Kellie Jo Art’s Post

The Leica UC Enuity ultramicrotome with the M205 fluorescence module is a compelling value...

Thank you for all who voted and shared! I've to say I am not surprised with the results. Results were close as finding the right provider, who collects samples respecting all ethics and legal considerations certainly has an impact on the quality of the biospecimens. Finding the right provider for human biospecimens can be a challenging task. With thousands of biospecimen providers (academic and commercial biobanks, hospitals, clinical sites, brokers, etc) around the world, and new ones continually launching, companies face a daunting task to locate a provider that can provide the right high-quality sample needed for research. Ensuring the quality and authenticity of the specimens is paramount, requiring providers to maintain stringent ethical and regulatory standards. The variability in sample types, donor demographics, and the specific requirements of different research projects further complicates the selection process. Additionally, logistical issues such as timely delivery, proper storage conditions, and transparent communication with the provider can significantly impact the research outcomes. These challenges necessitate a careful and thorough vetting process to identify a reliable and reputable biospecimen provider. Are you having difficulties finding the right biospecimen provider? Let’s talk.

✨ The reveal! ✨ Thank you to everyone who shared their guesses! No one got it exactly right (except my dear Michael), but the guesses were impressive 😁 This is the vascular network of the human optic nerve in 3D—the first of its kind (to my knowledge). This image is part of my ongoing work developing advanced protocols for various projects, and it's an exciting step forward in understanding the real architecture of the optic nerve. The blood vessels you see are labeled with smooth muscle actin, showing the large vascular structures inside the nerve. In the second part of the video, you can see the sheer complexity of the entire 3D organization, and the central vein and arteries. And this is just in one sample, from one (young) donor. Why does this matter? By revealing the true structure of the optic nerve, we can improve our understanding of diseases like glaucoma, optic neuropathy, and multiple sclerosis—potentially leading to better diagnostics and treatments. It’s such a tiny but crucial area for vision, and despite its sheer importance, so much is still unknown ! 🧐 Stay tuned for more developments and future collaborations as this research evolves!

Multiplayer presentations are really effective.

I am happy to share that our work titled “Time-Separated Pulse Release–Activation of an Enzyme from Alginate–Polyethylenimine Hydrogels Using Electrochemically Generated Local pH Changes” was recently published in ACS Applied Materials & Interfaces in the section "Biological and medical applications of materials and interfaces" The developed system has primary objective of controlling the activity of a releasing model drug (β-glucosidase enzyme), which was also coupled with controlled release of the enzyme out of the composite hydrogel. Both activation and release occurred in a pulsatile manner separately in time. Importantly, activity of the enzyme that was still encapsulated in the hydrogel was inhibited throughout the whole duration of the experiment. This approach aims reduced off-target action-associated toxicity to enable the drug to act exclusively on the target of interest, avoiding interaction with healthy tissues, and thus leading to reduced toxicity. It should be noted that only a single type of stimulus (electrochemically generated local pH changes) was used to control both release and activation in the proposed approach, while a lot of works used different types of stimuli to govern different processes in sophisticated systems. You can read the paper here: https://lnkd.in/es4t8MCC Huge thank you to my advisors Oleh Smutok and Evgeny Katz!!

The science behind connection And why screen time is so dangerous Did you know you're more likely to form a deep connection—or even fall in love—while sitting on a shaky bridge instead of a solid one? This is due to emotional resonance, which occurs when two people share an emotional experience. Emotional resonance builds rapport, but for a deeper bond, the brain releases oxytocin, the "bonding hormone," in face-to-face interactions. Dopamine, the brain's reward chemical, adds feelings of pleasure and satisfaction to this shared connection. However, in today's world, screen time overstimulates our brains with frequent dopamine surges from notifications, social media, and endless scrolling. This artificially high dopamine release leads to a crash, making real-world interactions feel less rewarding by comparison. Over time, this desensitisation reduces our motivation for in-person connections—those crucial interactions that release oxytocin and solidify deeper bonds. The takeaway? Reducing screen time and prioritising real-world connections will help restore emotional resonance, enhance oxytocin release, and improve both relationships and well-being. Dr Alok Kanojia & Steven Bartlett - thank you for all that you do. — 🚪 Leaving an open door to spontaneity… 📲 Download Kinnect now: https://lnkd.in/etWSd2FE 📨 Send us feedback or reach out to get involved.

I am happy to announce that I am a certified columnist with Médiamétrie to debate current topics on artificial intelligence, biotechnology, ecology, robotics, the digital industry, automobiles, aeronautics, maritime, rail, market economy, etc.. : Thank you to all of those (my family, my classmates, my friends, my formers, my mentors, my mentees and volunteers…) who helped me near or far for accomplishing my task. The QR code I have is listed below

Are you ready... ?   To discover autonomyo 2.0 and Laurent's first experience and life story?!   A big thanks to Simcast Prod. for the great video production 🎥 , to Carole Altenbach and Ergothérapie Renens for their facility and support 🏥, and to DIH-HERO for making it possible.   Autonomyo has built a platform to make physical activity and therapy accessible to people with reduced sensorimotor functions. This platform includes digital exercises 🏃♀️ and video games 🎮 for entertaining physical activity. It also combines a powered exoskeleton 🤖 providing extra muscles 💪 and a bodyweight support device 🎈 to make you feel extra lightweight.   While we keep on working on the evolution of the device and its market entry 🚀 . We want to have a short look back at our most important partners over the last 10 years and thank them for fueling this adventure.   ASRIMM and FSRMM(Swiss Foundation for Research on Muscle Diseases) along with Fondation Téléthon Action Suisse who initiated this vision in 2014. They were joined later by the Schweizerische Multiple Sklerose Gesellschaft association and Loterie Romande thanks to all of whom we initiated the first clinical trial (feasibility study) with 12 patients with and at CHUV | Lausanne university hospital. This study was conducted by the most important partner and supporter REHAssist from EPFL and lead by Dr Mohamed Bouri.   This first short study demonstrated how exoskeletons can impact the training of people with neuromuscular or sensorimotor conditions like muscular dystrophy or multiple sclerosis. We have seen patients recovering sensations on numb limbs or walking as if fatigue does not affect them anymore. A big thank you to all the great people who joined the study.   autonomyo has now been writing a new story as a startup for more than 3 years with amazing partners like FIT - Fondation pour l'Innovation Technologique, Etat de Vaud, Alternative Bank Schweiz and Innosuisse. We are now growing with amazing tech and dev partners like FAULHABER Drive Systems (advanced actuators), StickyStoneStudio GmbH (game development), Arcanys Ventures (digital dev) and Lake Lucerne Institute (rehab tech). We also benefit from the constant support of a clinical team between CHUV | Lausanne university hospital and Institution de Lavigny with Prof. Andrea Serino, Prof. MED Arseny Sokolov, Petr Grivaz, Dionys Rutz and Antoine Zaczyk. The detailed 2023-2024 autonomyo progress report will be available soon. Let us know at [email protected] if you are interested.

Yes, this isn’t your standard Linkedin post, but if this could help someone else take the right step towards better living, then mission accomplished! I did it. I achieved the goal I had set for myself: 10% body fat by 50. I’ve always been an active, athletic person, but with age came new restraints, and my body made sure to inform me of my new limitations. It was disheartening to say the least… no more 10Ks, no more rigorous exercise, it was over. Or so I thought. Through my research into wellness and longevity, I stumbled upon the wonderful Harjit Bahia and her company LONGEVITY, who helped me recapture the vitality that I mistakenly thought I’d lost. By focusing on multiple pillars of longevity, including nutrition, stress, sleep, movement, and community, I was able to get back in the driver’s seat. This isn’t a bragging post, nor is it an ad per se. It’s a thank you letter to the brilliant team at LONGEVITY and Harjit Bahia, the latter whom I will be working with on my next venture: ZOI. Our objective? To establish a data-driven, informed, monitored and measured approach to health, leveraging the latest technology, and empowering people to become the CEOs of their own health. We’re excited to bring this to all of you!

In my last post here which got over +8000 impressions (😯), I mentioned to be back to share some bits from some side projects I've been working quietly in the corner. And here I am, between "You should be proud" and "Man... really?!"; announcing the first post of my writing series. After many hours of brainstorm and burned brain cells, I chose the title "Trail to Thrive" for this series, resembling the life journey we are on, knowing I am not the only one on the way, some behind and many ahead. My goal is to share my learnings on certain topics that I outlined in my post, some through testing proven tools and concepts out there and some through sweet and/or bitter personal experiences on the way, hoping to trigger an easy action (where needed) to create a positive change regardless of scale/magnitude. Actually, let's rephrase, to create a very small change towards the positive direction. Hope this one is a good and easy read, thank you for your time and visual energy spent! https://lnkd.in/e7YeJG8z