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    Light On Radiation Therapy - Dr. Rao Papineni

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    Invited Talk at AMPICON 2013 34th National Conference of Association of Medical Physicists of India which is to be held during November 13 – 15,2013 and Symposium on “Particle Therapy” on November 16, 2013 at Saha Institute of Nuclear Physics Auditorium, 1/AF, Bidhannagar, Sector – I, Kolkata – 700064. Title: Light at the end of the tunnel in Radiation Therapy: Molecular Imaging in Radiation Research. Dr. Rao V. L. Papineni [email protected]

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    Light On Radiation Therapy - Dr. Rao Papineni

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    Invited Talk at AMPICON 2013 34th National Conference of Association of Medical Physicists of India which is to be held during November 13 – 15,2013 and Symposium on “Particle Therapy” on November 16, 2013 at Saha Institute of Nuclear Physics Auditorium, 1/AF, Bidhannagar, Sector – I, Kolkata – 700064. Title: Light at the end of the tunnel in Radiation Therapy: Molecular Imaging in Radiation Research. Dr. Rao V. L. Papineni [email protected]

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    Light on Radiation Therapy - Dr. Rao Papineni

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    Invited Talk at AMPICON 2013 34th National Conference of Association of Medical Physicists of India which is to be held during November 13 – 15,2013 and Symposium on “Particle Therapy” on November 16, 2013 at Saha Institute of Nuclear Physics Auditorium, 1/AF, Bidhannagar, Sector – I, Kolkata – 700064. Title: Light at the end of the tunnel in Radiation Therapy: Molecular Imaging in Radiation Research. Dr. Rao V. L. Papineni [email protected]

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    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    173 views3 pages

    Light On Radiation Therapy - Dr. Rao Papineni

    Uploaded by

    Papineni Labs
    Invited Talk at AMPICON 2013 34th National Conference of Association of Medical Physicists of India which is to be held during November 13 – 15,2013 and Symposium on “Particle Therapy” on November 16, 2013 at Saha Institute of Nuclear Physics Auditorium, 1/AF, Bidhannagar, Sector – I, Kolkata – 700064. Title: Light at the end of the tunnel in Radiation Therapy: Molecular Imaging in Radiation Research. Dr. Rao V. L. Papineni [email protected]

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    Light at the end of the tunnel in Radiation Therapy: Molecular Imaging in Radiation Research.

    Invited talk

    Dr. Rao V. L. Papineni


    [email protected]

    13 15 November 2013 AMPICON 2013

    VENUE: Saha Institute of Nuclear Physics (SINP) Calcutta (or Kolkata).

    Accurate dose delivery to malignant tissue in radiotherapy is quite important for enhancing the treatment efficacy while minimizing morbidity of surrounding normal tissues. Advances in therapeutic strategies and diagnosis technologies along with our understanding of the biology of tumor response to radiation therapy have paved way to allow nearly 60% of current cancer patients to be treated with Radiation Therapy. The confluence of molecular imaging and nanotechnology fields are bridging physics and medicine and are quickly making strides in opening new avenues and therapeutic strategies that complement radiation therapy- with a

    distinct footprint in immunotherapy, adoptive cell therapy, and targeted chemotherapy. Incorporating optical imaging in radiation therapy in my laboratory, we demonstrated that molecular probes can monitor radiation-induced physiological changes at the target and offtarget sites using in vivo molecular imaging approaches. Further we show endogenous bioluminescence resulting from whole body irradiation, which is distinct from the cherenkov radiation. Mice without anesthesia were held in ventilated mouse pie cage and subjected to 5 Gy X-ray irradiation using commercially available X-RAD 320 irradiator (1Gy/min; F2 beam hardening filter 1.5mm Al, 0.25mm Cu, 0.75mm Sn; Precision X-ray inc, USA). The endogenous bioluminescence from the subjects was captured using cooled CCD camera. Significant increase (up to 100 fold) in the amounts of photons released as bioluminescence was detected during 5 min capture from the mice subjected to irradiation compared to that of the control. To determine the early inflammatory response, the reactive oxygen species (ROS) activity was monitored using L-012 (8-amino-5-chloro-7-phenylpyridol [3,4-d]pyridazine-1,4(2H,3H) dione), a chemiluminescence reporter. L-012 was administered (i.p) after 15 min of irradiation. Chemiluminescence resulting from the irradiation induced ROS activity, possible through the action of the polymorphonuclear leucocytes (PMN), was imaged in real-time. Robust increase in ROS activity was determined in mice subjected to 5 Gy irradiation compared to the controls. The increased ROS activity and their potential role in treatment strategies will be discussed. Such molecular imaging methodologies and modalities described will be useful tools in treatment design and process. Further, such tools will be valuable in biodosimetry, assessing radiation damage in humans during nuclear terrorism or mass radiation accidents.

    Dr. Rao V. L. Papineni is a Distinguished scientist and an Adjunct Faculty member at University of Kansas. He received his doctoral degree in Biochemistry from University of Hong Kong (British Terr). Dr. Papineni had his early education from University of Madras, where he earned his Bachelors and Masters Degree. After ten years in Research and Faculty positions at University of Hong Kong and Baylor college of Medicine (USA), he joined R&D in Industry and developed Industry-academic partnership. He initiated advanced research programs to study Inflammation and oncology utilizing molecular imaging and nanotechnology based molecular tools. Dr. Papineni has made several inventions and chaired scientific sessions in International Biomedical Meetings and serves as senior editorial board member in Imaging, Nanotech and Experimental Pharmacology journals. "Molecular Imaging - Wisdom to See For Maladies to Flee" Dr. Rao V. L. Papineni

    Topics for AMPICON 2013


    1. 01. Contouring, Image Fusion and Image Registration. 2. 02. Radiotherapy Treatment Planning. 3. 03. Plan Evaluation Techniques. 4. 04. Quality Assurance in Radiotherapy. 5. 05. Dosimetry in Radiotherapy. 6. 06. Novel Dosimetric Techniques. 7. 07. Image Guidance. 8. 08. Gated Therapy. 9. 09. Particle Therapy. 10. 10. Brachytherapy Planning. 11. 11. Image Guided Radiotherapy. 12. 12. Radiation Safety. 13. 13. Radiobiology. 14. 14. Nuclear Medicine Imaging and Therapy. 15. 15. Radiodiagnostic Imaging. 16. 16. Quality Assurance in Radiodiagnosis. 17. 17. Patient Dose during Diagnostic Imaging.

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