BioMed X Institute’s Post

I am excited to share a compelling new blog post that delves into the innovative realm of genetically engineered cellular nanoparticles and their promising biomedical applications. This article offers valuable insights into how these advanced therapies are transforming medicine, enhancing drug delivery systems, and improving patient outcomes. For professionals interested in the intersection of biotechnology and healthcare, this is a must-read. Explore the details and discover how these cutting-edge developments are shaping the future of biomedical science. Read more at [Genetically engineered cellular nanoparticles for biomedical applications](https://ift.tt/2VCQwKZ).

🌟 NEW PAPER ALERT: New breakthrough liquid biopsy publication in Cell Press 🌟 We are thrilled to announce that our transformative liquid biopsy technology has been featured in the peer-reviewed journal, Cell Press' iScience! 🎉 Our latest paper, titled "An electro-optical platform for the ultrasensitive detection of small extracellular vesicle sub-types and their protein epitope counts", highlights our innovative Nano-Extracellular Omics Sensing (NEXOS) technology. This breakthrough platform addresses previous limitations in sensitivity and quantification of proteins in extracellular vesicles (EVs), opening new avenues for biological insights in liquid biopsy. 🧬🔬 EVs are increasingly enabling real-time disease phenotyping and represent the fastest-growing modality in liquid biopsy technology. Our NEXOS technology is paving the way for transformative applications in clinical settings. 🚀 Stay tuned for more peer-reviewed publications as we accelerate our scientific communication following the completion of our clinical study later this year. Read more about our innovative approach in the latest issue of iScience! 🔗 https://lnkd.in/eWA9UEUp #MurslaBio #LiquidBiopsy #ExtracellularVesicles #NEXOS #iScience #CellPress #Innovation #Biotechnology #ClinicalResearch #Healthcare

𝗖𝗼𝗻𝗴𝗿𝗮𝘁𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀, 𝗔𝘀𝗵𝘃𝗿𝗶𝘆𝗮 𝗧𝗵𝗮𝗽𝗮! In her latest research, Ashvriya is working to understand how venom-derived peptides influence voltage-gated sodium (NaV) channel gating. Last month, Ashvriya was awarded a Sophion travel grant to attend the Gordon Research Seminar and Conference on Venom Evolution, Function and Biomedical Applications to give a talk on 'The Ant Venom Peptide Ta3a Modulates the Voltage-gated Sodium Channel NaV1.7: Exploring Charges and Ionic Gradients' and present a poster on: 'Exploring the mechanism of action of the ant venom peptide Ta3a at voltage-gated sodium channel NaV1.7'.  When all data are published, her poster will be available for download here: https://lnkd.in/eGcfqdvX. Ashvriya Thapa, who is working in Irina Vetter's lab at UQ Institute for Molecular Bioscience, has been using both conventional and automated whole-cell electrophysiology techniques to gain insights into the mechanisms governing channel and peptide interactions to rationally design NaV channel blockers. Sophion Bioscience awards travel and research grants to support early career scientists studying ion channel-related research. With our travel grant, we offer the opportunity to present your data at international conferences, meetings, and possibly collaborate with peers. For more info and apply here: https://lnkd.in/efTc4ZUv #Venoms #QPatch #AutomatedPatchClamp #IonChannels #DrugDiscovery #Electrophysiology #Sophion

Attention researchers, companies and clinicians investigating #biointerfaces: The call for contributed talks at #BIC2024 is open until March 31, 2024. Don't miss the chance to present your research alongside leading scientists from the USA, UK, Australia, Netherlands, France, Germany, and Switzerland. The conference is taking place near Basel this year and topics include #biomaterials, #biofabrication, #bioprinting, #biosensors, #mechanobiology, #immunedisease interfaces, #computation, and science to market.

The #SLAS2024 in Boston is off to a good start! Attend our Exhibitor Tutorial this afternoon, Feb. 5, 2-3 PM ET: “Eurofins Discovery Leading Innovation: From Protein Degradation to Echo® MS HTS, two recent case studies” We will discuss innovative therapeutic approaches using two case studies. A first case study focusing on protein degraders design and the second will concentrate on label-free technological advances to drive High Throughput Screening (HTS) projects.   Key Takeaways · Learn how we design protein degrader strategies, including the visualization of ternary complex using biophysics. · Gather valuable information on the optimization of screening cascades with reduced assay set-up time and enzyme consumption using the Echo® MS. · Meet our experts in person and deepen your knowledge in hit finding from HTS to extended hit characterization.   For more details and links to the event: https://lnkd.in/gZQg7WZ6 #IntegratedDrugDiscovery #Eurofins

Join our seminar on Bioluminescent Reporter Assays for Cellular Responses and Metabolism at Weinberg Campus Technologiepark, Innovation HUB, Conference Room 325. Presented by Dr. Erik Bonke, Sr Scientific Application Specialist Cellular Reporters at Promega GmbH, this seminar will cover the following key topics: •Cell Viability: Reviews pros and cons of viability markers to help select the best for your research needs. •Cytotoxicity: Highlights common hurdles with cytotoxicity assays and introduces techniques to increase data consistency. •Apoptosis: Examines assays and strategies for in-depth study of programmed cell death, illustrating how they contribute to understanding cellular responses. •Cellular Metabolism: Focuses on the core principle of Promega's bioluminescent assays and their broad research applications. Register now: https://lnkd.in/eyqKxfNY

I wanted to share some reflections on the PSDI 2024 - 32nd Protein Structure Determination in Industry Meeting, which I attended with my colleague Amandine Gontier, Technical Consultant for NanoTemper Technologies, Team South Europe. I hope this overview isn’t too lengthy for LinkedIn standards 😊 First, the meeting took place in beautiful #Paris. It was an incredible three days with 27 speakers from companies, CROs, and academia, and around 200 attendees, all driven by a passion for science—especially #structuralbiology and #biophysics! The meeting covered a wide range of topics, divided into six sections: 1) Emerging Therapeutic Methods in Drug Discovery. I found @George Petzold’s talk on novel #CRBN neosubstrates and Paraskevi (Evi) Gkeka’s presentation on a new method to identify RNA binding sites especially inspiring. 2) Cryo-EM Advancements in Sample Preparation & Data Processing. Gergely Papp’s work developing EasyGrid to automate #CryoEM sample prep and imaging control was particularly innovative. 3) Challenging Targets: Cryo-EM of Membrane Proteins. Fantastic insights from Christian Löw on solute carriers and Dietmar Weichert on the #GPCR receptor, GPR55. 4) Structural Biophysics. Great to hear how Domainex, represented by Nathan Zaccai, is tackling challenging ion transporters. 5) Structural Biophysics: NMR in Structure-Based Drug Discovery (SBDD). Inspired by @Donald Rieck ’s quest to make NMR faster and cheaper for high-throughput screening and Roberto Maya Martinez’s work on using NMR to identify cryptic pockets. 6) Synergies between AI & Experimental Approaches Casper Goverde presented an exciting approach for designing soluble analogs of integral membrane proteins, while @Arwen Pearson shared how X-ray crystallography will evolve. It was also rewarding to see so many presentations featuring data generated with NanoTemper Technologies’ instruments, including #Prometheus & #Monolith (#nanoDSF, and #MST). Looking forward to the continued innovations in this field, and thanks to the organizers Sonja K., and Tatiana Isabet for having organized this fantastic meeting. See you in #Basel in 2026?

🌟 abm’s Latest Collaboration: Elevation in Cellular Research and Biobanking! 🔗 https://buff.ly/3N8I4kM We are thrilled to announce a powerful collaboration between Applied Biological Materials Inc. (abm) and DIVA Expertise aimed at revolutionizing biobanking and cellular research! By combining abm’s unparalleled expertise in cell biology—home to one of the largest and most diverse cell collections in the world—with DIVA’s specialized biobanking resources, we are set to unlock new possibilities for researchers worldwide. Through abm’s expansive global distribution network, the scientific community will gain greater access to DIVA’s biobank, which features a diverse range of customizable biological materials derived from human adipose and skin tissue (such as preadipocytes, fibroblasts, keratinocytes, RNA & protein extracts, and secretions media)— Researchers can select samples based on key donor characteristics such as gender, age, Body Mass Index and medical background. With prequalified samples and comprehensive clinical data, researchers can trust the quality and reliability of the materials. Together, we are committed to driving scientific innovation and supporting transformative research on a global scale. Let’s break new ground in life sciences! Join us on this exciting journey! #ABMxDIVA #CellResearch #PharmaceuticalResearch #Innovation #LifeSciences #ResearchExcellence #Collaboration

WEBINAR: 📣 Rebroadcast of the Live from the Lab: Solutions for Multi-Omics Research from June 13, 2024 📊 Title: Single-cell spatial metabolomics and lipidomics using AP-SMALDI and Orbitrap technology 🔬 Date: Thursday, August 22, 2024 📆 Time: 11:00 AM Central European Summer Time ⏰ Duration: 30 minutes ⏱ Register at https://rb.gy/3c3pdb In this session, Max A. Müller (TransMIT GmbH) discusses the importance of investigating single cells using mass spectrometry imaging. He explains how single cells come in various shapes and sizes, and how studying them at a bulk level may not provide accurate insights due to differences between cell phenotypes. Mass spectrometry imaging allows for high-resolution analysis, capturing the intricate details of single cells. Max delves into the technical aspects of mass spectrometry imaging, including the use of a specialized objective lens and the importance of high lateral resolution and mass resolving power. He showcases several examples, such as investigating schistosomiasis and its impact on liver tissue, exploring the biochemical processes of apoptosis in intestinal organoids, and analyzing microglial cells in the central nervous system. Don't miss this opportunity to learn from Max's expertise and gain insights into the cutting-edge field of mass spectrometry imaging! 🎯 Can't attend the webinar broadcast? No problem! Register anyway and you will automatically receive the link to the recording. 📄 Register at https://rb.gy/3c3pdb #MassSpectrometryImaging #SingleCellAnalysis #MultiOmicsResearch #Webinar #LifeSciences #Biotechnology #ResearchAndDevelopment #CuttingEdgeTechnology #Science #Innovation #WebChanges #AnatecyhWebChanges #Anatech