James Brown’s Post

𝐃𝐨 𝐭𝐡𝐞 𝐏𝐡𝐲𝐭𝐨𝐧𝐮𝐭𝐫𝐢𝐞𝐧𝐭𝐬 𝐜𝐨𝐧𝐭𝐚𝐢𝐧𝐞𝐝 𝐰𝐢𝐭𝐡𝐢𝐧 𝐭𝐡𝐞 𝐌𝐞𝐝𝐢𝐭𝐞𝐫𝐫𝐚𝐧𝐞𝐚𝐧 𝐝𝐢𝐞𝐭 𝐩𝐨𝐬𝐢𝐭𝐢𝐯𝐞𝐥𝐲 𝐚𝐟𝐟𝐞𝐜𝐭 𝐀𝐠𝐞𝐢𝐧𝐠? Muhdo Health has been fortunate enough to have been part of a landmark study with King's College London, National University of Singapore and Stavanger University Hospital looking at the effects of phytonutrients 🥗 on various biomarkers which are implicated in the ageing process 👵🏽 and many age-related diseases. Phytonutrients, also known as phytochemicals, are naturally occurring compounds found in plants 🥗 🫑🥕🍅 🍇 that have various health benefits. These compounds are not essential nutrients like vitamins and minerals, meaning the body doesn't require them to survive, but they can significantly contribute to health and well-being. “DailyColors™ is a supplement 💊 made up of several phytonutrients 🥗 🫑🥕🍅 🍇 that aims to replicate elements from the Mediterranean 🥗 diet. These include fruit 🍊🍍🍏, berry 🍇 🫐 and vegetable 🫑🥕🍅 extracts that are rich in key phytochemicals such as Quercetin, Catechins, Phloretin, Ellagic Acid, and Anthocyanins. Here, we determined the effects of DailyColors™ on the blood biomarkers associated with the diverse mechanisms implicated in ageing 👵🏽 and age-related diseases, including mitochondrial function, inflammation 🔥, and oxidative stress, as well as on saliva’s DNA methylation 🧬 pattern. (Muhdo Health) Thirty adult participants (mean (SD) age = 67.0 (7.5) years) with a body mass index over 25 were recruited into this randomised, double-blind, placebo-controlled, cross-over trial (two one-week treatment periods, separated by a one-week washout period). During the placebo period, we observed a significant increase in blood CD38 concentrations from the baseline to 24 h (p-value = 0.019). This was not observed in the active period. Increased CD38 is reportedly associated with subsequent mitochondrial dysfunction and inflammation. Next, there was a decreasing trend of plasma 4-HNE levels, an oxidative stress biomarker, after a one-week intake of DailyColors™. Furthermore, following a one-month open-label follow-up in 26 participants, we observed hypermethylation of the candidate CpG site cg13108341 (q-value = 0.021), which was against the observed trend for this site during ageing. Taken together, while minimal effects were observed in this study, DailyColors™ supplementation may be beneficial by altering and alleviating age-related changes. Longer and larger scale trials of DailyColors™ supplementation are warranted”. 👉 https://lnkd.in/evtQ97Fk 👈

𝐃𝐨 𝐭𝐡𝐞 𝐏𝐡𝐲𝐭𝐨𝐧𝐮𝐭𝐫𝐢𝐞𝐧𝐭𝐬 𝐜𝐨𝐧𝐭𝐚𝐢𝐧𝐞𝐝 𝐰𝐢𝐭𝐡𝐢𝐧 𝐭𝐡𝐞 𝐌𝐞𝐝𝐢𝐭𝐞𝐫𝐫𝐚𝐧𝐞𝐚𝐧 𝐝𝐢𝐞𝐭 𝐩𝐨𝐬𝐢𝐭𝐢𝐯𝐞𝐥𝐲 𝐚𝐟𝐟𝐞𝐜𝐭 𝐀𝐠𝐞𝐢𝐧𝐠? Muhdo Health has been fortunate enough to have been part of a landmark study with King's College London, National University of Singapore and Stavanger University Hospital looking at the effects of phytonutrients 🥗 on various biomarkers which are implicated in the ageing process 👵🏽 and many age-related diseases. Phytonutrients, also known as phytochemicals, are naturally occurring compounds found in plants 🥗 🫑🥕🍅 🍇 that have various health benefits. These compounds are not essential nutrients like vitamins and minerals, meaning the body doesn't require them to survive, but they can significantly contribute to health and well-being. “DailyColors™ is a supplement 💊 made up of several phytonutrients 🥗 🫑🥕🍅 🍇 that aims to replicate elements from the Mediterranean 🥗 diet. These include fruit 🍊🍍🍏, berry 🍇 🫐 and vegetable 🫑🥕🍅 extracts that are rich in key phytochemicals such as Quercetin, Catechins, Phloretin, Ellagic Acid, and Anthocyanins. Here, we determined the effects of DailyColors™ on the blood biomarkers associated with the diverse mechanisms implicated in ageing 👵🏽 and age-related diseases, including mitochondrial function, inflammation 🔥, and oxidative stress, as well as on saliva’s DNA methylation 🧬 pattern. (Muhdo Health) Thirty adult participants (mean (SD) age = 67.0 (7.5) years) with a body mass index over 25 were recruited into this randomised, double-blind, placebo-controlled, cross-over trial (two one-week treatment periods, separated by a one-week washout period). During the placebo period, we observed a significant increase in blood CD38 concentrations from the baseline to 24 h (p-value = 0.019). This was not observed in the active period. Increased CD38 is reportedly associated with subsequent mitochondrial dysfunction and inflammation. Next, there was a decreasing trend of plasma 4-HNE levels, an oxidative stress biomarker, after a one-week intake of DailyColors™. Furthermore, following a one-month open-label follow-up in 26 participants, we observed hypermethylation of the candidate CpG site cg13108341 (q-value = 0.021), which was against the observed trend for this site during ageing. Taken together, while minimal effects were observed in this study, DailyColors™ supplementation may be beneficial by altering and alleviating age-related changes. Longer and larger scale trials of DailyColors™ supplementation are warranted”. 👉 https://lnkd.in/evtQ97Fk 👈

Why losing weight is more than just Calories in and Calories Out. The food we eat has a metabolic effect. If a particular style of eating can help suppress your appetite and as a result you eat less you are going to get better results. What surprises a lot of people when they participate in a longer fast (36 hours +) is how little hunger they feel. When we fast, we break down fat and produce BHB for energy. I personally feel less hungry eating nothing than I do than when calorie restricting in the 800 to 2000 Calories per day level. This study highlights a small piece of what may be happening.

Discovery of a New Ketone Body Metabolite that Suppresses Appetite (Study Breakdown) The research, publish in Cell last week, documents the discovery of a byproduct of ketone body, beta hydroxybutyrate (BHB), metabolism: The BHB-Amino Acids. 👀 At a high level 👀 👉 The enzyme carnosine dipeptidase 2 (CNDP2) combines the ketone body, BHB, with amino acids to make BHB-amino acids. 👉 This pathway appears conserved in mice and humans. 👉 BHB-amino acids levels increase in response to ketogenic diets, fasting, or exogenous ketones. 👉 BHB-amino acids activate different brain regions to reduce food intake and promote weight loss. 👀 More Details 👀 The enzyme, CNDP2, is primary expressed in the kidney and gut cells and combines BHB with amino acids to make BHB-amino acids, the most prevalent of which is BHB-Phe. 🥑 Ketogenic diets 🍽️ fasting and 🩸 exogenous ketones (ester) each increase levels of BHB-Phe 🐁 Although BHB-amino acids are made in humans and present in human blood, to demonstrate causality it’s helpful to use mouse models. 🌟 Direct administration of a ketone supplement or BHB-Phe decreased food intake and prevented weight gain. 🌟 However – and IMPORTANTLY – mice who had been modified to have the CNDP2 gene knocked out, and thus could not generate BHB-Phe, did not respond to ketone supplementation with appetite suppression. To reinforce the point: Ketone supplementation AND/OR a ketogenic contributed to relative weight loss in animals with functional CNDP2 that could make BHB-Phe. But when this ability to make BHB-Phe was eliminated, so too were the appetite-reducing anti-obesogenic effects of ketones. This suggests that ketogenic interventions reduce appetite, at least in part, through the generation of BHB-Phe. 🧠 The also found that BHB-Phe activates various brain regions I the hypothalamus and brainstem that control feeding. However, the neuron populations appear largely distinct from those activated by Lac-Phe, and also don’t appear to act through other appetite suppressing pathways assessed in this study, including the GLP-1 pathway. ❓ Thus, how exactly BHB-Phe reduces appetite and contributes to weight loss remains somewhat of a mystery. In conclusion, these data reveal a new secondary metabolite of ketone body metabolism, BHB-Phe, that acts on the brain to reduce appetite and contribute to weight loss. 🧬 Of interest and clinical consequence, it’s very possible that there are variations in the human CNDP2 gene, leading some people to respond more strongly to ketogenic interventions (ketogenic diet, fasting, and supplementation) with more or less appetite reduction. This could be an explanation for why ketogenic diets may work better for some and not others. Ref: Moya-Garzon et al. A Beta-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites. Cell, 2024. PMID: 39536746 #ketogenicdiet #exogenousketones #ketones #fasting #intermittentfastig #metabolism #staycurious #neuroscience

🎤 On Wednesday, I had the pleasure of speaking in a webinar with NORSAN GmbH about how diet and essential nutrients can shape migraine outcomes. This topic is close to my heart not just professionally, but personally—I’m a migraine patient myself. I’ve faced the endless cycle of identifying triggers, searching for sustainable relief, and running from one specialist to another. Ultimately, I turned to my own knowledge as a nutritional scientist and participated in a clinical study with Perfood to find a more personalized approach. Through these experiences, I’ve seen firsthand how targeted nutrition and specific supplements can make a difference. 🥙 My Journey with #Nutrition and #Migraine #Management As a migraine patient, I know how complex it can be to understand and mitigate the underlying metabolic triggers. I studied how diet affects glycemia and energetic metabolism, which led me to restructure my eating patterns and explore specific nutrients. Over time, I began to see improvements—notably through the inclusion of certain supplements that reduce frequency and intensity. One supplement, #creatine (thanks to the recommendation by Robert Percy Dr. med. Marshall, MMA), truly transformed my experience. Although often linked with muscle health and barely any study is performed on migraine patients, creatine acts as a powerful energy buffer in the brain, helping maintain ATP levels that are often depleted during migraine episodes. Since integrating creatine alongside my daily dose of fish oil and magnesium, I’ve experienced fewer migraines, and when they do occur, they’re less severe and more manageable. 🔬 What is the scientific link between neuronal energy metabolism and migraines? Migraines are associated with distinct metabolic challenges in the brain, particularly energy deficits. During an attack, the brain suffers an energy deficit due to altered glycemic control and insulin signaling, contributing to symptoms like headache, dizziness, and light and sound sensitivity. The altered energy sensing affects mitochondrial metabolism and in turn triggers inflammatory processes through ROS production. Nutrients such as B-vitamins, DHA, L-carnitine, coenzyme Q10, and curcumin are critical in supporting energy metabolism, reducing neuroinflammation, and bolstering mitochondrial function. Creatine helps stabilize these cellular processes by acting as a high-energy phosphate reservoir, potentially offsetting the energy deficiencies that exacerbate migraine symptoms. ❣ This journey has reaffirmed my belief in the power of personalized, evidence-based nutrition to address complex health challenges like migraine. With the right strategy and support, migraine management can go beyond mere symptom relief and move toward genuine, sustained improvement. #MigraineRelief #NutritionalScience #Creatine #Migraine #PersonalizedNutrition #precisionnutrition #pain #brainfood #dorotheaportius #nutraceuticals reading tip: DOI: 10.1177/0333102420931055

🌟 New Research Highlights Synbiotic Supplements as a Potential Ally Against Post-COVID-19 Fatigue! 🌟 In the aftermath of the COVID-19 pandemic, many individuals are grappling with lingering health issues, particularly myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A recent study has explored a promising approach to alleviate these symptoms through synbiotic supplementation. 🧬 Conducted over three months with 26 participants, this rigorous study revealed that while both synbiotic and placebo groups reported reduced fatigue, the synbiotic group showed significant improvements in post-exercise recovery and tissue metabolism. Key Findings: - Synbiotics may enhance exercise tolerance and recovery. - Increased choline and creatine levels in brain regions suggest improved metabolism. This research opens doors for potential cost-effective interventions in managing post-COVID fatigue. However, experts urge caution against premature endorsements until further validation is conducted. 💡 The future of nutritional therapies could be shaped by these findings! 👉 Click to read more about this exciting development! #Fatigue #HealthEconomics #HealthcareInnovation #NutritionResearch #PostCOVID #Publications #Synbiotics #MarketAccess #MarketAccessToday

🌊 𝐂𝐚𝐧 𝐅𝐢𝐬𝐡 𝐎𝐢𝐥 𝐏𝐫𝐨𝐭𝐞𝐜𝐭 𝐘𝐨𝐮𝐫 𝐇𝐞𝐚𝐫𝐭? 𝐄𝐱𝐩𝐥𝐨𝐫𝐢𝐧𝐠 𝐎𝐦𝐞𝐠𝐚-𝟑'𝐬 𝐑𝐨𝐥𝐞 𝐢𝐧 𝐂𝐚𝐫𝐝𝐢𝐨𝐯𝐚𝐬𝐜𝐮𝐥𝐚𝐫 𝐇𝐞𝐚𝐥𝐭𝐡 🩺 🐟 Fish oil, rich in omega-3 fatty acids like EPA and DHA, has long been praised for its potential heart benefits. 𝐁𝐮𝐭 𝐝𝐨𝐞𝐬 𝐢𝐭 𝐫𝐞𝐚𝐥𝐥𝐲 𝐦𝐚𝐤𝐞 𝐚 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐜𝐞? Here’s a look at what recent studies reveal: 🔬 𝐖𝐡𝐚𝐭 𝐭𝐡𝐞 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐒𝐚𝐲𝐬: • 𝐀𝐧𝐭𝐢-𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 & 𝐏𝐫𝐨𝐭𝐞𝐜𝐭𝐢𝐯𝐞 𝐁𝐞𝐧𝐞𝐟𝐢𝐭𝐬: ◽ Studies suggest that omega-3s may reduce inflammation, protect vascular cells, improve heart function, and regulate blood lipid levels, potentially lowering cardiovascular risks. • 𝐌𝐢𝐱𝐞𝐝 𝐄𝐯𝐢𝐝𝐞𝐧𝐜𝐞 𝐢𝐧 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐒𝐭𝐮𝐝𝐢𝐞𝐬: ◽ Although some trials highlight benefits—like reducing heart attack and stroke risks for those with high triglycerides (REDUCE-IT trial)—others, like the ASCEND and VITAL trials, show limited effects on primary prevention in general populations. • 𝐑𝐢𝐬𝐤 𝐅𝐚𝐜𝐭𝐨𝐫𝐬 𝐚𝐧𝐝 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 𝐒𝐭𝐚𝐠𝐞𝐬: ◽ A recent cohort study in the UK Biobank followed over 400,000 participants and found that while fish oil may help people with existing cardiovascular disease (CVD) progress more slowly through serious complications, it might also be linked to an increased risk of atrial fibrillation for some individuals. 💡 𝐖𝐡𝐚𝐭 𝐓𝐡𝐢𝐬 𝐌𝐞𝐚𝐧𝐬 𝐟𝐨𝐫 𝐇𝐞𝐚𝐫𝐭 𝐇𝐞𝐚𝐥𝐭𝐡: ❄ For those at 𝙝𝙞𝙜𝙝 𝙧𝙞𝙨𝙠, particularly with high triglycerides, fish oil—especially in higher doses of EPA—might help reduce certain cardiovascular events. But, for others, results are less clear, and fish oil may not be a guaranteed protective measure. ❄ The 𝘼𝙢𝙚𝙧𝙞𝙘𝙖𝙣 𝙃𝙚𝙖𝙧𝙩 𝘼𝙨𝙨𝙤𝙘𝙞𝙖𝙩𝙞𝙤𝙣 still emphasizes a diet that includes fresh vegetables, fruits, and lean protein sources like fish. This balanced approach could provide a natural source of omega-3s without relying heavily on supplements. 🔘 𝐂𝐨𝐧𝐜𝐥𝐮𝐬𝐢𝐨𝐧: 🐳 While 𝙛𝙞𝙨𝙝 𝙤𝙞𝙡 may benefit those with specific heart risk factors, it’s not a one-size-fits-all solution. 🐳 Talk with your doctor about your individual heart health needs before adding fish oil to your routine. 𝘼 𝙝𝙚𝙖𝙧𝙩-𝙝𝙚𝙖𝙡𝙩𝙝𝙮 𝙙𝙞𝙚𝙩 𝙢𝙞𝙜𝙝𝙩 𝙗𝙚 𝙮𝙤𝙪𝙧 𝙗𝙚𝙨𝙩 𝙛𝙞𝙧𝙨𝙩 𝙨𝙩𝙚𝙥! 📚 For more information, you can refer to: 🔹 https://lnkd.in/dfTbVW7c 🔹 https://lnkd.in/d4_pNsB5 🔹 https://lnkd.in/dWxC_Hi8 #Heart #CardiovascularDisease #Nutrition #Nutrient #ClinicalResearch #HealthCare #Healthy

In a recent 12-week randomized controlled trial, researchers explored how the nutrient composition of energy-restricted (ER) diets influences the endocannabinoid system (ECS) in individuals with abdominal obesity. The ECS plays a pivotal role in regulating metabolism and energy balance, and its disruption is closely linked to obesity and metabolic disorders. The study involved 73 obese participants, who were assigned to either a low nutrient quality ER diet high in saturated fats and fructose, a high nutrient quality ER diet enriched in omega-3 polyunsaturated fatty acids (PUFAs), or a control group maintaining their habitual diet. 𝗧𝗵𝗲 𝗿𝗲𝘀𝘂𝗹𝘁𝘀 𝗿𝗲𝘃𝗲𝗮𝗹𝗲𝗱 𝘀𝗶𝗴𝗻𝗶𝗳𝗶𝗰𝗮𝗻𝘁 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝗰𝗲𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗘𝗖𝗦 𝗽𝗿𝗼𝗳𝗶𝗹𝗲𝘀 𝗮𝗻𝗱 𝗴𝗲𝗻𝗲 𝗲𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝘁𝗵𝗲 𝗱𝗶𝗲𝘁 𝗴𝗿𝗼𝘂𝗽𝘀: 𝗣𝗹𝗮𝘀𝗺𝗮 𝗘𝗻𝗱𝗼𝗰𝗮𝗻𝗻𝗮𝗯𝗶𝗻𝗼𝗶𝗱 𝗟𝗲𝘃𝗲𝗹𝘀:  Participants on the low nutrient quality ER diet showed a significant decrease in the DHA-derived compound DHEA, whereas those on the high nutrient quality ER diet maintained their DHEA levels. Notably, levels of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) remained unchanged across diets. 𝗔𝗱𝗶𝗽𝗼𝘀𝗲 𝗧𝗶𝘀𝘀𝘂𝗲 𝗚𝗲𝗻𝗲 𝗘𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻:  The expression of the enzyme diacylglycerol lipase alpha (DAGL-α), which synthesizes 2-AG, increased in the adipose tissue of participants on the low nutrient quality ER diet. 𝗧𝗵𝗲𝘀𝗲 𝗳𝗶𝗻𝗱𝗶𝗻𝗴𝘀 𝗵𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁 𝘁𝗵𝗲 𝗰𝗿𝗶𝘁𝗶𝗰𝗮𝗹 𝗿𝗼𝗹𝗲 𝗼𝗳 𝗱𝗶𝗲𝘁 𝗾𝘂𝗮𝗹𝗶𝘁𝘆 𝗶𝗻 𝗺𝗮𝗻𝗮𝗴𝗶𝗻𝗴 𝘁𝗵𝗲 𝗘𝗖𝗦 𝗮𝗻𝗱 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗵𝗲𝗮𝗹𝘁𝗵 𝗱𝘂𝗿𝗶𝗻𝗴 𝘄𝗲𝗶𝗴𝗵𝘁 𝗹𝗼𝘀𝘀.  A high-quality ER diet, especially one rich in omega-3 PUFAs, not only supports weight loss but also positively influences the ECS, preventing the decline in beneficial compounds like DHEA and the adverse increase in enzymes like DAGL-α. As we continue to unravel the complexities of diet and the ECS, it becomes increasingly clear that the quality of our dietary choices is paramount in managing obesity and its related metabolic disorders. For more details, read the full study published in the Journal of Nutritional Biochemistry. Wang, Y., Balvers, M.G.J., Esser, D., Schutte, S., Vincken, J.-P., Afman, L.A., Witkamp, R.F., Meijerink, J. (2024). Nutrient composition of different energy-restricted diets determines plasma endocannabinoid profiles and adipose tissue DAGL-α expression; a 12-week randomized controlled trial in subjects with abdominal obesity. Journal of Nutritional Biochemistry, 128, 109605.  https://lnkd.in/dfECrFf9

#nutrition #health  #medicine #medicalsciences https://lnkd.in/gsErc_HU Abstract Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate #nutrition treatments are the golden criterion for extending #healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound #nutritional #therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.

✨ GLUTATHIONE💊👩🏻⚕️💉 🤷🏻♀️What is Glutathione? Glutathione is a tripeptide composed of three amino acids: glutamine, cysteine, and glycine. It is a crucial antioxidant present in almost every cell of the human body. 📚📚📚 1. Antioxidant Defense : Neutralize free radicals and reactive oxygen species (ROS), protecting cells from oxidative stress and damage. 2. Detoxification : It plays a significant role in the detoxification process, particularly in the liver, by binding to harmful substances and making them water-soluble for easier excretion. 3. Immune Support : Glutathione supports the immune system by maintaining the function of lymphocytes, a type of white blood cell vital for immune responses. 4. Cellular Function : It helps maintain the redox balance within cells, which is essential for proper cellular functions and signaling. 5. Protein and DNA Repair : Glutathione aids in the repair and synthesis of DNA and proteins, ensuring cellular health and longevity. Sources of Glutathione👀🥦🥬 1. Diet : Foods rich in sulfur-containing amino acids, such as garlic, onions, and cruciferous vegetables (broccoli, kale, cauliflower), can help boost glutathione levels. Other sources include avocados, spinach, and asparagus. 2. Supplements : Glutathione is available as an IV, Topical and oral supplement, though its effectiveness can vary due to poor absorption. N-acetylcysteine (NAC) and alpha-lipoic acid are often used to support and increase glutathione levels indirectly. 3. Production in the Body : The body naturally synthesizes glutathione, provided it has adequate supplies of the necessary precursor amino acids and cofactors like selenium and vitamin C. Factors Depleting Glutathione Levels 😱🤔 - Aging : Natural production of glutathione decreases with age. - Chronic Diseases : Conditions such as diabetes, cancer, and liver diseases can reduce glutathione levels. - Environmental Toxins : Exposure to pollutants, heavy metals, and chemicals can deplete glutathione. - Poor Diet : Lack of necessary nutrients can hinder the body's ability to produce glutathione. Importance in Health and Disease🚨 📌 Neurodegenerative Diseases : Lower glutathione levels are linked to diseases like Parkinson's and Alzheimer's, where oxidative stress plays a significant role. 📌Liver Health : As a primary detoxifier, glutathione is critical in preventing liver diseases. 📌Skin Health : Glutathione is used for its skin-lightening properties, as it can inhibit melanin production. #pharmacy #clinicalpharmacist #glutathione #skin #liver #melanin #pigmentation #melasma #medicine #cpe #pharmacyeducation