Department of Chemistry at the University of Toronto’s Post

Abstract DNA-encoded library (DEL) is a powerful hit selection technique in both basic science and innovative drug discovery. In this study, we report a robust and straightforward DNA-compatible diazo-transfer reaction utilizing FSO2N3 as the diazo-transfer reagent in solution. This reaction demonstrates high conversions and facile operation while being metal-free and maintaining high levels of DNA fidelity. It is also compatible with a wide range of substrates, allowing for convenient access to both aliphatic and aromatic amines. Consequently, it will further enrich the DEL chemistry toolbox.

🔬 Excited to share the publication on "Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris". 🚀  In this study, chemical synthetic methods and the biosynthesis pathway of Cordycepin were reviewed. This study provides a reference for the production of COR in the future. Welcome to access the full article freely here 👉 https://lnkd.in/dirBegu2. And welcome to follow our LinkedIn account: https://lnkd.in/grPNkBrg. 👏 #Cordyceps #cordycepin #biosynthesis #genetic_modification

Join us for our next virtual chemistry lecture on Thursday, March 28, 2024, at 9:15 am (China Standard Time).     𝐎𝐱𝐲𝐠𝐞𝐧 𝐃𝐫𝐢𝐯𝐞𝐧 𝐅𝐫𝐚𝐠𝐦𝐞𝐧𝐭 𝐂𝐨𝐮𝐩𝐥𝐢𝐧𝐠 𝐟𝐨𝐫 𝐭𝐡𝐞 𝐒𝐲𝐧𝐭𝐡𝐞𝐬𝐢𝐬 𝐨𝐟 𝐍𝐚𝐭𝐮𝐫𝐚𝐥 𝐏𝐫𝐨𝐝𝐮𝐜𝐭𝐬 𝐚𝐧𝐝 𝐀𝐧𝐭𝐢𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐚𝐥𝐬  Prof. Marisa Kozlowski  Department of Chemistry,   University of Pennsylvania,  Philadelphia, PA, USA    Register for the webinar: https://lnkd.in/dCarKenh     In this lecture, Prof. Marisa Kozlowski will discuss the use of parallel microscale screening to discover selective and efficient catalysts using oxygen as the terminal oxidant. The unexpected outcomes obtained highlight the value of interrogating large numbers of rationally selected variables under the umbrella of general hypothesis. The development of selective oxidative catalytic processes for phenol coupling, enol coupling, and alkyl C-H activation will be discussed. Applications in total synthesis of hypocrellin honokiol chaetoglobin and pyrolaside B will be presented. Finally, studies on the mechanisms of these transformations will be described with the goal of understanding the governing principles and how they might be used to discover further new transformations. 

On this day in science German Chemist Ernst Otto Fischer was born on He was the co-recipient of the Nobel Prize in Chemistry in 1973 for determining the structure of ferrocene (Fe(C5H5)2), a single iron (Fe) atom sandwiched between two five-sided carbon rings. There are many analogues of ferrocene, which together have led to the rapid growth of organometallic chemistry. Here is an #infographic from Compound Interest | Chemistry infographics to explain the history of "Molecular Sandwiches 🥪 " #sciencecommunication #science #onthisday #organicchemistry #chemistry #scienceandtechnology #biotech #innovation #pharma

Make sure you read the exciting latest article on electrochemical biosensors for the detection of viruses, authored by Karin Chumbimuni Torres and Yulia Gerasimova and published at American Chemical Society The journal of Analytical Chemistry! Read full article here: https://lnkd.in/dq7uj-XK This innovative and cost-effective research discovery made the cover of the journal for April 2024! #UCF #biochemistry #electrochemistry #sensor #ACS #chemistry

Excited to share our latest publication in Chem. Eur. J. titled “Partially Sulfated Pillar[5]arenes: Synthesis and Molecular Recognition Properties” - exploring stepwise synthesis, detailed characterization and host-guest chemistry of highly water soluble partially sulfated pillar[5]arenes (P5S2n , n = 1-5). The research proves the tunability of host•guest binding affinities of P5S2n across a wide range by simply changing the number of the ionic sulfate substituents. We firmly believe the work will optimize the application of sulfated pillararenes in supramolecular polymers, separation materials, and latching applications. Check it out here: https://lnkd.in/ecmKAzwW Kudos to the team and grateful to Dr. Lyle Isaacs for all the guidance and support! 🙌 #research #supramolecularchemistry #molecularrecognition #syntheticchemistry ReplyForward

Researchers led by Jin Kim Montclare, Professor in the Department of Chemical and Biomolecular Engineering, have embarked on a pioneering mission to develop enzymatic defenses against chemical threats, as revealed in a recent study. The team's focus lies in crafting enzymes capable of neutralizing notorious warfare agents such as VX, renowned for their swift and devastating effects on the nervous system. Through meticulous computational design, they harnessed the power of enzymes like phosphotesterase (PTE), traditionally adept at detoxifying organophosphates found in pesticides, to target VX agents. Click the link to learn more about this research. #NYUTandonMade

✨🤩Chemiluminescence is a fascinating phenomenon where light is emitted as a result of a chemical reaction. Unlike bioluminescence, which involves living organisms, chemiluminescence occurs in the absence of biological processes. This means it's purely driven by chemical reactions, making it a valuable tool in various fields such as analytical chemistry, biochemistry, and forensics. ✨One classic example of chemiluminescence is the reaction between luminol and hydrogen peroxide in the presence of a catalyst, often a metal ion like iron or copper. ✨When luminol reacts with hydrogen peroxide in an alkaline solution, it undergoes oxidation, forming an excited-state intermediate. ✨As this intermediate returns to its ground state, it releases energy in the form of light. This light emission can be observed as a blue glow, and it's often used in forensic investigations to detect trace amounts of blood at crime scenes. The iron in hemoglobin acts as a catalyst, triggering the reaction and causing the luminol to emit light in the presence of blood.

Random experiments to guidelines for MALDI-TOF MS. Proud to have this one out, started out at the beginning of my PhD and only realized during the writing of my thesis that some of these insights and data might be relevant to the conjugated polymer community. This became exactly the goal, to further educate on the use of MALDI-ToF MS for conjugated polymer analysis. How representative is analysis on low molecular weight species? Can we actually measure longer polymer chains? How can we get a better overview of all the polymer species that make up a complex polymer sample? What are the approaches to MALDI-ToF MS analysis? Are there pitfalls? What can we learn? All of these questions are addressed! We coupled preparative-GPC with MALDI-ToF MS. Check it out! https://lnkd.in/eik7syea Big thanks to Pieter Verstappen and Wouter Maes! But also to my PhD committee members with their encouraging words to this work's relevance during the reading of my thesis. UHasselt