Broad Institute of MIT and Harvard’s Post

Targeting mitochondrial function in #glaucoma using a gene-independent approach by over expressing enhanced NDI1 gene (eNdi1) have shown to reduce #retinalganglioncell loss in a #glaucoma mouse model. I look forward to see the next steps of the work being developed by Vzarii Therapeutics (https://lnkd.in/ewG9PPBF). https://lnkd.in/eeErg_FX

Revolutionizing Medicine: Human iPS Cell Chemical Reprogramming Kit Cellular reprogramming tools can manipulate cell identity, enabling the generation of desired cell types that provide broad applications in disease modeling, drug discovery and regenerative medicine. Chemical reprogramming approach synergistically targets cell signaling pathways and epigenetic modifiers without gene manipulation, and offers considerable advantages for the development of pharmacological and therapeutic strategies. Recently, a new scalable, efficient, and rapid chemical reprogramming approach was reported, which can induce human somatic cells into pluripotent stem cells (Guan, J et al., Nature, 2022; Liuyang, S et al., Cell Stem Cell, 2023). This kit, optimized from a patent in filing (METHODS FOR CHEMICAL REPROGRAMMING AND PLURIPOTENT STEM CELLS, PCT/CN2022/124960) and publication (Liuyang, S et al., Cell Stem Cell, 2023), can be used to generate human chemically induced pluripotent stem cell (hCiPSCs) from human adult adipose-derived stromal cells (hADSC) or skin dermal fibroblasts (HDFs).

#UPNAT and Haiyan Zhou featured in a recent news article on STAT: U.K. health officials and researchers try to carve a path for more individualized genetic treatments NATA is proud to be part of UPNAT (UK Platform for Nucleic Acid Therapeutics), a collaboration with UCL and the University of Oxford to develop a translational and regulatory roadmap for nucleic acid therapies for rare diseases. We are committed to advancing personalised precision medicine and 'N of 1' therapeutics to target For the full article: https://lnkd.in/eJ4Bnnu6 #NATA #PrecisionMedicine #Nof1 #RareDisease #PersonalisedTherapeutics #Collaboration #Innovation #NucleicAcidTherapy #NATs #Therapeutics #DrugDiscovery #AdvancedTherapies #RareDiseases

New WPC Blog Post! Synaptic Telephone by Casey Mahoney-Crane, PhD Have you or someone you know played the game “Telephone?” In this game, a group of people are in a circle and share a message starting with Person A all the way until it reaches the last person. You can think of our synapses functioning in the same way. But what happens if Person A tries to share the message, but there is no Person B to carry it forward? This generates a physical gap hindering the message from reaching the final person. This principle mimics cellular dysfunction in neurodegenerative disease when synaptic degeneration occurs. Continue Reading: https://lnkd.in/eeHVCVgJ WPC blog made possible with support from Supernus Pharmaceuticals, Inc., Mitsubishi Tanabe Pharma America and CND Life Sciences.

Cystic Fibrosis or CF is a genetic disease that can be caused by many different mutations in the DNA. Therefore, when someone is diagnosed with cystic fibrosis, many questions remain unanswered about the course of treatment. For part of the people with CF, medication is available, and for the remaining part, screening with organoids offers perspective. Lisa Rodenburg received her doctorate on February 8th for her research into improved forms of this screening. Congratulations Lisa! Read more about her work and time as a PhD student on our website: https://lnkd.in/gV29rpUX #cysticfibrosis #organoids #regenerativemedicine #regmed #umcutrecht #biotechnology #regenerativetherapy

🔬 Unlocking the Power of Cortisone: How It Activates the Body’s Natural Brakes on Inflammation Great to see #macrophage biology featured in my msn news digest this morning! 🌐 Read the full study: https://lnkd.in/e7sdqjcG 📌 Key Takeaways: Cortisone, a widely used anti-inflammatory medication, has long been a mystery in terms of its precise mechanism. New research shows that cortisone acts by reprogramming the mitochondrial metabolism in macrophages via the metabolite itaconate. Understanding this process could lead to more targeted treatments for inflammatory conditions, including rheumatoid arthritis. Having revealed the mechanism of cortisone’s activity in mouse macrophages, the authors suspect that the processes in humans may be a bit more complex. That should leave room for the Berlin scientists to get ahead with drug development, develop a solid #IP position around new drug candidates and attract commercial interest. #macropharma

New WPC Blog Post! Synaptic Telephone by Casey Mahoney-Crane, PhD Have you or someone you know played the game “Telephone?” In this game, a group of people are in a circle and share a message starting with Person A all the way until it reaches the last person. You can think of our synapses functioning in the same way. But what happens if Person A tries to share the message, but there is no Person B to carry it forward? This generates a physical gap hindering the message from reaching the final person. This principle mimics cellular dysfunction in neurodegenerative disease when synaptic degeneration occurs. Continue Reading: https://lnkd.in/eREE99EX WPC blog made possible with support from Supernus Pharmaceuticals, Inc., Mitsubishi Tanabe Pharma America and CND Life Sciences.

Incredible progress - 👏 in the fight against diabetes! This innovation represents a monumental leap forward in our understanding and treatment of diabetes, moving us closer to reversing the disease rather than just managing its symptoms. Such advancements highlight the power of cutting-edge science and the dedication of researchers worldwide. This new drug has the potential to transform treatment protocols, significantly reduce dependence on external insulin, and vastly improve the quality of life for millions. Kudos to the brilliant minds driving this revolutionary work! ✨🎉The future of personalized and effective diabetes treatment looks brighter than ever. 🌟 #diabetes #fightagainsttype1 #insulin #personalizedmedicine

#BtBsPUB by Laura Legnani ( #BtBsUNIMIB ) and co-authors "Effect of Ferulic Acid Loaded in Nanoparticle on Tissue Transglutaminase Expression Levels in Human Glioblastoma Cell Line" in Int. Journal of Molecular Sciences. abstract: Glioblastoma (GBM) is one of the most aggressive cancers, characterized by a decrease in antioxidant levels. Evidence has demonstrated that ferulic acid (FA), a natural antioxidant particularly abundant in vegetables and fruits, could be a promising candidate for GBM treatment. Since FA shows a high instability that compromises its therapeutic application, it has been encapsulated into Nanostructured Lipid Carriers (NLCs) to improve its bioavailability in the brain. It has been demonstrated that tissue transglutaminase (TG2) is a multi-functional protein implicated in many physiological and pathological processes, including cancer. TG2 is also involved in GBM correlated with metastasis formation and drug resistance. Therefore, the evaluation of TG2 expression levels and ... https://lnkd.in/d4W8FVNP Università degli Studi di Milano-Bicocca

📢📢 International Pharmaco-EEG Society Conference (IPEG) 2024: Meet SynapCell’s scientists in Izmir, Turkey, from November 21 to 24, 2024. Let’s discuss Science and explore how #preclinical #EEG can accelerate #CNS drug discovery. Our team will be presenting two posters: 👉Direct Electrical Stimulation to Assess Brain Excitability & Connectivity, presented by Eloïse GRONLIER, Research Engineer 👉Standardized Pharmaco-Sleep-Electroencephalography as a Preclinical Tool for Antidepressant Drug Profiling, presented by Chloé Habermacher, Principal Scientist #Epilepsy #Parkinson #EssentialTremor #autism #Schizophrenia #anxiety