Mitch Bardenwerper’s Post

ABOUT PRE-FILLABLE SYRINGE COP/COC It is uitable for diverse application fields, especially for sensitive biologicalproducts. ADVANTAGES AND CHARACTERISTICS 1.Adhesive and tungsten free 2.Avoid protein aggregation 3.Excellent chemical resistance 4.Good drug compatibility 5.Strongimpact resistance 6.Strict manufacturing tolerances #PRE-FILLABLE SYRINGE COP/COC #COP/COC #ZEMLEY

Have you ever faced challenges in maintaining a steady flow rate during your liquid handling experiments? Achieve unparalleled response time compared to peristaltic or syringe pumps. Whether you're in academia or industry, our technology ensures you get the most reliable and accurate results every time. 👉https://lnkd.in/dtmrCEkd #Elveflow #liquidhandling #flowcontrol #flowrate #Microfluidics

𝗔𝗱𝘀𝗼𝗿𝗽𝘁𝗶𝗼𝗻: 𝗧𝗵𝗲 𝗚𝗹𝘂𝗲 𝘁𝗵𝗮𝘁 𝗕𝗶𝗻𝗱𝘀 In extrusion-spheronization, binders act as a glue that hold drug particles together through a process called adsorption. This creates a strong bond that ensures the particles stick together during extrusion. 𝗕𝗲𝘆𝗼𝗻𝗱 𝗺𝗲𝗿𝗲 𝗮𝗱𝗵𝗲𝘀𝗶𝗼𝗻, 𝗮𝗱𝘀𝗼𝗿𝗽𝘁𝗶𝗼𝗻 𝗮𝗹𝘀𝗼 𝗼𝗳𝗳𝗲𝗿𝘀 𝘁𝗵𝗲 𝗳𝗼𝗹𝗹𝗼𝘄𝗶𝗻𝗴 𝗯𝗲𝗻𝗲𝗳𝗶𝘁𝘀: ✅ 𝗜𝗺𝗽𝗿𝗼𝘃𝗲𝗱 𝗪𝗲𝘁𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆: The binder layer can attract moisture which is crucial for even distribution of water during the subsequent spheronization step. ✅ 𝗖𝗼𝗻𝘁𝗿𝗼𝗹𝗹𝗲𝗱 𝗗𝗿𝘂𝗴 𝗥𝗲𝗹𝗲𝗮𝘀𝗲: Depending on the binder's properties, the adsorbed layer can regulate how quickly the drug dissolves from the final tablet. For example, binders with high water solubility can create a more porous structure, promoting faster drug release. Read the full blog to learn more about the benefits and influencing factors of adsorption in the wet granulation extrusion-spheronization process: https://lnkd.in/eJ3-wx6R #Adsorption #WetGranulation #Extrusion #Spheronization #Binders #DrugDevelopment #FormulationDevelopment #PharmaceuticalScience

Discover the benefits of using polyvinyl alcohol (PVA) and how it can be applied in spray drying for oral solid dosage forms. During this webinar, our experts Lena Mareczek and Markus Lubda will share with you how this versatile polymer stabilizes small molecules, both traditional and emerging (e.g. PROTACs), and how it enhances their solubility. Register for our webinar now! #solidformulation #formulation #osd #drugdevelopment

Good morning everyone In continuation of the previous post In addition to the reasons I mentioned previously, there are other reasons that can lead to disc lamination: 1-Excessive Lubrication: Using an excessive amount of magnesium stearate can reduce the cohesion between the powder molecules, leading to separation of the layers. 2- Irregular granule size variation: The difference in the size of the granules used in the tablet compression process can lead to uneven packing and create weak points inside the tablet, which facilitates separation. 3- Non-homogeneous mixture composition: The heterogeneous mixture may lead to an uneven distribution of active and inactive ingredients, which leads to weak points in the tablet that facilitate the separation of the layers. 4- Entrapped Air in Powder or Granules: The presence of air trapped inside the powder can lead to an increase in air pressure during the pressing process, causing the layers to separate. 5- Defects in the Improper Blending Process: Insufficient or excessive mixing may lead to uneven distribution of ingredients within the powder and granules, which leads to weak cohesion between the particles. 6-Weak Interparticulate Bonding Forces: The forces that bind the powder particles or granules may be weak, whether due to the properties of the powder or a lack of appropriate bonding agents, which leads to separation of the layers. 7- To prevent the occurrence of lamination, it is necessary to conduct careful examinations and analyzes of all stages of the manufacturing process and adjust the standards to suit the nature of the materials and production conditions. #PharmaCeutical #Compression #Compression #tablets #byHazemFathy [email protected]

Comparing the Best Binding Affinity of Acalypha indica Chemical Drug with Mouth Ulcer Tablets Using Pyrx Software

Discover the benefits of using polyvinyl alcohol (PVA) and how it can be applied in spray drying for oral solid dosage forms. During this webinar, you will learn how this versatile polymer stabilizes small molecules, both traditional and emerging (e.g. PROTACs), and how it enhances their solubility. Register for our webinar now! #solidformulation #formulation #osd #drugdevelopment

Continuous twin-screw melt granulation of drug-loaded electrospun fibers https://lnkd.in/eGxEPc73

The condensation reaction between cyanopyridines and 1,2-aminothiols stands out as a particularly favorable nitrile modification strategy that proceeds under biocompatible conditions. Cyanopyridines can be seamlessly incorporated into peptides and proteins through both chemical and biotechnological approaches. Similarly, the selective integration of 1,2-aminothiols into peptides and proteins is achievable, leveraging the uniquely reactive N-terminal cysteine functional group.