SciStories LLC’s Post

Last week, Mo Benkheil, PhD attended the VIB-conference "The Brain Mosaic: Cellular heterogeneity in the CNS". 🧠 Some of his key take-aways of the conference... ✔️ Next-gen multiomics is cracking open brain circuits in real-time and across diseases—aiming to bring clarity to complexity (though not everyone may feel so 😅). It felt like we’re all-in on brain multiomics! ✔️ The ongoing construction of high-resolution brain atlases, in all their flavors, is producing game-changing tools for you and me to explore. ✔️ Targeted Brain Circuit Therapies: S. Aerts (VIB) showcased the power of high-res enhancer mapping, while Boaz Levi (Allen Institute for Brain Science) applied enhancer-AAV tools to develop gene therapies for neurological disorders, with impressive data in preclinical models. #brain #neuroscience #multiomics Montis Biosciences

New Neuroscience Article! DFNB9 affects 1 to 16 newborns every 50,000 Two (TWO!) AAV gene therapies have restored hearing in deaf patients! Scientists have corrected DFNB9 deafness! These are headlines you have likely read last January. The technology making this achievement possible rightfully took the spotlight (even I chimed in!). But what is DFNB9 deafness in the first place? Why do DFNB9 patients lose their hearing? In a nutshell, DFNB9 deafness is the failure of the ear to share what it has heard with the brain because of mutations in the OTOF gene. Do you want to learn more? Let me explain………… Read the rest of the article: https://lnkd.in/ejp5UsPW Written by: Matteo Cortese, PhD Check it out and share! #neuroscience #gene #therapy #article #website #deafness #cure #DFNB9 #neuron #research Neuroscience News British Neuroscience Association (BNA) Action Deafness

🧠 Gene Repair Restores #Brain Signal Efficiency in #Autism 🔷 A groundbreaking study from Tel Aviv University expands the understanding of the biological mechanism underlying genetically-based autism, specifically mutations in the #SHANK3 gene, responsible for nearly one million cases of autism worldwide. Key Facts: 🔷 SHANK3 mutations impair myelin production, disrupting neural signal efficiency. 🔷 Gene therapy restored proper function in #oligodendrocytes in mice and human cells. 🔷 Findings highlight oligodendrocytes’ critical role beyond #neuronal support in autism. 🔷 “This finding offers hope for developing #genetic treatment for humans, which could improve the #myelin production process in the brain. Furthermore, recognizing the significance of myelin impairment in autism—whether linked to the SHANK3 gene or not—opens new pathways for understanding the brain mechanisms underlying autism and paves the way for future treatment development.” By Neuroscience News 👉https://lnkd.in/eidVm8rA #neuroscience #genetics #neuroscience #asd #autistic #sensory #healthtech #digitalhealth #brainhealth #healthcare

Wired Miniature Brains’ Protocol UC San Diego researchers have developed a revolutionary method for creating miniature brains with functioning neural networks, potentially transforming research on autism, schizophrenia, and other neurological disorders. Led by Dr. Alysson Muotri, this new technique allows for the creation of realistic brain cortical organoids. These organoids replicate the complexity of the fetal brain’s neural network, enabling detailed studies of electrical activity alterations in neurodevelopmental conditions. Published in Nature Protocols, this method could revolutionize drug and gene therapy testing. Collaborations with researchers in Brazil and support from a Humans in Space grant will further explore these organoids' potential, including studying Amazonian remedies for Alzheimer’s. This innovative protocol paves the way for advanced neurological research and space-based experiments. Amit Saxena Ajay Nandgaonkar Sanju Senthil Kumar Suchitaa Paatil #ai #access #accessAlchemy #neuroscience #organoid #behavorialhealth read more: Pic credit Sinclair lab https://lnkd.in/gjWMzqbX

🔬 New Insights on Alzheimer's Risk Linked to APOE4 Gene 🧬 A groundbreaking study published in Nature Medicine reveals a significant link between the APOE4 gene and Alzheimer's disease. Key findings include: 🧠 High Incidence of Alzheimer's Pathology: Over 95% of individuals over 65 with two copies of the APOE4 gene show biological markers of Alzheimer's. ⏳ Early Onset: APOE4 homozygotes develop Alzheimer's earlier than those with other gene variants, with significant pathology detected as early as age 55. 🎯 Targeted Treatments: These insights suggest that APOE4 might be considered a distinct genetic form of Alzheimer's, paving the way for more personalized prevention strategies and treatments for this specific demographic. Researchers from the Sant Pau Research Institute, led by Dr. Juan Fortea, highlight the importance of these findings for developing individualized approaches to combat this debilitating disease. Read more about this breakthrough on Neuroscience News: https://lnkd.in/eN9MzbPP #Alzheimers #Neuroscience #Genetics #Healthcare #Research #APOE4 #PersonalizedMedicine #MosaicBiodata

🧬 #Epigenetics in Action: The rapidly advancing field of epigenetics reveals how environmental factors influence gene expression. Understanding Parkinson's Disease (PD) requires exploring how epigenetic modifications affect inflammation, synaptic plasticity, and neuroprotection, contributing to cognitive deficits. 🧠 🎯 How can advancements in epigenetic research pave the way for innovative therapies in Parkinson's Disease? Read Prof. Andre Surguchov et al's preprint and share your thoughts: https://lnkd.in/gziHqG7U #ParkinsonsDisease #CognitiveFunction #Neuroscience

New Neuroscience Article! Huntington’s disease (HD) is an inherited neurodegenerative disease caused by a CAG extension in exon 1 of the huntingtin gene. An extended polyglutamine tract in the huntingtin protein is developed due to the expanded alleles, resulting in intracellular signalling defects.Antisense Oligonucleotide (ASO) gene therapy is currently being pioneered to treat HD………… Read the rest of the article: https://lnkd.in/gma_icsT Written by: Maria K Neuroscience News British Neuroscience Association (BNA) Neuroscience, Surgery and Trauma Centre #neuroscience #huntington #huntingtondisease #genetherapy #disease

I am thrilled to announce that our review paper, titled " A review of the advanced, insight, and prospects of gene therapy for Alzheimer's disease: A novel target for therapeutic medicine" has been successfully published in the Gene journal ( Elsevier, Q2, IF:3.5). For those who wish to delve into the comprehensive details, the complete paper can be accessed through the following links: https://lnkd.in/d63ZG7qy The entire paper is available via this link until 4 May 2024. #genetherapy #alzheimersdisease #geneticmedicine #crisprcas9 #neurodegenerativediseases #neuroscience #neurology #alzheimersresearch #alzheimers

How can direct brain stimulation reshape our approach to neurological disorders? A study from the Chinese Academy of Sciences used our #Starstim device to look into how intracranial alternating current stimulation (#iACS) on rats can influence gene expression and cellular diversity in the brain. 🐀🧠 🔍 The team used Starstim to apply a 40 Hz current to the rat's brain, tracking the changes in neuronal populations and gene expression, focusing on the Rgs9 gene, known for its role in dopaminergic signaling. This approach unveiled potential new pathways for treating neurological disorders by enhancing neurogenesis and #neuron sensitivity. Want to learn more about how they achieved this? Check out the full #research study here: https://lnkd.in/dc9VWDHG 📄 Congratulations to Yan Wang, Yongchao Ma, Qiuling Zhong, Bing Song, and Ming Qian from the Shenzhen Institutes of Advanced Technology! Your work is paving the way for future innovations in brain health treatments. 👏 #Medtech #Electroceuticals #Technology #Healthtech #Healthcare #Science #Innovation #Study #RNA #ResearchArticle #Neuroscience #Neurotechnology #Starstim #tDCS #BrainStimulation #tACS #tES #Neurotech SHENZHEN INSTITUTE OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

🚀 Exciting breakthrough in Alzheimer's research! 🚀 A recent MIT study, published in Nature, uncovers key factors in Alzheimer's vulnerability and resilience. By comparing gene expression across multiple brain regions, the study identifies the crucial role of Reelin in neuronal vulnerability and highlights how choline and antioxidants can help sustain cognition. This comprehensive analysis of over 1.3 million cells reveals groundbreaking insights into the cellular and molecular mechanisms of Alzheimer's, paving the way for new therapeutic strategies. Dive into the details and discover how this research is revolutionizing our understanding of Alzheimer's disease! 🌟 #AlzheimersResearch #Neuroscience #Genomics #MIT #NaturePublications Read more: https://lnkd.in/ePS5Ed8v