National Stem Cell Foundation of Australia’s Post

Our recent paper describes how chemoresistance depend upon Autophagy-ID-TCF12 network in Cancer stem cells of recurrent epithelial ovarian cancer https://lnkd.in/duuQ_ZbR or as a PDF here https://lnkd.in/dStXpCKA

One of the most often repeated fallacies in cancer care is that cancer cells are committed to Warburg metabolism. The Warburg effect is the cancer cells' use of anaerobic glycolysis despite the presence of oxygen (an inherently inefficient way to derive energy from glucose). Yes, the Warburg effect happens, but it is by no means the ONLY way they derive energy (Note: glioblastoma may be an exception). Fatty acids are another ready source of carbons for both energy production and as structural components of new cancer cells. A recent study showed that lung cancer cells were able to spur macrophages to become cholesterol-manufacturing machines! The cancer cells could then use the cholesterol for their fuel/structural needs. The authors propose that EGFR inhibitors may be more effective when paired with statins. #integrativeoncology #repurposeddrugs #lungcancer #EGFRinhibitors

A new flow cytometry system could help scientists develop more targeted, personalized strategies for treating cancer by enabling them to follow disease progression and therapeutic response in different cancer cell subpopulations simultaneously. The technique, called diffuse in vivo flow cytometry (DiFC), was developed by researchers at Northeastern University and Dartmouth College. #photonics #BioPhotonics

🔬 I´m thrilled to share our latest paper titled "Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells," just published in the British Journal of Cancer. Our study delves into the interplay between AURKA and YAP1 phosphorylation shedding light on cetuximab resistance mechanisms in colorectal cancer patients with wild-type RAS/RAF. Through transcriptomic analysis and in vitro/vivo models, we´ve identified AURKA inhibition as a promising strategy to restore cetuximab sensitivity and suppress cancer stem cell phenotypes associated with resistance. Excited about the potential implications of our findings for overcoming treatment resistance in CRC. A huge thanks to our dedicated team for their hard work and commitment! 🌟 #Research #ColorectalCancer #Therapeutics #Science #CancerResearch https://lnkd.in/eU7HRHi7

📢 Newly Published Paper Sharing: Cancer stem cell, chromosomal instability, and cancer immunity #cancerimmunity 👥 Authors: Laxmi Kumari, Saloni Munjal, Reena Yadav, Yashwant Kumar, Alka Bhatia 🔑 Keywords: #Cancer stem cells, chromosomal instability, #stemcells, #immunesystem, non-stem cancer cells, extracellular matrix 🎯 "...So, in this review article, an attempt has been made to understand the nature of the interaction between the triad of CIN, CSC, and the immune response in tumors and some of the pathways governing the same. Understanding the above may be a positive step towards the complete cure for malignant diseases." 🔗 Read the full article: https://lnkd.in/gGT9RUww

📢 Newly Published Paper Sharing: Cancer stem cell, chromosomal instability, and cancer immunity #cancerimmunity 👥 Authors: Laxmi Kumari, Saloni Munjal, Reena Yadav, Yashwant Kumar, Alka Bhatia 🔑 Keywords: #Cancer stem cells, chromosomal instability, #stemcells, #immunesystem, non-stem cancer cells, extracellular matrix 🎯 "...So, in this review article, an attempt has been made to understand the nature of the interaction between the triad of CIN, CSC, and the immune response in tumors and some of the pathways governing the same. Understanding the above may be a positive step towards the complete cure for malignant diseases." 🔗 Read the full article: https://lnkd.in/gGT9RUww

🚀 Exciting Development in Precision Medicine! 🚀 MIT researchers, led by Michael Yaffe, have unveiled a groundbreaking atlas of human tyrosine kinases, key players in cell signaling during inflammation and cancer progression. Dubbed the "Rosetta Stone" of cell signaling, this comprehensive resource is set to revolutionize precision cancer medicine by enabling the identification of specific kinases involved in these processes. This innovative atlas, combined with mass spectrometry data, holds the potential to expedite the development of targeted cancer therapies, ultimately improving patient outcomes and advancing the field of oncology. Discover more about this pioneering research and its implications for precision medicine! Read More Here: https://lnkd.in/eQ696BVu #PrecisionMedicine #CancerResearch #Oncology #MITResearch #MedicalInnovation #HealthcareAdvancement #CellSignaling #TargetedTherapies #Biotechnology

How can we enhance our #immune cells' ability to fight #cancer?🩸🧪 Recent research offers an intriguing 𝒂𝒏𝒔𝒘𝒆𝒓. Published in Nature, innovative studies reveal a promising strategy: giving CAR T cells 𝐬𝐭𝐞𝐦 𝐜𝐞𝐥𝐥-𝐥𝐢𝐤𝐞 𝐜𝐡𝐚𝐫𝐚𝐜𝐭𝐞𝐫𝐢𝐬𝐭𝐢𝐜𝐬, with the #FOXO1 protein emerging as a critical catalyst in reshaping these cells to mirror memory stem cells.🧬💪 By equipping these cells with stem cell-like abilities, researchers witnessed a remarkable #boost in both their 𝐥𝐨𝐧𝐠𝐞𝐯𝐢𝐭𝐲 and 𝐞𝐟𝐟𝐞𝐜𝐭𝐢𝐯𝐞𝐧𝐞𝐬𝐬 in battling tumors.🌟 This breakthrough not only advances our understanding of #immunotherapy but also paves the way for more potent and durable 𝐜𝐚𝐧𝐜𝐞𝐫 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭𝐬.🩺🏥 Springer Medizin Österreich #CancerResearch #Immunotherapy #StemCellCharacteristics #MedicalBreakthroughs #FightCancer

The non coding RNAs such as miRNA are emerging as the molecular handlers within a cell, deciding which mRNA translates to functional proteins. Delighted to share that our latest review has been published in Cancers, wherein we review the roles of miRNA in the insiduous cancer stem cells and the signals driving it especially with reference to Wnt pathway. The impact of miRNA in cancer as potential diagnostic markers and therapeutic targets is delineated. https://lnkd.in/eCGmZd7H

Exciting breakthrough in cancer research! Scientists from MIT, Harvard, and Yale have unveiled a comprehensive atlas of human tyrosine kinases, marking a monumental leap in precision cancer medicine. This new "Rosetta Stone" of cell signaling accelerates the mapping of pathways, unveiling actionable insights for personalized therapies. Imagine using this atlas to decode individual tumors' signaling states, revealing new drug targets and combination treatments. With this powerful tool, we're on the brink of revolutionizing how we approach cancer treatment, turning complex data into clear, life-saving strategies. #CancerResearch #PrecisionMedicine #MedicalInnovation