Helaina’s Post

A Complete Guide of " 𝐀𝐧𝐭𝐢𝐦𝐢𝐜𝐫𝐨𝐛𝐢𝐚𝐥 𝐒𝐮𝐬𝐜𝐞𝐩𝐭𝐢𝐛𝐢𝐥𝐢𝐭𝐲 𝐓𝐞𝐬𝐭𝐢𝐧𝐠 " [PDF Guide] ⏩𝐆𝐫𝐚𝐛 𝐭𝐡𝐞 𝐏𝐃𝐅 𝐁𝐫𝐨𝐜𝐡𝐮𝐫𝐞 𝐍𝐨𝐰 @https://lnkd.in/ex33wKzj #Antimicrobialsusceptibilitytesting is used in the determination of the antimicrobials inhibiting the growth of the #bacteria or fungi causing a specific infection. The aim of antimicrobial susceptibility testing is to predict the in vivo success or failure of #antibiotictherapy. Tests performed measure the growth response of an isolated organism to a particular drug or drugs. The global burden of #infectious diseases is resulting into growing need for susceptibility testing and scientists are striving to develop broad spectrum antibiotics and check microbial susceptibility against them. 𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: 1. Clinical Diagnostics 2. Drug Discovery and Development 3. Epidemiology 4. Veterinary Diagnostic 5. Environmental Monitoring 𝐊𝐞𝐲 𝐏𝐥𝐚𝐲𝐞𝐫𝐬: Thermo Fisher Scientific Inc. (U.S.), Merck KGaA (Germany), Bio-Rad Laboratories, Inc. (U.S.), bioMérieux S.A. (France), Becton, Dickinson and Company (U.S.), Danaher Corporation (U.S.), HiMedia Laboratories Pvt. Ltd. (India), etc. ⏩ 𝐑𝐞𝐚𝐝 𝐭𝐡𝐞 𝐭𝐫𝐞𝐧𝐝𝐢𝐧𝐠 𝐛𝐥𝐨𝐠: @ https://lnkd.in/eBKzZgZD #antimicrobial #antibiotics #microbes #testing #fungi #incubation #automatedtesting #antibioticresistance #clinicaldiagnostics #Pharma #ClinicalPharmacy #antimicrobialresistance #pharmaceuticals #biotech #biotechnology #healthcare #research #microbiology

𝗜𝗻𝗱𝗶𝗮’𝘀 𝗠𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗹𝗼𝗴𝘆 𝗥𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻: 𝗡𝗮𝗳𝗶𝘁𝗵𝗿𝗼𝗺𝘆𝗰𝗶𝗻 𝗙𝗶𝗴𝗵𝘁𝘀 𝗗𝗿𝘂𝗴-𝗥𝗲𝘀𝗶𝘀𝘁𝗮𝗻𝘁 𝗜𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻𝘀💊🧫🧬🧫👨🏻🔬🫁👩🏻🔬🔬🏥☣️ 👉 It is an antibiotic which has been developed with the support of Biotechnology Industry Research Assistance Council (BIRAC). 👉 It has been brought to market under the trade name "𝗠𝗶𝗾𝗻𝗮𝗳". 👉 Developed by Mumbai-based Wockhardt Ltd. 👉 It is the country's first indigenously developed antibiotic aimed at 𝘁𝗮𝗰𝗸𝗹𝗶𝗻𝗴 𝗔𝗻𝘁𝗶𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗥𝗲𝘀𝗶𝘀𝘁𝗮𝗻𝗰𝗲 (𝗔𝗠𝗥). 👉 This innovation is designed to treat 𝗖𝗼𝗺𝗺𝘂𝗻𝗶𝘁𝘆-𝗔𝗰𝗾𝘂𝗶𝗿𝗲𝗱 𝗕𝗮𝗰𝘁𝗲𝗿𝗶𝗮𝗹 𝗣𝗻𝗲𝘂𝗺𝗼𝗻𝗶𝗮 (𝗖𝗔𝗕𝗣). 👉 Nafithromycin’s efficacy stands out as it targets both typical and atypical pathogens, offering a potent solution where no new antibiotic in this class has been developed worldwide for over three decades. 👉 The antibiotic has 𝗺𝗶𝗻𝗶𝗺𝗮𝗹 𝗴𝗮𝘀𝘁𝗿𝗼𝗶𝗻𝘁𝗲𝘀𝘁𝗶𝗻𝗮𝗹 𝘀𝗶𝗱𝗲 𝗲𝗳𝗳𝗲𝗰𝘁𝘀, no significant drug interactions, and remains unaffected by food, making it a versatile option for patients. 👉 It offers 𝟭𝟬𝘅 𝗘𝗳𝗳𝗶𝗰𝗮𝗰𝘆 with Just 3 doses to Combat Drug-Resistant Pneumonia. 👉 The development of Nafithromycin represents 14 years of dedicated research and an investment of ₹500 crores, with clinical trials spanning the U.S., Europe, and India. 👉 Nafithromycin has completed Phase III clinical trials in India and is awaiting official approval from the Drug Controller General of India (DCGI). 👉 Nafithromycin is expected to play a pivotal role in combating pneumonia caused by drug-resistant pathogens and can be an essential tool in global health efforts. #biotechnology #microbiology #AMR #pharmacology #biochemistry #toxicology #medicine #publichealth #infectioncontrol #antibiotics #science #biology #infection #bacteriology #antimicrobialresistance #nafithromycin #pneumonia #health #india

Pleased to share our new article! Journal: Biochemical and Molecular Toxicology (Q2) IF: 3.2 Title: The ameliorative effect of carvacrol on sodium arsenite-induced hepatotoxicity in rats: Possible role of Nrf2/HO-1, RAGE/NLRP3, Bax/Bcl-2/Caspase-3, and Beclin-1 pathways

🚀 Exciting News! 🚀 I'm thrilled to share that my latest research has been published in Archives of Toxicology! 📚 This article marks the end of the research I've performed during my PhD project at Wageningen University & Research. Our study delves into the complexities of cholestasis, a condition marked by the accumulation of bile acids in the liver. Some drugs interfere with the transporter responsible for bile acid efflux from the liver. Interestingly, only a small proportion of individuals exposed to these drugs develop clinical symptoms. We used a modeling approach to further look into the factors that pose an individual at extra risk. 🔬 The research: We've developed a New Approach Methodology (NAM) to predict drug-induced cholestasis. This approach leverages a physiologically based kinetic (PBK) model to simulate the effect of a drug on hepatic bile acid efflux. We applied the model to a set of reference drugs and compared our predictions with real-life data. We also used the model to explore why some individuals are at extra risk to develop cholestasis. Individuals with slower drug clearance, larger bile acid pools, reduced transporter abundance, or higher drug doses were at extra risk. 🌟 This research provides a proof-of-principle for using PBK-based NAMs for cholestasis risk prioritization, emphasizing the role of transporter inhibition and individual risk factors. A set of drugs was used as an example in this case study, but the developed NAM can be applied to other chemicals e.g. environmental pollutants in the future. Read the full study here: https://lnkd.in/e5eGw-kX #Research #Cholestasis #Toxicology #PBKModel #DrugSafety

I'm thrilled to share that our review paper titled "Cefepime/Enmetazobactam: A Microbiological, Pharmacokinetic, Pharmacodynamic, and Clinical Evaluation" has been published in Expert Opinion on Drug Metabolism and Toxicology! In this comprehensive review, we explore the potential of this β-lactam/β-lactamase inhibitor combination as a promising carbapenem-sparing option for combating ESBL-producing Enterobacterales. With its broad spectrum of activity, cefepime/enmetazobactam shows significant promise for treating serious infections such as neonatal sepsis, reproductive tract infections, and abdominal infections. Further clinical and non-clinical studies are essential to fully realize its potential applications. A heartfelt thank you to Christopher Darlow and William Hope for letting me be a part of this. Looking forward to contributing further to the field and exploring innovative solutions to antimicrobial resistance. #AntimicrobialResistance #Pharmacology #DrugDevelopment #InfectiousDiseases #Antibiotics #UniversityOfLiverpool #PharmacologyResearch #InfectiousDiseasesResearch #UoLImpact https://lnkd.in/eUqVq_Zz

🔬 How Skanda’s Services Propel Nutraceutical & Immunity Research 🌱As more people turn to herbal wellness, we’re here to bring the science that makes these products shine. Curious to know more? 🌿 Immunology Expertise: Leveraging immunophenotyping and flow cytometry, we analyze immune cells like B cells, NK cells, and T-cell subtypes with screening proinflammatory cytokines. 🔬 Bioanalytical Quality Control: Using advanced HPLC, Skanda ensures the standardization of natural products through bioactive markers, such as gallic and ascorbic acid. 🧪 Toxicology Assessments: Our acute and chronic toxicology studies confirm formulation safety. 💊 Prophylactic Efficacy: Through robust in vivo models, we assess the preventive potential of nutraceuticals, demonstrating a drastic reduction in viral RNA load in this study, underscoring its immune-supportive potential. 🌱As the demand for herbal wellness solutions grows, Skanda Life Sciences provides the scientific rigor needed to validate and enhance the efficacy of these products. 📩Reach out at [email protected] or [email protected]. Dr. Yogisha. S Ajay Kumar Patra #Nutraceuticals #ImmuneHealth #LifeSciences #Innovation #HerbalWellness #PreclinicalResearch #Bioanalytics #Toxicology #Immunology #SkandaLifeSciences

I am thrilled to share that my recent review paper has been published in the "Journal of Traditional and Complementary Medicine" IF=4.5, CiteScore=8.5, Q1, The paper is titled: "A comprehensive review on ethnomedicinal uses, phytochemistry, toxicology, and pharmacological activities of Dittrichia viscosa (L.) Greuter." You can read the full paper here: https://lnkd.in/eJh9iamv

What can non-antibiotics teach us about antibiotic resistance? Drug resistance is a growing problem, with contributors including overuse of antibiotics and a limited number of mechanisms. This interesting study looked at the antimicrobial properties of 1280 drugs, including 226 antibiotics and 1054 non-antibiotics, to identify their mechanisms of action. The study found that non-antibiotics had distinct and non-overlapping toxicity mechanisms compared to antibiotics, suggesting new strategies for developing new antibiotics. This paper used a creative approach by exploiting non-antibiotics to answer a key question in microbiology: "Are there other ways we can kill bacteria?" Since the answer seems to be yes, the next steps will be to see how we can exploit these newly identified pathways with a durable effect and a favorable safety profile. Perhaps these new approaches could pair with existing antibiotics for a combination approach to tackle resistance. #antibioticResistance #microbiology #science https://buff.ly/4alsMmA +++ 💬 Let's chat more about the emerging health threats from infectious agents. 🌐 Drop a line or book a free discovery call at www.quillscience.com and let's discuss your projects!

Marveling Molecular Toxins in Medicinal Plant: Overdose Omen Mechanisms of action of medicinal plants or pharmaceutical drugs may seem complex but exploring the molecular implication will illuminate a clearer pathway to moderation of their usage. By unraveling the genetic intrigues that accentuate microbial resilience, my new article at https://lnkd.in/db2zztkz advocates for strategic methods in combating drug resistance, steering clear of the precipice of therapeutic impotence. The delicate equilibrium between efficacy and harm hinges on dosage. Simply appropriate dosage for individual, not too much and not too low. Remember, either too much or too low of everything is detrimental to health. My findings buttressed this popular assertion with view to caution overdose of medicinal plants, provide insight into resistance of infectious microbes and the need to fortify research with molecular techniques. Hence, the clarion call arises for a deeper exploration, guided by molecular intuitions, to chart the optimal course. This will serve as a beacon, spotlighting the dangers of overdose in medicinal plant consumption and underscoring the urgent need for dosage vigilance. Do you agree every study should include molecular techniques? If yes, Why?

Recently a group of researchers have shown that phytochemicals from plant extract can be excellent antibacterial agents against E.coli and S. aureus. They further used computations tools and gained insights into ther drug likeness properties. These findings will open new insights towards safety and efficacy of medicinal plants for drug delivery. To know more here is the link to my blog: https://lnkd.in/gUyAHW6s #Phytochemicals #AMR #MDR #Toxicity #DrugDiscovery #Microbiology #Bioinformatics #ScienceBlogger #SUPERBUGHUNTERS #Sciencecommunications