Infected F/BEVAR Explant Dear friends, Thank you again for the academic discussion about this case. Our decision to explant and stay out of the very purulent sac was based on the sac aspirant being frankly purulent and the microbiology consisting of gram positives, gram negatives and yeast (likely foregut source). Patient was treated with broad spectrum IV antibiotics and antifungals for a week prior to explant. Intraoperatively we noticed unexpected progression of infection transmurally into the supraceliac aorta. Our initial plan was to create a stump with the celiac beveled into it however the aorta, that looked ok on preop imaging, would not even hold a clamp and sutures kept tearing till I went about 6 centimeter above the celiac after temporary clamping above the branching allograft. There was pus within the wall of supraceliac aorta, something I have not seen before. Plan is to continue outpatient antibiotic and antifungal treatment for minimum of 6 months and continue interval imaging. This is our second instance of infection in a F/BEVAR in over 150 implants. Unfortunately graft infection, although rare, is something that we need to be prepared for. Strategies discussed on this thread are all appropriate options in different settings. I would love to hear more thoughts. #aortaed #unmvascularsurgery Gustavo Oderich MD Jesse Manunga Peter Gloviczki, MD, PhD Rafael Demarchi Malgor, MD, MBA FACS Faisal Aziz MD, MBA, FACS, Distinguished-FSVS Naveed Saqib Muhammad Aftab MD, FACS, FACC Ross Clark, MD, MBA, RPVI Firas Mussa
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Infected F/BEVAR Explant I tried to post this last week but Linkedin continues to tag the video to have "sensitive content" so it gets removed from the feed. I have tried to remove the operative clips so may be video may not be tagged as being objectionable. Once again our decision to explant and stay out of the very purulent sac was based on the sac aspirant being frankly purulent and the microbiology consisting of gram positives, gram negatives and yeast (likely foregut source). Patient was treated with broad spectrum IV antibiotics and antifungals for a week prior to explant. This is our second instance of infection in a F/BEVAR in over 150 implants. Unfortunately graft infection, although rare, is something that we need to be prepared for. Strategies discussed on this thread are all appropriate options in different settings. I would love to hear more thoughts. Please follow the link below to see full video with operative clips. https://lnkd.in/g-inGmgX #aortaed #unmvascularsurgery
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🔍 Understanding Procalcitonin Interpretation in Clinical Practice 🔬 Procalcitonin (PCT) is a valuable biomarker that helps in diagnosing bacterial infections and guiding antimicrobial therapy decisions. Here’s a quick guide to interpreting PCT levels: 🧪 Normal PCT Levels (<0.1 ng/mL): Indicates a low likelihood of bacterial infection. Antibiotic therapy may not be necessary. 🧪 Low to Moderate Levels (0.1–0.5 ng/mL): Suggests a potential bacterial infection but might also be elevated due to other factors like trauma or surgery. Monitor closely and consider the clinical context. 🧪 High Levels (0.5–2.0 ng/mL): Indicates a probable bacterial infection. Antimicrobial therapy may be warranted based on clinical assessment. 🧪 Very High Levels (>2.0 ng/mL): Strongly suggests severe bacterial infection or sepsis. Immediate intervention and antimicrobial therapy are often necessary. 🔑 Key Points to Remember: Always interpret PCT levels alongside clinical signs, symptoms, and other laboratory findings. PCT can guide antibiotic stewardship by helping to avoid unnecessary antibiotic use and reducing antibiotic resistance. Effective PCT interpretation aids in timely and appropriate management, improving patient outcomes and promoting #AntimicrobialStewardship. 💡 #Procalcitonin #InfectionControl #ClinicalMicrobiology #QualityCare #Healthcare
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Double-blinded MOBILE2-trial found that mechanical bowel preparation and oral antibiotics reduced the rate of overall morbidity, surgical site infections and anastomotic leaks compared to mechanical bowel preparation only prior anterior rectal resection. https://ja.ma/3RmZpc4
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Our recent presentation at #CIDSCON 2024 Innovations in the Management of Difficult-to-Treat Bone Infections At **CIDSCON 2024** in Hyderabad, I had the opportunity to present a poster highlighting cutting-edge strategies in the management of **challenging bone infections** - role of multiplex PCR for early diagnosis & novel treatment options with good bone penetration, anti biofilm activity, tolerability especially when used for weeks & months ! 😊 Bone infections, particularly osteomyelitis, present complex treatment challenges due to resistant organisms and poor antibiotic penetration. However, **novel treatment modalities** are offering promising solutions. Key highlights from our presentation: 🔹 **Personalized treatment regimens** involving tailored antibiotic therapies based on culture sensitivities and infection kinetics. Use of novel antibiotics like levonadi 🔹 The role of **local antibiotic delivery systems** for enhanced efficacy in eradicating biofilms and achieving therapeutic concentrations. 🔹 Innovative surgical techniques, including **debridement and bone stabilization & stimulans to create an optimal environment for healing. This presentation emphasizes the importance of a **multidisciplinary approach**, integrating infectious disease specialists, microbiologists, and orthopedic surgeons, to achieve **better patient outcomes**. It’s the friendship which will bring good patient outcomes ! #InfectiousDiseases #BoneInfections #Osteomyelitis #CIDSCon2024 #NovelTherapies #ClinicalInnovation #PatientCare #AntibioticResistance #OrthopedicInfections
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As Sepsis Awareness Month concludes, we share the story of Jeroen Bursens, who almost lost his life to this deadly disease, a condition that kills about one-third of the 49 million people it affects annually. Jeroen's hospital-acquired infection that triggered sepsis after a routine surgery highlights the critical need for early detection and treatment. Thermo Fisher's diagnostic tools play a vital role in this fight and help clinicians make informed decisions and improve patient outcomes. As we wrap up Sepsis Awareness Month, let's commit to spreading awareness and supporting advancements in sepsis detection and treatment for people like Jeroen and his family. #SepsisAwarenessMonth
Microbiologist's near-fatal battle with sepsis highlights urgent need for awareness and better treatment protocols
corporate.thermofisher.com
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🚀 Excited to Share My Latest Research! 🚀 I’m thrilled to announce the publication of my new article in reputed Surgical Infections Journal on the "An In Vitro Assessment of Exofin High Viscosity Topical Skin Adhesive (HVTSA)" 🧪🔬 Abstract Overview: In wound care, the choice of closure method is crucial in preventing infections. Traditional sutures and staples can introduce foreign material, increasing infection risk. Exofin High Viscosity Topical Skin Adhesive (HVTSA)—a topical skin adhesive with promising antimicrobial properties. Key Findings: Objective: Assess Exofin HVTSA’s effectiveness as a microbial barrier against various pathogens. Methods: Conducted by NAMSA, this study tested Exofin HVTSA against organisms like Staphylococcus aureus, MRSA, Pseudomonas aeruginosa, and more. Results: Exofin HVTSA showed robust barrier properties against most challenge organisms for 14 days. It effectively blocked growth of Staphylococcus aureus, MRSA, and Candida albicans and Pseudomonas Aeruginosa. Conclusion: This adhesive demonstrates significant potential as a safer, effective alternative to traditional wound closure methods, particularly in complex surgeries. A special thank you to James Cooke, CEO of Chemence Medical, for the opportunity to work with Exofin HVTSA and contribute to advancing wound care solutions. 🙏 🔍 For a detailed look at the study and its implications, read the full article https://lnkd.in/ePFApeD8 . I believe this could pave the way for more effective and safer wound management practices! #WoundCare #MedicalResearch #TopicalAdhesives #HealthcareInnovation #ExofinHVTSA #SurgicalCare #InfectionControl #ChemenceMedical
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The use of antimicrobials underpins modern medicine. Without effective antibiotics, even minor surgery and routine operations could become high-risk procedures if serious infections cannot be treated. Microorganisms which become resistant to antimicrobials, so-called ‘superbugs,’ do not respond or respond less well to available treatments. The emergence and spread of these superbugs affects: ✔️Global public health ✔️Animal health ✔️Food security ✔️The economy ✔️Sustainable development Read more in the latest Policy paper Confronting antimicrobial resistance 2024 to 2029 Updated 8 May 2024 https://lnkd.in/gxtHhKn9
Confronting antimicrobial resistance 2024 to 2029
gov.uk
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Understanding Ear Culture and Sensitivity (C/S) Test What is an Ear C/S Test? An Ear Culture and Sensitivity (C/S) test involves collecting a sample from the ear, typically using a swab, and culturing it in a laboratory to identify the presence of bacteria, fungi, or viruses. The test also determines which antibiotics or antifungal medications are most effective against the identified pathogens¹³. Procedure: 1. Sample Collection: A healthcare provider uses a sterile swab to collect a sample of fluid, pus, or discharge from the outer ear canal. In some cases, a sample may be collected from the middle ear during surgery¹³. 2. Culturing: The sample is placed on a culture medium and incubated to allow any microorganisms present to grow¹³. 3. Sensitivity Testing: Once the microorganisms are identified, they are tested against various antibiotics or antifungal agents to determine the most effective treatment¹³. Clinical Significance: - Diagnosis: The test helps diagnose ear infections, such as otitis externa (outer ear infection) and otitis media (middle ear infection), especially when initial treatments are ineffective¹³. - Treatment Guidance: By identifying the specific pathogens and their antibiotic sensitivities, the test guides healthcare providers in selecting the most appropriate and effective treatment¹³. - Monitoring: It can also be used to monitor the effectiveness of treatment and detect any resistant strains of microorganisms¹³. Conclusion: The Ear Culture and Sensitivity (C/S) test is a valuable tool in diagnosing and managing ear infections. It provides critical information that helps tailor treatment plans to effectively. #MedicalLaboratoryTechnology #Microbiology #Phlebotomy #LaboratoryTesting #DiagnosticTesting #HealthcareProfessional #MedicalTesting #ClinicalLaboratory #BiomedicalScience #HealthcareIndustry #MedicalScience #LaboratoryMedicine #ClinicalMicrobiology #InfectionControl #PhlebotomyTechnician #MedicalLabTechnician #MicrobiologyLab #ClinicalLab #HealthcareCareer #MedicalCareer #ScienceCareer #COVID19Testing #Virology #Bacteriology #Parasitology #MolecularDiagnosis #GeneticTesting #Cytology #Histopathology #Immunology #Serology
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Damage from repeated catheter use can weaken the urethral defense increasing the risk of UTIs.¹,² Traditional hydrophilic catheters have coatings that make them slippery on the way in, but they can become sticky when removed.³ This can cause discomfort, bleeding, and damage to the urethra leading to a higher chance of getting UTIs.³,⁴ GentleCath™ catheters with FeelClean Technology™ are designed with the slippery hydrophilic properties integrated inside the catheter itself rather than having a sticky coating. Without this coating, FeelClean Technology™ does not stick, so protects the delicate urethra,³,⁵ the body's first line of defense against UTIs.*,⁴ We know the urethra plays an important part in protecting against urinary tract infections, so it’s crucial to provide a catheter option that's as gentle as possible. Learn more about why users choose GentleCath™ with FeelClean Technology™. https://lnkd.in/eV6qfP2u #ForeverCaring #ForeverConvatec #ContinenceMatters 1. Werneburg GT. Catheter-Associated Urinary Tract Infections: Current Challenges and Future Prospects. Res Rep Urol. 2022;14:109-133. doi:10.2147/RRU.S273663 2. Jacobsen SM, Stickler DJ, Mobley HLT, Shirtliff ME. Complicated catheter-associated urinary tract infections due to Escherichia coli and Proteus mirabilis. Clin Microbiol Rev. 2008;21(1):26-59. doi:10.1128/CMR.00019-07 3. Pollard D, Allen D, Irwin N J, Moore J V, McClelland N, McCoy C P. Evaluation of an Integrated Amphiphilic Surfactant as an Alternative to Traditional Polyvinylpyrrolidone Coatings for Hydrophilic Intermittent Urinary Catheters. Biotribology. 2022;32(Dec 2022):100223. 4. Dellimore KH, Helyer AR, Franklin SE. A scoping review of important urinary catheter induced complications. J Mater Sci Mater Med. 2013;24(8):1825-1835. doi:10.1007/s10856-013-4953-y 5. In vitro data on file. *Urethral trauma is a risk factor of UTIs AP-70354-GBL-ENG-v1
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As Sepsis Awareness Month concludes, we share the story of Jeroen Bursens, who almost lost his life to this deadly disease, a condition that kills about one-third of the 49 million people it affects annually. Jeroen's hospital-acquired infection that triggered sepsis after a routine surgery highlights the critical need for early detection and treatment. Thermo Fisher's diagnostic tools play a vital role in this fight and help clinicians make informed decisions and improve patient outcomes. As we wrap up Sepsis Awareness Month, let's commit to spreading awareness and supporting advancements in sepsis detection and treatment for people like Jeroen and his family. #SepsisAwarenessMonth
Microbiologist's near-fatal battle with sepsis highlights urgent need for awareness and better treatment protocols
corporate.thermofisher.com
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