Protoberberine Alkaloids

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protoberberine alkaloids (berberine, palmatine, jatrorrhizine, and coptisine) have been investigated by using

electrospray ionization mass spectrometry (ESI-MS) (Chen et al., 2004). The results indicated that palmatine
exhibited the greatest binding affinity with the double-stranded DNA, while berberine had the lowest affinity.
The preliminary results indicated that the berberine showed

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