Ian Marks’ Post

New research from UCL, led by Prof. Karen Duff, Dr. Stephanie Fowler, and colleagues, has uncovered how toxic tau proteins spread through the brain in Alzheimer’s disease- via extracellular vesicles. Vesicles are tiny, bubble-like structures that play key roles in cellular processes, including transporting materials and clearing waste, such as unwanted proteins. However, the study reveals that when vesicles carry toxic tau, rather than disposing of it, they spread it to neighboring neurons, accelerating the progression of Alzheimer's. This discovery provides much needed insights into tau's mechanism of spread, paving the way for potential therapies that could stop or slow this spread. Read more: (https://lnkd.in/exzFXJv8). #AlzheimersResearch #TauProtein #EndAlz

Strategic Questions: Driving the Discussion at #RedoxMedicine2024. Join us on June 27-28 in Paris and take part in answering critical questions that aim to reshape the understanding of redox processes and their role in human health. 🎙 Among the questions to be discussed: 1️⃣ How do SuperInflammasome complexes modify disease progression through redox signaling? 2️⃣ What role does the prokineticin antagonist play in cerebral dementia? 3️⃣ How does redox signaling regulate cardiac metabolism and health? 4️⃣ How do gender differences influence mitochondrial function and cardiac health through epigenetic modulation? 5️⃣ What impact do interactions between reactive species and mitochondria have on brain metabolism by gender? Learn more about what to expect during Redox Medicine 2024 on our conference website: https://lnkd.in/dkNzFQZU #RedoxMedicineSociety #RedoxMedicine #biomarkers #redoxbiology #redox #antioxidants #innovation #oxidativestress #RedoxResearch

Nice overview about how astrocytes, the most abundant non-neuronal cells in the central nervous system, play a vital function in neurodegenerative disorders, particularly tauopathies like Alzheimer's disease. These cells are key players in eliminating detrimental tau protein aggregates. However, this process faces a significant challenge due to the genetic risk factor ApoE4, which disrupts astrocytes' ability to regulate and clear tau by disrupting endosomal pathways, reducing tau uptake, and altering mitochondrial dynamics, which in turn complicates potential therapeutic approaches. https://lnkd.in/dXSz9_5a #alzheimersdisease #alzheimersresearch #astrocytes #tauopathies #ApoE4

Exciting advancement in Alzheimer’s research! Researchers from the The University of Texas Medical Branch have developed an innovative nasal spray treatment that targets and clears harmful tau protein build-up, showing significant cognitive improvements in aged mice models. This non-invasive method bypasses the blood-brain barrier, promising a new era in neurodegenerative disease therapy. With further trials, this could revolutionize treatment for millions affected by Alzheimer’s and related conditions. Read more here: https://lnkd.in/gi2KtXAY And find the original publication here: https://lnkd.in/da7MkjzY #AlzheimersResearch #NeurodegenerativeDiseases #MedicalInnovation #HealthcareAdvancements

I can see into you…? While much investigation remains before this can be tested with people, #NSFfunded researchers at Stanford University have used common food dye to make skin and muscle safely and reversibly transparent, revealing organs, blood flow and even digestion in sleeping animals. This groundbreaking discovery has the potential to be applied to various medical diagnostics, from locating injuries to monitoring digestive disorders to identifying cancers. Results were published in Science Magazine. Learn more at: https://bit.ly/3yXxQjV (Do not try this at home!) #science

WOW! An interesting discovery about Yellow 5, a common food dye. Further research is required to test the safety of this application in humans. I believe certain food dyes are banned in places around the world due to their association with health issues. Worth a read.

Explore the dynamic process of #autophagy with our innovative range of chemical products! From autophagy inducers to lysosomal inhibitors, our solutions provide researchers with the tools they need to investigate cellular recycling mechanisms and their implications for health and disease. Whether you're unraveling the mysteries of aging or studying neurodegenerative disorders, our autophagy products offer precise and reliable tools for advancing #scientific discovery. Join us in unlocking the secrets of cellular self-eating and shaping the future of biomedical research! #Autophagy #CellularRecycling #InnovativeResearch 🧬🔬 https://lnkd.in/eGwSP6E9

🧬 Cellular Transformations 🔄 From boosting autophagy to enhancing mitochondrial efficiency, your body is hard at work behind the scenes. Discover how fasting can supercharge your cells and improve your health! 💪 🎬 Watch the video to learn more! 👇 reference: Mizushima, N., & Levine, B. (2010). Autophagy in Mammalian Development and Differentiation. Nature Cell Biology, 12(9), 823-830. Longo, V. D., & Mattson, M. P. (2014). Fasting: Molecular Mechanisms and Clinical Applications. Cell Metabolism, 19(2), 181-192.  Mattson, M. P., et al. (2018). Impact of Intermittent Fasting on Health and Disease Processes. Ageing Research Reviews, 39, 46-5. Mizushima, N., & Levine, B. (2010). Autophagy in Mammalian Development and Differentiation. Nature Cell Biology, 12(9), 823-830. doi:10.1038/ncb0910-823 #FastingScience #IntermittentFasting #CellularAdaptation #Autophagy #Mitochondria #HealthTransformation #WellnessTips #Biohacking #HealthyLiving #Longevity #MetabolismBoost #InflammationReduction #InsulinSensitivity #CleanEating #FitnessJourney #WellnessCommunity #stanfitnesshq

Progress in Alzheimer's research: For years, research has focused on the deposition of beta-amyloid as a central feature of Alzheimer's disease. However, the exact process by which these toxic protein fibrils are formed remained unclear for a long time.   Now, scientists at the Swiss EMPA have succeeded in visualizing this process with unprecedented precision: Using an atomic force microscope, they documented the formation of these harmful molecules directly on the surface of the fibrils over a period of many hours. The results have been published in the journal Science Advances:   https://lnkd.in/gsjwVDPa   #alzheimers #alzheimersdementia #alzheimersresearch #betaamyloid