WuXi Chemistry’s Post

Introducing the Invitrogen Quant-iT Endotoxin Detection Assay Kit - a sensitive and easy-to-use fluorescent endpoint assay for use on fluorescence microplate readers that uses amebocyte lysates to quantify endotoxin in protein, peptide, antibody, or nucleic acid samples. Check out the usage video https://lnkd.in/gj_xceUv Features of the Quant-iT Endotoxin Detection Assay Kit include: • Highly sensitive with a broad range—detect as little as 0.01 EU/mL to 10.0 EU/mL • Flexible—suitable for wide range of samples, including proteins, plasmids, DNA and RNA • Easy to use—the simple workflow requires one incubation prior to measurement Learn more https://lnkd.in/gxyw9uW9 #endotoxin #nucleicacid #protein #peptide #antibodies #QuantIt #invitrogen #loveofinnovation #ThermoFisherScientific 

Introducing the Invitrogen Quant-iT Endotoxin Detection Assay Kit - a sensitive and easy-to-use fluorescent endpoint assay for use on fluorescence microplate readers that uses amebocyte lysates to quantify endotoxin in protein, peptide, antibody, or nucleic acid samples. Check out the usage video https://lnkd.in/gj_xceUv Features of the Quant-iT Endotoxin Detection Assay Kit include: • Highly sensitive with a broad range—detect as little as 0.01 EU/mL to 10.0 EU/mL • Flexible—suitable for wide range of samples, including proteins, plasmids, DNA and RNA • Easy to use—the simple workflow requires one incubation prior to measurement Learn more https://lnkd.in/gxyw9uW9 #endotoxin #nucleicacid #protein #peptide #antibodies #QuantIt #invitrogen #loveofinnovation #ThermoFisherScientific 

Rockland's Custom Anti-Oligonucleotide Antibodies Our polyclonal and monoclonal reagents are optimized for sensitivity and specificity in immunoassay applications. We work closely with you to understand your target nucleic acid antigen, offering expertise in conventional oligonucleotides (12-15 bases), DNA-RNA hybrids, modified oligonucleotides (PS and PdiS), single-stranded oligonucleotide mixtures, ssRNA and dsRNA, and nucleotides and modified nucleosides. Our advanced conjugation methods enhance immunogenicity, ensuring antibodies that specifically recognize modified nucleic acids and compositions. Explore our custom solutions today - https://lnkd.in/gJP2dswS #ASO #Oligonucleotides #therapeutics

Introducing the Invitrogen Quant-iT Endotoxin Detection Assay Kit - a sensitive and easy-to-use fluorescent endpoint assay for use on fluorescence microplate readers that uses amebocyte lysates to quantify endotoxin in protein, peptide, antibody, or nucleic acid samples. Check out the usage video https://lnkd.in/gj_xceUv Features of the Quant-iT Endotoxin Detection Assay Kit include: • Highly sensitive with a broad range—detect as little as 0.01 EU/mL to 10.0 EU/mL • Flexible—suitable for wide range of samples, including proteins, plasmids, DNA and RNA • Easy to use—the simple workflow requires one incubation prior to measurement Learn more https://lnkd.in/gxyw9uW9 #endotoxin #nucleicacid #protein #peptide #antibodies #QuantIt #invitrogen #loveofinnovation #ThermoFisherScientific 

We’re giving away one free antibody characterization service to our followers! Why? We’ve launched new LC-MS services and we want the world to know: ➡ Peptide Mapping ➡ Glycan analysis ➡ Disulfide bond analysis ➡ Intact mass analysis and more! What you win: One of the above LC-MS characterization services for an antibody. See promotion details here: https://hubs.li/Q02CS2kB0 How to win: 1️⃣Follow Rapid Novor on LinkedIn 2️⃣“Like” and “Share” this post to your feed! 3️⃣Stay tuned for the announcement on July 31 #AntibodyCharacterization #MassSpectrometry #Proteomics

How does #buntanetap work? It targets the iron regulatory protein 1 (IRP1) and keeps the mRNA bound inhibiting the translation of neurotoxic proteins. Amyloid precursor protein (APP) is one of such neurotoxic proteins, which is crucial for the production of amyloid beta, a key player in #Alzheimers. Check our latest publication that provides further support for buntanetap's role as an inhibitor of APP in humans. Check our latest publication https://lnkd.in/eQGWSmJu

It is excited to share this article with you. This study introduces an #exolinker approach, repositioning the cleavable #peptide linker at the exo position of the p-aminobenzylcarbamate moiety, as an advancement over conventional linear linkers. This design, which incorporates hydrophilic glutamic acid, addresses the limitations of the #Val-Cit platform and improves the #ADC in vivo profiles. In vitro and in vivo evaluations showed that exolinker #ADCs reduced premature #payload release, increased drug-to-antibody ratios, and avoided significant aggregation, even with hydrophobic payloads. Furthermore, the payload remained stably attached to the #ADC even in the presence of enzymes like carboxylesterases and human neutrophil elastase, indicating the potential for a favorable safety profile. #ADC #Payload #Linker #CRO #CDMO

📢 Published in Cell Discovery: The article reveal that, beside generating tethers between endoplasmic reticulum and other organelle membranes, VAPB (an ER-anchored protein) also mediates condensate-membrane contact. Notably, ablation of VAPB impaired insulin signaling by downregulating the IRS-1 expression levels and AKT activation in vivo. 🔔 Direct binding assay: The desired proteins were eluted from the beads with 200 ng/μL FLAG peptide (MCE, HY-P0319). Subsequently GST fusion protein-beads were incubated with eluted FLAG-tagged proteins at 4 °C for 2–3 h in binding buffer. The bound proteins were separated by SDS-PAGE for Western blot using anti-FLAG antibody. 👉 Related Product Recommendation: 3X FLAG peptide: 👉 MCE Related Prouduct：https://lnkd.in/dJ2uxigX 👉 For more detailed information: https://lnkd.in/dw6q7Y8Z

While the COVID-19 pandemic is officially over, efforts to inhibit the main protease of SARS-CoV-2 continue. In this article, a series of thiazolo-thiophenes based on (+)- and (−)-usnic acid were studied for ability to inhibit the main protease of SARS-CoV-2. CPC Scientific prepared the fluorescently labeled peptide substrate (Dabcyl-KTSAVLQSGFRKME(EDANS)NH2) used in this assay to determine antiviral activity. 📢 Read the link below to learn more about this research. 🔗 https://lnkd.in/gbHCDABJ #peptides #CDMO #CMO #COVID #FRET #enzyme #therapeutics #peptidesynthesis

📰 Read the #newlypublished Article "Novel Inhibitor of #Keap1-Nrf2 Protein–Protein Interaction Attenuates #Osteoclastogenesis In Vitro and Prevents OVX-Induced #BoneLoss In Vivo" by Zhihao Chen et al. 📑 Access the full text at: https://lnkd.in/gmWznu2t