Breast Cancer Awareness Month 2024

In recognition of Breast Cancer Awareness Month, we’re proud to highlight some of the transformative research being conducted by our customers using SCIEX instruments. These advancements are driving significant progress in the fight against cancer, helping researchers uncover critical insights that could lead to earlier diagnoses and more effective treatments.

One of our customers has harnessed the power of the SCIEX ZenoTOF 7600 platform to establish an advanced workflow for intact glycopeptide identification, crucial in breast cancer research. By optimizing mass spectrometry acquisition parameters, this team was able to profile glycopeptides and site-specific glycans in breast cancer patients with unmatched precision. These findings are essential for understanding glycosylation patterns and could play a pivotal role in developing future diagnostic and therapeutic tools.

🔗 Learn more about this study here

Additionally, we want to highlight the incredible work of Dr. Birgit Schilling from the Buck Institute for Research on Aging. Dr. Schilling is pioneering breast cancer research by utilizing the SCIEX ZenoTOF 7600 system to explore the complex biology of breast cancer subtypes. Her team developed an innovative FFPE-deparaffinization protocol, combined with SWATH DIA assays, which enabled the quantitation of up to 6,000 proteins. This approach revealed significant remodeling of the extracellular matrix (ECM) in breast cancer tissues, identifying key biomarkers such as SerpinH1 and periostin that are upregulated across cancer subtypes. These findings suggest potential therapeutic strategies that could target these pathways and combat cancer progression.

Key takeaways from Dr. Schilling’s work include:

• Comprehensive SWATH DIA with 80 variable windows deciphers disease mechanisms and pathways with exceptional clarity.

• Short microflow gradients significantly accelerate quantitation workflows while maintaining high accuracy, even in complex mammalian tissues.

• Complete remodeling of the kidney proteome observed in acute kidney injury showcases the versatility of this approach.

• Optimized FFPE tissue analysis with SWATH DIA highlights breast cancer biology and progression across 5 distinct subtypes, revealing new insights into ECM biology and potential therapeutic targets.

These findings are reshaping our understanding of breast cancer at the molecular level, offering hope for the development of precision medicine in oncology.

🔗 Watch Dr. Schilling’s journey and dive deeper into her extraordinary research

We are deeply grateful to our customers for choosing SCIEX instruments to participate in their revolutionary cancer research. Your trust in our technology allows us to contribute to groundbreaking discoveries that bring us closer to better treatments and outcomes for those affected by breast cancer. Together, we are making strides towards a brighter future.

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