How Lyobead Technology Works Lyophilization Process Preparation: The material to be lyophilized (e.g., a biological sample or drug solution) is prepared and mixed with stabilizers if necessary. Freezing: The material is rapidly frozen, often to very low temperatures, turning the water content into ice. Primary Drying: Under vacuum, the ice sublimates (turns directly from solid to gas) without melting, leaving behind a dry, porous structure. Secondary Drying: Further drying removes residual moisture to ensure long-term stability. Bead Formation: The dried material is then processed into bead form, often using techniques like extrusion or molding. Bead Integration Diagnostics: Lyobeads are integrated into diagnostic assays or test formats, where they dissolve upon contact with a liquid sample, releasing their contents for analysis. Pharma: In pharmaceuticals, lyobeads can be incorporated into drug formulations, such as injectables, or used in devices that administer the drug. #Lyobeadtechnology #Lyophilization #Diagnostics #Freezedrying
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Bio-pharmaceutical Single Use Customized System - refers to specialized containers used in biopharmaceutical manufacturing for the storage, transportation, and processing of biological fluids, powders, and other materials. These bags are made from high-quality, sterile materials such as polyethylene or multi-layer barrier films, ensuring sterility and minimizing the risk of contamination. Key advantages of these bags include: * Single-use: Eliminates the need for cleaning and re-sterilization. * Customization: The bags can be tailored to meet specific bioprocessing requirements. * High-barrier protection: Shields the contents from moisture, oxygen, and other external factors. They are commonly used in processes such as mixing, storage, or transportation of materials in biopharmaceutical production.
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RB Flowmeter's Clamp-on Ultrasonic Flow Sensor: Your Ideal Choice for Flow Measurement In the contemporary industrial panorama, precise flow measurement constitutes a pivotal factor. RB Flowmeter's clamp - on ultrasonic flow sensor adeptly addresses this exigency. This sensor features a non - invasive design, thereby obviating cross - contamination risks, which is of utmost significance in medical and bio-pharmaceutical applications. In scenarios such as drug formulation and chemical synthesis, its high - precision measurement capability is indispensable. The sensor's streamlined internal structure precludes any impedance to fluid flow, ensuring laminar flow within the pipeline. Its maintenance - friendly nature allows for seamless upgrades without system shutdown. Moreover, real - time monitoring and advanced communication interfaces empower seamless integration into industrial control systems. Widely utilise in medical, bio-pharmaceutical, chemical, and food industries, this sensor is set to undergo further enhancements, facilitating enhanced integration into intelligent manufacturing systems, and thus emerging as an optimal choice for diverse users. More information visit our website: https://lnkd.in/g55rzVXm #flowSensor #nonContact #ClampOn #medical #blood #bioPharmaceutical #Ultrasonic #nonInductive #RBFlowmeter
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Knowledge and experience of over 20 years in liquid and semi-solid mixing transferred into the new syDry Series of #PowerMixers and #Grinders https://bit.ly/3mkBWc0 #healthcare #pharmacology #pharma #pharmacy #pharmacist #pharmaceuticals #pharmacystudent #science #pharmacyschool #pharmd #biotech #pharmaceutical #pharmacists #pharmacytechnician #pharmacylife #biotechnology #pharmacognosy #research #manager #inos #inostechnologies
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🌟 Exploring Humidity and Temperature-Dependent XRPD 🌡️💧 At Seven Star Pharmaceutical Services, we specialize in providing advanced humidity and temperature-controlled X-ray Powder Diffraction (XRPD) services, offering vital insights into how materials behave under varying environmental conditions. Moisture or temperature changes can induce polymorphic transformations or trigger hydrate and anhydrate transitions, which are critical for understanding material stability, especially in pharmaceuticals. 🔬 Our XRPD solutions are applicable across industries like pharmaceuticals, biotechnology, materials science, and food industry. From initial research to final product formulation, understanding how materials respond to humidity and temperature is key to ensuring product integrity and performance. Let us help you uncover the complexities of your materials! 💡 👉 Learn more about how our capabilities can support your projects: https://lnkd.in/eskxPxxv #XRPD #HTdependentXRPD #pharmaceuticals #CMC #CMCconsulting #pharmaceuticaldevelopment #drugdevelopment #SolidStateChemistry #research #SaltScreening #CrystallizationScreening #Crystallizationprocessdevelopment #CocrystalScreening #PolymorphScreening #preformulations #formulationdevelopment #chemistry #MedicinalChemistry #SingleCrystalXrayDiffraction #materialsscience #analyticalresearch #materialsresearch #cdmo #CRO #contractresearch #drugdiscovery #api #crystalform #SyntheticOrganicChemistry #entrepreneurship
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🎉 Unlocking the Power of #Neusilin®US2 🧪 Did you know that #Neusilin®US2 can be a game-changer in #liquisolid #compact #formulations? 🤯 Our #October2024 newsletter is out which delves into Exploring the #Neusilin®US2 as a Versatile Carrier by assessing its #Liquid-#Loading #Potential and #Mechanical #Strength in #Liquisolid #Systems💊. Here are the key findings: 💫 #Maximum #Liquid #Loading: The optimal liquid loading for #Neusilin®US2 was identified, which is crucial for achieving desired formulation properties. 💫#Compressibility #Analysis: The #Heckelequation proved to be the most effective model for quantifying the compressibility of #PEG #liquisolid #blends, providing a solid foundation for future formulations. 💫 #Compactibility #Insights: Utilizing the #Leuenbergermodel allowed to gain valuable insights into the compactibility and strength of the compacts, ensuring their efficacy in drug delivery. By leveraging these findings, more efficient and effective liquisolid compact formulations can be developed, enhancing drug delivery systems. Let's continue pushing the boundaries of pharmaceutical innovation! 💊 Megha Marwah, Ph.D (Tech.) Jeffrey Langa Mark Plunkett Pankaj Negi #Fujichemicals #NeusilinUS2 #liquisolidcompacts #drugdelivery #pharmaceuticalresearch #innovation #science
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Troubleshooting with #NeusilinUS2 and exploring #Liquisolidtechnology in greater depths.. want to know more?? Go ahead and read on! #excipients #pharmaceuticals #fujichemicalindustries #oiltopowder #compactability
Manager - Technical Services & Business Development at AstaReal India / Fuji Chemicals | IMCD Group | ICT, Mumbai | Accutest Research Laboratories | NMIMS, Mumbai | Elder Pharmaceuticals | GIP
🎉 Unlocking the Power of #Neusilin®US2 🧪 Did you know that #Neusilin®US2 can be a game-changer in #liquisolid #compact #formulations? 🤯 Our #October2024 newsletter is out which delves into Exploring the #Neusilin®US2 as a Versatile Carrier by assessing its #Liquid-#Loading #Potential and #Mechanical #Strength in #Liquisolid #Systems💊. Here are the key findings: 💫 #Maximum #Liquid #Loading: The optimal liquid loading for #Neusilin®US2 was identified, which is crucial for achieving desired formulation properties. 💫#Compressibility #Analysis: The #Heckelequation proved to be the most effective model for quantifying the compressibility of #PEG #liquisolid #blends, providing a solid foundation for future formulations. 💫 #Compactibility #Insights: Utilizing the #Leuenbergermodel allowed to gain valuable insights into the compactibility and strength of the compacts, ensuring their efficacy in drug delivery. By leveraging these findings, more efficient and effective liquisolid compact formulations can be developed, enhancing drug delivery systems. Let's continue pushing the boundaries of pharmaceutical innovation! 💊 Megha Marwah, Ph.D (Tech.) Jeffrey Langa Mark Plunkett Pankaj Negi #Fujichemicals #NeusilinUS2 #liquisolidcompacts #drugdelivery #pharmaceuticalresearch #innovation #science
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𝗣𝗿𝗼𝗼𝗳 𝗼𝗳 𝗮 𝗟𝗢𝗗 𝗽𝗿𝗲𝗱𝗶𝗰𝘁𝗶𝗼𝗻 𝗺𝗼𝗱𝗲𝗹 𝘄𝗶𝘁𝗵 𝗼𝗿𝘁𝗵𝗼𝗴𝗼𝗻𝗮𝗹 𝗣𝗔𝗧 𝗺𝗲𝘁𝗵𝗼𝗱𝘀 𝗶𝗻 𝗰𝗼𝗻𝘁𝗶𝗻𝘂𝗼𝘂𝘀 𝘄𝗲𝘁 𝗴𝗿𝗮𝗻𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗱𝗿𝘆𝗶𝗻𝗴 by Katharina Kiricenko , Stefan Klinken , Peter Kleinebudde Real-time monitoring of critical quality attributes, such as residual water in granules after drying which can be determined through loss-on-drying (LOD), during wet granulation and drying is essential in continuous manufacturing. Near-infrared (NIR) spectroscopy has been widely used as process analytical technology (PAT) for in-line LOD monitoring. This study aims to develop and apply a model for predicting the LOD based on process parameters. Additionally, the efficacy of an orthogonal PAT approach using NIR and mass balance (MB) for a vibrating fluidized bed dryer (VFBD) is demonstrated. #pharmaceutical #PAT
Proof of a LOD prediction model with orthogonal PAT methods in continuous wet granulation and drying - Pharma Excipients
https://www.pharmaexcipients.com
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In the world of biopharmaceutical manufacturing, the stakes couldn't be higher! Traditional tubing frequently falls short when faced with the intense demands of peristaltic pumping, leading to a cascade of challenges that can cripple production timelines. Imagine this: frequent tubing failures, causing costly production downtime, escalating maintenance requirements, and a significant potential for contamination due to wear and tear. Additionally, as the tubing interior degrades over time, it poses a serious threat by diminishing the efficiency of filtration systems—ultimately impacting product quality. However, there’s a beacon of hope! Enter PharMed® BPT Tubing—the revolutionary solution specifically crafted to tackle the challenges posed by peristaltic pumping in biopharmaceutical processes. Designed with durability and biocompatibility in mind, PharMed® BPT Tubing provides a robust surface conducive to sensitive applications, ensuring that your manufacturing processes remain unimpeded. What’s more? PharMed® BPT boasts a remarkable flex life that drastically cuts down on downtimes and the need for frequent replacements. This not only optimizes production efficiency but also safeguards against the interruptions that traditional tubing woes can introduce. Thanks to its advanced wear resistance, the risk of interior wall erosion is significantly minimized, which in turn enhances filtration efficiency and nurtures a more reliable manufacturing operation from start to finish. Don't let tubing failures hold you back! Elevate your biopharmaceutical manufacturing process with PharMed® BPT Tubing and experience the difference for yourself. For inquiries, feel free to 𝗖𝗼𝗻𝘁𝗮𝗰𝘁 𝘂𝘀 📩 𝗰𝗼𝗻𝘁𝗮𝗰𝘁@𝗯𝗶𝗼𝗺𝗮𝘁𝗶q.𝗰𝗼𝗺 #biomatiq #saintgobain #lifesciences #biopharma #bioprocessing #biotech #tubing #TPE #biopharmaceutical #innovation #pharmedbpt #peristalticpumptubing
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Sterilization is crucial in scientific research, healthcare, and pharmaceutical manufacturing, ensuring safety and quality by eliminating all life forms, including bacteria and spores. Effective sterilization requires a robust monitoring system, primarily using chemical and biological indicators. Chemical indicators, or process indicators, confirm that sterilization parameters like temperature and time have been met, providing a quick visual confirmation. Biological indicators, containing resistant spores, directly measure sterilization effectiveness, confirming microbial elimination. While chemical indicators are ideal for routine checks, biological indicators offer a more definitive assessment, essential for high-risk items such as surgical tools and pharmaceutical products. 🌱 IT Tech 👉 Click the link to view: https://lnkd.in/g4Cg3Npk #sterilization #chemical #Biological #indicator #scientific #lab #consumable #monitoring #ITTech #ITtechnologies #singapore #malaysia
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𝗟𝗶𝗾𝘂𝗶𝘀𝗼𝗹𝗶𝗱𝘀: 𝗔 𝗠𝗼𝗱𝗲𝗿𝗻𝗶𝘀𝘁𝗶𝗰 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 𝗶𝗻 𝗗𝗿𝘂𝗴 𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝘆 𝗦𝘆𝘀𝘁𝗲𝗺 Liquisolid Technology aims to make drug entities more soluble that have low solubility and low permeability, through the cosolvency theory in a reasonably simple setup that doesn’t require expensive technology. A non-volatile solvent is used to dissolve a medicine into molecular dispersion, which is then converted into a powder that has the appearance of being dry and is easily compressible. Extrudates are produced from the material by extrusion using an extruder. To create spherical particles known as Pellets, the extrudates are placed beneath the spheronizer. These pellets or granules can be filled in capsules or can be compacted into tablets according to their dose and can be utilized. Various evaluation parameters like Carr`s Index, Angle of Repose, FTIR, etc was studied. Overall, the study demonstrated that the liqui-pellet might improve a liquisolid formulation’s poor flowability, which is thought to be a significant development in the concept’s commercial viability. The current review aims to unfurl the utilization of liquisolid technology as a potential drug delivery system for BCS class 2 and 3 drugs. Continue reading here: https://lnkd.in/eXdmiXs2 #excipients #drugdelivery #formulation
Liquisolids: A Modernistic approach in Drug Delivery System - Pharma Excipients
https://www.pharmaexcipients.com
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