Nordic Bioscience’s Post

RheumaTrace™ is a carefully selected biomarker panel for rheumatic diseases. These biomarkers delve deep into connective tissue degradation and immune cell dynamics, offering insights to researchers and drug developers. They can pinpoint disease pathways and help determine optimal drug dosages for effective treatment. 🧬 Key Features of RheumaTrace™: ✅ Three decades of research-backed development ✅ Seven distinct biomarkers for precise analysis ✅ Rapid response to drug interventions within days and weeks ✅ Ideal for dose-finding and efficacy prediction in trials ✅ Useful for comparing drug responses in head-to-head studies 💡Interested? Learn more at https://lnkd.in/ek-Pqc3N or reach out to Anne C. Bay-Jensen and Mayuur Bajaj. #RheumaTrace #Rheumatology #RheumatoidArthritis #PrecisionMedicine #DrugDevelopment

Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases https://lnkd.in/empjwCmJ #cancer #Celastrol #diabetes #inflammation #neurodegeneration #obesity

Advancing Therapies for Fibrotic Diseases and Anti-Aging with IL-11 Antibodies IL-11 plays a crucial role in fibrogenesis, organ dysfunction, and inflammation, making it a promising therapeutic target for conditions like idiopathic pulmonary fibrosis (IPF), liver fibrosis, and non-alcoholic steatohepatitis (NASH). Recent studies even suggest that IL-11 inhibition can extend the lifespan of aged mice. Therefore, anti-IL-11 therapy holds potential as a dual-purpose treatment aimed at both disease mitigation and delaying aging. At Biocytogen, we've developed fully human IL-11 antagonist antibodies using our RenMice platform, demonstrating cross-species affinity and superior blocking activity. In addition to IL-11, our portfolio includes antibodies targeting key markers in inflammatory, autoimmune, and metabolic diseases. Explore partnership opportunities with Biocytogen to bring innovative treatments to life. #Biocytogen #IL11 #Fibrosis #AntiAging #Biotech #DrugDevelopment #Innovation #Partnerships

Over the past decades our understanding of rheumatoid arthritis (RA) pathogenesis has improved remarkably and major breakthroughs in the treatment of RA were made with the advent of numerous targeted therapies and new treatment strategies. Despite these advances, several unmet needs remain, namely in achieving earlier and more accurate diagnosis, monitoring disease activity, predicting disease prognosis and optimizing treatment. To address these gaps, recent research has focused on identifying biomarkers that may enhance diagnostic precision, predict disease prognosis, and optimize treatment strategies. In this narrative review we will describe recent developments in RA biomarkers with demonstrated or promising clinical relevance. José António Pereira da Silva

NEW from #ASCO2024 | Gut microbiome and treatment outcomes in #HR+/#HER2- #breastcancer🎥 🇺🇸 Alexis Ann LeVee, MD, City of Hope, comments on the utility of #stool #microbialprofiling in a Phase I/II study (NCT02778685), which assessed #palbociclib, #pembrolizumab, and #endocrinetherapy (ET) in patients with HR+/HER2- #metastaticbreastcancer (#MBC) #Gutmicrobiome profiling suggests specific bacterial taxa and #metabolic pathways are associated with treatment response, indicating a potential #biomarker for #immune #checkpointinhibitor efficacy Learn more 👉 https://lnkd.in/emPDBttN #VJOncology #Oncologynews #BCsm

#Review Current Status and Future Perspectives of Lactate Dehydrogenase Detection and Medical Implications: A Review by Yangzhe Zhou, Min Qi and Minghui Yang https://lnkd.in/dEd3RuA2   #MDPI #fluorescence #tumor #glucose #biosensors #sensors #openaccess   #Abstract The demand for glucose uptake and the accompanying enhanced glycolytic energy metabolism is one of the most important features of cancer cells. Unlike the aerobic metabolic pathway in normal cells, the large amount of pyruvate produced by the dramatic increase of glycolysis in cancer cells needs to be converted to lactate in the cytoplasm, which cannot be done without a large amount of lactate dehydrogenase (LDH). This explains why elevated serum LDH concentrations are usually seen in cancer patient populations. LDH not only correlates with clinical prognostic survival indicators, but also guides subsequent drug therapy. Besides their role in cancers, LDH is also a biomarker for malaria and other diseases. Therefore, it is urgent to develop methods for sensitive and convenient LDH detection. Here, this review systematically summarizes the clinical impact of lactate dehydrogenase detection and principles for LDH detection. The advantages as well as limitations of different detection methods and the future trends for LDH detection were also discussed.

Source: Heliyon This article discusses the use of metabolomics approaches to identify biomarkers for diagnosing and monitoring the progression of Parkinson's disease (PD). The study analyzed the serum metabolome of PD patients and controls using LC-MS/MS and GC-TOF MS techniques. The researchers found that levels of certain metabolites were significantly different in PD patients compared to controls, including cysteine-S-sulfate and N-acetyl tryptophan. Xanthines, including caffeine and its metabolites, were lower in PD patients, suggesting a potential protective role against neuronal damage. The study also identified seven metabolites that yielded a high classification accuracy for PD diagnosis. Furthermore, the levels of cysteine-S-sulfate and LPI 20:4 were found to change with the progression of PD. These findings provide potential biomarkers for PD diagnosis and monitoring and suggest new therapeutic targets for the development of novel treatments.

🌍 𝗪𝗼𝗿𝗹𝗱 𝗗𝗶𝗮𝗯𝗲𝘁𝗲𝘀 𝗗𝗮𝘆 𝟮𝟬𝟮𝟰: 𝗕𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗕𝗮𝗿𝗿𝗶𝗲𝗿𝘀, 𝗕𝗿𝗶𝗱𝗴𝗶𝗻𝗴 𝗚𝗮𝗽𝘀 💙 On 𝗪𝗼𝗿𝗹𝗱 𝗗𝗶𝗮𝗯𝗲𝘁𝗲𝘀 𝗗𝗮𝘆, we at 𝗦𝗰𝗶𝗼𝗺𝗶𝗰𝘀 𝗚𝗺𝗯𝗛 reflect on the profound impact of diabetes research and our contributions toward advancing science for better patient outcomes. We work with partners from academia and biotech to discover 𝗯𝗶𝗼𝗺𝗮𝗿𝗸𝗲𝗿𝘀 and to understand the 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 underlying diabetes and its complications, including its relationship with cancer, neurodegenerative diseases, and other metabolic diseases. 🔬 In recent years, the 𝗦𝗰𝗶𝗼𝗺𝗶𝗰𝘀 𝘁𝗲𝗮𝗺 contributed to a study titled "𝗖𝗵𝗮𝗻𝗴𝗲𝘀 𝗶𝗻 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗲𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝗱𝘂𝗲 𝘁𝗼 𝗺𝗲𝘁𝗳𝗼𝗿𝗺𝗶𝗻 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗮𝗻𝗱 𝗵𝘆𝗽𝗲𝗿𝗶𝗻𝘀𝘂𝗹𝗶𝗻𝗲𝗺𝗶𝗮 𝗶𝗻 𝗮 𝗵𝘂𝗺𝗮𝗻 𝗲𝗻𝗱𝗼𝗺𝗲𝘁𝗿𝗶𝗮𝗹 𝗰𝗮𝗻𝗰𝗲𝗿 𝗰𝗲𝗹𝗹 𝗹𝗶𝗻𝗲". This research explored how metformin, a commonly prescribed medication for type II diabetes mellitus, influences protein expression in cancer cells, particularly in the context of hyperinsulinemia – a condition commonly seen in diabetic patients. 👩🔬 👨🔬 Through our 𝘀𝗰𝗶𝗼𝗗𝗶𝘀𝗰𝗼𝘃𝗲𝗿 antibody microarray service, we helped to uncover key insights into how metformin may counteract some of the pro-cancerous effects induced by high insulin levels. These findings bring us closer to understanding how diabetes treatments can play a role not only in managing diabetes but also in preventing or treating associated conditions, such as endometrial cancer. Carsten Lange | Amanda Machado Weber | Ronny Schmidt | Dr. Christoph Schröder | Thomas Strowitzki | Ariane Prof. Dr. Germeyer   #WorldDiabetesDay #DiabetesAwareness #DiabetesResearch #Sciomics #Proteomics #HealthcareInnovation

🔍 𝐈𝐫𝐨𝐧 𝐃𝐞𝐟𝐢𝐜𝐢𝐞𝐧𝐜𝐲 𝐀𝐧𝐞𝐦𝐢𝐚 𝐂𝐨𝐮𝐥𝐝 𝐁𝐞 𝐒𝐞𝐜𝐫𝐞𝐭𝐥𝐲 𝐑𝐚𝐢𝐬𝐢𝐧𝐠 𝐘𝐨𝐮𝐫 𝐂𝐚𝐧𝐜𝐞𝐫 𝐑𝐢𝐬𝐤 📊 Recent population-based research reveals that patients with Iron Deficiency Anemia (IDA) face a significantly higher risk of developing various cancers compared to the general population. 𝑲𝒆𝒚 𝒇𝒊𝒏𝒅𝒊𝒏𝒈𝒔: -> IDA patients have a 2.15x higher cancer risk. -> Specific cancer risks: Pancreatic (SIR 2.31), Kidney (SIR 2.23), Liver (SIR 1.94), Bladder (SIR 1.74). -> Cancer risk remains elevated even after excluding first-year diagnoses. 𝐁𝐮𝐭 𝐰𝐡𝐲? IDA may contribute to mitochondrial dysfunction, genomic instability, and immune alterations that create a vulnerable environment for cancer. 🔔 𝐓𝐚𝐤𝐞𝐚𝐰𝐚𝐲: Early detection and treatment of IDA could reduce long-term health risks. Don’t overlook anemia—it could be a warning sign of deeper health concerns. 𝐒𝐭𝐮𝐝𝐲 𝐥𝐢𝐧𝐤: 𝘥𝘰𝘪: 10.1371/𝘫𝘰𝘶𝘳𝘯𝘢𝘭.𝘱𝘰𝘯𝘦.0119647 #IronDeficiency #Anemia #CancerResearch #Healthcare #PublicHealth #MedicalResearch #Cancer #Biotechnology #Bioinformatics #Publicawareness #KhushbukhatKhan #clinicaltrials #Pharmaindustry --------------------------------------------------------- I'm 𝐃𝐫 𝐊𝐡𝐮𝐬𝐡𝐛𝐮𝐤𝐡𝐚𝐭 𝐊𝐡𝐚𝐧, 𝐏𝐡𝐃. Do you want to know more about nutrition and cancer prevention? Repost 🔁 & Follow for more updates on my research and insights! ---------------------------------------------------------

Check out our latest article entitled “Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy” now published in ACS Applied Bio Materials https://lnkd.in/gwhkCKnD