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    1 Physical Pharmacy (2220001)

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    vanita
    This document outlines the course contents for Physical Pharmacy for the second semester of the B.Pharm program at Gujarat Technological University. The theory portion covers 7 topics related to states of matter, solubility, surface phenomena, complexation, disperse systems, micromeritics, and rheology over 45 hours. The practical portion involves 15 experiments related to solubility, phase diagrams, latent heat, distribution, surface tension, particle size analysis, powder properties, viscosity, and sedimentation parameters. Recommended textbooks for the course are also provided.

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    1 Physical Pharmacy (2220001)

    Uploaded by

    vanita
    68 views2 pages
    This document outlines the course contents for Physical Pharmacy for the second semester of the B.Pharm program at Gujarat Technological University. The theory portion covers 7 topics related to states of matter, solubility, surface phenomena, complexation, disperse systems, micromeritics, and rheology over 45 hours. The practical portion involves 15 experiments related to solubility, phase diagrams, latent heat, distribution, surface tension, particle size analysis, powder properties, viscosity, and sedimentation parameters. Recommended textbooks for the course are also provided.

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    This document outlines the course contents for Physical Pharmacy for the second semester of the B.Pharm program at Gujarat Technological University. The theory portion covers 7 topics related to states of matter, solubility, surface phenomena, complexation, disperse systems, micromeritics, and rheology over 45 hours. The practical portion involves 15 experiments related to solubility, phase diagrams, latent heat, distribution, surface tension, particle size analysis, powder properties, viscosity, and sedimentation parameters. Recommended textbooks for the course are also provided.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    68 views2 pages

    1 Physical Pharmacy (2220001)

    Uploaded by

    vanita
    This document outlines the course contents for Physical Pharmacy for the second semester of the B.Pharm program at Gujarat Technological University. The theory portion covers 7 topics related to states of matter, solubility, surface phenomena, complexation, disperse systems, micromeritics, and rheology over 45 hours. The practical portion involves 15 experiments related to solubility, phase diagrams, latent heat, distribution, surface tension, particle size analysis, powder properties, viscosity, and sedimentation parameters. Recommended textbooks for the course are also provided.

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    © All Rights Reserved
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    of 2

    GUJARAT TECHNOLOGICAL UNIVERSITY

    B.PHARM SEMESTER-II
    PHYSICAL PHARMACY
    Subject code: 2220001
    THEORY (3 Hours / Week; 3 Credits, 45 Hours)

    Sr. Course Contents Hours


    No.
    1. States of Matter: 5
    Introduction, binding forces between molecules, states of matter-solids,
    liquids, gases, liquid crystals, glassy state, phase equilibrium and phase rule,
    condensed systems
    2. Solubility and Distribution Phenomenon: 6
    General principles, solvent-solute interactions, solubility of gases in liquids,
    solubility of liquids in liquids, solubility of solids in liquids, distribution of solutes
    between immiscible solvents.
    3. Surface and Interfacial phenomenon: 6
    Liquid interface, adsorption at liquid interfaces, adsorption at solid interface,
    applications of surface active agents, electrical properties of interfaces.
    4. Complexation and protein binding : 5
    Metal complexes, organic molecular complexes, protein binding, thermodynamic
    treatment of stability constants, applications of complexes in dosage forms.
    5. Disperse systems: 9
    a. Colloidal dispersions: Definition, types, properties of colloids, protective
    colloids, applications of colloids in pharmacy.
    b. Suspensions and Emulsions : Interfacial properties of suspended
    particles/globules, settling in suspensions, theory of sedimentation, effect of
    Brownian movement, sedimentation of flocculated particles, sedimentation
    parameters, wetting of particles, controlled flocculation, flocculation in structured
    vehicle, rheological considerations, emulsions ; types, theories, physical stability.
    6. Micromeritics: 6
    Particle size and distribution, methods for determining particle size, particle
    shape and surface area, methods for determining surface area, derived
    properties of powders,
    7. Rheology : 8
    a. Newtonian system, Non-Newtonian systems, thixotropy in formulation,
    determination of rheological properties, applications in pharmacy.
    b. Flow of Powders: Introduction, methods to determine, factors affecting powder
    flow, pharmacopeial specification of angle of repose, hausner’s ratio, carr's
    index.
    B.PHARM SEMESTER-II
    PHYSICAL PHARMACY
    Subject code: 22200P1
    PACTICAL (3 Hours / Week; 3 Credits, 45 Hours)

    Practical related to following topics should be covered:


    Sr. Course Contents Hours
    No.
    1. Solubility of solids.
    2. Determination of phenol water coefficient.
    3. Preparation of thymol salol eutectic system.
    4. Preparation of ternary phase system with one pair of partially
    miscible liquid.
    5. Determination of latent heat, vapor pressure, critical point.
    6. To find out the distribution coefficient of given solid.
    7. Determination of surface / interfacial tension, HLB value and CMC
    of surfactants 45
    8. Determination of particle size and size distribution of powders by
    different methods.
    9. Determination of derived properties of powder
    10. Determination of particle shape and surface area
    11. Determination of viscosity of Newtonian and Non-newtonian systems
    12. Effect of temperature on viscosity of liquids.
    13. Effect of particle size, porosity, moisture, lubricants, glidants on flow
    property of powder.
    14. Studies on different types of complexes and determination of their
    stability constants
    15. Determination of sedimentation parameters for suspensions and
    emulsions.
    Books Recommended (Latest Editions):
    1. Martin’s Physical pharmacy by Patrick J. Sinko, 5th edition, Lippincott Williams &
    Wilkins, New York, 2006.
    2. Pharmaceutics: The Science of Dosage Form Design, 2nd edition, Aulton, Michael E.,
    Chrchill Livingstone, London, 2002.
    3. Remington: The Science and Practice of Pharmacy, Vol-I & II, 20th edition, Gennaro,
    Alfonso R.,Lippincott Williams & Wilkins, New York, 2002.
    4. Physicochemical Principles of Pharmacy, 3rd edition, Florence, A. T. Atwood, D.
    Macmillan Press Ltd., London 1998.
    5. Pharmaceutical Dosage Forms and Drug Delivery Systems, Ansel, Howard. C., Allen,
    Loyd V., Popovich, Nicholas G. Lippincott Williams & Wilkins, New York, 2002.
    6. Cooper and Gunn’s Tutorial Pharmacy, ed. Carter, S. J., 6th edition, CBS Publishers &
    Distributors, Delhi, 2000.
    7. Bentley’s textbook of Pharmaceutics by E. A. Rawlins

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