Gajanan S Inamdar PhD’s Post

Hello, glycosidically oriented scientists. Progress of your projects with glycosides can be accelerated by reading a post from scimers.com referreing a recent research article on N-glycosides.

This research article presents a palladium-catalyzed glycosylation method for synthesizing heterocyclic N-glycosides, which are important in drug discovery and development due to their wide-ranging biological activities. The approach allows for efficient, regio- and stereoselective synthesis with high site selectivity, accommodating a broad range of substrates and functional groups. It is scalable and effective for modifying pharmaceutically relevant molecules and performing diastereoselective transformations, making it a valuable tool for creating N-glycosylated heterocycles. Here is the link to the original article: https://lnkd.in/eusUquig For any custom synthesis of glycosides, let's connect. Our Integrated Vendor Network (IVN) has the expertise to meet your expectation. #Glycosides #SmallMolecules #DrugDiscovery #DrugDevelopment #CustomSynthesis #Scaleup #ProcessChemistry #MedicinalChemistry

Vapourtec’s continuous flow peptide synthesis system delivers high-quality peptides, significantly reducing purification demands. This efficient process saves time and reduces solvent and reagent usage. Manuel Nuño of Vapourtec explains, "As the success of new peptide-based drugs continues to spur growth, this configuration expands the potential for impactful chemistry." Learn more here https://lnkd.in/eSc7qYKR #Vapourtec #PeptideSynthesis #ContinuousFlow #Chemistry

Selective 1,4-syn-Addition to Cyclic 1,3-Dienes via Hybrid Palladium Catalysis 1,4-cis-disubstituted cyclic framework represents a pivotal structural motif within a wide spectrum of pharmaceutical molecules due to their intricate three-dimensional geometries, which often impart superior bioactivities and physical properties compared to their planar bioisosteres. However, their stereoselective and modular synthesis remains a long-standing challenge. Now comes an innovative strategy for accessing 1,4-cis-substituted cyclic compounds with different ring sizes, spiro structures, and aza-heterocycles via mild conditions employing cyclic 1,3-dienes/alkyl(aryl)halides and amines, and a diverse array of electrophiles (trifluoromethylaromatics, aryl bromides, and alkyl iodides). Maintaining remarkable diastereoselectivity, the methodology exhibits a wide substrate scope that tolerates various functional groups. https://lnkd.in/gNxfr9c7

The following study explores the unexpected competitive host-guest interactions of β-cyclodextrin with polymers in aqueous solution, specifically using poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) and poly(glycerol mono methacrylate) (PGMA) as examples. For a deeper insight, click on the link and read Eva Fenyvesi's blog post on Cyclodextrin News: https://lnkd.in/dU3QNKm7 #cyclolab #cyclodextrin #betacyclodextrin #solubility #host #guest #hostguestchemistry #polyacrylates #molecularphotoswitches #pharma #pharmaceutical #pharmaindustry #science #chemistry #research

🎉 NATA Publication Announcement! We are excited to announce the publication of our first original research article, titled "Thiol-Specific Linkers for the Synthesis of Oligonucleotide Conjugates via Metal-Free Thiol–Ene Click Reaction," authored by Anna Malinowska, Harley Huynh, Andrés F. Correa-Sánchez, and Sritama Bose, PhD, in Bioconjugate Chemistry, published by the American Chemical Society. The article introduces novel linkers that can be easily incorporated into oligonucleotides and conjugated with thiol-containing molecules. This method offers sustainability, versatility, and efficiency, with significant potential for both therapeutic and diagnostic applications. Read the full article here: https://lnkd.in/eJM5Rbsr 🚀 Stay tuned for more exciting updates from NATA as we continue to advance research in nucleic acid therapies! #Science #Research #Chemistry #Biology #Oligonucleotides #Pharma #Pharmaceutical #Therapeutics #DrugDiscovery #Biotech #Biotechnology #AdvancedTherapies #Healthcare #Impact #Innovation #Biochem #HealthcareInnovation

My review on "Recent Advances in Fluoroalkylation Strategies: Exploring Novel Reactivities and Synthetic Applications of Sulfone-and Sulfinate-Based Reagents for Mono-, Di-, and Trifluoromethylation" has just been published in SYNTHESIS Journal Thieme If you're curious about the latest breakthroughs in fluoroalkylation strategies and how sulfone and sulfinate reagents are being utilized to introduce valuable fluorinated motifs like -CH2F, CF2H, and -CF3, this review might be of interest for you! These methodologies summarized in this review article are crucial for altering and fine-tune molecular properties, which is of immense importance for drug discovery purposes. This review provides a comprehensive summary of the current state-of-the-art research and hopefully inspires future advancements in these areas. 🔗 https://lnkd.in/eNj2cKa7 #OrganicChemistry #FluorineChemistry #Synthesis #Pharmaceuticals #Agrochemicals #Fluoroalkylation #DrugDiscovery

"Copper-catalyzed highly switchable defluoroborylation and hydrodefluorination of 1-(trifluoromethyl)alkynes" 📚 Summary 👨🏫 A recent study from Nature Communications has introduced a versatile Cu-catalyzed method that allows for the selective synthesis of different CF2 containing compounds from trifluoromethylated alkynes. Why It’s Interesting 💡 This method only the formation of different containing CF2 compound just with changing the reaction conditions (solvant, base, ligand). Many interesting synthetic applications are presented in the end to show the interested of this method for drug development. #Chemistry #OrganicChemistry #FluorineChemistry #Catalysis #DrugDiscovery #MedicinalChemistry #PublicationOfTheDay #DrugDevelopment

In Dr John Studley's recent article in Scientific Update Ltd's "The Lab Notes", he refers to Nick Tyrell's presentation at their Winer Process Chemistry Conference on the proposed EU ban of all per– and poly-fluorinated materials, including polymers and the fluorinating reagents we use routinely to introduce fluorine or fluorine-containing functional groups into complex molecules. The implications of such a ban for the chemical and (bio)pharma industries in Europe cannot be overstated, and applies both to preparative and analytical work. Read more in Nick's paper, published in OPRD, which highlights details of the proposed changes: https://hubs.li/Q02mQcQY0

N-Heteroaromatics are key elements of pharmaceuticals, agrochemicals, and materials. N-Heteroarynes provide a scaffold to build these essential molecules, but have been underutilized because five-membered N-heteroarynes have been largely inaccessible due to the strain of a triple bond in such a small ring. On the basis of principles of metal-ligand interactions that are foundational to organometallic chemistry, Roberts et al. report the stabilization of five-membered N-heteroarynes in the nickel coordination sphere. A series of 1,2-bis(dicyclohexylphosphino)ethane nickel 7-azaindol-2,3-yne complexes were synthesized and characterized crystallographically and spectroscopically. Ambiphilic reactivity of the nickel 7-azaindol-2,3-yne complexes was observed with multiple nucleophilic, electrophilic, and enophilic coupling partners.