James Westcott’s Post

Gen X Projected to Experience Greater Increases in Cancer Incidence than Previous Generations. A recent study published in JAMA Network Open reveals that Generation X (born 1965-1980) is projected to face higher cancer rates than any previous generation. Despite overall declining trends for many cancers, Gen X is expected to see significant increases in thyroid, kidney, rectal, uterine, colon, pancreatic, and ovarian cancers, among others. This alarming trend is linked to lifestyle factors such as obesity and sedentary habits. The study, led by Dr. Philip S. Rosenberg, utilized data from 3.8 million cancer cases and highlights the need for further research and preventive measures. The Cancer Moonshot 2.0 aims to reduce cancer mortality by 50% by 2047, but these findings suggest that achieving this goal will require addressing the unique challenges faced by Gen X.

In this model-based cohort analysis of incident invasive cancer in the general population, decreases in lung and cervical cancers in Generation X may be offset by gains at other sites. Generation X may be experiencing larger per-capita increases in the incidence of leading cancers than any prior generation born in 1908 through 1964. On current trajectories, cancer incidence could remain high for decades.

The annual incidence of #ovariancancer is about 11.6 cases per 100,000 US women, with 60% diagnosed at an advanced stage. According to a new study published in BMC Cancer, patients with #hyperthyroidism (a condition when the thyroid gland makes excessive thyroid hormone, causing weight loss, hand tremors, and a rapid or irregular heartbeat) may be at an increased risk of ovarian cancer. The origin of ovarian cancer development is poorly understood, but reported risk factors include genetic and endocrine factors. As the body’s principal endocrine gland, the thyroid synthesizes and secretes hormones crucial for regulating various functions, such as metabolism and growth. In the study, the researchers noted that thyroid hormones possess cancer-promoting effects by stimulating cell differentiation and proliferation. Therefore, thyroid dysfunction is considered a potential risk factor for cancer development and prevention. The researchers assessed the potential causal and effect of thyroid dysfunction on ovarian cancer. The researchers discovered a significant correlation between hyperthyroidism levels and an elevated ovarian cancer risk. This study suggests a causal relationship between hyperthyroidism and ovarian cancer, underscoring the importance of thyroid hormones in the prevention and treatment of the female reproductive system. https://lnkd.in/e4H9yBAj #CancerResearch

Conclusions and Relevance In this model-based cohort analysis of incident invasive cancer in the general population, decreases in lung and cervical cancers in Generation X may be offset by gains at other sites. Generation X may be experiencing larger per-capita increases in the incidence of leading cancers than any prior generation born in 1908 through 1964. On current trajectories, cancer incidence could remain high for decades.

Losing couple close friends and a grandparent for pancreatic cancer' this study made me very hopeful of the research coming in the arena of PDAC, Pancreatic ductal adenocarcinoma. In this comparative cohort study, surveillance of high-risk individuals for PDAC using Endoscopic Ultra Sound (EUS) and MRI within established programs at academic centers was observed to lead to the detection of smaller pancreatic cancers, a greater number of patients with stage I disease, lower mortality, and a much higher likelihood of long-term survival than unscreened patients in the general population diagnosed with PDAC. These findings suggest that selective surveillance of individuals at high risk for pancreatic cancer may improve clinical outcomes. SURVEILLANCE aka Observation aka Responsibility is key from a common man perspective !! American Society of Clinical Oncology (ASCO) ESMO - European Society for Medical Oncology American Cancer Society Pancreatic Cancer Action Network Zetz Family Pancreatic Cancer Research Foundation Pancreatic Cancer UK Gryt Health Leal Health Massive Bio Thanks to my dear friend Dr William Oh for sharing this wonderful article.

In this model-based cohort analysis of incident invasive cancer in the general population, decreases in lung and cervical cancers in Generation X may be offset by gains at other sites. Generation X may be experiencing larger per-capita increases in the incidence of leading cancers than any prior generation born in 1908 through 1964. On current trajectories, cancer incidence could remain high for decades.

A new large study by the American Cancer Society reveals that incidence rates for various cancers, including breast and pancreatic, are rising across successive younger generations, alongside increasing mortality rates for cancers such as liver and colorectal in these groups. The research, analysing data from millions of patients and deaths, underscores a generational shift in cancer risk, highlighting the need for targeted prevention strategies and policy advocacy to address rising cancer burdens among younger populations. The lead author of the study comments that “Birth cohorts (groups of people classified by their birth year) share unique social, economic, political, and climate environments, which affect their exposure to cancer risk factors during their crucial developmental years. Although we have identified cancer trends associated with birth years, we don’t yet have a clear explanation for why these rates are rising.” The potential role, in the incidence of some cancers, of obesity, lack of exercise, and the status of the gut microbiome, is reported. August 2024, The Lancet Public Health. DOI: 10.1016/S2468-2667(24)00156-7

“Among Generation X women, statistically significant declines in lung and cervical cancers have been overtaken by significant increases in thyroid, kidney, rectal, corpus, colon, pancreatic, and ovarian cancer and NHL and leukemia. Among Generation X men, declines in lung, liver, and gallbladder cancers and NHL have been overtaken by gains in thyroid, kidney, rectal, colon, and prostate cancers and leukemia. Some portion of these increases can be attributed to rising obesity rates and increasingly sedentary lifestyles. Another portion might be explained by changes in cancer registry policies, leading to inclusion of relatively indolent lesions in more recent periods that might not have been diagnosed as cancer in earlier periods. Furthermore, radiologic diagnoses have become more common following widespread deployment of sophisticated medical imaging technologies.”

Generation X faces a higher risk of cancer than their parents and grandparents Gen X (born between 1965 and 1980) may be experiencing larger per-capita increases in the incidence of leading cancers than any prior generation born in 1908 through 1964. Among Gen X, significant increases in thyroid, kidney, rectal, colon, pancreas, and as well gynecologic cancer (corpus and ovarian cancer) for women, prostate cancer for men, and also leukemia True success in cancer research will be complete once risk factors of cancer could be identified with scrutinity , for Gen X and more younger generations. When there is a bleeding, this is crucial to understand from where. Putting a bandage is not always enough...

A recent study provides important insights into global trends in male cancer rates. The research, analyzing data from 185 countries, projects an 84% increase in cancer cases among men worldwide by 2050. Developing countries are expected to see larger increases, highlighting the need for targeted interventions in these regions. Currently, prostate cancer is the most commonly diagnosed cancer in men, while lung cancer remains the leading cause of cancer-related deaths. The study also reveals significant variations in cancer survival rates across different regions, emphasizing the importance of addressing global health disparities. These findings underscore the need for continued focus on cancer prevention, early detection, and treatment initiatives worldwide. As health professionals, we must work towards improving cancer outcomes and reducing inequalities in care across all regions. #GlobalHealth #CancerResearch #PublicHealth