Terry Sachlos’ Post

▸ Enhancing understanding of pathological mechanisms in auditory deficiencies. ▸ Facilitating testing of new therapies, including cellular and gene therapies, and medications. ▸ Replacing of animal testing with in vitro models designed to mimic the human inner ear. ▸ Acceleration of therapy development. ▸ Reducing reliance on animal experimentation.   This is what we want to tackle at Cilcare with OrgaEar, a pivotal advancement in audiology research, blending technological innovation with ethical scientific practices. It’s important to know that genetic factors contribute to about 60% of sensorineural hearing loss cases, with over 400 genes implicated. The challenge in developing effective treatments is substantial.   Our collaborations with prestigious institutions like University of Montpellier and Mass. Eye and Ear underscore our dedication to advancing regenerative medicine and addressing its challenges. This post is an opportunity to highlight some of the major players in the field, including Rinri Therapeutics, Lineage Cell Therapeutics, Mogrify, Akouos (Lilly), Regeneron, Sensorion, Refresh Gen Tx, Rescue Hearing Inc./ Myrtelle, Skylark Bio, and Aposense. We anticipate many more to come, as major pharmaceutical companies also enter this exciting field 😉.    #TherapyDevelopment #EthicalScience #Genetics #HearingLoss

Unlocking the potential of iPSCs for personalized therapies – groundbreaking research by Klara Molnar-Tanaka, a high school prodigy from the American School of Paris in #France. 🌟 Klara's study was conducted as a part of the Research Scholars Program by Harvard Student Agencies. The research explores how induced pluripotent stem cells (iPSCs) can revolutionize stem cell transplants due to their ability to differentiate into all three germ layers and circumvent graft rejection issues. 🩺 The study highlights the superiority of iPSCs compared to adult stem cells and embryonic stem cells, emphasizing their potential in personalized therapies. It underscores the scarcity of iPSC studies reaching clinical trials and encourages more research in this promising field. 👏 Join us in celebrating Klara's incredible contribution to stem cell research and the future of personalized medicine! #ResearchScholar #StemCellResearch #HarvardStudentAgencies #iPSCs #PersonalizedTherapies #StemCellTransplants #FutureOfMedicine #LearnWithLeaders

These days is the anniversary of my award for the best paper at the international congress on stem cell and regenerative medicine which their result was published in biosensor and bioelectronic journal. 😊   This article was about "Early-stage detection of VE-cadherin during endothelial differentiation of human mesenchymal stem cells using SPR biosensor". https://lnkd.in/gQ-Zbk_5

🌟 Inner Ear Organoids: Exciting in vitro model development showcased at the global Stem Cell Event last week in Hambourg 🌟 Last week at ISSCR, Sylvie Pucheu, Léa Jaillot, Ezeddine Harmouch and Azel Z. from LBN Montpellier University presented their recent work on an Efficient Embryoid-based Method to Improve Generation of Otic Vesicles from Human Induced Pluripotent Stem Cells. This 3D in vitro strategy aims to better understand the mechanisms of human otic development and test novel regenerative therapies to combat hearing loss and balance impairments. 🔬 Innovation: The research team adapted a protocol to improve embryoid body-based otic induction from hiPSCs, preserving the integrity and viability of cells forming the otic embryoid bodies (OEBs) and otic vesicle-like structures. Using a Sox2-GFP reporter hiPSC line, we tracked the progression from pluripotency to otic progenitors, showing robust otic induction and improved vesicle generation between days 11-60 of cell cultures. This is a great milestone for the OrgaEar project directed by Professor Azel Zine, that we conduct in collaboration with the University of Montpellier and the support of SATT AxLR. #Organoids #Innovation #StemCells #InVitroModels #TherapiesDevelopment #InnerEarPathologies #ISSCR2024 #HearingResearch #RegenerativeMedicine

Are you up to speed on the ongoing debate reshaping our approach to stem cell research, emphasising a more ethically considerate path? Our latest update delves into induced Pluripotent Stem Cells (iPSCs). Unlike embryonic stem cells, iPSCs present a less contentious alternative, steering clear of the ethical and moral debates. iPSC technology is changing regenerative medicine, enabling researchers to bypass the ethical concerns of using embryos. It's a fundamental shift in the scientific community's approach to exploring potential treatments and therapies. Stay informed with our iPSC-dedicated series of articles on how these induced Pluripotent Stem Cells could impact future medical breakthroughs. It's an exciting time for #CGT, and we're here to keep you updated, so don't forget to follow us! Do you have questions? Start a conversation with our BDs Tristan Pritchard-Meaker and Sophia Kolbe! #ipsc #stemcellresearch #celltherapymanufacturing

International Society for Stem Cell Research #ISSCR2024 is around the corner, and we would like to pinpoint why it is highly relevant for you to visit the conference itself and talk to us in hall H, booth SUP9. Besides the fact that we specialize in gentle live-cell imaging, here are 3 more reasons to visit us: ✔️Research focused on stem cell, genomics and machine learning can leverage Quantitative Phase Imaging (QPI) for precise, label-free imaging to enhance data accuracy and analysis.  ✔️QPI can support clinical trials to monitor cell health and differentiation of stem cells in therapies, crucial for research areas such as Parkinson's disease.  ✔️Several innovative showcases focused on cell culture systems, where QPI can be integrated into automated cell culture systems and cell line generation for non-invasive, detailed cellular imaging.  Our microscopes provide solutions for stem cell researchers that need: - Imaging cells over long time periods  - Following growth of cell colonies  - Artifact-free imaging  - Non-invasive imaging even with the use of fluorescence labels Zuzana Nováková and Peter Zehetmayer are waiting for you at our booth SUP9. Stop by to see our solution for stem cell imaging.

Journal of Stem Cell Research | Submission Open Stem cell research is a broad field, dealing with embryonic and adult stem cells (e.g. mesenchymal and neural stem cells) or induced pluripotent cells. Understanding cell cycle control, cell specialization, and cell-host interactions are some of the challenges. In drug discovery, stem cells are evolving into cell culture models and tools for cell-based assays. Read our recent published work: https://lnkd.in/dxxTKrmM Submit your work online: https://lnkd.in/gakUevWi For any queries whatsapp at: +1 (438) 699-5365 #stemcell #adultstemcells #neuralstemcells #pluripotentcells #cellcycle #biology #cellculture #embryonic #mesenchymal #cellbiology #regenerativemedicine #regeneration #regenerativebiology #submissionopen #openaccess #Submitmanuscript

Secondary Publication: Proposal for Points of Consideration for Pluripotent Stem Cell Culture Journal In Vitro Cellular & Developmental Biology - Animal 10.1007/s11626-024-00863-w In 2019, the basics of hPSC culture were compiled as a Japanese review in Tissue Culture Research Communications (TCRC) of the Japanese Tissue Culture Association (JTCA) (Akutsu, H et al.) Five years have passed, this area has expanded and the number of users has increased. Therefore, we consider that basic information for culturing hiPS cells is important. Therefore, with the permission of the TCRC, we decided to publish a secondary publication in English. The International Society for Stem Cell Research (ISSCR) has published the ISSCR Standards for the Research Use of Human Stem Cells.https://https://lnkd.in/gF7__dTK We believe that our review serves as a brief introduction before reading the formal ISSCR Standards. We hope it will be useful to researchers. https://lnkd.in/gTvQ5jaj