Egg-citing times! Five of the nine final grants in the US Department of Defense’s biomanufacturing program went to precision fermentation startup companies. The EVERY Company specialising in bioidentical egg proteins for a range of nutritional foods and functional products was awarded $2M to conduct a feasibility assessment for US-based manufacturing for its two core proteins. Later in 2025 follow-on funding of up to $100M may be awarded for building or upgrading industrial scale fermentation plants in the US to secure large scale supply.
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This is a great encouragement to #Startups and a positive news globally for the growth of #AlternativeProtein / #Smartprotein using #precisionfermentation technology. Incentivising and supporting #Biomanufacturing are gaining momentum globally. #GovernmentofIndia, recently launched the #BioE3 policy to nurture Biomanufacturing opportunities in #India. This initiative will boost the growth of country’s #BioEconomy, address #Environment Challenges, create #Employment opportunities. #Sustainable #Biotech solutions are poised to make bigger contributions to a country’s economy and protect the planet.
Egg-citing times! Five of the nine final grants in the US Department of Defense’s biomanufacturing program went to precision fermentation startup companies. The EVERY Company specialising in bioidentical egg proteins for a range of nutritional foods and functional products was awarded $2M to conduct a feasibility assessment for US-based manufacturing for its two core proteins. Later in 2025 follow-on funding of up to $100M may be awarded for building or upgrading industrial scale fermentation plants in the US to secure large scale supply.
DOD Releases Final Nine Awards for Distributed Bioindustrial Manufacturing Program
defense.gov
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Biomanufacturing uses fermentation, enzymes and microorganisms instead of energy-intensive, synthetic processes to make many of the products used every day: pharmaceuticals, raw materials (plastics, paper and textiles), chemicals to develop soaps and detergents, food fortification, and more. Synonym, a strategic partner for biomanufacturing companies, predicts that it will become a $200 billion market over the next decade. We spoke with Co-Founder Joshua Lachter to learn more about this trajectory and how Synonym supports what they believe to be the “next manufacturing revolution.”
A Moment for Biomanufacturing
https://www.musingsmag.com
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In the evolving field of biotechnology and alternative proteins, Ziemann Holvrieka remains a key player, leveraging its expertise in fermentation and bioreactor technologies to meet growing industry demands. Known for pioneering brewhouse automation, the company now offers advanced solutions that address challenges in scaling production, ensuring regulatory compliance, and promoting sustainability. As Senior Sales Manager Tim Elbert emphasizes in the huge Q4 2024 edition of Protein Production Technology International, “Scaling from lab scale to industrial scale is not an easy transition. Not every process that works in the lab can be adapted seamlessly to large-scale production.” Ziemann Holvrieka’s fermenters are designed for flexibility and scalability, helping customers overcome these hurdles while integrating sustainable practices like using green steel and advanced automation. With comprehensive support services, including on-site training and remote monitoring, the company’s solutions optimize operations across food, biotech, and pharmaceutical sectors, ensuring production efficiency and consistent quality. Read more expert thoughts from Tim in the latest edition today! https://hubs.ly/Q02SjWXV0 #bioreactors #fermentation #cellularagriculture #alternativeproteins #foodtech
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In the evolving field of biotechnology and alternative proteins, Ziemann Holvrieka remains a key player, leveraging its expertise in fermentation and bioreactor technologies to meet growing industry demands. Known for pioneering brewhouse automation, the company now offers advanced solutions that address challenges in scaling production, ensuring regulatory compliance, and promoting sustainability. As Senior Sales Manager Tim Elbert emphasizes in the huge Q4 2024 edition of Protein Production Technology International, “Scaling from lab scale to industrial scale is not an easy transition. Not every process that works in the lab can be adapted seamlessly to large-scale production.” Ziemann Holvrieka’s fermenters are designed for flexibility and scalability, helping customers overcome these hurdles while integrating sustainable practices like using green steel and advanced automation. With comprehensive support services, including on-site training and remote monitoring, the company’s solutions optimize operations across food, biotech, and pharmaceutical sectors, ensuring production efficiency and consistent quality. Read more expert thoughts from Tim in the latest edition today! https://hubs.ly/Q02SjWpr0 #bioreactors #fermentation #cellularagriculture #alternativeproteins #foodtech
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Thought I'd follow up on recent discussions about UK manufacturing/industrial processing grants with a few facts & figures. Current open funds for innovation in manufacturing & industrial processing include primary agricultural produce & food manufacturing by businesses in Mid/North Wales (17jul-£400K pot), smart/advanced manufacturing & materials with Taiwanese/ Singaporean businesses (17jul/28aug-£5M each), & manufacturing biologics/advanced therapies with Canadian SMEs (16oct-£3M). If those don't fit, UK funding chances in this area remain strong. Innovate UK Smart grants (£25M pot, deadline 24-Jul) are often written off as too competitive. This is oversimplistic: - National average success rate for manufacturing-related innovations in the Sep23 cut-off was 8.6%, vs 4.4% across the whole programme (see Fig.) - Such higher rates happen when there aren't coinciding themed calls. - Similar for diagnostics, med tech & devices (10.5% success sep-23 cut-off, when BMC deadlines fell on 1mar & 8nov 2023) - ditto for food production (chem & bio processes 13.3%, enhancing food quality 14.3%, for the jan-24 smart cut-off, whereas 'better food for all' themed calls fell earlier in 2023). - We help clients reach 5-10x these success rates (Fig. below). Being in a grant sweet spot sector is generally necessary, but not sufficient, for success. - Key to our offering is 1. Validate call fit, 2. Position/scope/design project, 3. impeccable bid execution. Whether we review or write it for you. PNO Consultants Ltd (UK), Dr Carl Dale, Andy Clayton, Pavlos Sgardelis, Andrew Punton, Mark Errington, Nikolaos Reppas, Martin Wickham, Alistair Foster, Pierluigi Ferri, Dennis Camilleri, Adam Inche, Raj Tugnet, Ruth Kearney, Ian Russell, Huw Durban, Sam Baynham
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Challenges and Solutions in Precision Fermentation In recent years, precision fermentation has emerged as a groundbreaking technology with the potential to revolutionize various industries, from food production to pharmaceuticals. This biotechnological process involves the use of microorganisms to produce specific compounds under controlled conditions, offering a sustainable alternative to traditional methods. While the prospects are exciting, the journey of precision fermentation is not without its challenges. Yet, for every hurdle, innovative solutions are being developed to ensure the technology's successful integration into our future. One of the main challenges in precision fermentation is scaling up production from laboratory settings to industrial scales. Small-scale experiments can demonstrate feasibility and efficiency, but replicating these results on a larger scale involves complex logistical and engineering challenges. Issues such as maintaining the purity of cultures, ensuring consistent environmental conditions, and managing the cost of production can be daunting. However, advancements in bioreactor design, automation, and process optimization are making it increasingly feasible to produce large quantities of fermented products. Companies are investing in research and development to create more efficient strains of microorganisms and scalable fermentation processes that reduce costs and enhance productivity. Another significant factor crucial for the success of products derived from precision fermentation is consumer acceptance. Educating the public about the benefits and safety of these products is essential to overcoming skepticism. Transparent marketing strategies and clear labeling can help build trust and acceptance among consumers. As awareness grows, more people are recognizing the potential of precision fermentation to provide sustainable alternatives to traditional products, driving demand and encouraging further investment in the field. Precision fermentation is at the forefront of biotechnological innovation, offering solutions to some of the most pressing challenges of our time. Despite the hurdles, continuous advancements in technology, regulatory strategies, and consumer education are paving the way for its success. As we look to the future, the potential of precision fermentation to transform industries and contribute to a more sustainable world is undeniably exciting. https://buff.ly/43XMgvp
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Great summary. Not industrial but still relevant. Another very good call is the Investor Partnerships (Innovate UK Investor Partnerships: SME round 7). SME's can apply for Innovate UK grant funding alongside private investment from selected investor partners. It's a win win for those looking to commercialise R&D.
Innovation Projects Specialist | Health | Manufacturing | Biotech | Mechanical & Chemical Engineering | Automation | Industry 4.0 | Energy-Intensive Industry
Thought I'd follow up on recent discussions about UK manufacturing/industrial processing grants with a few facts & figures. Current open funds for innovation in manufacturing & industrial processing include primary agricultural produce & food manufacturing by businesses in Mid/North Wales (17jul-£400K pot), smart/advanced manufacturing & materials with Taiwanese/ Singaporean businesses (17jul/28aug-£5M each), & manufacturing biologics/advanced therapies with Canadian SMEs (16oct-£3M). If those don't fit, UK funding chances in this area remain strong. Innovate UK Smart grants (£25M pot, deadline 24-Jul) are often written off as too competitive. This is oversimplistic: - National average success rate for manufacturing-related innovations in the Sep23 cut-off was 8.6%, vs 4.4% across the whole programme (see Fig.) - Such higher rates happen when there aren't coinciding themed calls. - Similar for diagnostics, med tech & devices (10.5% success sep-23 cut-off, when BMC deadlines fell on 1mar & 8nov 2023) - ditto for food production (chem & bio processes 13.3%, enhancing food quality 14.3%, for the jan-24 smart cut-off, whereas 'better food for all' themed calls fell earlier in 2023). - We help clients reach 5-10x these success rates (Fig. below). Being in a grant sweet spot sector is generally necessary, but not sufficient, for success. - Key to our offering is 1. Validate call fit, 2. Position/scope/design project, 3. impeccable bid execution. Whether we review or write it for you. PNO Consultants Ltd (UK), Dr Carl Dale, Andy Clayton, Pavlos Sgardelis, Andrew Punton, Mark Errington, Nikolaos Reppas, Martin Wickham, Alistair Foster, Pierluigi Ferri, Dennis Camilleri, Adam Inche, Raj Tugnet, Ruth Kearney, Ian Russell, Huw Durban, Sam Baynham
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We have just been informed that Bio Base Europe Pilot Plant has launched its new 75,000-liter fermenter, providing companies with a critical resource for scaling precision fermentation processes to industrial levels. Completed just 14 months after construction began, the facility enables cost-competitive production of market-ready, food-grade materials. Dutch company Vivici was the first to test the setup, successfully validating its Vivitein BLG technology at large scale. “Successfully running our production at large scale will strengthen our commercial rollout, giving customers confidence in Vivici as a reliable and trusted supply partner,” said Vivici CEO Stephan van Sint Fiet. Hendrik Waegeman, Head of Business Operations at BBEPP, added: “This new fermenter helps innovators bridge the gap to industrial manufacturing while avoiding significant investments in downstream operations.” Part of a €34 million investment, the fermenter triples BBEPP’s capacity and strengthens its role in supporting biotechnological innovation. #foodtech #alternativeproteins #fermentation #foodproduction
Bio Base Europe Pilot Plant launches 75,000-liter fermenter, validating Vivici’s BLG technology | PPTI News
proteinproductiontechnology.com
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What a day! Last Friday, we unveiled our pilot plant facility in presence of Margrethe Vestager, Executive Vice President of the European Commission, and many others. In total, over a hundred guests from the industrial, political, and financial sectors joined us to learn about the potential of biosolutions, visit the facility, and discuss what it will take to get the first large-scale purpose-built protein factories, with all the benefits of industrial manufacturing on cost and efficiency. With the opening of our pilot plant, we at 21st.BIO are now making the most advanced and most productive production technology and know-how available to innovators in industrial biotech, as well as global majors within food and materials for bulk products to be produced via fermentation. Our pilot facility will support customers’ journey from the lab to large scale manufacturing. We will be with our customers all the way. But the journey towards industrial biomanufacturing does not stop there. We need many large-scale protein facilities to be built across the world to provide high-quality nutrition and biomaterials, produced in a sustainable and cost-effective manner. From the enthusiasm we felt on Friday, we are confident that all actors are ready to set up the right partnerships, and drive forward the biorevolution. Read our press release: https://lnkd.in/dgck4S4x #biotechnology #precisionfermentation #pilotplant
21st.BIO unveils new pilot plant facility to accelerate impact of biotech innovations globally
https://21st.bio
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In the lupin fractionation industry, achieving over 90% yield is critical for sustainable success. Are you extracting sensory-neutral lupin protein efficiently? If not, it's time to consider Flottweg technology. Here’s a glimpse at how it transforms lupin processing: First, lupin kernels are shelled and rolled into wafer-thin flakes, then defatted using supercritical CO2 extraction. This process occurs at high pressure and temperatures, where CO2 takes on liquid-like properties to dissolve oils and accompanying materials, leaving oil-free flakes. These are mashed in a stirring tank to prepare for separation. Using a Flottweg Decanter, the mixture is divided into a solid phase containing fibers and a liquid phase rich in lupin proteins, bitter compounds, and other soluble materials. The solid phase is further processed by adjusting its pH to solubilize the proteins. A subsequent decanter centrifugation step removes insoluble fibers, which can be utilized in animal feed. Finally, the clear phase is acidified to precipitate the lupin proteins, which are then efficiently separated using a Flottweg Sedicanter®. This is ideal for handling the low-volume, hard-to-sediment lupin proteins, ensuring a high yield of purified product. Curious about optimizing your lupin protein extraction process? Let’s elevate your production efficiency together.
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