National Stem Cell Foundation of Australia’s Post

🚀 Exciting Development in Precision Medicine! 🚀 MIT researchers, led by Michael Yaffe, have unveiled a groundbreaking atlas of human tyrosine kinases, key players in cell signaling during inflammation and cancer progression. Dubbed the "Rosetta Stone" of cell signaling, this comprehensive resource is set to revolutionize precision cancer medicine by enabling the identification of specific kinases involved in these processes. This innovative atlas, combined with mass spectrometry data, holds the potential to expedite the development of targeted cancer therapies, ultimately improving patient outcomes and advancing the field of oncology. Discover more about this pioneering research and its implications for precision medicine! Read More Here: https://lnkd.in/eQ696BVu #PrecisionMedicine #CancerResearch #Oncology #MITResearch #MedicalInnovation #HealthcareAdvancement #CellSignaling #TargetedTherapies #Biotechnology

🧬 New Hypothesis on Cancer Mechanisms! 🧬 In "Interactions between the DNA Damage Response and the Telomere Complex in Carcinogenesis," Antonio Torres-Montaner explores how telomere damage and DNA repair dysfunction contribute to the early stages of cancer development. 👉 This hypothesis delves into the role of telomere maintenance in transformation and the survival of cancer stem cells, offering new insights into the progression of carcinogenesis. 🔎 Discover more about this fascinating intersection of DNA damage and cancer stem cells in Current Issues in Molecular Biology: https://lnkd.in/eW_6i9Va #CancerResearch #Telomeres #DNARepair #StemCells #Carcinogenesis

🌟 Excited to Share My Latest Publication! 🌟 I am thrilled to announce that my review paper, "Intricate Relationship Between Cancer Stemness, Metastasis, and Drug Resistance", has been published in MedComm (Impact Factor: 10.7). This paper explores the complex interplay between cancer stem cells, their role in metastasis, and their contribution to drug resistance, offering insights into potential therapeutic strategies. A heartfelt thank you to my mentors, colleagues, and everyone who supported this endeavor. I hope this work contributes meaningfully to the ongoing research in cancer biology. You can access the publication here: https://lnkd.in/dWnzng4C. I’d love to hear your thoughts and feedback! #Research #CancerBiology #DrugResistance #CancerStemCells #MedComm #LifeSciences #Publication

One of the most often repeated fallacies in cancer care is that cancer cells are committed to Warburg metabolism. The Warburg effect is the cancer cells' use of anaerobic glycolysis despite the presence of oxygen (an inherently inefficient way to derive energy from glucose). Yes, the Warburg effect happens, but it is by no means the ONLY way they derive energy (Note: glioblastoma may be an exception). Fatty acids are another ready source of carbons for both energy production and as structural components of new cancer cells. A recent study showed that lung cancer cells were able to spur macrophages to become cholesterol-manufacturing machines! The cancer cells could then use the cholesterol for their fuel/structural needs. The authors propose that EGFR inhibitors may be more effective when paired with statins. #integrativeoncology #repurposeddrugs #lungcancer #EGFRinhibitors

Exciting advancements in CAR-T therapy offer new hope for challenging conditions like glioblastoma (GBM). Despite some concerns about manageable clinical adverse reactions, CAR-T’s potential is immense. GBM remains a formidable adversary in the oncology field due to its aggressive nature and limited treatment options. However, recent articles like below (GEN) in CAR-T therapy bring renewed optimism for solid tumor treatments. The below study in CAR-T therapy is a promising step forward for patients and the oncology practice. Let’s continue to support and explore these innovative therapies that can transform lives.🤞🤞🧠🧠🧬🧬 #CART #PrecisionOncology #Glioblastoma #HopefulNews #GEN

Here is an intriguing and exciting discovery in cancer biology: the molecular jackhammer! Researchers at Rice University have developed a remarkable way to specifically destroy cancer cells by targeting tumors with a chemical dye that can be activated by near-infrared light to create "molecular jackhammers" that destroy cancer cells. The synchronous vibrations of the atomic nuclei induced by the near-infrared irradiation of the dye molecules can mechanically and lethally disrupt the cell membranes of the cancer cells. Because near-infrared light can penetrate several (about 4) inches into the body without causing cellular damage (infrared radiation has lower energy than visible light), this method can theoretically be used to target any cancer for which a tumor-specific monoclonal antibody is available to carry the dye to the tumor. It is probably too early to call this a life-changing therapy- it is a long way from clinical testing-but we can grant that the purpose of a headline is to grab the attention of readers. For the tag line, we can use "Let’s shine a light on cancer!" Maybe not. #cancer #oncology #biochemistry #cellbiology #immunotherapy #genetics #lungcancer #breastcancer #livercancer #cancerresearch #melanoma #biotechnology #cancerresearchprofessionals #topicsincancerresearch #sciencewriters #lifesciencesnetwork #biotechnologyandbiopharmaprofessionals #globalcancerinnovationsgroup #biotechnologyandbiopharmacommunity #proteinbiochemistryandbiophysics

Exciting breakthrough in cancer research! Scientists from MIT, Harvard, and Yale have unveiled a comprehensive atlas of human tyrosine kinases, marking a monumental leap in precision cancer medicine. This new "Rosetta Stone" of cell signaling accelerates the mapping of pathways, unveiling actionable insights for personalized therapies. Imagine using this atlas to decode individual tumors' signaling states, revealing new drug targets and combination treatments. With this powerful tool, we're on the brink of revolutionizing how we approach cancer treatment, turning complex data into clear, life-saving strategies. #CancerResearch #PrecisionMedicine #MedicalInnovation

Understanding Early Cancer and Pre Cancer Biology Plenary Speakers in a session discuss various aspects of understanding the biology of early cancer. This helps in developing strategies for early detection which in turn can help in increasing the chances of cure. Key topics- errors in DNA replication Hematopoietic stem cells , Chromothripsis, Biomarkers in early breast cancer , DNA damage response

🔬 I´m thrilled to share our latest paper titled "Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells," just published in the British Journal of Cancer. Our study delves into the interplay between AURKA and YAP1 phosphorylation shedding light on cetuximab resistance mechanisms in colorectal cancer patients with wild-type RAS/RAF. Through transcriptomic analysis and in vitro/vivo models, we´ve identified AURKA inhibition as a promising strategy to restore cetuximab sensitivity and suppress cancer stem cell phenotypes associated with resistance. Excited about the potential implications of our findings for overcoming treatment resistance in CRC. A huge thanks to our dedicated team for their hard work and commitment! 🌟 #Research #ColorectalCancer #Therapeutics #Science #CancerResearch https://lnkd.in/eU7HRHi7

Brittany Allen-Petersen's journey into cancer biology is deeply personal, rooted in the profound loss of her friend Sean Robins to Ewing sarcoma—a tragedy that ignited her unwavering commitment to understanding and combating this relentless disease. Ewing sarcoma is a type of tumor that forms from a certain kind of cell in bone or soft tissue. As an assistant professor of biological sciences at Purdue University's College of Science, Allen-Petersen's research delves into the intricate mechanisms underpinning cancer progression, with a focus on unraveling the mysteries of protein phosphatases. Read more about her research in the full article: bit.ly/3TBpyVa #Purdue #Science #Research #Biology #Cancer #CancerResearch #MyGiantLeap #TheNextGiantLeap