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To better understand the host-pathogen interactions underlying tuberculosis (TB), Yang Luo and Soumya Raychaudhuri teamed up with Brigham and Women's Hospital's Chuan-Chin Huang and Megan Murray; the Harvard T.H. Chan School of Public Health's Nicole Howard, Xin Wang, Qingyun Liu, and Sarah Fortune; and colleagues to study host and Mycobacterium tuberculosis (Mtb) genomes from TB patients in Peru. Their findings, published in Nature Communications, reveal an association between a noncoding variant in the human FLOT1 gene and an Mtb lineage with an altered metabolic state, but also highlight the dynamic and complex interplay of host, pathogen, and environmental factors that shape infectious diseases. #BroadInstitute #Science #ScienceNews #Research #ScientificResearch

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis - Nature Communications

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis - Nature Communications

nature.com

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