone)
46661 Petaling Jaya, Selangor. 03 - 79556764 (fax)
52
APPENDIX 5
STANDARD OPERATING PROCEDURE FOR SETTING UP OF AN

OPERATIONS ROOM
When to set up an Operations Room

1. Infectious disease outbreak occurring in more than one states (national level),
more than one district (state level) and if only one district (district level).
2. Infectious disease outbreak causing lost of life.
3. Incidence of bioterrorism.
4. Global alert on any infectious disease that may occur locally.
5. When ordered by a higher authority.
Term of Reference (TOR)
1. To compile and monitor all information on activities concerning the infectious

disease outbreak done at the relevant level.
2. To coordinate all activities involving inter-agency co-operation and
collaboration. e.g. education, veterinary services, defense , information etc.
3. Updating of information concerning the outbreak
• Number of cases reported (case listing)
• Control activities
• Health education activities
• Current situation of the outbreak.
4. To manage the hotline – to provide information
5. To prepare the daily report.
6. To prepare press release if require.
7. To prepare information for dissemination to relevant parties.
Function of every unit at National Operations Room

for the control of an Infectious Disease Outbreak.
A. Task Force Secretariat.

• Secretariat to National Outbreak Control Task Force.
• Secretariat to Inter-agency Committee
• Arrange Task Force Meeting
• Co-ordinate activity reports from all departments involved.
B. Technical Information Unit.

• Managing source of technical information about the outbreak.
• Download all information related to the disease from the internet.
• Compile the technical information.
• Distribute the technical information to those concerned.
53
C. Epidemiological Analysis Unit
• Analyse the epidemiological data from case investigation /
notifications received.
• Input of data to data base.
• Perform epidemiological analysis.
• Prepare and distribute of reports to the secretariat.
D. Supplies and Procurement Unit

• Manage supply of vaccines / insecticides / drugs / personal protective
equipment (PPE) and other supplies wherever applicable.
E. Health Education Unit

• Prepare of health education materials.
• Distribute of the health education material to related agencies and the
public.
• Coordinate health education activities with mass media.
F. Logistic Unit
• Prepare Operations Room equipment
• Prepare transportation
• Prepare refreshments
• Maintain the cleanliness of Operation Room.
• Act as the secretariat for Operations Room daily meeting.
G. Human Resource Unit

• Prepare the duty roster (according to shift).
• List down the telephone numbers of all officers on duty.
• Ensure the presence of officers on duty according to the roster (or their
replacement). However it is the officer responsibility to find the
replacement and inform the Human Resource Officer.
• Coordinate with other departments for officers to be on called.
H. Documentation Unit
• Receive daily reports from various departments.
• Prepare the daily report.
• Distribute the daily report to the relevant parties.
• Document the chronology of events taken place in the outbreak.
• Review newspaper cuttings.
• Be responsible in maintaining the letters in–out files.
I. IT Support Unit
• Update the Homepage Information (if any).
• Response to queries received through e-mail.
• Manage guidelines in a software form.
54
J. Guidelines Preparation Unit
• Prepare guidelines related to the infectious disease outbreak i.e.
9 case management,
9 case follow-up,
9 quarantine,
9 screening,
9 transportation of cases
9 surveillance of health staff
K. Hotline Unit
• Answer the hotline telephone calls.
Equipment needed in an Operations Room.
1. Telephones for
• direct lines,
• hotlines,
• mobile telephones / intercom / ATUR phone
2. Facsimile machines.
3. Computers (with installed related software) and printers.
4. INTERNET with homepage and e-mail group
5. White boards.
6. Soft board.
7. Stationery.
8. Television with ASTRO.
9. Maps and / or GIS.
10. Directory of state health departments, district health offices, government /
NGO / private hospitals and laboratories / staff / personnel with address
and contact numbers.
11. Protocols and guidelines (related to outbreak).
12. Rapid response kits.
13. Health information materials.
14. Files with systematic filing system.
When to close an Operation Room.
1. No new cases / transmission within 2 incubation periods or longer if

necessary. However monitoring should be continued by a designated unit /
personnel.
2. Ordered by a higher authority.
State health department and district health office should modify the functions according
to available staff.
55
APPENDIX 6
PROTOCOLS AND GUIDELINES AVAILABLE

AT MINISTRY OF HEALTH
1. General Guidelines On Food-Water-Borne Disease In Malaysia.

2. Plan Of Action For Control Of Cholera.
3. National Guidelines For Food Poisoning Control.
4. National Guidelines For Typhoid Management.
5. National Guidelines for Management of Dysentry.
6. National Guidelines for Management of Hepatitis A.
7. Guidelines For The Prevention And Control Of Dengue Fever And Dengue
Haemorrhagic Fever.
8. Manual Of Dengue Control.
9. Management Of Severe And Complicated Malaria.
10. Guidelines On Enterovirus Epidemic Control.
11. Guidelines On The Management And Follow-Up Of Nipah Infection.
12. Epidemiologic Studies And Guidelines Of JE / Nipah Outbreak.
13. Preparedness And Response To Wild Poliovirus Importation.
14. National Polio Eradication Programme.
15. National Plan Of Action For Laboratory Containment Of Wild Poliovirus.
16. Practice Guidelines For The Control And Management Of Tuberculosis, 2002.
17. Guidelines For The Prevention And Control Of Plague, 1996.
18. Field Guidelines for Laboratory based Surveillance.
19. Case definition for infectious disease in Malaysia
20. Syndromic Notification and Laboratory Investigation Manual.
56
APPENDIX 7
FORMAT FOR WRITING A FINAL REPORT

ON AN OUTBREAK/EPIDEMIC
1. TITLE OF REPORT (short)

Informative (to include what, where and when);
Name of author(s) and department(s)
2. SYNOPSIS (summary) (short)

Epidemic (what, where and when);
Main findings;
Actions taken (control measures) and recommendations
3. INTRODUCTION (brief)
Background of the setting in which the outbreak/epidemic exists
(geography, climate, socio-demography, health facilities);
Surveillance system, EWS, and epidemic preparedness (RRT);
Usual incidence/prevalence;
Previous case(s)/ experience of epidemics of similar disease in the same
locality/nearby areas;
Other related/significant disease(s) in the locality/nearby areas;
(Chronology of events)
Describes the circumstances leading to the initiation of the
investigation (to include index case(s) and significant event(s) leading to the
epidemic)
4. OBJECTIVE OF THE INVESTIGATION
5. METHODOLOGY (materials and methods)

Definitions & criteria used;
Questionnaire used for epidemiological investigations;
Type of study (study design eg. case-control, etc);
I. Investigative methods taken to verify diagnosis and confirm the
existence of epidemic;
Lab specimen: type of specimen, collection and transport;
Lab techniques;
Data handling and analysis
6. RESULTS
Clinical data: signs and symptoms, course of disease, complications, deaths,
differential diagnoses;
Epidemiological data: characteristics of outbreak by T.P.P.,
asymptomatic cases, contacts, death rate;
Description of index & secondary cases;
57
Epidemic curve: time of exposure, incubation period;
Mode of transmission: source of infection, risk factors;
Lab data: causative agent (bacterial/viral/fungal/chemical),
serological confirmation. (may include tables, maps, diagrams/graphs
if indicated/necessary….but please be selective)
7. DISCUSSION
(Overall picture of the outbreak/epidemic)
Interpretation of results:
testing of hypothesis - hypothesis with regards to source of infection,
mode of transmission, and causative agent
Statistical (significant) tests to test hypotheses
Epidemic curve – describes in details
8. REMEDIAL ACTIONS
(A description of the action taken/control measures)
To control the epidemic immediately;
Methods employed; (what, how, when, where, and by whom)
Follow-up (results);
Evaluate effectiveness/constraints;
To prevent recurrence of epidemic;
9. CONCLUSION AND RECOMMENDATION

Status of epidemic encountered;
Control measures
Problems faced (if any);
Recommendations (if any), and
Lessons learnt
10. ACKNOWLEDGEMENT
Where relevant
11. ANNEXES
(If not included under the RESULTS)
Maps;
Master case list;
Tables/Diagrams, etc
Organisation chart (where relevant)
Committee(s) (where necessary)
amal.IDRC.IMR.2002
58
ACKNOWLEDGEMENT
Participants of Rapid Response Workshop

September 2002 at Seremban, Negeri Sembilan.
1 Dr. Abdul Karim Tajudin

Senior Consultant Forensic Pathologist, Tengku Ampuan Rahimah Hospital, Klang.
2 Dr. Abu Hassan Assari

Senior Consultant Surgeon, HKL.
3 Dr. Ahmad Faudzi Yusoff

Principal Assisstant Director, Epidemiology and Disease Control Division, PHI
4 Dr. Amal Nasir Mustafa

Epidemiologist, Epid & Biostistic Division, IMR.
5 Dr. Ariza Adnan

Pathologist, HKL.
6 Dr. Arumugam Lingam

Director of National Public Health Laboratory.
7 Dr. Azizah Mustafa

Patologist, Tengku Ampuan Rahimah Hospital, Klang.
8 Dr. Cheng Hoei Hon

Deputy Director of Disease Control (Surveillance), MOH
9 Dr. Christopher Lee

Senior Consultant Physician, HKL
10 Dr. Chua Siew Kee

Physician, Tengku Ampuan Rahimah Hospital, Klang.
11 Dr. Devan Kurup

Principal Assisstant Director, Disease Control Division, MOH
12 Dr. Halimah Yahaya

Senior Consultant Pathologist, HKL
13 Prof. Dr. Hamimah Hassan

Head of Bacteriology Department, UMMC.
14 Dr. Hasni Hanapi

Epidemiologist, National Public Health Laboratory.
15 Prof. Dr Ilina Isahak

Microbiologist, HUKM.
16 Dr. Faizul Mansoor

Medical Officer of Health, Miri Division, Sarawak.
17 Dr. Kamarul Azhar bin Mohd Razali

Paediatrician, Institute of Paediatric, Kuala Lumpur.
59
18 Dr. Kuldip Kaur a/p Prem Singh
Principal Assisstant Director, Perkembangan Perubatan Division, MOH.
19 Dr. Johara Mohamad Yob

Head of Bacteriology Unit, Veterinar Research Institute, Ipoh Perak.
20 Dr. Lee Cheow Pheng

Public Health Specialist, Disease Control Division, MOH
21 Dr. Lokman Hakim Sulaiman

Head of Parasitology Unit, IMR.
22 Dr. Mahiran Mustafa

Family Physician, Kota Bahru Hospital, Kelantan.
23 Assoc. Prof Dr. Md. Radzi Johari

Head of Bacteriology Department, HUSM.
24 Dr. Musa Ashaari

State Epidemiologist, Sabah.
25 Dr. Nirmala Amplavanar

26 Dr. Norazah Ahmad

Microbiologist, IMR.
27 Dr. Noorani Baba

State Deputy Director of Health, Malacca.
28 Dr. Norliza Ariffin

Infectious Disease Physician, UMMC.
29 Mrs. Normah Untong

Director of Ipoh Public Health Laboratory.
30 Dr. Norshahidah Khairullah

Head of Virology Unit, IMR.
31 Dr. Nurahan Mahing

Microbiologist, Tengku Ampuan Rahimah Hospital, Klang.
32 Dr. Odhayakumar
Head of Epidemiology and Disease Control Division, PHI
33 Dr. Ooi Choo Huck

State Epidemiologist, Sarawak.
34 Dr. Revathy Nallusamy

Paediatrician, Penang Hospital
35 Dr. Rohani Jahis

Assisstant Director, Disease Control Division, MOH
60
36 Dr. Rohani Mohd Yassin
Head of Bacteriology Unit, IMR.
37 Dr. Rushidi Ramly

Medicah Officer of Health, Petaling Selangor.
38 Datin Dr. Salbiah Hj Nawi

Microbiologist, National Public Health Laboratory.
39 Mr. Shamshulbahrin Sidik

Scientist, Johor Bahru Public Health Laboratory.
40 Ms. Siti Fatimah

Clerk, IMR.
41 Mrs. Soshila Ramayah

Scientist, National Public Health Laboratory.
42 Dr. Sulaiman Che Rus

Director of Public Health Institute (PHI)
43 Dr. Tan Kah Kee

Paediatrician, Seremban Hospital, NS.
44 Dr. Thaherah Nor bt Mohd Kassim

Medicah Officer of Health, Selama-Larut-Matang, Perak.
45 Mr. Thavaraj Subramaniam

Health Education Officer, IPH
46 Dr. Satwant Singh

Assisstant Director, Disease Control Division, MOH
47 Dr. Venugopalan
State Epidemiologist, Selangor.
48 Prof. Dr. Victor Lim

Director of Infectious Disease Research Centre, IMR.
49 Dr. Wan Mansur Hamzah

State Epidemiologist, Kelantan.
50 Dr. Wong Swee Lan

Senior Consultant Paediatrician, Institute of Paediatric, Kuala Lumpur.
51 Dr. Zaharah Salleh

Medical Officer of Health (II), Johor Bharu, Johor.
52 Dr. Zainah Saat

Virologist, IMR.
53 Dr. Zainudin Abdul Wahab

61

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MOH / K / EPI / 39.

INFECTIOUS DISEASES OUTBREAK

Disease Control Division

ADVISOR: Dr. Shafie Ooyub

MEMBERS: Prof. Dr. Victor Lim

Dr. Lee Cheow Pheng

Dr. Cheng Hoei Hon

Dr. Zainudin Abdul Wahab

Dr. Amal Nasir Mustafa

Dr. Fadzilah Kamaludin

Datin Dr. Salbiah Hj Nawi

Dr. Leela Anthony

Dr. Rohani Jahis

2.0 Outbreak Preparedness 9

3.0 Surveillance and Alert 28

4.0 Outbreak Management. 40

5.0 Risk Communication 49

6.0 Occupational Health And Safety For Health Care Workers 49

7.0 Criteria For Recommending The Invoking Of ‘Arahan’ 20 49

LIST OF APPENDICES PAGE

1. List of notifiable communicable diseases 55

2. Microbiological services available at the Reference Laboratories. 58

3. Directory Of Laboratory Services 59

4. Contact number of reference laboratories 66

5. Standard operating procedure for setting up of an operations room 67

6. Protocols and guidelines available at ministry of health 70

7. Format for writing a final report on an outbreak/epidemic 71

1. Existing and future regional reference laboratories 17

2. International laboratory resources. 19

3. Stockpiles of critical materials 24

4. List of Personal Protective Equipment 27

5. List of zoonotic diseases with public health importance 33

6. Proxy indicators of existing surveillance system 39

LIST OF FIGURES PAGE

1. Surveillance mechanism in Malaysia 30

2. Laboratory based surveillance flow chart 31

3. Syndromic surveillance flow chart 32

4. Flow of surveillance data and information dissemination 36

5. Outbreak management framework 40

6. Outbreak management flow chart 41

7. Line of communication (outbreak information and support request) 43

The Director General of World Health Organisation (WHO), Dr.

As detection and response to infectious disease outbreaks require

TAN SRI DATU DR MOHAMAD TAHA BIN ARIF

APW Alkaline peptone water CSF Cerebro-spinal fluid

CDSS Communicable Disease DCD Disease Control Division

FOMEMA Foreign Workers Medical GIS Geographical Information System

HFMD Hand-foot-mouth disease HKL Kuala Lumpur Hospital

HUKM Hopsital Universiti HUSM Hospital Universiti Sains Malaysia

ID Infectious Diseases IMR Institute for Medical Research

MAb Monoclonal antibody MOH Medical Officer of Health

NPHL National Public Health PCID Prevention And Control of

PHI Public Health Inspector PHL Public Health Laboratory

PPE Personnel Protective Equipment RAT Rapid Assessment Team

RRT Rapid Response Team Scl-F Salenite-F

SHD State Health Department UMMC University Malaya Medical Centre

UNIMAS University Malaysia Sarawak USM, PP University Sains Malaysia, Pulau

VRI Veterinary Research Institute VTM Viral transport media

WHO World Health Organisation