PharmaExcipients.com’s Post

When PTP choose to use a laboratory prepared PT item (Formulations) the matrix constituents shall be studied well to follow the ideal steps for the formulation that regrading their physical and characteristics to ensure its suitability and homogeneity and to stick : in liquid formulations that use methyl, propyl parabens the solubility behavior of propyl paraben in aqueous solution, when tested separately and together with methylparaben, it has been investigated in detail. The results clearly indicate ≈50% decrement in solubility compared to its solubility alone

Although wet granulation is one of the most versatile unit operations for improving blend properties for further processing, it is often considered not amenable to APIs prone to forming hydrates. However, little literature exists probing the extent of form conversion for such API when processed with wet granulation methods. Despite the process's versatility, these claims lead the risk-averse formulator to avoid wet granulation for such API altogether. In our most recent publication (https://rdcu.be/dzhwF), we delve into common wet granulation processes to explore whether high-shear (HSG) or fluid bed granulation (FBG) may have differing degrees of anhydrous form conversion. Using two model compounds, Fexofenadine HCl and Carbamazepine, we explored the extent of anhydrous form conversion following HSG or FBG. We made some interesting observations, which may convince some formulators to consider wet granulation processing for such compounds. A big thanks to my co-authors, Yue Schuman, John Gawel, Robert Garmise, Admassu Abebe, and Divyakant Desai, for their invaluable contributions to this project!

🧣Dimethyl sulfoxide (DMSO) CAS#: 67-68-5 Purity: ≥99.9% Package: 250kg/Drum 1. It can be used for the extraction of arene, also as the reaction medium used for resins and dyes, and applied to acrylic polymerization and spinning solvent. 2.In the field of medicine, dimethyl sulfoxide has anti-inflammatory and analgesic effect with a strong capability of penetration through the skin, and thus being able to dissolve certain drugs and boost their penetration into the human body to achieve the therapeutic purposes. 3. It can be used as analytic solvents and fixing agent of gas chromatography as well as the solvent for analyzing UV spectra. Mail: [email protected] Phone & WhatsApp:+86 19120312963 #highpurity #solvents #chemical #intermediate #dimethylsulfoxide #DMSO #resin #dyeing #AcrylicPolymer #gaschromatography #uvspectra

Protect your results with Millex® hydrophilic PTFE syringe filters that are HPLC-certified for low levels of UV-absorbing extractables. Curious? Click to learn more. #Millex #filtration

Borosil HPLC Vials vs. Plastic HPLC Vials: Which is Better? Explore the advantages of Borosil HPLC vials vs. plastic HPLC vials in your analytical workflows. Discover the key factors to consider, including inertness, temperature resistance, and UV protection. Optimize your HPLC results with the right vial choice.

Looking forward to presenting an overview of Organotin Stabilizer Chemistry, Regulatory, and Sustainability today at AMI PVC Formulations. #PVC #PVCFormulations

👉CPR MCQs? 👉Refresh Your Basic Knowledge? 👉 van't Hoff equation? 👉API Degradation Occurs By? 👉Simple Syrup is? 👉Tweens Vs Spans? 👉Cracking Of Emulsion? 👉Eutexia Of Aspirin Read All In Following 👇👇👇👇👇 https://lnkd.in/eVe7jMsg

👉CPR MCQs? 👉Refresh Your Basic Knowledge? 👉 van't Hoff equation? 👉API Degradation Occurs By? 👉Simple Syrup is? 👉Tweens Vs Spans? 👉Cracking Of Emulsion? 👉Eutexia Of Aspirin Read All In Following 👇👇👇👇👇 https://lnkd.in/eVe7jMsg

𝗘𝘃𝗮𝗹𝘂𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗯𝗶𝗻𝗱𝗲𝗿𝘀 𝗶𝗻 𝘁𝘄𝗶𝗻-𝘀𝗰𝗿𝗲𝘄 𝘄𝗲𝘁 𝗴𝗿𝗮𝗻𝘂𝗹𝗮𝘁𝗶𝗼𝗻 – 𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝘁𝗮𝗯𝗹𝗲𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆 by Claudia Köster, Peter Kleinebudde The influence of hydroxypropyl cellulose type (HPC-SSL SFP, HPC-SSL), concentration (2 %, 3.5 %, 5 %) and filler (lactose, calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on twin-screw wet granulation and subsequent tableting was studied. The aim was to identify the formulation of the highest tabletability which still fulfills the requirements of the disintegration. Lactose combined with 5 % binder enabled a higher tabletability and a faster disintegration than DCP/MCC. #excipients #HPC #MCC #DCP

👉CPR MCQs? 👉Refresh Your Basic Knowledge? 👉 van't Hoff equation? 👉API Degradation Occurs By? 👉Simple Syrup is? 👉Tweens Vs Spans? 👉Cracking Of Emulsion? 👉Eutexia Of Aspirin Read All In Following 👇👇👇👇👇 https://lnkd.in/dsWtNgeN