LGC Clinical Diagnostics’ Post

Excited to share our 2024 AACR poster on optimizing DNA extraction from Formalin-Fixed Paraffin-Embedded (#FFPE) tissues, crucial for cancer diagnostics. Our refined extraction methods significantly improve DNA yield and integrity, enhancing Homologous Recombination Deficiency (#HRD) detection—a key biomarker for cancer treatment. Access the full poster here: https://hubs.ly/Q02ZJZ820 Stay tuned for our upcoming launch of Seraseq® Solid Tumor FFPE DNA Reference Material, designed to further boost genomic profiling accuracy for FFPE samples in cancer research. #AACR2024 #CancerDiagnostics #GenomicProfiling #DNAExtraction #CancerResearch #Biomarkers #NextGenSequencing #PrecisionMedicine #SolidTumor #CancerTreatment

#Solid and #Liquid Biopsy: A Powerful Duo in Precision Oncology 👉 Solid biopsies analyze the tumor’s foundation—providing a clear picture of its biology, mutations, and treatment targets. 👉Liquid biopsies detect the ripples—capturing real-time changes in cancer through circulating tumor DNA (#ctDNA) and other biomarkers in blood. ➕When combined, they offer a comprehensive view of cancer:- 1. Solid biopsy identifies the tumor’s core characteristics. 2. Liquid biopsy monitors treatment response, tracks disease progression, and detects resistance early. Together, they address every layer of #cancer—making care more targeted, monitoring proactive, and outcomes more effective ! #PrecisionOncology #4baseCare #TargetedTherapy #CancerResearch #CancerCare #GoSoliQ

#Solid and #Liquid Biopsy: A Powerful Duo in Precision Oncology 👉 Solid biopsies analyze the tumor’s foundation—providing a clear picture of its biology, mutations, and treatment targets. 👉Liquid biopsies detect the ripples—capturing real-time changes in cancer through circulating tumor DNA (#ctDNA) and other biomarkers in blood. ➕When combined, they offer a comprehensive view of cancer:- 1. Solid biopsy identifies the tumor’s core characteristics. 2. Liquid biopsy monitors treatment response, tracks disease progression, and detects resistance early. Together, they address every layer of #cancer—making care more targeted, monitoring proactive, and outcomes more effective ! #PrecisionOncology #4baseCare #TargetedTherapy #CancerResearch #CancerCare #GoSoliQ

Even the sharpest arrow falls short without a clear target—cancer therapies often face the challenge of heterogeneity and resistance. #SoLiQ aids in solving the puzzle of #Tumor heterogeneity fishing out more #genomic #variants for more #therapy options to personalize #treatment. Go #SoLiQ

Classification of Breast Cancer Using FNA Biopsies 🩺 For women facing breast cancer, proper classification is key to effective treatment. A Fine Needle Aspiration (FNA) biopsy can help provide an early diagnosis, leading to quicker treatment decisions. Breast cancer classification includes: Histopathology: Identifies the origin of cancer cells. Grade: Compares cancer cells to normal cells—the higher the grade, the worse the prognosis. Stage: Determines if the cancer has spread, affecting survival rates. Receptor Status: Hormone sensitivity impacts treatment options. DNA: Genetic mutations guide personalized therapies. Early classification leads to better outcomes. #BreastCancerAwareness #FNA #Biopsy #BreastCancerClassification #HealthMatters

Classification of Breast Cancer Using FNA Biopsies 🩺 For women facing breast cancer, proper classification is key to effective treatment. A Fine Needle Aspiration (FNA) biopsy can help provide an early diagnosis, leading to quicker treatment decisions. Breast cancer classification includes: Histopathology: Identifies the origin of cancer cells. Grade: Compares cancer cells to normal cells—the higher the grade, the worse the prognosis. Stage: Determines if the cancer has spread, affecting survival rates. Receptor Status: Hormone sensitivity impacts treatment options. DNA: Genetic mutations guide personalized therapies. Early classification leads to better outcomes. #BreastCancerAwareness #FNA #Biopsy #BreastCancerClassification #HealthMatters

Molecular profiling is vital for identifying targetable alterations in lung cancer, with three essential phases: pre-analytical, analytical, and post-analytical. Download this infographic, endorsed by the Association for Molecular Pathology (AMP), where Dr. Alexander Wyatt (GU cancer genomics) and Prof. Frédéric Bibeau (pathology) outline best practices to ensure tissue samples meet the quality and quantity standards needed for accurate biomarker testing. Download here: https://ow.ly/svep50UohyE #MedEd #MedicalEducation #FreeMedEd #IndependentMedEd #PrescisionMedicine #Oncology This educational programme is supported by an Independent Educational Grant from AstraZeneca and Amoy Diagnostics.

If you understand cancer as a network of molecular signaling pathways which seeks adaptation to treatments by switching to alternative pathways, does that mean that if you attack as many of the network nodes as possible with a combination of therapies, the cancer will collapse? This is the thesis of Michael Castro, MD, Chief Medical Officer of Cellworks. He is uniquely qualified as a clinician who is also an expert in molecular pathology to look at molecular pathways and personalize treatments for cancer patients. Cellworks provides a report on the signaling pathways and the convergence of particular biochemical enzymes which he uses to understand master regulators, network nodes, DNA repair, and transcriptional (RNA) drivers. Identifying the dysregulated proteins that contribute to your cancer is crucial for developing personalized treatment plans. For more, please see our conversation with Dr. Castro here https://lnkd.in/efBmjwxe

Molecular profiling is vital for identifying targetable alterations in gastric cancer, with three essential phases: pre-analytical, analytical, and post-analytical. Download this infographic, endorsed by the Association for Molecular Pathology (AMP), where Dr. Alexander Wyatt (GU cancer genomics) and Prof. Frédéric Bibeau (pathology) outline best practices to ensure tissue samples meet the quality and quantity standards needed for accurate biomarker testing. Download here: https://ow.ly/61MC50UohqL #MedEd #MedicalEducation #FreeMedEd #IndependentMedEd #PrescisionMedicine #Oncology This educational programme is supported by an Independent Educational Grant from AstraZeneca and Amoy Diagnostics.

Researchers have developed a #CRISPRCas9 system to target tumor-associated macrophages (TAMs), offering new avenues for cancer immunotherapies.   The study used bacterial protoplast-derived nanovesicles, loaded with a Cas9-sgRNA targeting a key macrophage polarization switch, and bacterial DNA fragments acting as potent ligands. The approach aims to reshape TAMs into an anti-tumor phenotype and inhibit tumor growth. It has shown potential for scalable clinical production and promising applications in #cancer #immunotherapy, addressing challenges related to cell viability and in vivo delivery.   Read more Nature Portfolio: https://shorturl.at/64sKP