Lorena Senador-Gómez Lázaro’s Post

Shapson-Coe et al. recently published a 1 mm^3 volume electron microscopy reconstruction (and draft segmentation) of human cortical tissue. Beautiful work! Their initial analyses revealed intriguing phenomena such as 'mirror image' neurons and rare multisynaptic connections. According to their preprint (available at https://lnkd.in/gEqNYxD2), the imaging alone took 326 days. So, new approaches will likely be necessary to scale up to whole brains such as mouse brain (500 mm^3) and human brain (1,200,000 mm^3). Nonetheless, this effort represents a remarkable step forward in the field of connectomics. #neuroscience #neurons #connectomics https://lnkd.in/gbhWs-Ge

Our iMIND research team "has got me workin' workin' day and night" 🎶 Optical coherence tomography (OCT) ganglion cell–inner plexiform layer (GC-IPL) thickness color maps, OCT angiography 6×6mm en face macular images, and ultra-widefield (UWF) fundus color and autofluorescence photographs from 371 eyes of 249 controls and 75 eyes of 52 Parkinson's subjects were used for training, validation, and testing. Best convolutional neural network variant achieved an AUC of 0.918. UWF color photographs were most effective imaging input. GC-IPL thickness maps were least contributory. This pilot model supports the collection of larger imaging datasets to develop clinical-grade algorithms. Read more here: https://lnkd.in/ewYSU-Pd #oculomics Association for Research in Vision and Ophthalmology (ARVO) TVST journal. Duke Eye Center Duke Neurology Duke University Medical Center Duke AI Health Duke Institute for Brain Sciences #ParkinsonsDisease Parkinson's Foundation #RetinalImaging #aiMIND Alexander Richardson BS Anita Kundu MD Ricardo Henao PhD Terry (Jinwon) Lee MD Burton L Scott MD PhD Dilraj Grewal, MD, FASRS

I am thrilled to share that my first scientific article, co-authored with Alice Longhena and M. Chavez, has been published in Chaos! The paper, titled "Detecting local perturbations of networks in a latent hyperbolic embedding space" introduces two novel scores for identifying local perturbations in networks using the Poincaré disk model of hyperbolic geometry. Our study demonstrates the effectiveness of these scores in both homogeneous and heterogeneous network models. As a significant application, we utilized these methods to analyze latent geometric representations of real brain networks, shedding light on the impact of epilepsy surgery on different brain regions. This research marks the first application of hyperbolic geometric network embedding in the context of epilepsy, and I am excited about the potential it holds for future advancements. You can read the full paper here: https://lnkd.in/ecyp_AMD. Institut du Cerveau – Paris Brain Institute, Sorbonne Université, Inria , CNRS - Centre national de la recherche scientifique

Transcend Vivoscope is set to unveil the SUPERNOVA-600, a revolutionary two-photon microscopy system, at Neuroscience 2024! Equipped with TLens tunable optics, this advanced solution provides real-time imaging of brain activity and cellular functions. It’s a big step forward for research in Alzheimer’s, Parkinson’s, epilepsy, and more. 🧬 Join the conversation and dive deeper into the future of biomedical imaging! 👇 https://lnkd.in/gPkjpPdm #Neuroscience #BiomedicalImaging #Innovation #Research #TechNews #BrainScience #Alzheimers #Parkinsons #Microscopy [Neuroscience, biomedical imaging, two-photon microscopy, SUPERNOVA-600, Transcend Vivoscope, TLens, brain science, research innovation, Alzheimer’s, Parkinson’s}

This is not a scene from a sci fi movie. This is the demo video of a startup BrainBridge that introduces an AI-driven robotic system that is capable of transfering a patient’s head or face onto a donor body. It aims to help patients with terminal illnesses and paralysis. The company hopes to conduct the first surgery within eight years, and is releasing the concept early to attract top scientists. What do you think about this mind blowing concept, is it going to become a reality? #AI #AIstartups #science #neuroscience

Elon Musk’s project Neuralink aims to develop technology that could potentially enable telepathic communication by linking human brains with artificial intelligence. While this concept remains speculative and raises ethical considerations related to privacy and consent, it underscores the growing interest in understanding and manipulating brain functions. Neuroscientists have made significant progress in understanding the localisation of different functions within the brain. Certain brain regions are associated with specific functions, and, for those functions that are known, they are able to create a precise “map” or “catalogue” of these functions. Researchers have identified different types of memory storage within the brain. The hippocampus, located in the temporal lobe, is crucial for forming new memories. Damage to this area can result in anterograde amnesia, where individuals struggle to form new memories. On the other hand, long-term memories are believed to be stored in various regions distributed throughout the cortex. It is theoretically possible to access certain brain regions through surgery to address issues related to traumatic memories or neurological disorders, such interventions are highly complex and risky. #neuroscience #neuralink #science #brain

Envisioning a future begins with imagining the past...BUT that is not the full story. ----- The short of it: Actively engaging in rich and complex memory formation can exercise the same part of the brain that allows for rich and complex strategic foresight. As your ability to remember depletes, so does your ability for foresight. ------- The long of it: In 1953 an experimental brain surgery was performed by a renowned neurosurgeon by the name of W. B. Scoville on a patient famously known as HM. Part of HM's hippocampus was removed and surprisingly the surgery worked. HM’s seizers, that he had suffered from for over 20 years, were severely abated. However, upon further investigation, an unintended consequence appeared…HM was left with retrograde amnesia, loosing the ability to generate new long-term semantic and episodic memories. Further, when HM was asked to imagine the future, his thinking was constrained: 1. Impaired Episodic Foresight: HM could not imagine a personalized understanding of himself participating in future events. For example: "I am there." 2. Lack of Future Details: HM could not imagine the future rich in detail. It was very vague and simplicity, for example. "At the beach, there is sand and water." 3. Deficient Spatial-Temporal Coherence: HM could not string together events to create complex future narratives. What the HM story demonstrates is that the hippocampus is not only important for encoding and consolidating new memories, but it is also essential for imagining the future. Memory servers as both data for the future and a process for imagining the future. 1. Memories can serve as data and information for understanding the future. 2. The process of forming memories is similar to the process of forming the future. SO what are the practical implications for strategic foresight? Actively engaging in rich and complex memory formation can exercise the same part of the brain (hippocampus) that allows for rich and complex strategic foresight. As your ability to remember depletes, so does your ability for future thinking. I think this is especially important to remember as we move into a more AI/TECH driven future, where more and more of our memory is outsourced to digital devices. How many phone numbers do you know? #foresight #neuroscience #strategicforesight #leadership #imagination #creativity

Imagine a world where disabled individuals can interact with their environment effortlessly—controlling computers or robotic limbs just by thinking. Neural dust offers a less invasive approach, making this dream a reality. This advancement could significantly enhance treatment options for neurological disorders, eliminating the need for frequent surgeries to replace devices. As we continue to explore the possibilities of neural dust, we stand on the brink of a new era in medicine and human potential. #NeuralDust #BioelectronicMedicine #BrainMachineInterface #Neuroscience #Innovation #MedicalTechnology

🚀 Unlock the Mysteries of Vision! 👁️✨Ever wondered how our eyes and brain work together? Paulo Fontoura's latest article dives deep into the connection beyond the optic nerve, revealing how our vision shapes perception and memory. It's a must-read for anyone passionate about neuroscience and human biology or like me, interested in learning something new. Discover the hidden marvels of your own senses! 👉 Dive into the full article below: Beyond the Optic Nerve: The Fascinating Connection Between the Eye and the Brain #Neuroscience #VisionScience #Innovation #HumanBiology

🧠 What If We Could Heal the Brain Without Surgery? 🧠 Seeing my father’s progress after his stroke inspires me daily. While he’s made great strides, not everyone is as fortunate. What if we could go further? What if we could repair brain damage caused by strokes without surgery—using mind mapping, robotics, and neural technology? The future of neuroscience and technology holds the potential to restore mobility, eliminate the need for canes, and reduce invisible suffering. How can we accelerate these innovations to help more people heal fully? #Innovation #Neuroscience #StrokeRecovery #Robotics #AI #HealingThroughTechnology