Syngene International Limited’s Post

Our latest ChemRxiv preprint is now available! 📜 In this work, we explore reactive crystallizations that are equilibrium-limited due to the inherent nature of the participating chemical species. The unknown equilibrium bottleneck poses a massive challenge to the development of purification and particle engineering technologies. 💡 We’ve developed a thermodynamic model that predicts the progress of these equilibrium-limited crystallizations, especially in the context of an Active Pharmaceutical Ingredient (API) synthesis and isolation.   🌟 We demonstrate our model predictions against experimental assays on crude reaction mixture. Our model is easy to implement, making it an accessible tool for developing and optimizing reactive crystallization processes. Check out the full preprint in the link below. #Pharmaceuticals #Crystallization #ProcessEngineering #Thermodynamics #ChemicalEngineering #PharmaScience #ChemRxiv

Chemocatalysis has transformed industries such as pharmaceuticals, energy, and environmental technology. At Symeres, we routinely harness chemocatalysis to efficiently assemble complex molecules in a convergent and atom-efficient manner, resulting in cost-effective and eco-friendly synthetic processes. Our expertise includes: ·       Parallel experimentation for compound libraries ·       Late-stage functionalization for drug discovery ·       Advanced metal catalysis at the pilot-plant scale for manufacturing APIs for clinical trials With chemocatalysis, we achieve complex transformations, including the enantioselective creation of multiple chiral centers in a single step. Discover how we leverage chemocatalysis to drive innovation in drug discovery and beyond. Visit our webpage to explore our advanced capabilities. https://lnkd.in/dS6ekV8U #Chemocatalysis #Pharmaceuticals #CRO #Innovation #Symeres

Stuck in a rut with your chemistry? Why not give #Symeres a call and see if our experienced and creative chemists cannot come up with a smart solution. Our team of expert chemists employs state-of-the-art techniques, such as cross-coupling and asymmetric #hydrogenation, to streamline the #synthesis of these complex molecules. This approach reduces time and costs, while increasing the yield of potential drug candidates. Additionally, our toolbox includes #parallelchemistry and #catalyst screening, which facilitate the rapid synthesis of analogues using the most suitable catalytic systems.

Traditional resin #Chromatography has some significant limitations that slow down mAb #Purification. Watch our on-demand webinar where scientists from Altruist Biologics discuss how switching to membranes could solve efficiency and cost challenges in #Downstream processes. https://ow.ly/AKvg50TyT0l Explore now the outcomes of performance and cost evaluations of membrane chromatography. #SimplifyingProgress #InThisTogether #ProcessIntensification

Bring efficiency to your #downstreamprocessing with #Sartorius membrane chromatography solutions.

Membrane Chromatography. A field of ongoing innovation. Learn more about the advantages with respect to efficency and cost in this on-demand webinar.

Technoeconomic Analysis of Intensified PEGylated Biopharmaceutical Recombinant Protein Production: Alpha Antitrypsin as a Model Case In this study, the technoeconomic analysis of different processes (conventional and intensified) producing 200 kg/year of PEGylated recombinant AAT (PEG-AAT) using a Chinese hamster ovary cell line was investigated. All bioprocesses consist of upstream, downstream, and PEGylation sections. A base-case model (process A) of the conventional fed-batch production bioreactor was developed using SuperPro Designer software (Version 13) to evaluate the economic feasibility of the process. The cost of goods (COG) was estimated to be approximately USD 387.6/g. Furthermore, an intensified process (B) was modeled and evaluated to reduce the COG. Process intensification was implemented in the process (N-1 perfusion bioreactor). The specific operating COG for process B was found to be 10% less than that of process A. https://lnkd.in/dMMiUQVK #aspenalert #biotech #bioprocess

Welcome to Wednesday Words, where I will define one word used in biotechnology or biopharma each Wednesday morning! What is dissolved oxygen? Dissolved oxygen (DO) is the amount of oxygen in water. Measurements of dissolved oxygen (DO) or gaseous oxygen in industrial processes serve to control the oxygen concentration, optimize the process and yield. Dissolved oxygen (DO) plays an important role in cell growth, especially in industry-scale microbial production. Measurements of dissolved oxygen (DO) or gaseous oxygen in industrial processes control the oxygen concentration, optimize the process, and yield. In the pharmaceutical industry, there is a high demand for hygienic design and traceability for validation purposes. If you want to learn more, check out: https://lnkd.in/gYYPdAtB #wednesdaywords #biotechnology #biopharma

I am very proud to reveal what was in the Box....Ireland very first Tribrid Orbitrap Ascend Biophama.....with the mini Ascend on top 😍😍 https://lnkd.in/eu_w3wH9 This instrument represents a step change in our ability to support heightened characterization of complex and highly sialylated biotherapeutic. Our new toy has an extended mass range of 16,000 m/z. Along with Proton Transfer Charge Reduction (PTCR). Which can unfold the chage states of highly heterogeneous biotherapeutics allow for intact analysis not normally amiable to standard mass spectrometry instrumentation #massspectrometry #massspec #biopharmaceutical #biotech #analytical #analyticalchemistry #ASMS2024 #pharma #lcms #biotech #chemistry #ireland #thermo #sciencewillwin #pfizerproud Thermo Fisher Scientific ionBench

Here Zhai et al describes the implementation and associated advantages of native nanoflow SEC MS for intact proteoforms 🎯 Summary: Zhai et al approach was observed to have a number of advantages. Such as achieving a 4-fold increase in MS peak intensity, despite using a sample 20 times less concentrated. Futhermore the method allowed for buffer exchange, oligomer separation, and mild ionization conditions. 📌 Full publication available: https://lnkd.in/eSaYUCaQ #science #scienceandtechnology #massspec #massspectrometry #chemistry #biochemistry #bioanalytical #pharma #biopharmaceutical