Buletin LP 1.1

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Case No.

1
Test
Hgb
Hct
RBCs/eritrocite
MCV/VEM
MCHC/CHEM
RDW
Reticulocyte
count/reticulocite
WBC/Leucocite
Platelets/trombocite
Total serum
proteins/proteine serice
totale
Fibrinogen
Bleeding Time/Timp de
sngerare
LTA ADP/test de agregare la
ADP
LTA Ristocetin/test de
aglutinare la ristocetin
Ristocetin Cofactor
Assay/Activitatea
cofactorului ristocetinic
APTT
Prothrombin Time/TQ
dRVVT
Thrombin Time/TT
ALT
AST
LDH
Total bilirubin
Unconjugated (indirect)
bilirubin
Direct bilirubin
Total serum iron/sideremie
TIBC/CTLF
Transferrin
saturation/saturaia
transferinei
Serum ferritin/feritina seric
Serum folate/folai serici
Serum vitamin B12/vit. B12
seric
Case No. 2
Test
Hgb
Hct
RBCs/eritrocite
MCV/VEM
MCHC/CHEM
Reticulocyte
count/reticulocite
WBC/Leucocite
Platelets/trombocite
Total serum iron/sideremie
TIBC/CTLF

Patients value
6.6
23%
3.4 x 10/mm
68
28.7
21.5%
7

Normal values
11.5 15.5
41 47%
4.1 4.6 x 10/mm
80 - 100
32 - 34
11 15%
5 - 15

8,100/mm
480.000/mm

4,000 10,000/mm
150,000
400,000/mm
6.5 - 8

g/dl

200 - 400
6 - 10

mg/dl
minutes

7.1

Units
g/dl
f
g/dl erythrocytes

1
440
11.5
Normal

12%

65 120%

55
14.5
34
14
33
25
212
1.1
0.9

27 - 35
13 15.5
25 - 35
10 - 15
10 - 40
10 - 35
115 - 220
0.3 1.2
0.2 1

seconds
seconds
seconds
seconds
U/l
U/l
U/l
mg/dl
mg/dl

0.2
20
400
5%

0 0.2
50 150
300 - 400
20 50%

mg/dl
g/dl
g/dl

12
6.9
560

30 - 300
>5,5
220 - 850

ng/ml
ng/dl
pg/dl

Patients value
5.4
18
2.9 x 10/ mm
62
30
1

Normal values
11.5 15.5
41 47%
4.1 4.6 x 10/ mm
80 - 100
32 - 34
5 - 15

Units
g/dl

8.900
500.000

4,000 10,000/ mm
150,000 400,000/
mm
50 150
300 - 400

172
258

f
g/dl erythrocytes

g/dl
g/dl

Transferrin
66.6%
20 50%
saturation/saturaia
transferinei
Serum ferritin/feritina seric 391
30 - 300
Hb electrophoresis = normal
Bone marrow (MOH): 60% ringed sideroblasts (sideroblati inelari)
Case No. 3
Test
Hgb
Hct
RBCs/eritrocite
MCV/VEM
MCHC/CHEM
Reticulocyte
count/reticulocite
WBC/Leucocite
Platelets/trombocite
Total serum
proteins/proteine serice
totale
Fibrinogen
APTT
Prothrombin Time/TQ
ALT
AST
GGT
LDH
ALP
Amylase
CK-MB
Total bilirubin
Unconjugated (indirect)
bilirubin
Direct bilirubin
Total cholesterol
Triglycerides
Glucose
Total serum iron/sideremie
Serum folate/folai serici
Serum vitamin B12/vit. B12
seric

Patients value
6.7
20.9%
1.77 x 10/ mm
118
32
2
25

Normal values
11.5 15.5
41 47%
4.1 4.6 x 10/ mm
80 - 100
32 - 34
5 - 15

2,800/ mm
96,000/ mm
6.5

4,000 10,000/ mm
150,000 400,000/
mm
6.5 - 8

g/dl

378
35
15.5
29
25
41
1,354
62
20
2.1
2.6
2.2

200 - 400
27 - 35
13 15.5
10 - 40
10 - 35
10 - 55
115 - 220
35 - 96
20 - 96
0 5.5
0.3 1.2
0.2 1

mg/dl
seconds
seconds
U/l
U/l
U/l
U/l
U/l
U/l
g/l
mg/dl
mg/dl

0.4
220
290
145
145
6.1
115

0 0.2
120 - 200
45 - 150
70 - 120
50 150
>5,5
220 850

mg/dl
mg/dl
mg/dl
mg/dl
g/dl
ng/dl
pg/dl

Schilling test
1st phase = 1.2 % (N>7%)
2nd phase = 12.4 % (N>7%)
Antibodies anti FI (+)
Case No. 4
Test
Hgb
Hct
RBCs/eritrocite
MCV/VEM
MCHC/CHEM
Reticulocyte
count/reticulocite
RDW

ng/ml

Units
g/dl
f
g/dl erythrocytes

Testul Schilling
Prima etap = 1.2 % (N>7%)
A II- a etap = 12.4 % (N>7%)
Anticorpi anti FI (+)

Patients value
7.9
24.5%
2.3 x 10/ mm
106.5
32.2
34%

Normal values
11.5 15.5
41 47%
4.1 4.6 x 10/ mm
80 - 100
32 - 34
0.5 1.5%

19%

11 15%

Units
g/dl
f
g/dl erythrocytes

WBC/Leucocite
Platelets/trombocite

11,410
358,000
6.7

4,000 10,000/ mm
150,000 400,000/
mm
6.5 - 8

Total serum
proteins/proteine serice
totale
Fibrinogen
APTT
Prothrombin Time/TQ
ALT
AST
LDH
Total bilirubin
Unconjugated (indirect)
bilirubin
Direct bilirubin
Haptoglobin
Glucose

g/dl

470
32
14
38
21
557
2.4
2.2

200 - 400
27 - 35
13 15.5
10 - 40
10 - 35
115 - 220
0.3 1.2
0.2 1

mg/dl
seconds
seconds
U/l
U/l
U/l
mg/dl
mg/dl

0 0.2
40 - 200
70 - 120

mg/dl
mg/dl
mg/dl

0.2
<20
142

Coombs direct test (+) for antibodies


Case No. 5 (42ys, 42 ani)
Test
Hgb
Hct
RBCs/eritrocite
MCV/VEM
MCHC/CHEM
Reticulocyte
count/reticulocite
RDW
WBC/Leucocite
Platelets/trombocite
Fibrinogen
APTT
Prothrombin Time/TQ
ALT
AST
GGT
LDH
ALP
Amylase
CK-MB
Total bilirubin
Unconjugated (indirect)
bilirubin
Direct bilirubin
Total cholesterol
Triglycerides
Glucose
Total serum iron/sideremie
TIBC/CTLF
Transferrin
saturation/saturaia
transferinei
Serum ferritin/feritina seric
Serum folate/folai serici
Serum vitamin B12/vit. B12
seric

Test Coombs direct (+) pt. anticorpi

Patients value
6.81
23.5%
3.59 x 10/ mm
65.3
29
27

Normal values
11.5 15.5
41 47%
4.1 4.6 x 10/ mm
80 - 100
32 - 34
5 - 15

Units
g/dl

17%
3,700/ mm
289,000/ mm
278
37
16.5
98
81
101
450
112
78
4.1
4.5
3.7

11 15%
4,000 10,000/ mm
150,000 400,000/
mm
200 - 400
27 - 35
13 15.5
10 - 40
10 - 35
10 - 55
115 - 220
35 - 96
20 - 96
0 5.5
0.3 1.2
0.2 1

0.8
225
197
134
185
280
66%

0 0.2
120 - 200
45 - 150
70 - 120
50 150
300 - 400
20 50%

mg/dl
mg/dl
mg/dl
mg/dl
g/dl
g/dl

345
5.6
310

30 - 300
>5,5
220 - 850

ng/ml
ng/dl
pg/dl

f
g/dl erythrocytes

mg/dl
seconds
seconds
U/l
U/l
U/l
U/l
U/l
U/l
g/l
mg/dl
mg/dl

Haptoglobin
35
40 - 200
Total serum
6.1
6.5 - 8
proteins/proteine serice
totale
Serum proteins electrophoresis/electroforeza proteinelor serice
Albumin
47%
60%
1 - globulins
4%
4 6%
2 - globulins
6%
6 9%
- globulins
12%
9 12%
- globulins
31% (polyclonal)
12 20%
Hemoglobin electrophoresis: HbA1 =81.5%, HbA2 = 6.5% , HbF = 12%

mg/dl
g/dl

4
Case No. 6
Test
Hgb
Hct
RBCs/eritrocite
MCV/VEM
MCHC/CHEM
Reticulocyte
count/reticulocite
RDW
WBC/Leucocite

Patients value
13.2
41%
4.55
90
32
11

Normal values
11.5 15.5
41 47%
4.1 4.6 x 10/ mm
80 - 100
32 - 34
5 - 15

13.5%
7,800

11 15%
4,000 10,000/
mm
150,000 400,000/
mm
200 - 400
6 10

mg/dl
minutes

27 - 35
13 15.5
25 - 35

seconds
seconds
seconds

Platelets/trombocite

346,800

Fibrinogen
Bleeding Time/Timp de
sngerare
LTA ADP/test de agregare
la ADP
LTA Ristocetin/test de
aglutinare la ristocetin
APTT
Prothrombin Time/TQ
dRVVT

332
8.7

f
g/dl erythrocytes

normal
normal
76
14
32

Correction tests for APTT


APTT is corrected with old serum and normal
fresh plasma
APTT is NOT corrected by fresh plama adsorbed
on BaSO
Case No.7
Test
Hgb
Hct
RBCs/eritrocite
MCV/VEM
MCHC/CHEM
Reticulocyte
count/reticulocite

Units
g/dl

Patients value
6.5
19.1%
1.94 x 10/ mm
98.4
34
2.2

Teste de corecie pt. APTT


APTT se corecteaz cu ser vechi i plam
proapt normal (integral)
APTT NU se corecteaz cu plasm adsorbit pe
BaSO

Normal values
11.5 15.5
41 47%
4.1 4.6 x 10/ mm
80 - 100
32 - 34
5 - 15

Units
g/dl
f
g/dl erythrocytes

RDW
WBC/Leucocite

15%
2,200

118
14.5

11 15%
4,000 10,000/
mm
150,000 400,000/
mm
200 - 400
6 - 10

Platelets/trombocite

10,500

Fibrinogen
Bleeding Time/Timp de
sngerare
APTT
Prothrombin Time/TQ
D-dimer
LDH
ALP

mg/dl
minutes

43
17.5
7.8
670
376

27 - 35
13 15.5
<0.5
115 - 220
35 - 96

seconds
seconds
g/ml
U/l
U/l

5
Bone marrow
Hypercellular bone marrow due to abnormal
immature cells acute mieloid leukemia

Case No.8
Test
Hgb
Hct
RBCs/eritrocite
MCV/VEM
MCHC/CHEM
Reticulocyte
count/reticulocite
RDW
WBC/Leucocite

MOH
Mduv hipercelular datorit unor celule
anormale i imature leucemie acut
mielocitar

Patients value
10.1
30.6%
3.15 x 10/ mm
97
33
15

Normal values
11.5 15.5
41 47%
4.1 4.6 x 10/ mm
80 - 100
32 - 34
5 - 15

16%
11,300

mg/dl
seconds
seconds
pg/ml
g/ml
U/l
U/l
U/l
U/l
U/l
U/l
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mmol/l
mmol/l

Platelets/trombocite

58,000

Fibrinogen
APTT
Prothrombin Time/TQ
FDP/PDF
D-dimer
ALT
AST
GGT
LDH
ALP
Amylase
Total bilirubin
Unconjugated (indirect)
bilirubin
Direct bilirubin
Glucose
Creatinine
Haptoglobin
K
Na

157
89
19.8
67
4.7
62
72
34
1,890
158
249
2.5
2.1

11 15%
4,000 10,000/
mm
150,000 400,000/
mm
200 - 400
27 - 35
13 15
<5
<0.5
10 - 40
10 - 35
10 - 55
115 - 220
35 - 96
20 - 96
0.3 1.2
0.2 1

0.4
55
3.6
<5
4.8
134

0 0.2
70 - 120
0.6 1.2
40 - 200
3.5 - 5
136 - 146

WBC differentiated count: Ne = 87% (52%

Units
g/dl
f
g/dl erythrocytes

Formula leucocitar: Ne = 87% (52%

immature forms)

neutrofile tinere)

Case No. 9
Test
Hgb
WBC/Leucocite

Patients value
12.6
6,200

Platelets/trombocite

170,000

Total serum
proteins/proteine serice
totale
Serum proteins
electrophoresis/electrofore
za proteinelor serice
Albumin
1 - globulins
2 - globulins
- globulins
- globulins
Fibrinogen
APTT
Prothrombin Time/TQ
ALT
AST
ALP
Total bilirubin
Direct bilirubin
Glucose
Creatinine

7.9

Normal values
11.5 15.5
4,000 10,000/
mm
150,000 400,000/
mm
6.5 - 8

58%
4%
6%
12%
20%
220
52.7
18.2
2262
3017
128
24.7
13.7
70
0.8

60%
4 6%
6 9%
9 12%
12 20%
200 - 400
27 - 35
13 15.5
7 - 40
10 - 35
35 - 96
0.3 1.2
0 0.2
70 - 120
0,6 1,2

Units
g/dl

g/dl

mg/dl
seconds
seconds
U/l
U/l
U/l
mg/dl
mg/dl
mg/dl
mg/dl

Urea

16

10 - 48

mg/dl

Case No. 10
Test
Hgb
MCV/VEM
WBC/Leucocite

Patients value
11.8
91
7,000

Units
g/dl
f

Platelets/trombocite

236,000

Normal values
11.5 15.5
80 - 100
4,000 10,000/
mm
150,000 400,000/
mm
6.5 - 8

Total serum
6.3
proteins/proteine serice
totale
Serum proteins
electrophoresis/electrofore
za proteinelor serice
Albumin
43%
1 - globulins
4%
2 - globulins
6.5%
- globulins
12.5%
- globulins
34%
Fibrinogen
237
Prothrombin Time/TQ
13
ALT
111
AST
47
LDH
304
ALP
177
Direct bilirubin
0.6
Glucose
134
Creatinine
1.1
Urea
43
Anti HVC antibodies (+)/Ac anti VHC (+)

g/dl

7
60%
4 6%
6 9%
9 12%
12 20%
200 - 400
13 15.5
7 - 40
10 - 35
115 - 220
35 - 96
0 0.2
70 - 120
0.6 1.2
10 - 48

mg/dl
seconds
U/l
U/l
U/l
U/l
mg/dl
mg/dl
mg/dl
mg/dl

Case No. 11
46 ys. Old, male/46 ani sex masculine
History: end-stage liver disease secondary to hepatitis C and alcohol; insulin-dependent
diabetes mellitus/ istoric hepatopatie severa secundara infectiei cronice cu VHC si consumului
cronic de alcool; diabet zaharat insulin-dependent
Presentation for abdominal pain in right upper and lower quadrant, nausea, decreased
apetite, watery diarrhea, chills, fever/ se prezinta pt. dureri in hemiabdomenul drept, greata,
scaune diareice apoase, frison, febra
Test
Patients value
Normal values
Units
Hgb
10
11.5 15.5
g/dl
Hct
31.8%
41 47%
WBC/Leucocite
6,000
4,000 10,000/
mm
Platelets/trombocite
49,000
150,000 400,000/
mm
Serum albumin/albumina
2.6
3.5 - 5
mg/dl
serica
- globulins
31% (polyclonal)
12 20%
Fibrinogen
181
200 - 400
mg/dl
APTT
49
27 - 35
seconds
Prothrombin Time/TQ
19
13 15.5
seconds
D-dimer
2.1
<0.5
g/ml
ALT
36
7 - 40
U/l
AST
207
10 - 35
U/l

GGT
121
10 - 55
U/l
LDH
290
115 - 220
U/l
ALP
143
35 - 96
U/l
Direct bilirubin
6.1
0 0.2
mg/dl
Glucose
227
70 - 120
mg/dl
Creatinine
1.4
0.6 1.2
mg/dl
BUN
33
6 - 20
mg/dl
WBC differential count/formula leucocitara: Ne =60%, Lf = 18%
Rectal exam : heme-positive brown stool (gastro-intestinal bleeding)/ tuseu rectal: fecale cu
reactie pozitiva pt. hem (sangerare digestive)
Gram negative rod septicemia/septicemia cu bacili Gram(-)
Case No. 12
Test
Hgb
WBC/Leucocite

Patients value8
12.4
15,200

Platelets/trombocite

470,000

Normal values
11.5 15.5
4,000 10,000/
mm
150,000 400,000/
mm
6.5 - 8

Total serum
6.8
proteins/proteine serice
totale
Serum proteins
electrophoresis/electrofore
za proteinelor serice
Albumin
54%
60%
1 - globulins
7.5%
4 6%
2 - globulins
12.5%
6 9%
- globulins
12%
9 12%
- globulins
14%
12 20%
CRP
21
0.3 - 3
Fibrinogen
445
200 - 400
APTT
34
27 - 35
ALT
110
7 - 40
AST
95
10 - 35
GGT
100
10 - 55
LDH
380
115 - 220
ALP
250
35 - 96
Amylase
750
20 - 96
Lipase
200
3 - 45
CK-MB
1.8
0 5.5
Total bilirubin
3.5
0.3 1.2
Unconjugated (indirect)
1
0.2 1
bilirubin
Direct bilirubin
2.5
0 0.2
Total cholesterol
270
120 - 200
Triglycerides
435
45 - 150
Glucose
210
70 - 120
Creatinine
1.5
0.6 1.2
Urea
120
10 - 48
WBC differential count/ formula leucocitara: 85% Ne
Urine: bilirubin (+)
Case No. 13
Test
Hgb

Patients value
9.5

Normal values
11.5 15.5

Units
g/dl

g/dl

mg/l
mg/dl
seconds
U/l
U/l
U/l
U/l
U/l
U/l
U/l
g/l
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl

Units
g/dl

Hct
RBCs/eritrocite
MCV/VEM
MCHC/CHEM
Reticulocyte
count/reticulocite
RDW
WBC/Leucocite

30.4%
4 x 10/ mm
76
31.2
14

41 47%
4.1 4.6 x 10/ mm
80 - 100
32 - 34
5 - 15

14.55
8,900

Platelets/trombocite

358,000

11 15%
4,000 10,000/
mm
150,000 400,000/
mm
6.5 - 8

g/dl

3.5 - 5

mg/dl

60%
4 6%
6 9%
9 12%
12 20%
200 - 400
120 - 200
>58
<130
45 - 150
70 - 120
0,6 1,2
10 - 48
6 - 20
50 150
300 - 400

mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
g/dl
g/dl

Total serum
5.9
proteins/proteine serice
totale
9
Serum albumin/albumina
2.8
serica
Serum proteins
electrophoresis/electrofore
za proteinelor serice
Albumin
47%
1 - globulins
3%
2 - globulins
25%
- globulins
15%
- globulins
10%
Fibrinogen
524
Total cholesterol
375
HDL-cholesterol
44
LDL-cholesterol
176
Triglycerides
400
Glucose
106
Creatinine
0.8
Urea
39
BUN
18
Total serum iron/sideremie
34
TIBC/CTLF
205
24-hr urine protein /proteinuria pe 24 h= 11.2g

f
g/dl erythrocytes

Case No. 14
Test
Hgb
WBC/Leucocite

Patients value
14.3
11,000

Platelets/trombocite

475,000

Total serum
proteins/proteine serice
totale
Serum proteins
electrophoresis/electrofore
za proteinelor serice

7.1

Normal values
11.5 15.5
4,000 10,000/
mm
150,000 400,000/
mm
6.5 - 8

Units
g/dl

g/dl

Albumin
1 - globulins
2 - globulins
- globulins
- globulins
Fibrinogen
CRP
APTT
Prothrombin Time/TQ
ALT
AST
GGT
LDH
CK-MB
Direct bilirubin
Troponin T
Total cholesterol
HDL-cholesterol
LDL-cholesterol
Triglycerides
Glucose
Creatinine
Urea
Obs. Heparin treatment

52%
7%
14%
10%
17%
479
15.9
61
17
79
556
43
245
18
0.2
14
268
22
143
320
250
1.3
56

10

60%
4 6%
6 9%
9 12%
12 20%
200 - 400
0.3 - 3
27 - 35
13 15.5
7 - 40
10 - 35
10 - 55
115 - 220
0 5.5
0 0.2
<0.2
120 - 200
>58
<130
45 - 150
70 - 120
0.6 1.2
10 - 48

Case No. 15
18 ys old, no significant medical hystory/ 18 ani, fr APP semnificative.
Test
Patients value
Normal values
Hgb
12.1
11.5 15.5
WBC/Leucocite
11,500
4,000 10,000/
mm
Platelets/trombocite
347,800
150,000 400,000/
mm
Glucose
475
70 - 110
BUN
35
9 - 20
K
5.3
3.5 5.2
Na
131
137 - 145

mg/dl
mg/l
seconds
seconds
U/l
U/l
U/l
U/l
g/l
mg/dl
ng/ml
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl

Units
g/dl

mg/dl
mg/dl
mmol/l
mmol/l

Cl
pHa
Pa CO
HCO
Urine(stick tests/teste
calitative)
Glucose
Ketone bodies/ corpi cetonici

103
7.12
24
9

102 - 109
7.35 7.45
40
22 - 26

mmHg
mmol/l

Normal values
+++
+++

Case No. 16
47ys old, no significant medical hystory/ 47 ani, fr APP semnificative.
Test
Patients value
Normal values
Hgb
13.7
11.5 15.5
11
WBC/Leucocite
24,500
4,000 10,000/
mm
Glucose
670
70 - 110
BUN
68
6 - 20
K
7.3
3.5 - 5
Na
126
136 - 146
Cl
102
102 - 109
pHa
6.95
7.35 7.45
Pa CO
10
40
HCO
5
22 - 26
Urine(stick tests/teste
calitative)
Glucose
Ketone bodies/corpi cetonici

mmol/l

Units
g/dl

mg/dl
mg/dl
mmol/l
mmol/l
mmol/l
mmHg
mmol/l

Normal values
+++
+++

Case No. 17
70 ys old male, significant medical hystory of diabetes, HBP, obesity/ 70 ani, sex masculin,
APP semnificative pt. DZ, HTA, obezitate
Test
Patients value
Normal values
Units
Hgb
13.2
11.5 15.5
g/dl
WBC/Leucocite
10,500
4,000 10,000/
mm
Platelets/trombocite
436,000
150,000 400,000/
mm
Total serum
7.1
6.5 - 8
g/dl
proteins/proteine serice
totale
Serum albumin
3.5 - 5
g/dl
Serum proteins
electrophoresis/electrofore
za proteinelor serice
Albumin
50%
60%
1 - globulins
7%
4 6%
2 - globulins
12%
6 9%
- globulins
11%
9 12%
- globulins
20%
12 20%
ESR/VSH
95
< 20
mm/h
CRP
8.2
<3
mg/l
Fibrinogen
490
200 - 400
mg/dl
Total cholesterol
248
120 - 200
mg/dl

HDL-cholesterol
LDL-cholesterol
Triglycerides
Glucose
HbAc
Creatinine
BUN
K
Na
Urine (stick tests/teste
calitative)
Glucose
Ketone bodies/ corpi cetonici
Proteins

42.7
162
210
215
9%
1.2
18
5.1
139

>58
<130
45 - 150
70 - 110
< 6%
0.6 1.2
6 - 20
3.5 5.3
136 - 146

mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mg/dl
mmol/l
mmol/l

Normal values
+
-

12

Case No. 18
32 ys, episodes of headaches, dizziness, loss of consciousness in the morning/ 32 ani
episoade de cefalee, ameeal i pierdere a contienei dimineaa
Plasma glucose in the morning/ Glicemia a jeun = 40 mg/dl (N = 70 110)
After 24-hour fast/dup post alimentar de 24 ore:
Plasma glucose/ glicemia = 38 mg/dl
Serum insulin = 35 U/ml (N = 10 - 20)
C-peptide = 5 ng/ml (N = 0.5 2)
CT scan of the abdomen small tumor in the body of the pancreas (2 cm diameter)/
examinarea CT a abdomenului mic tumor de 2 cm diametru n corpul pancreasului.

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