Nikolay's Genetics Lessons’ Post

The Latest Developments for the Treatment of Ataxia Telangiectasia: A Narrative Review #ataxiatelangiectasia #journals #articles More info | ⬇️ https://lnkd.in/dsX299xb

Creating universal hypoimmunogenic iPSC through selective knock out! For allogeneic transplantation purpose iPSC’s need to be configured to prevent mismatching and rejection by the immune system, e.g. through NK cells. Functional validation of successful genetic engineering is realized by #SimpleWestern technology at the protein level.   Check out the groundbreaking application: https://lnkd.in/efKdgb-J #iPCS #CGT #Genetherapy #Celltherapy

The Latest Developments for the Treatment of Ataxia Telangiectasia: A Narrative Review #ataxiatelangiectasia #journals #articles More info | ⬇️ https://lnkd.in/dsX299xb

This study highlights the long-term neurological effects of COVID-19, particularly in post-hospitalized survivors. These researchers observed brainstem changes linked to inflammatory processes. This research contributes to the growing understanding of COVID-19's lasting impact on brain health. In the next few weeks, we plan to announce our Research-Use-Only blood test, which could detect neurological damage before brain imaging and significantly enhance early diagnosis and intervention strategies. #dementia #alzheimers #venturecapital #angelinvestor #cancer #hivaids  #bioOS #biotechnology #diagnostics #innovation #technology #management #startups #liquidbiopsy #neurodegenerativediseases #multiplesclerosis #parkinsonsdisease #alzheimersdisease #longhaulers #longcovid #humangenome #onetestonelife #longevity #artificialintelligence #rna #rnaseq #personalizedprevention #PersonalizedMedicine #ClinicalResearch #COVID19 #Parkinsons https://lnkd.in/eYauKhxm

Want to learn more about the Future of Cell Gene Therapy? Listen to this Podcast with McKesson's Joe DePinto!"

Facioscapulohumeral muscular dystrophy (FSHD) is the third most common type of muscular dystrophy and is named after the primary body parts that it affects—the face, shoulders, and arms. FSHD affects 3,000 Australians, and one million individuals globally. It is thought that the actual number of people with FSHD is probably much higher because of misdiagnosis and a significant number of undiagnosed cases. Next week we will be hearing about the latest findings in FSHD research from Professor Marnie Blewitt. Marnie and her team are working on a number of projects to improve diagnosis, treatment and prevention of FSHD muscular dystrophy. To attend go to: https://loom.ly/6JtQZJ8 #fshd #mda #nmd #musculardystrophyaustralia #neuromusculardisease #research

📢 Are you interested in RNA interference? Maybe this conference is for you? "ABOUT The ARGONAUTES 2024 🧬The meeting centers on #RNAinterference phenomena with a focus on the key protein component common to all of them, the #ARGONAUTE protein family. It brings together researchers working on deciphering the molecular mechanisms by which ARGONAUTE proteins bring about RNA interference in diverse #prokaryotic and #eukaryotic systems. 🧬It also includes the newest developments on human #neurological disorders caused by mutations in ARGONAUTE-encoding genes and creates a setting to advance an understanding of their biochemical basis using the progress made to understand ARGONAUTE functions in many model systems." 👇Read more and sign up! https://lnkd.in/dNmB_Asc

Rh factor: how to find allele frequency Blood typing is determined by the molecules on the surface of the red blood cells \(RBCs\). In general, we can classify someone s blood type by the absence or presence of A or B antigens and Rh factor on the surface of blood cells. The most commonly recognized blood groups are A positive, A negative, B positive, B negative, AB positive, AB negative, O positive, and O negative. The positive or negative sign next to the blood groups is known as the Rhesus \(Rh\) factor. The Rh factor is an inherited protein that can be found on the surface of the red blood cell. If your blood type is positive, then your blood cells have the Rh protein. If your blood type is negative, then your blood cells lack the Rh protein. Although Rh positive is the most common blood type, having a Rh-negative typing does not indicate illness and usually doesn t affect your health. Why Is Rh Factor Important? The Rh factor is one of the proteins on RBCs used to indicate whether the blood of two different people is compatible when mixed \_ such as blood of a mother and her baby at birth. It is routine and important that the Rh factor for a mother and unborn child be determined during pregnancy. If an expecting mother is Rh negative and her baby is RH is negative, there aren t usually any concerns. Conversely if the expecting mother is RH negative and her baby is Rh positive, the mother s blood might produce the anti-D antibodies. The effect of these antibodies on the development of the unborn child, who is Rh positive, are determined by many factors. There are medical interventions that can be taken under the supervision of a physician to protect the baby in utero. The Rh factor is important to determine in blood donations and transfusions. A person with the Rh positive factor will not make anti-Rh antibodies. Those with Rh negative factor will produce the antibodies. Therefore, someone with Rh+ blood can receive both Rh+ and Rh- transfusions, but those with Rh- can only receive Rh- blood. Blood type and Rh factor screening are done not only to categorize a blood donation. The Rh screening test result also allows a healthcare provider to give additional support to a patient if incompatibility is detected. Problem: In humans, the Rh factor genetic information is inherited from our parents, but it is inherited independently of the ABO blood type alleles. In humans, Rh+ individuals have the Rh antigen on their red blood cells, while Rh individuals do not. There are two different alleles for the Rh factor known as Rh+ and rh. Assume that a dominant gene Rh produces the Rh+ phenotype, and that the recessive rh allele produces the Rh phenotype. In a population that is in Hardy-Weinberg equilibrium, if 160 out of 200 individuals are Rh+, calculate the frequencies of both alleles. Youtube video: https://lnkd.in/dDBxqZ6w \#nikolays_genetics_lessons

https://zurl.co/dNpB This is a great example of achieving focus by abandoning excess.

p53: A tale of complexity and context https://lnkd.in/daBnDTCq