To better understand the host-pathogen interactions underlying tuberculosis (TB), Yang Luo and Soumya Raychaudhuri teamed up with Brigham and Women's Hospital's Chuan-Chin Huang and Megan Murray; the Harvard T.H. Chan School of Public Health's Nicole Howard, Xin Wang, Qingyun Liu, and Sarah Fortune; and colleagues to study host and Mycobacterium tuberculosis (Mtb) genomes from TB patients in Peru. Their findings, published in Nature Communications, reveal an association between a noncoding variant in the human FLOT1 gene and an Mtb lineage with an altered metabolic state, but also highlight the dynamic and complex interplay of host, pathogen, and environmental factors that shape infectious diseases. #BroadInstitute #Science #ScienceNews #Research #ScientificResearch
Broad Institute of MIT and Harvard’s Post
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Attending #ASCO2024? Meet our real-world evidence experts in booth 10087: Epidemiology and Real-World Evidence: Firas Dabbous, PHD, MS Implementation Science (IS) Methods: Meredith Smith, PhD, MPA, FISPE Market Access Communications: Malinda O'Donnell, MSc Rare Disease and Cell and Gene Therapy: Elizabeth (Liz) Donahue, BSc Epidemiology and Real-World Data: Kelechi "Kacy" Emeanuru, MPH,CPH Direct-to-Provider Research: Mariah Baltezegar, MBA Evidence Synthesis: Heather Burnett, MSc Disease Modeling and Simulation: Hector Toro-Diaz, PhD, MSc, BSc #RWE #RWD #RWDE #oncologyexpertise
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#Genomics and #metabolomics are a perfect combination for who wants to study the synergistic effects of #nature and #nurture. The addition of metabolomics to genome-wide association studies into #mGWAS has demonstrated time and again its capacity to bring GWAS to a whole new level: 🔌 Identifying new associations with disease, 💪 Drastically reducing p-values and 💡 Providing a deeper level of understanding of the mechanistic links between a SNP and a phenotype 👉mGWAS should be part of every #epidemiologist ’s toolkit. Standardized metabolomics has provided a wealth of phenotypic traits to countless GWAS over the years, starting in 2008 when the first ever mGWAS was published (DOI: 10.1371/journal.pgen.1000282) by Karsten Suhre 's group. Since then all leading omics experts have given metabolomics a go and combined it with genomics and other omics to harness the unique link it provides to the phenotype, from Claudia Langenberg to Gabi Kastenmüller. This week, we’ll dive deeper into this powerful omic match with a selection of podcast episodes, blogs and other references. Stay tuned and #followme to receive this directly in your feed.
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𝐂𝐚𝐧𝐜𝐞𝐫 𝐁𝐢𝐨𝐦𝐚𝐫𝐤𝐞𝐫𝐬 𝐈𝐧𝐝𝐮𝐬𝐭𝐫𝐲 𝐖𝐨𝐫𝐭𝐡 $42.0 𝐛𝐢𝐥𝐥𝐢𝐨𝐧 𝐛𝐲 2029, 𝐰𝐢𝐭𝐡 𝐚 𝐂𝐀𝐆𝐑 𝐨𝐟 11.3% 🔶 𝐃𝐨𝐰𝐧𝐥𝐨𝐚𝐝 𝐏𝐃𝐅 𝐁𝐫𝐨𝐜𝐡𝐮𝐫𝐞: https://lnkd.in/duS9raNz Cancer biomarkers are widely used in epidemiology studies to examine various phases of human disease. In order to minimize future research expenditures using banked samples and extract a great deal of information from a small number of samples, this calls for cautious handling and storage of priceless biological samples. 🌐 𝐓𝐡𝐞 𝐜𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐫𝐞𝐩𝐨𝐫𝐭 𝐢𝐧𝐜𝐥𝐮𝐝𝐞: Pensionskasse der F. Hoffmann-La Roche AG Thermo Fisher Scientific QIAGEN Illumina Bio-Rad Laboratories
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Dear All, Let us all work together to overcome the problem... I wanted to highlight how BiomLife® by Ruhvenile® (www.ruhvenile.com) can significantly contribute to Disease X research, especially in light of recent concerns about the bird flu outbreak. BiomLife®'s unique formulation, which preserves diverse specimens and microbes for extended periods, makes it an invaluable tool for disease investigation. Its formalin-free composition ensures sample integrity, enabling researchers to explore the intricacies of Disease X with precision and reliability. BiomLife® is used in four continents and growing... Preserved any kind of specimens can also be utilized for revival of microbes (aerobic, anaerobic, fastidious)| microbiome analysis | functional genomics | nucleic acid (RNA, DNA) isolation | PCR, RT-PCR | metagenomics | OMICS studies | cancer analysis | Epidemiology and more... If you're interested in leveraging BiomLife® for your research on bird flu or any other disease, I'm available to provide further details or arrange a discussion at your convenience. Looking forward to your response. [email protected] | +91 858 703 3367 | +91 11 3501 7209 #birdflu #diseaseX #microbiome #infectiousdisease #pandemic #doctors #prevention
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BiomLife and Monkeypox: Enhancing Research and Response Monkeypox, a viral zoonotic disease, has emerged as a growing global health concern. Effective sample collection, preservation, and analysis are crucial for monitoring and controlling outbreaks. BiomLife® by Ruhvenile® (www.ruhvenile.com) plays a pivotal role in combating diseases like Monkeypox by offering a robust solution for the safe transport and preservation of biological specimens. BiomLife® ensures the integrity of samples, whether they are solid or liquid, and supports the isolation and study of viruses like Monkeypox over extended periods. This capability is vital for researchers conducting epidemiological studies, diagnostics, and vaccine development. · Revive elusive microbes (aerobic, anaerobic, fastidious of bacteria, virus, fungi, parasites and more…) · Formalin free, transport sample at RT (first 48H) without any spoilage… · Unravel the mysteries of microbiome analysis, functional genomics, metagenomics · Isolate 2.5-3X nucleic acid (RNA, DNA) with precision · Perform advanced molecular biology techniques, including NGS| WGS | PCR | RT-PCR | metagenomics and OMICS studies… Trusted by over 100 esteemed institutions, including AIIMS and John Hopkins University, USA, BiomLife® is the media you need to take your research to the next level. Scientific validation: 1) The Lancet (https://lnkd.in/gs2cEGSh), 2) J. Med. Virology – (https://lnkd.in/dHF-Vp3s) and coming more… Recommendation Letters: https://lnkd.in/gJn7CGdJ) With its proven efficacy in preserving genetic material without degradation and enabling advanced molecular biology techniques, including NGS, PCR, and metagenomics, BiomLife® is an essential tool in the global fight against infectious diseases. By facilitating accurate, reliable, and reproducible data, BiomLife® supports public health efforts to monitor, understand, and ultimately control the spread of Monkeypox and other viral pathogens. +91 858 703 3367 | +91 11 3501 7209 | [email protected] #who #BiomLife #publichealth #monkeypox #hospital #PMO #gatesfoundation #microbiology #ruhvenile
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🌍 National Geographic has published a compelling article about cutting-edge mosquito control methods! Imagine the peace of mind that comes with knowing your community is safe from mosquito-borne diseases. This is what journalist, Jonathan Lambert, explores in his fascinating read about innovative mosquito control methods. As Lea Paré Toe from Burkina Faso says in the article, ‘We have all these tools, medicines, bed nets, but the disease is still there.’” In his piece, Lambert explores three emerging technologies to control mosquito populations: gene editing, gene drives, and of course, our Wolbachia method. Among these, Wolbachia stands out as the only natural and self-sustaining approach. Lambert details how Wolbachia, a natural bacterium, can block disease transmission when introduced into mosquito populations. Since 2011, we’ve released millions of Wolbachia-infected mosquitoes across 14 countries, achieving remarkable success in reducing dengue cases. As our CEO Scott O'Neill notes, ‘In parts of Australia, we’ve essentially eliminated dengue transmission.’ It’s a fascinating read and highly recommended. Find the link to the full article in the comments below.
🌍 National Geographic has published a compelling article about cutting-edge mosquito control methods! Imagine the peace of mind that comes with knowing your community is safe from mosquito-borne diseases. This is what journalist, Jonathan Lambert, explores in this fascinating read about innovative mosquito control methods. As Lea Paré Toe from Burkina Faso says in the article, ‘We have all these tools, medicines, bed nets, but the disease is still there.’” In his piece, Lambert explores three emerging technologies to control mosquito populations: gene editing, gene drives, and of course, our Wolbachia method. Among these, Wolbachia stands out as the only natural and self-sustaining approach. Lambert details how Wolbachia, a natural bacterium, can block disease transmission when introduced into mosquito populations. Since 2011, we’ve released millions of Wolbachia-infected mosquitoes across 14 countries, achieving remarkable success in reducing dengue cases. As our CEO Scott O'Neill notes, ‘In parts of Australia, we’ve essentially eliminated dengue transmission.’ It’s a fascinating read and highly recommended. Find the link to the full article in the comments below.
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BiomLife and Monkeypox: Enhancing Research and Response Monkeypox, a viral zoonotic disease, has emerged as a growing global health concern. Effective sample collection, preservation, and analysis are crucial for monitoring and controlling outbreaks. BiomLife® by Ruhvenile® (www.ruhvenile.com) plays a pivotal role in combating diseases like Monkeypox by offering a robust solution for the safe transport and preservation of biological specimens. BiomLife® ensures the integrity of samples, whether they are solid or liquid, and supports the isolation and study of viruses like Monkeypox over extended periods. This capability is vital for researchers conducting epidemiological studies, diagnostics, and vaccine development. · Revive elusive microbes (aerobic, anaerobic, fastidious of bacteria, virus, fungi, parasites and more…) · Formalin free, transport sample at RT (first 48H) without any spoilage… · Unravel the mysteries of microbiome analysis, functional genomics, metagenomics · Isolate 2.5-3X nucleic acid (RNA, DNA) with precision · Perform advanced molecular biology techniques, including NGS| WGS | PCR | RT-PCR | metagenomics and OMICS studies… Trusted by over 100 esteemed institutions, including AIIMS and John Hopkins University, USA, BiomLife® is the media you need to take your research to the next level. Scientific validation: 1) The Lancet (https://lnkd.in/dVzgEZKd), 2) J. Med. Virology – (https://lnkd.in/dc8ekKxi) and coming more… Recommendation Letters: https://lnkd.in/geHpHw98) With its proven efficacy in preserving genetic material without degradation and enabling advanced molecular biology techniques, including NGS, PCR, and metagenomics, BiomLife® is an essential tool in the global fight against infectious diseases. By facilitating accurate, reliable, and reproducible data, BiomLife® supports public health efforts to monitor, understand, and ultimately control the spread of Monkeypox and other viral pathogens. +91 858 703 3367 | +91 11 3501 7209 | [email protected] #who #BiomLife #publichealth #monkeypox #hospital #PMO #gatesfoundation #microbiology #ruhvenile
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As a charity committed to providing greater choice for those affected by genetic conditions PET is supporting 'Rare Disease Day 2024'. Please share this post and help the Genetic Alliance UK get #RareDiseaseDay trending!. Rare Disease Day is an important international awareness day that takes place annually on 28 February (or 29 February in leap years). This date was chosen because 29 February is the rarest day of the year. Many rare diseases are caused by genetic conditions. Here are some facts and figures from the UK Rare Disease Framework (Department of Health, 2021) - 8 in 10 rare diseases are caused by a change to someone’s genetic code - Some rare gene disorders affect only 1 or 2 people in the UK and a handful of people around the world - Some people may be the only person in the world affected by a particular change to their genetic code - Every year around 6,000 children in the UK are born with a genetic condition so rare that it does not yet have a name. This might be because the right test has not yet been developed to diagnose it, or the genetic cause of the condition has not been discovered. An undiagnosed genetic condition is known as a ‘syndrome without a name’ or SWAN You can learn more about Rare Disease Day 2024 and how to get involved by going to https://lnkd.in/eV2w_nt2 All images and information via Genetic Alliance UK, https://lnkd.in/egxpdNtX, Accessed February 2024. #RareDiseaseDay #genomics #genetics # #rarediseaseawareness #rarediseases #DNA
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Class 12 Biology Human Population & Health Disorders, Applied Biology Notes Welcome to this extensive resource of important topics from Class 12 Biology, where the following are included: Human Population and Health Disorders, Tissue & Organ Transplantation, Test-Tube Baby Technology, and more. In this post, detailed notes will be provided on very important topics such as Amniocentesis, Genetically Modified Organisms (GMOs), Risk Groups of Microorganisms, along with a detailed explanation of Human Diseases related to Typhoid, Tuberculosis, AIDS, Cholera, Influenza, and Hepatitis. We also cover Candidiasis and discuss the important role Vaccines play in fighting these diseases. Finally, be sure to download the embedded PDF for a structured overview and deep understanding of these topics.\ https://lnkd.in/ebv8Qjrz
Class 12 Biology Human Population & Health Disorders, Applied Biology Notes
pathakmanish.com.np
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🌐 Stay ahead in the fight against global health threats by harnessing the power of Nanopore sequencing for precise and cost-effective genomic analysis. Read this protocol to unlock valuable insights into the battle against antimicrobial resistance. Link: https://lnkd.in/eMECkjEa #Genomics #AMR #NanoporeSequencing #Epidemiology
Genomic Epidemiological Analysis of Antimicrobial-Resistant Bacteria with Nanopore Sequencing
link.springer.com
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