NIcholas Kelly Final Bioethics Paper
NIcholas Kelly Final Bioethics Paper
NIcholas Kelly Final Bioethics Paper
Bioethics
Final Paper
A defense of modest genetic enhancement
Genetic engineering has never been so plausible. Recent developments in genetics have
significantly lowered the barrier to entry into genetic experimentation. With these changes have come
increased calls for prohibitions on researching and developing these new technologies. However,
genetics are not destiny, even in an age of potential engineering. Now more than ever it is clear
enhancing humanity is not as simple as plugging in one new gene. Ethics must respond to scientific
developments, but it must also be shaped by reality. An increasing body of evidence suggests that many
of the most compelling arguments for prohibiting human genetic enhancement are based on unrealistic
understandings of what the technology can and cannot do. The interventions that many find most
concerning, physical and cognitive enhancements, would require modifying dozens or hundreds of genes
and provide only limited results. Meanwhile, the least objectionable genetic changes, curing genetic
defects, are often the simplest because they require fewer edits to better understood genes. Restricting
the possible and desirable based on the theoretical and undesirable is a poor course.
This paper will argue two related points. First, inheritable human genetic treatments through
genetic germline editing (GGE) should be permitted because the benefits outweigh the reality of the
consequences. Second, that the therapy/enhancement distinction that many ethicists use to divide
permissible and impermissible intervention should be discarded, and our concerns should be focused on
developing techniques that are safe and useful. There may be interventions that should be prohibited,
but not based on these distinctions. Considering these two points along with the potential benefits of
these techniques, it is desirable for our society to permit parents to choose some germline enhancements
for their children. This is not a proposal for immediate implementation of genetic enhancement; even
the strongest proponents agree that it will be years before it is sufficiently safe for human use. This paper
operates on the assumption, shared by many in the field, that this technology will one day be sufficiently
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safe and accurate for human use. While we cannot prove that germline enhancement will certainly be
safe, we also cannot prove it never will be; therefore, in the face of it plausibly becoming safe, the more
prudent course is to consider the issue and devise rules while we have time to deliberate. Essentially, this
argument will treat as its baseline the likely future commercial implementation of current clinical
CRISPR (pronounced crisper) stands for Clustered Regularly Interspaced Short Palindromic
Repeat; the name refers to a technique that certain bacteria species use to defeat attacking viruses.1 The
bacteria copies part of the virus DNA and attaches it to an DNA-sundering enzyme called Cas, which
uses the virus DNA sample to find and destroy matching strands. 2 In 2012, using a specific and more
effective version of Cas called Cas9, researchers invented a biological version of find-and-replace
one that could work in virtually any species [the inventors] chose to work on. 3 CRISPR/Cas9, often just
called CRISPR, permits scientists to precisely excise targeted genes, which are then replaced with other
genes chosen by the scientists.4 This makes genetic engineering cheaper and more practical than ever.
Due to its unprecedented precision, academics have hailed CRISPR as a revolutionary advance in
genetics, with possible applications ranging from reviving extinct animals to ending the threat of
malaria.5 With this great potential comes great concerns as well, specifically with regards to the potential
use of CRISPR in GGE.6 GGE consists of modifying DNA in reproductive cells that pass DNA from
parent to child.7 GGE editing could be used to eradicate genetic diseases, but it could also be used to
1 Abigail Beall, Genetically-modified humans: what is CRISPR and how does it work?, WIRED (FEB. 5, 2017),
http://www.wired.co.uk/article/crispr-cas9-technique-explained.
2 Id.
3 Carl Zimmer, Breakthrough DNA Editor Born of Bacteria, QUANTA MAG. (Feb. 6, 2015),
https://www.quantamagazine.org/20150206-crispr-dna-editor-bacteria/.
4 Id.
5 Beall, supra note 1.
6 Cormac Sheridan, CRISPR germline editing reverberates through biotech industry, 33 NAT. BIOTECHNOLOGY, 429, 431 (2015)
(reporting on the IGI forum on Bioethicists call for a moratorium on germline editing research).
7 NATL ACAD. OF SCI., ENGINEERING, AND MED. HUMAN GENOME EDITING: SCIENCE, ETHICS, AND GOVERNANCE
2
enhance humanity beyond what is currently possible.8 This second practice is controversial both because
of the potential dangers it poses to its subjects and because of underlying concerns regarding the ethics
of engineering humanity, with some critics explicitly comparing it to the eugenics movements of
previous centuries.9 The appropriate regulation of this technology is controversial to say the least.
While many scientists have called for a moratorium on human germline editing, others are
skeptical that that is practicable.10 Simply put, the genie may be out of the bottle; CRISPRs simplicity
has led to the conclusion that GGE is inevitable.11 That is debatable, but regulation of this technology
has still never been more salient. Even if the latest advances in genetics dont lead to the full range of
interventions that many scientists believe will become available in the future, it is more prudent to
attempt to establish those principles now than to wait until the techniques are being implemented. For
this paper, the assumed level of functionality is that a doctor can confidently remove one or more
segments of DNA and replace those segments with specified alternate segments, which are chosen based
what the gene does. Its impossible to form meaningful assumptions about how much well know about
genetics in 20 years, but given what we know about the state of technology, this level of accuracy and
safety is plausible.
Historically, there has been a split in bioethics about somatic germline editing (SGE) and GGE,
with far more opposition to the former. 12 Some degree of increased opposition or caution is to be
expected; GGE necessarily has the potential for greater mishaps than SGE because a defective gene
introduced through SGE would usually only impact one person, but that same defective gene would
8 Carolyn Brokowski et al., Cutting Eugenics Out of CRISPR-Cas9, 6 ETHICS IN BIOLOGY, ENGINEERING AND MED.: AN
INTL J. 263, 263 (2015)[hereinafter Eugenics Out of CRISPR].
9 Id. at 270
10 Katrine S Bosley et al., CRISPR germline engineering the community speaks, 33 NAT. BIOTECHNOLOGY, 429, 478 (2015).
11 Id. at 47879.
12 HUMAN GENOME EDITING, supra note 7, at 91100 (laying out the general landscape of opposition to germline
intervention).
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have the potential to manifest and be passed to offspring through GGE. However, concerns go far
beyond the acknowledgement of an increase in the potential impact of a defective intervention. As stated
previously, this paper is working from the assumption that the technical issues are solvable and that we
should be developing rules for the best possible version of this technology. The concern here is not
whether it works, but what to do if it does.13 It is only under these conditions of safety and
understanding that GGE should be done; to the extent the technology is far from that standard of
reliability and safety, I am in complete agreement with those who oppose diving into the practice.14
This section of the paper will be focusing on promoting therapeutic GGE; though the
distinction between therapy and enhancement will later be shown to be not as strong as many suggest, it
is a structural conceit that is common throughout the literature on this topic and will be useful for
organizing the argument.15 This analysis will focus on curing diseases, which is the weaker but universally
agreed upon definition of therapy, which excludes prevention of disease by boosting human immunities.
During the discussion of whether enhancement should be permitted, it will be taken as a given that the
enhancement in question is GGE, which should justify SGE a fortiori. First, we will examine the common
arguments against GGE to determine if they hold water, given an assumption of safety and efficacy. If
the case against is weak enough to proceed, the discussion can shift to the case in favor of GGE.
One common critique of GGE is that it is an attack on the autonomy of the unborn. This takes
a few forms. Jrgen Habermas, for example, generally opposes GGE because any change to our default
genetics constitutes a limitation on autonomy. 16 When a change is made to a childs genome, it alienates
that child from their ability to distinguish their natural self from their social self.17 In doing so, the childs
13 A great deal of the current opposition to germline editing is from those who understandably doubt that it can be used
safely anytime soon. While this is completely logical, it is outside the scope of this piece. HUMAN GENOME EDITING,
supra note 7, at 9394.
14 E.g., Edward Lanphier et al., Dont edit the human germ line, 519 NAT. 410 (2015).
15 HUMAN GENOME EDITING, supra note 7, at 94 (directing readers away from the germline discussion to a separate
chapter to read about enhancement, though that enhancement chapter acknowledges the difficulty in fully forming that
distinction).
16 Jonathan Pugh, Autonomy, Natality and Freedom: A Liberal Re-examination of Habermas in the Enhancement Debate., 29
BIOETHICS, 145, 147 (2015) (defending and clarifying Habermass objections to germline editing).
17 Id. at 146.
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ability to conceive of themselves autonomously is compromised because they lack the reference point of
their own natality, meaning their own phenomenon of birth where they were born into the social
setting that influences them. This reduced conception of autonomy in turn impacts their actual ability to
act autonomously. This is a difficult argument to respond to in the sense that it has premises that are not
obviously true and developed through Habermass larger body of work. However, as a beginning point,
the mechanism of how ones genetics influence ones natality. Habermas denies that his position is
genetic determinism, arguing instead that the change he is concerned with would take place in the mind
after the child learns of their modification.18 It is the reaction to this information that provokes the
damage to ones autonomous conception. This seems to present a tension though. If our identity is
shaped by the social and we have our inherent natural fate, how can we say that all humans will react
in this specific negative way to learning about their own genetic editing, no matter the context of that
disclosure? Does reading an in-depth report by the doctor who engineered dozens of your genes
provoke the same response as hearing in casual conversation that you had some unknown gene changed?
This is further complicated by the fact that Habermas ascribes the same harm to embryo screening that
he does to GGE, because both reduce the subjects understanding of autonomy. 19 The weak form of this
argument, that some people suffer some form of psychological harm or autonomy impairment, is
difficult to rebut.20 However, the strong form of the argument, that all people will respond to this broad
set of stimuli by having their autonomy impaired in a specific way is at odds with the autonomy that
Habermas centers in his argument. The weak form does not do enough work to justify a prohibition; if
anything, it suggests we should research if the psychological harm that concerns Habermas has
manifested in the thousands of people who have been born through embryo screening to determine if
this problem is real. If it is, then it can be weighed against the potential benefits of GGE.
266.
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Another formulation of the autonomy argument is that GGE has the potential to alter character
and thus autonomy in a morally-negative way.21 Robert Sparrow focuses on interventions that can
impact a persons mental or emotional state, arguing that these are dehumanizing and autonomy-
reducing because they treat the person as an object to be acted upon. 22 In emphasizing this
objectification, Sparrow distinguishes GGE from moral education and the like by noting that even
education of a child involves communicative acts, which implicitly frame the student and teacher as
moral equals in some sense because they are both members of a linguistic community.23 Biological
Acts, on the other hand, are performed by actors upon objects (fetuses etc.). Thus, while moral
education may not constrain freedom, genetic intervention does by manipulating the person as an object
This account misses that GGE as it is typically proposed is in the context of parental decisions
about their children. While it is true that parents parent their children as fellow humans who have been
born, the truth is that parents exercise extensive manipulation and control of children from their birth, a
point which significantly predates any potential for moral education. Legally and socially, parents own
their children, subject to certain baseline welfare concerns; the Supreme Courts basis for finding
compulsory public school unconstitutional was that it violated the rights of parents to control their
childrens upbringing; this is not a right to look out for your child but an explicit right to control your
child.24 Even in the case of childrens civil rights, they are often explicitly collapsed into those of the
parent.25 This same phenomenon can be seen in custody cases, where parents have legally recognized
interests in controlling their children that are distinct from any analysis of the childs needs and interest
21 Robert Sparrow, Better Living Through Chemistry? A Reply to Savulescu and Persson on Moral Enhancement, 31 J. OF APPLIED
PHIL. 23 (2014).
22 Id. at 26.
23 Id.
24 Barbara Bennett Woodhouse, "Who Owns the Child?": Meyer and Pierce and the Child as Property, 33 WM. & MARY L. REV.
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and those interests are adjudicated in the way one would adjudicate competing claims on property. 26
These decisions form the constitutional backbone of contemporary family law, and the patriarchal
philosophy undergirding them has been enshrined into our substantive due process. 27 Parents can deny
their children medical care on the grounds of personal preference, and most states explicitly provide
religious exceptions to laws prohibiting child neglect and abuse. 28 This is not to denounce parenthood or
American family law. Rather, all of this is to say that phenomenologically, the relationship between
parents and children goes far beyond that of the linguistic community members that Sparrow identifies.
If it is parents that are choosing these edits for the children, which is the generally proposed form, then
the autonomy concern is not as robust as it would otherwise be. Above certain harm baselines which are
implicitly accounted for in this arguments safety assumptions, germline engineering falls well within the
parameters of normal parental authority. Under a more purely liberal approach we might say that
extensive GGE could restricts childrens autonomy by guiding them towards one path or another, but
those liberal principles would be out of step with our social norms.
This relates to a third version of the autonomy argument focuses on the inability of the unborn
to consent to genetic modification of any sort. 29 While the nature of the obligation that now living
people owe to unknown future people who do not exist is an ethically interesting one, it is not actually of
very much importance in responding to this. Humans generally and parents specifically make all manner
of decisions that impact the lives of future generations in more ways than we could ever measure and
future persons do not consent to any of them. It would be impossible to do otherwise. Some of these
impacts are intentional, such as long term climate change regulation. Others are accidental. If our
approach to germline editing is guided by the same principles of concern for the wellbeing of future
26 Id. at 1048.
27 Id. at 1113.
28 Aleksandra Sandstrom, Most states allow religious exceptions from child abuse and neglect laws, PEW RES. CTR. (Aug. 12, 2016),
http://www.pewresearch.org/fact-tank/2016/08/12/most-states-allow-religious-exemptions-from-child-abuse-and-
neglect-laws/.
29 E.g. Francis Collins, Statement on NIH funding of research using gene-editing technologies in human embryos, (Apr. 28, 2015),
https://www.nih.gov/about-nih/who-we-are/nih-director/statements/statement-nih-funding-research-using-gene-
editing-technologies-human-embryos.
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persons as are other actions are or should be, then this is no more of a moral issue than other decisions
we make that will impact the world of the future. Children do not consent to neo-natal vitamin
supplements and they do not consent to the use of lead paint in what will one day be there nursery. If
germline editing is more like the former than the lack of consent is acceptable for the same reason it is
acceptable for the vitamins; if germline editing is more like the latter than it should not be conducted
under the premises of this argument and is objectionable for the same reasons as the lead. Like with any
other intervention taken on behalf of future people, germline editing should be assessed based on the
The other response to the autonomy argument is to note the potential autonomy-increasing
consequences of germline editing. The most obvious version of this argument is the increased autonomy
of a healthier world. One could certainly quibble about how to value the increase in autonomy that
followed the eradication of smallpox, but its difficult to contest that removing a source of disease and
pain did in fact improve peoples autonomy. In the same way, we can imagine the improved outcomes of
a world with reduced genetic diseases.30 Overtime, GGE that corrected for various mental conditions
could lead to increases in values such economic productivity31 and civic virtue,32 both of which improve
the overall quality of society and may offer increased autonomy. This is not to say that these
improvements will necessarily materialize or outweigh any damage to autonomy that GGE could entail,
The final argument against GGE is the most emotionally potent: that GGE will promote
eugenics.33 Its true the 20th centurys authoritarian eugenics movement sought to improve public health
through controlling which heritable traits are passed down through reproduction and that the same
improvement is a justification employed in this very paper. Indeed, GGE advocate Nicholas Agar refers
30 Christopher Gyngell et al., The Ethics of Germline Gene Editing, in J. OF APPLIED PHIL 1, 1112 (2016) [hereinafter
ETHICS OF GGE].
31 Allen Buchanan: Enhancement and the Ethics of Development, KENNEDY INST. OF ETHICS J. 18 (2008).
32 Will Jefferson et al., Enhancement and Civic Virtue, 40 SOCIAL THEORY AND PRAC., 499 (2014).
33 E.g., Eugenics Out of CRISPR, supra note 8.
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to his proposal as liberal eugenics, and he is not the only one. 34 Agars position is that GGE of any type
is within the sphere of autonomy traditionally afforded to parents, comparing it to choices in upbringing.
He justifies this under a Rawlsian framework, delineating between GGE that impacts a persons
capacities (health, intelligence, etc.) and GGE that influences their life plan, meaning their conception of
the good life.35 Agar argues that it is permissible to engineer someones capacities, it is not permissible to
engineer their life plan, because that infringes on autonomy. Capacities are to varying degrees amenable
to GGE, though he notes that intelligence is particularly difficult to engineer.36 However, he goes on to
note that a life plan has much more to do with parenting and environment than it does with genetics and
that a modern liberal society has a greater array of reasonable life plans available than ever before, which
causes new people to have a greater array of possible life plans.37 Like many critiques of GGE, the
eugenics argument assumes a degree of genetic determinism that is just not substantiated by our actual
knowledge. Therefore, he concludes that society should generally permit GGE to the degree that
capacities are not imbalanced to the point where a person is poorly-suited to pursue a reasonable array of
life-plans.
Autonomy is at the center of liberal eugenics. To reframe an earlier point, parents exercise
control over their childrens genes every time they chose a reproductive partner. Though we may not
think of it in these terms, humans have been purposefully altering our own genome for nearly the
entirety of our history. The intent that humans will soon be able to apply is just a little more specific than
current options. Beyond our own gene pool, humans have been driving evolution across the globe
through our ecological impact for centuries if not longer. 38 Having seen the horrors of authoritarian
eugenics we still have no objection to people considering the outcome for their children when they pick
a mate. Our society openly permits the selection of sperm and egg donors based on genetic health. One
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of the most common justifications given for our societys incest taboo is an explicit concern for the
reproductive consequences. If we are willing to accept that parents already make many choices that
influence the gene pool, what is the problem with them doing so intentionally?
To put it provocatively, what is wrong about authoritarian eugenics? A few answers spring to
mind: compulsion, violence, discrimination against minorities and those possessing undesirable
phenotypes. There are undoubtedly more, but the point is that none of these overlap with liberal
eugenics at the surface level. However, liberal eugenics cannot escape its ugly brother so easily. Dov Fox
embraces all of Agars points regarding autonomy and parental discretion to engage in GGE. 39 However
he notes that the same liberal principles that permit the paternalism of compulsory vaccination and
education lend themselves to mandatory GGE, with only a lack of bigotry separating our society from
the worst of authoritarian eugenics.40 Fox defines Rawlsian natural primary goods as those health traits
that any rational person would desire. Like education and immunization, these fit a universal notion of
the good. Therefore, justice demands that we provide them for everyone, even those who do not want
them.41 Fox believes that this synthesis of liberal eugenics and the liberal paternalism demonstrates that
liberal eugenics has not provided an accurate internal moral account of itself; liberals because though
they believe they are comfortable with both parts but will generally not accept the whole because they do
not actually accept the full implication of the parts. If Fox is right, then society cannot accept liberal
eugenics without opening an easy door to eugenics that are at the very least compulsory, if not as
As elegant as this critique is, it does not defeat GGE. Fox notes that childrens bodily autonomy
as well as parents childrearing authority is at times compromised in the interests of children; as noted
above, children must go to school even if their parents object. Therefore, Fox argues, we have already
accepted infringements upon autonomy to serve those interests of children we meet paternalistically.
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However, this is where the analogy breaks. Authoritarian and liberal eugenics both concern themselves
with future children, but they accomplish their goals by acting before the children are born, on the
parents. GGE must target each parents sexual cells before reproduction or the zygote shortly after
fertilization. So, what he proposes is not an infringement on childrearing authority to protect an existing
child, but an infringement on bodily autonomy to protect a future child. There may be arguments for
that practice, but they are not consistent with the liberal framework employed here or the value our
society places on a competent adults bodily autonomy. We require that parents give their children
baseline nutrition, we dont mandate folic acid supplements to enhance fetuses. While there are
individuals who believe a zygote has enough moral value to compel action in its interests, those are likely
There is a sub-category of liberal eugenics that does raise plausible concerns: female infanticide.
While this is not and seems unlikely to become a concern in the United States, it is a very real
phenomenon in some other countries where male children are considered more valuable than female
children. The full consequences of the resulting gender imbalance will not be known for years, but there
are already significant concerns about crime and social instability.42 In practice, it would likely be simpler
to employ PGS to screen zygotes sexes rather than use GGE to alter them. However, that does not
make it any less true that firm restrictions should be put in place on sexually altering zygotes with GGE.
A current rule used by fertility some clinics is to only offer sexual selection services to families seeking to
balance out their children, 43 this is a prudent rule that should be adopted as a policy in areas where
There is also a weaker eugenics-lite argument, which instead of actual eugenics posits a sort of
genetic caste system, where differences in genetic endowment fuels further inequality in our society: 44
42 Therese Hesketh & Jiang Min Min, The effects of artificial gender imbalance, 13 EMBO REP. 487, 491 (2012).
43 Sandel, supra note 70.
44 Eugenics Out of CRISPR, supra note 8 at 270.
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the Gattaca scenario.45 Though Gattacas society employs widespread embryo screening instead of
genetic enhancement, it presents a grim picture of a future that is defined by genetic castes and
discrimination. However, the ultimate issue with Gattacas society isnt the genetic discrepancy per se,
but rather that society is so geared towards acting on it inappropriately. Discrimination based on genetics
is already a recognized hazard in our own society with its mostly un-altered genomes, which is why it was
outlawed in the United States ten years ago under the Genetic Information Nondiscrimination Act
(GINA).46 Genetic testing and the incentive to use it unjustly will exist regardless of how substantial
actual genetic differences are; computers and cheap testing equipment will make the transaction cost so
low that even a minor marginal profit will rationally justify it, which is why employers are currently trying
to have GINA weakened.47 In fact, is should be strengthened by incorporating the sort of disparate
impact analysis that is present in other landmark employment discrimination laws, an addition that the
original Act explicitly contemplates.48 The market for private genetic testing is exploding, and with that
comes further dangers of private genetic information being disclosed and put to nefarious ends; this is an
excellent example of an area ripe for further regulation.49 Genetic discrimination is a real threat, but it is
already here and restricting science wont change that; firm anti-discrimination laws will.
The final argument against GGE is also rooted in social equality. If genetics in fact contribute to
accomplishments in life, GGE may have the potential to compound existing inequalities as the rich give
their children genetic advantages.50 In that regard, GGE is not immoral per se but rather a typical benefit
45 The 1997 movie Gattaca takes place in a future where ubiquitous embryo screening has created a divide between those
subject to genetic selection with strong genetic profiles (valids) and those born naturally who are subject to genetic
disorders (in-valids). Though genetic discrimination is ostensibly illegal, it is widespread due to government genome
registration and mandatory genetic tests as a prerequisite to finding employment. In-valids are relegated to low-status
work and subject to social stigma.
46 Pub. L. No. 110233, 122 Stat. 881.
47 Lena H. Sun, Employees who decline genetic testing could face penalties under proposed bill, THE WASHINGTON POST (Mar. 11,
2017), https://www.washingtonpost.com/news/to-your-health/wp/2017/03/11/employees-who-decline-genetic-
testing-could-face-penalities-under-proposed-bill/
48 U.S. EQUAL EMPLOYMENT OPPORTUNITY COMMISSION, BACKGROUND INFORMATION FOR EEOC FINAL RULE ON
NEUROLOGY A7 (2009).
50 Eugenics Out of CRISPR, supra note 8 at 270.
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that may be bestowed unequally in society and that has the potential to worsen inequality. Health,
education, and social opportunities are just a few of the benefits privileged people can provide to their
offspring that help them achieve future success.51 We typically address this inequality in benefits by
regulating our society to ensure that differences political liberties do not attach to these disparities and by
enacting policies to equalize access to benefits.52 If GGE is going to be handled in a different manner
than private schools and braces, then we should first determine how it is substantively different from
those other benefits. But a society that will treat its weakest unjustly under GGE is likely to do so despite
its absence; how the most vulnerable are treated depends far more on our underlying social institutions
than on whether we permit GGE.53 Everyone believes that genetics are important to ones success in
life, but the pertinent question is how do genetics compare to other factors, primarily environment.
Genetic determinism pervades discussions of GGE on all sides. Its a natural outcome in a field
that is so dominated by the idea of a code that unlocks the secrets to human functioning. Given the
relative immaturity of our understanding of genetics, our ability to answer the question of just how
important genes are to who we are and how we will do in life is limited. There is no question that ones
genome has a real impact on how they do in life. The most recent research suggests that genetics have a
definite but small impact on success, as defined by several development metrics.54 Unsurprisingly,
there is no gene for education; there are a number alleles associated with educational success. The study
looked at 900 people and assigned them a polygenic score based on how many of those alleles they
had. It then determined if the men with higher scores did better in non-education measures of success,55
and they did. Furthermore, people with the genes for success tend to come from more successful
families, which makes sense since were looking at inheritable causes of success. There was no
51 David Resnik, Debunking the Slippery Slope, 19 THE J. OF MED. AND PHIL. 23, 36 (1994).
52 Id. at 37.
53 Julian Savulescu, Genetic interventions and the ethics of enhancement of human beings, in THE OXFORD HANDBOOK OF
Relate to Life-Course Development, 27 PSYCHOL. SCI. 957 (2016) [hereinafter Genetics of Success].
55 These included relationship success, physical health, geographic mobility, and financial planfulness, among others.
Id. at 959.
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correlation between the score and health. None of this is terribly surprising, considering that the score
was devised based on its known relation to educational attainment. What this does not show is that
genetics determines outcomes to a greater degree than environmental factors. Instead, most scholars
have come to the agreement that both are important and neither is deterministic.56 Environmental
factors impact the expression of genetic traits and genetic traits impact how individuals respond to their
environment. They can magnify the impact of the other or dampen it. They can also trigger feedback
cycles.57 The point is, a conception of success or health or any other complicated trait that is entirely
based on genetics is unrealistic. Our current scientific understanding does not bear out the idea of
genetic super-castes dominating everyone else. The more that geneticists learn the more they are
essential to not take an increased understanding of the causation power of genetics as a reason to ignore
the importance of egalitarian social policy.58 Genetics can work hand in hand with social science to
The first argument in favor of germline therapy is, unsurprisingly, to treat genetic diseases.59
Treating genetic diseases (which roughly 6% of babies are born with) pre-birth is significantly cheaper
and easier than changing the genes in a fully grown human60 and GGE allows treatments that are
impossible under SGE.61 Currently, some of what could be done with effective germline editing is
accomplished now through Preimplantation genetic screening (PGS) and in-vitro fertilization. With this
method, multiple fertilized embryos are created and then tested for genetic defects. The embryo that is
healthiest or most desirable to the parent(s) is implanted and carried to term. In this way, many at risk
parents are already actively working to influence the genome that their child is born with. Others will
56 Frank M. Spinath & Wiebke Bleidorn, The New Look of Behavioral Genetics in Social Inequality: Gene-Environment Interplay
and Life Chances, 85 J. OF PERSONALITY 5 (2017).
57 Id. at 7.
58 Id. at 8.
59 Christopher Gyngell et al., The Ethics of Germline Gene Editing, J. OF APPLIED PHIL. 1, 2 (2016).
60 Id. at 2, 8.
61 Eugenics Out of CRISPR, supra note 8 at 267.
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become pregnant and then have an abortion if they discover the presence of conditions like Downs
Syndrome; a recent meta-analysis concluded that fetuses diagnosed with Downs Syndrome are aborted
at a rate of approximately 67%.62 Some find the screening and termination of embryos problematic;
germline editing has the potential to drastically reduce those practices. Beyond that though, this indicates
that the basic use of germline editing is to do something that people are already doing now, purposefully
caused by a single gene. A couple with at least one disease-carrying member must produce a few
embryos to ensure that they get at least one with healthy genes. Thats not always possible due to fertility
issues.63 Furthermore, some of the embryos that wont manifest the disease will still be carriers, and the
parents will presumably want to prevent a risk to their grandchildren if possible. This too increases the
number of embryos needed. However, even if it is possible to use PGS to help couples with monogenic
conditions like cystic fibrosis, it quickly becomes impossible for any couple struggling against a polygenic
condition. Polygenic conditions are caused by many traits in concert. For example, a recent study
suggested that major depression is a polygenic condition with over a dozen associated genetic
sequences.64 PGS would require literally hundreds of embryos to be reasonably confident of getting one
without the traits. Meanwhile, germline editing can address multiple negative factors at once; a recent lab
experiment executed more than 60 simultaneous changes in an animal embryo.65 While it is true that
many polygenic conditions have environmental causes as well, the elimination of the genetic factors
would still reduce the incidence and severity of these diseases. Furthermore, in the case of diseases like
cancer, it may be more realistic to improve our bodies defenses than it is to fully address carcinogenic
environmental conditions. GGE offers a way to accomplish the same goals as PGS, but on a much larger
62 Jaime L. Natoli et al., Prenatal diagnosis of Down syndrome: a systematic review of termination rates (19952011), 32 PRENATAL
DIAGNOSIS 142, 150 (2012).
63 Gyngell et al, supra, note 48 at 4.
64 Morgan Levine et al., A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults, 60
15
scale, both in terms of access and in terms of what individuals can screen for. Even if one attaches no
moral weight to embryo destruction, GGE has the potential to employ far fewer resources to accomplish
introduced even before that. By modifying a parents germline before they even conceive, doctors could
ensure that beneficial genes are passed down to all their children. If humanity is serious about lowering
the incidence of genetic diseases, then employing technology that requires fewer applications and
presents fewer failure points is better. Many of these benefits may sound speculative, and in a sense, they
are. However, they are also based on the current predictions of scientists. Genetic diseases are a
In addition to the improvements for people treated with germline editing, there are also
significant research opportunities. Even the most strident opponents of germline editing acknowledge
that it presents an opportunity for ground breaking research, though these opponents may not believe
that it is worth pursuing. There is still so much that is unknown about the mechanics of DNA, and a tool
that would allow scientists to create controlled variant tissue lines to study could prove invaluable in
bridging that gap.66 The research potential extends beyond medicine and biology. As discussed earlier,
genetics are an increasingly central element of social sciences; the ability to do more extensive and
tailored research can only give us better data for understanding the impact of environmental factors and
It is true that GGE has the potential to increase polygenic scores in the wealth and increase the
scores of the genetically well-endowed with the accompanying improvements in outcome. But it also has
the chance to improve outcomes at the lowest level, and that wont happen unless the technology is
explored and early implementations are accessible to those who can afford the price of cutting edge
technology. Social change is difficult and slow work, and supplementing it with optional GGE for those
66 Id. at 6.
16
who want to offer that opportunity is one way to uplift the socially disadvantaged. Undue genetic
determinism aside, this technology does offer the chance to make significant improvements to the
human condition by challenging the premises of our limitations. A blanket ban on GGE must have a
stronger showing than the speculative and intangible objections that define so much of the opposition.
Finally, it bears repeating that there is a real autonomy interest here. We do not stop parents
from sending their children to the best school they can or from reading to them at night or doing any
other of a thousand things that gain them an advantage in life. Its hard to imagine what our society
would look like if we decided we wanted to. Consistent with a reasonable interest of the childs best
interest, we should let parents make this choice for their children as we do other choices.67 We cannot
ensure or enforce real equality of opportunity. We can ensure an equality of access and we can take
affirmative steps to promote a more just society. GGE is not inconsistent with that and it offers
opportunities to better realize that goal. Altering humanities underlying health and capabilities is a long-
term project. A more immediately realizable one is eradicating dozens of painful and deadly monogenic
conditions. By permitting GGE, we can start on the latter while moving toward the former.
With the case for GGE established, the question becomes whether it should be limited to
therapy or extended to enhancement. This distinction between therapeutic editing and enhancement is a
central element of genetic ethics. The line is generally drawn between therapies, which cures diseases and
enhancements, which push the subject beyond human norms.68 Decades of survey data reveals that the
American public recognizes this distinction and is somewhat wary of genetic engineering generally but
much warier of genetic enhancement.69 It is no surprise that that this distinction retains its significance in
the world of ethicists. Michael Sandel argues that while therapy permits the sick to flourish, enhancement
17
will corrupt our appreciation of life and diminish the value of human achievement.70 However, as the
National Academies of Sciences, Engineering, and Medicine recognized in their report on genetic editing
earlier this year, that distinction is not as clear as it might intuitively seem. 71 Sandel doesnt define
enhancement in his arguments, though he partially describes it as individuals lift[ing] themselves above
the norm. 72 This seemingly intuitive reference point does not actually offer much guidance at all.
Furthermore, even if this line can be established with any clarity, it does not offer the moral meaning that
its proponents would claim. The same techniques will be therapeutic or enhancing, depending on the
patient; doctors cannot realistically maintain this restriction with a level of rigor that proponents would
desire. Considering the previous section, this argument will assume germline intervention as the baseline;
health and disease. There is the descriptivist account, which examines normal human ability to
determine a sort of species baseline, and then conceives of disease in relation to that. There are two
varieties of this framework, differing in their conception of disease: the Normal Function framework and
what I will call the disease-centric framework. Then there is the deconstructive account, which regards
disease as a social construct which is reflective of social values. This second account is not typically
employed to challenge the propriety of genetic enhancement, so it will receive less attention here. 73
normal for either an individual or humanity overall.74 Defining normal as meaning the genetic
endowment with which an individual is born is simple enough, but it would be out of step with actual
medicine, which employs methods involving unnatural changes to an individual to improve health.75 This
70 Michael Sandel, The Case Against Perfection, THE ATLANTIC, (Apr. 2004)
https://www.theatlantic.com/magazine/archive/2004/04/the-case-against-perfection/302927/).
71 HUMAN GENOME EDITING, supra note 7, at 111.
72 Sandel, supra note 70.
73 For a general demonstration of this framework, see Ron Amundson, Against Normal Function, 31 STUD. IN HIST. PHIL.
BIOL. & BIOMED. SCI. 33 (2000) (challenging the scientific and ethical basis of Normal Function).
74 Human Genome Editing, supra note 7, at 105.
75 Sandel, supra, note 70
18
leaves a definition of normal that regards humanity as a group. While this may be superficially satisfying,
it only kicks the inquiry up a level. What does it mean to be normal in a group? It could mean average;
many human traits are quantifiable and thus can be subjected to large number statistical analysis. 76 But
that isnt true of actual genes. While metrics like height can be averaged, many phenotypes are not
quantifiable in the sense that one can determine the mean value. Whats an average eye color?
Furthermore, there is a difference between average phenotypes and average genotypes. It is not difficult
to calculate the average height of a group, but that simple metric is controlled by dozens of genes.77
Even if society determines a normal height or height range that one may be genetically edited to reach, is
that line even meaningful in the context of such a highly polygenic trait? There can be no average value
of the dozens of genes which account for something as simple as height. While many traits are simpler
than that, or even monogenic, height is a classic example of a trait that could be edited for the sake of
enhancement or therapy. 78 Due to the prevalence of bias against short people (heightism), an increase
in height can have an objectively desirable impact on ones life.79 This is true whether its correction
towards the mean or an increase to the top quintile, with the advantages that go with it.80 If the
therapy/enhancement line cannot help us determine a rule for height, it has questionable value as
principle.
Normal could instead mean common. However, a genetic arrangement that may be normal and
beneficial in some areas of the world may be unusual and harmful in others, such as in the case of sickle-
cell anemia and the resistance it confers to malaria.81 Even if there is a phenotype that everyone around
the world agrees to be desirable, it isnt clear which quantitative data should determine our norms.
(The positive association between height and social status is one of the most consistent findings in the social
sciences.).
81 Human Genome Editing, supra note 7, at 106.
19
Returning to the example of height, mean adult male height varies by about twelve inches between
countries.82 Should someone seeking to enhance their height be permitted to go no higher than the
average of their own country? That would excessive advantage over ones co-nationals, but it may be
antiquated considering the mobility of the modern world; furthermore, restricting people from
improving their lives based on where they are born does not seem very just. This is especially true
considering the apparent correlation between development and height, which would suggest that at least
The average value for a phenotype could alternatively be calculated across the world, but that
would provide great assistance to those in shorter countries and very little assistance to those in taller
countries, while still leaving them with the negative impact of heightism. Beyond that, such a policy
would have to determine how common a genotype would have to be before it qualified as sufficiently
common to be a permissible genetic edit. Theres no obvious line here, no divine ratio that can tell us
what percentage of the population must naturally have a desirable gene before it is accessible to those
Some ethicists have argued that, even if the position of the line is uncertain, we can use quasi-
statistical concepts of normality to guide this rule.84 This language is borrowed from the work of
Norm Daniels, which uses this Normal Function framework to structure ethical discussions on a
variety of medical policy issues.85 Though Daniels is a proponent of the Normal Function framework to
distinguish therapy and enhancement, he has explicitly not endorsed it as the appropriate tool for solving
the issue of permissible genetic interventions.86 The argument employing the Normal Function
framework proceeds that, even if we cannot be certain of a true normal value, we can determine a range
82 Oliver Smith, Mapped: The worlds tallest (and shortest) countries, THE TELEGRAPH (Feb. 26, 2017, 8:00 AM)
http://www.telegraph.co.uk/travel/maps-and-graphics/the-tallest-and-shortest-countries-in-the-world/.
83 Angus Deaton, Height, health, and development, 104 PROCEEDINGS OF THE NATL. ACAD. OF SCI. OF THE U.S.A. 13232
(2007).
84 Patrick Lin and Fritz Allhoff, Against Unrestricted Human Enhancement, 18 J. OF EVOLUTION AND TECH. 35, 37 (2008)
20
of values that are our species-typical values and designate genetic edits that move someone from inside
that range to above it an enhancement. This accomplishes the general moral goals of prohibiting
enhancement and promoting therapy without foundering on relatively minor details.87 However, as
Professor Daniels himself states,88 this framework is much better suited to assessing the contours of
societys obligation to provide genetic interventions than it is to assess which treatments ought to be
prohibited. These notions of human norms are the foundation of Danielss concepts of health
distributive justice; everyone deserves a fair shot at life, and ensuring a baseline level of health is essential
to that.89 While therapy/enhancement is not a perfect guideline for what society should provide for
people, it is instructive as one of a set of rationales and provides a relatively coherent account of the line
We will return to this definition when we assess the moral strength of this framework. However,
its worth noting that the Normal Function model inherently runs into the issue of bootstrapping. Once
genetic treatments have significantly improved the lower end of the range of human abilities, there will
be a new bottom X% in whatever category is at issue, which will in turn raise the normal value. There
will always be a shortest height, and by raising the floor more and different people will now be on the
lower end of the spectrum. Furthermore, the top range is always shifting and we have no way of
knowing the actual top end of human potential even without genetic modification.91 Advances in
medicine as well as environmental factors can prompt all manner of increases in the normal range for
a human. Reducing childhood lead exposure has led to IQ improvements, which will raise the normal
intelligence range among humans; at some point individuals without lead exposure who are on the lower
(1997)[hereinafter Juengst, Can enhancement be distinguished?] (arguing that Danielss purportedly normative Normal
Function framework suffers from the same epistemological problems as explicitly positive health models: we cannot
know the true ceiling of human potential and so cannot know when the line from treatment to enhancement is being
crossed.).
21
range of normal will move out of that range and into sub-normality. Will they be eligible for genetic
treatments to raise their intelligence, assuming such intervention are predictably possible? Under the
normal function framework, as non-genetic factors become more favorable and raise human baselines,
more people will become eligible for more intensive genetic therapy, which will move us farther and
farther from our default genetics. The normal function version of the therapy/enhancement line will
gradually permit more intensive improvements over humanitys unmodified genome, which is an odd
Rather than define enhancement positively, some ethicists do so negatively, framing it as those
actions which do not fall under the umbrella of therapy. This is what I have termed the disease-centric
descriptive model. Perhaps the most notable advocate for this framework is Eric T. Juengst.92 Juengst
attempts to strengthen the Normal Function framework by refocusing it on the classical understanding
of disease as a distinct phenomenon, what he calls an ontological way of considering disease. 93 Instead
of drawing the enhancement/treatment line with regards to human ability baselines, Juengst anchors the
definition of treatment to those genetic interventions which address a disease, e.g., a biological process
that moves from discoverable causes (genes, germs, or environmental insults) through a ... pathogenesis
that yields characteristic signs and symptoms that, in turn, reduce function below species-typical
norms.94 Enhancements are those genetic interventions that cannot describe an adequately robust
story of the pathological process their improvement will defend against.95 Juengst conceptualizes his
position as a strengthening of the Normal Function argument, but by centering his position on the
nature of disease rather than baseline health he does more than that. This formulation, unlike the
original, can account for genetic interventions that mimic the effects of vaccines and other obvious
22
enhancements, which is a defect in the Normal Function framework as a tool of sorting categories of
is itself highly controversial,97 but it may be the strongest form of the treatment/enhancement
distinction because it provides a clear test for individual cases. The same intervention can be a treatment
or an enhancement depending on the patient, such with steroids. By centering intent Jeungst permits
That strength is also a weakness though. By centering the conception of treatment on disease,
this model by Juengsts own account permits and justifies treating cases of like suffering and
disadvantage differently. 98 To revisit a classic Daniels exception: two boys are abnormally short and on
track to remain so into adulthood. 99 One boys condition is from cancer (caused by a mutation) that has
damaged his endocrine system so that it produces less HGH. The second boys condition is due to a
mutation that makes his body have fewer growth hormone receptors than average. The two boys are in
the same position, they will each be subject to disadvantage due to their heights and both conditions
were caused by genes, but only one of them merits genetic treatment or hormone treatment to correct
his height under the traditional understanding of disease. Daniels ultimate insight, drawing more than a
little from the deconstructive account of disease, is that if our classic conception of disease determines
that two people with the same factual problem (shortness) and the same general cause (bad genetics)
should be afforded unequal access to a treatment, then the classic conception of disease promoted by
We have identified the two strongest forms of the treatment/enhancement distinction. Each of
them has flaws identified by the others proponents. If nothing else, the fact that such a fundamental
disagreement exists between major figures in the medical ethics field about what is treatment and
96 Id. at 133 (both normal immunization and the new "genetic immunizations" are hard cases for the Normal Function
account. Susceptibility to infection by the polio virus is not a deviation from normal species typical functioning.).
97 Id. at 136137 (noting that Juengsts break from Daniels is reflective of centuries of dispute on the nature of
medicine).
98 Id. at 138.
99 Normal Functioning, supra note 78, at 311.
23
whether diseases exist as distinct metaphysical entities ought to give one pause on relying too heavily on
this distinction in formulating policy. Resolving a centuries long dispute over the meaning of health is far
beyond the scope of this issue and this paper. Laying that aside, there is a greater issue with both with
regards to genetic enhancement: neither provides a strong moral case against it. These accounts treat the
fact of disease as morally neutral (just a matter of physiological observation) and the act of treatment as
morally good. Treatments are morally good because they improve the ability of the sick to fully
participate in life, which serves important justice interests. 100 It does not follow from that point that
enhancements are bad. They may be neutral or they may be good. Some of them may be moral
imperatives.101 It could be argued that providing enhancements may raise the baseline in such a way that
more individuals would be subject to injustice by being at a disadvantage compared to the norm
(diseased in the Normal Framework). That argument, however, applies equally well to lead abatement,
which disproportionately helps those who would otherwise be exposed to lead. It may be that the social
consequences of genetic enhancement will in fact be greater inequality, but the improvement of one
person relative to another cannot, consistent with any sort of aim towards social progress, be an
The deconstructive account of health and disease does no better: if the entire meaning of disease
is arbitrary then grounding our policies in what does and does not address disease is illogical.102 Even
within the observed morality of this framework, in which disease is bad in as much as it reflects social
understandings of badness, there is no implication that enhancement is bad as well. The last several
pages of assessing these definitions only serve to help us distinguish what exactly is meant by this
distinction. When Sandel and others argue that we should not cross the enhancement line, we can
24
There are a few classic objections to enhancement. The first one, which Sandel is a notable
proponent of, could be called the authenticity argument. If we use genetic enhancement (and other tools
of similar capability) to improve and create our own genetic endowment, we diminish the value of both
our achievements and our natural endowment.103 The achievement point is a little odd, because most
people are at least somewhat aware of their existence of their talents and the role that those play in their
accomplishments. The idea that enhancement could render accomplishments hollow makes some sense,
but it doesnt hold up to scrutiny. The athletes with world records probably know that their being the
best recorded at their endeavor is due in part to an accumulation of knowledge on how to diet, train, and
so on. The comparison to performance enhancing drugs is common in this subject, but hard to
formalize as a rule. Why is genetic enhancement more like taking a performance enhancing drug than it
is like having access to the greatest trainers and nutritionists in the world?104 Sandel and others of his ilk
would likely agree that meaningful accomplishment requires work and the application of humanitys
accumulated knowledge; we cannot triumph without changing ourselves. Ultimately what most people
find objectionable about PEDs is that they subvert the rules of a competition. Life is not the sort of
competition that has rigid external rules though. More broadly, almost every generation in human history
has had an easier time doing thing than their parents. I do not find my accomplishments meaningless just
because my home has amenities that would make a roman emperor envious; instead I just adjust my
goals and expectations in light of my capabilities. A prohibition on enhancement will have to make a
clearer argument about what is special about the gene, such that nutritional enhancements are
Sandels other point about endowment is not much more persuasive. He claims that when we
take control of our genetics we revoke our sense of giftedness and it is that giftedness that forms an
underlying justification for redistribution. Maybe someone fresh out of gene therapy would believe
25
themselves to be fully aware of and in control of their gifts. That wouldnt make it true though. Genetic
manifestation isnt that simple and its hard to believe it ever will be. In practice, a world that had gone
through everything it will take to develop precision gene enhancement will have an acute understanding
of what that does and does not mean. It doesnt seem plausible that learning so much more about how
complicated human capabilities are would make someone have a more simplistic view of the world. Also,
it isnt clear that our current situation drives people to contemplate the luck of their giftedness. LeBron
James probably knows he has a lot of talent and good genes, but that doesnt necessarily mean it informs
his morality. The Rawlsian notion of giftedness does not predominate moral dialog in this country,
implicitly or explicitly.
Sandel has a third argument that deserves more attention. He writes about the responsibility that
comes with the power to change ones DNA. If we have the power to change that then we may have an
obligation to. If we dont others will blame us for not doing so, either to make the most of ourselves or
those under our care. While enhancement may not be obligatory, declining will have social or economic
consequences.105 Sandel proposes an athlete whos chided for being too short and the metaphor could be
extended to a worker whos disadvantaged due to their lack of enhancement. Putting aside the fact that
genetic employment discrimination is illegal, it does raise a question about competitive pressures. There
is no denying that, to the degree the genetically enhanced are noticeably superior to the unenhanced,
there will probably be some pressure on the unenhanced to change. However, there is already a wide
range of skills and abilities in our society that result in productivity gaps and differing employment
experiences. If the basic employment levels in this country are similar in the enhanced future to their
current levels, by the time that a requirement for enhanced performance became widespread enough to
impact everyday people, enhancement would almost have to have become more affordable. If it is
affordable, and people chose to not pursue it, then there may ultimately be some consequences for their
employment prospects. This is true of any productivity implement from computer skills to higher
26
education. Employers have preferences for workers who live nearby, who dont have other large time
commitments, and who have pursued degrees that are sometimes only tangentially related to the actual
work. All are major lifestyle points, but only one of them is an illegal mode of discrimination that many
find morally offensive. This is undoubtedly a much more concrete and plausible consequence than his
others, but its important to remember that a better response to known unjust tendencies is to respond
to those tendencies, rather than to discard anything that may exacerbate them, no matter the benefit it
requires.
This paper is concerned not just with ethics, but with policy. In assessing the
treatment/enhancement divide, a major concern is how well it can work as an actual safeguard against
the concerns of its critics. If we accept that we can only use GGE for therapy, what will happen? It will
make little difference in which techniques are developed. Steroids can be used to treat or to enhance, and
the ED drug industry got started as cardiac medication, but now those prescribing those drugs is its own
cottage industry. Meanwhile, its hard to think of a single medical technique that has no therapeutic
value, aside from perhaps some niche cosmetic surgeries that are never used reconstructively. Some
critics of genetic enhancement claim we can prevent the development of enhancement by restricting
this rule, but almost nothing else. Genetics is an important role in disease development, but not a
dominant role;107 many healthy people will still have weaker genes and thus able to be enhanced by
therapeutic treatments.
We may restrict the usage of enhancements to treating disease (using whatever definition we
settle on), but even that is not so simple. Nosological elasticity is a very real phenomenon; definitions of
27
diseases change and not always for purely medical reasons.108 As the suite of changes medicine can offer
humans expands, the urge to classify more and more difficulties of life as medical expands as well. 109 As
cultural norms change or different cultures collide, this becomes even more pronounced.110 This has
problematic consequences well outside this conversation, but its enough to say that on top of whatever
strain genetic enhancement might impose on the notion of disease, it is already a highly dynamic and
social concept. The pressure to realign therapeutic orientation comes from patients as well as doctors.
Cognitive enhancement offers a groundbreaking alternative to the pain of Alzheimers disease. It also
offers an opportunity to help millions of aging but cognitively normal adults the chance to retain what
many humans consider the most essential faculties as the reach the end of their lives.111 Patients will ask
their doctors about genetic treatments and it is hard to see how well doctors will say no.
Our current medical system is built on the idea of trusting clinicians to prescribe drugs offlabel,
using their best judgments; we trust that doctors will make good decisions for their patients in exercising
this power. However, if treatment/enhancement is a firm line that cant be crossed, then we will need to
rework how these therapies are controlled. Genetic treatments as safe as the ones this paper imagines
would be as safe or safer than contemporary pharmaceuticals; our current ethical regime would likely
enhancements. One aggravating factor is that the fear of recreational usage that currently tempers the
urge to prescribe some pharmaceuticals would likely not be as prominent in the genetic context, letting
doctors feel freer to address their patients needs. Alternatively, if we want to impose new restrictions to
ensure that enhancement is not prescribed, then that will either require a massive change in how
medicine is practiced or make it exceedingly difficult for doctors to use the latest technology to heal their
108 Erik Parens, On Good and Bad Forms of Medicalization, 27 BIOETHICS 28, 30.
109 Id. at 3132.
110 Laurence J. Kirmayer & Duncan Pedersen, Toward a new architecture for global mental health, 51 TRANSCULTURAL
PSYCHIATRY 759, 765 (2005) (discussing the problems of medicalization in light of cultural differences).
111 Peter J. Whitehouse et al., Enhancing Cognition in the Intellectually Intact, 37 THE HASTINGS CTR. REP. 14, 22 (1997).
28
patients. Monitoring compliance with the disease/treatment rule will be burdensome and highly
disruptive to medicine.
A final question about an enhancement prohibition is what to do if someone violates it? Doctors
can be disbarred or even imprisoned if thats how harshly society wants to punish them, but what do we
do with patients who violate these rules? If someone gets drugs that they shouldnt the drugs can be
taken away. If someone gets genes that they shouldnt, its not clear what would be an appropriate
response. In theory, theres nothing to say that an enhanced person couldnt be de-enhanced with the
same techniques. That said, criminalizing someones (new) genetic code and forcibly changing it back is
an uncomfortable thought. First, punitive medical techniques shock the modern conscience. Corporal
punishment hasnt been practiced regularly in our society for a long time. A second, related issue, is that
the trend in our criminal justice system is towards a narrow range of all-encompassing sanctions: fines,
imprisonment, or non-imprisonment liberty sanctions. Creating this new category of punishment tailored
to one crime would be an odd deviation from that trend. Furthermore, it would raise the specter of other
penal implementations of genetic intervention. If we can punish people for getting a prohibited medical
procedure by changing their genes to be more normal, why would it be unethical to punish a violent
criminal by adjusting their genes that are associated with aggression. On the other hand, perhaps we
would use traditional punishments on the infringers we managed to catch. It wouldnt reverse the
damage but it would deter. A third option would be to only punish the practitioner. However, that would
create the possibility of genetic tourism, where one need only travel to a permissive country to get a
treatment and can then return to exert the corrupting influence of genetic enhancement on your home
country. The point is, if we are going to enact a prohibition on human enhancement, we need to know
Ultimately, the therapy/enhancement line is a very difficult one to draw and an even harder one
to enforce. Restricting genetic interventions on this line in any effective manner would require serious re-
evaluations of the role of doctors in the United States. Instead, we should leave it to doctors ethical
29
judgments as to their patients best interests, subject to the same restrictions we currently have for
controlled substances.
Conclusion
Genetic engineering is not a panacea. It will require extensive research to be done with any sort
of efficacy and will require a nuanced understanding of epigenetic factors to reliably produce desirable
results. Genetics can only take us so far. Without synergistic environmental factors, genetic traits are
distorted or counterbalanced to a large degree. However, these limitations make genetic enhancement
more appealing in some ways. The simplest genetic alterations the eradication of diseases like Cystic
Fibrosis. These are also the most uncontroversial ones. Fears of super humans are understandable, but
misplaced because the sort of alterations that would be necessary to seriously move the needle on
broader mental or physical capacity are the most complicated and least plausible enhancements. These
factors have complex etiologies, and it is far too easy to get caught up in genetic determinism when
That we should discard the limits discussed here does not mean there should be no limits. First
and foremost, US law against genetic discrimination must be maintained and expanded. This is not
because genetic enhancement poses this threat, but because the same technical advances that have given
us the option of enhancement have also made this new and insidious form of oppression possible. As
mentioned above, sexual discrimination against zygotes poses a special social threat that should be
guarded against. Further, parental decisions on a childs genetic intervention should be subject to the
same scrutiny as any other decision, if not more. Finally, while doctors cannot give us the sort of firm
definitions to build prohibition around, they have a vital role in ethically helping their patients determine
whether genetic intervention is right for them. As we learn more about the true potential of genetic
science we may have to revisit some of the conclusions here, but for now the form a basis for boldly
30