Faron’s Post

Ever have difficulty identifying ideal donors for your studies? Would you prefer to find them before committing to large amounts of cells? Before laborious bench work and analysis, just to find they aren't the right fit? Take a look at Sanguine Biosciences' LeukoLots as a solution - I'd love to explore how they would benefit your process, let me know if this would be of interest to your team!

#Biomarkers can play a crucial role in de-risking drug development by providing measurable indicators of biological processes associated with disease onset, progression, and treatment response. In this episode of Data Bytes, we spoke with Dr. Alexander Koch, Team Lead #Bioinformatics at BioLizard, about the important place of biomarkers in drug development, and what you need to develop a successful biomarker 👀 https://lnkd.in/d6WMbqe7 #biomarkers #drugdevelopment #therapeutics #diagnostics #patientstratification #personalizedmedicine #datascience | Biopôle Lausanne

I knew I should have worn a jacket! Thanks again to Faron for inviting us along to speak at their capital markets day and present our work on payer interviews, KOL interviews and epi forecasting. If you want to watch the presentation you can see it in the link below. #biotech #marketresearch #pricing #forecasting PharmaVentures

Today I came across with a very recent review by Maryam Rahnama, Mohammad Heidari, Zahra Poursalehi, and Ali Golchin, focusing on global trends in EV-based clinical applications. It was not surprising to see the focus is mostly on cancer and wound healing, yet the confirmation was helpful in the sense that trend is still supported in the similar direction by the growing understanding of the field. What was more surprising to me, on the other hand, was to see that MSCs are by far the mostly used cell source in the investigated studies. Even though I was aware that MSCs gained much higher attraction recently, I was not expecting such a domination. Moreover, it felt satisfactory to see that tangential flow filtration (TFF) started to demonstrate itself in the statistics as well. The comparison between TFF and ultracentrifugation stating that the former has advantages like higher yield and purity as well as better suitability for downstream applications was more or less what I would like to point out when I speak about our TFF offers by HansaBioMed Life Sciences Ltd. If you are interested in further reading: https://lnkd.in/dd6HYHkz #extracellularvesicles #exosomes #evdiagnostics #evtherapeutics

Just a quick bump for Ralph Hughes who has been doing a great job building out our pricing and market access practice. He recently presented some of their work at Faron's recently capital markets day. Jacket or no jacket, its a good piece of analysis on the potential of #Bexmarilimab in MDS. #marketaccess #mds #biotech #marketresearch

🚀 Monthly Dosing Confirmed in Our Kv1.3 Program! 🚀 We are thrilled to announce a breakthrough in our lead program targeting Kv1.3 on pathogenic T cells, offering a truly immune-sparing MoA for chronic inflammatory and autoimmune diseases. 🎯 Recently, we've been working on extending the half-life of our lead molecule, and we’ve succeeded! By incorporating an innovative fusion partner, we've not only preserved our exceptional affinity and selectivity, but also enhanced our Kv1.3 inhibitor with an extended half-life, enabling once-monthly dosing. This represents a potential game-changing advantage for patients, improving adherence and convenience. 💊 With this clinically meaningful differentiation, we’re poised to deliver the best-in-class treatment for atopic dermatitis (AD) – as a primary indication – surpassing current therapies like antibodies, JAK inhibitors, and emerging treatments with a superior safety profile. This focus on safety offers a clear advantage in ensuring long-term patient well-being. 💥💡   Zalán Péterfi, our CEO and Co-Founder will be attending #BIOEurope and Investival Showcase London and will be happy to share more updates on our developments. 🤝 #biotech #autoimmunedisease #Chronicinflammatorydisease #Kv1.3 #atopicdermatitis #safetyfirst #innovation #nextgenmedicine

NEWS ALERT: Tomorrow morning, we will report interim data from the Phase 1 clinical trial for SPY001, our lead clinical asset targeting Inflammatory Bowel Disease (IBD). Following the announcement, a conference call and webcast will be held at 8:00am ET to discuss the results. If you are interested in participating be sure to visit the Investor Relations page at https://ir.spyre.com/. A replay will be available for a limited time. At Spyre, our mission is to create next-generation products for IBD through antibody engineering, rational therapeutic combinations, and precision medicine approaches. #data #clinicaltrial #IBD #biotech

Applying extracellular vesicles and lipoproteins in therapeutics: in this invited review article, Krisztina Németh, Edit Buzás at Semmelweis University and collaborators provided an overview of common methods used for isolating and detecting EVs and lipoproteins, followed by a review of their potential shared cargo https://lnkd.in/eCiSfH9v Additionally, they explored current literature from physiological, pathological, therapeutic, and pharmacological perspectives to highlight the diverse roles these particles play in health and disease. An article co-authored by Brachyahu M. Kestecher, Sayam Ghosal 🇮🇳 🇭🇺, Bernadett Reka Bodnar, Agnes Kittel, Szabolcs Hambalkó, Csenger Kovácsházi, Zoltán Giricz, Péter Ferdinandy, Xabier Osteikoetxea Vélez, Ralph Burkhardt and Evelyn Orsó. #extracellularvesicles #exosomes #HDL #LDL #statins #Vesiculab

The full 2023 Cytokine Landscape Review is now available to download! Access our comprehensive analysis to explore: 💊 The Drug Landscape: A deep-dive into 2900+ cytokine assets by drug phase, status, and disease indication. Plus a spotlight on top targets investigated in H2 2023. 🧪The Trial Landscape: An analysis of 8500+ cytokine trials, unveiling research trends surrounding disease indications and cytokine classes. 🚀The Future of Cytokines: Insights into the future trajectory of cytokine therapies based on trials initiating and ending in 2024. Download your copy today! https://ter.li/btl8kf #Cytokines #Antibodies #PrecisionMedicine #Biotech

🎶 Biomarkers, oh, they hold the key, To the secrets of my destiny 🎶 * Proud of the contributions that we at BioLizard have made to our clients' #biomarker and drug development research! * 𝘊𝘩𝘢𝘵 𝘎𝘗𝘛 𝘱𝘳𝘰𝘮𝘱𝘵: "𝘞𝘳𝘪𝘵𝘦 𝘢 𝘷𝘦𝘳𝘴𝘦 𝘢𝘣𝘰𝘶𝘵 𝘣𝘪𝘰𝘮𝘢𝘳𝘬𝘦𝘳𝘴 𝘵𝘩𝘢𝘵 𝘴𝘰𝘶𝘯𝘥𝘴 𝘭𝘪𝘬𝘦 𝘪𝘵 𝘤𝘰𝘶𝘭𝘥 𝘣𝘦 𝘢 𝘯𝘦𝘸 𝘛𝘢𝘺𝘭𝘰𝘳 𝘚𝘸𝘪𝘧𝘵 𝘴𝘰𝘯𝘨."