AI-Driven Drug Development: Safer, But Is It also More Effective?🚀 Recent studies (link in first comment) reveal that #AI-derived drugs have a higher success rate in phase 1 clinical trials compared to historic averages. Yet, efficacy remains a challenge, with no notable improvement in phase 2 and 3 success rates. 📊 What does this mean for the future of drug development? 🔬 Higher safety: AI-discovered molecules have an 80–90% success rate in phase 1 clinical trials, substantially higher than historic industry averages. 📈 Comparable efficacy: In phase 2, the success rate is ∼40%, based on a limited sample size, similar to historic industry averages. 🧩 Room for growth: No significant improvements have been observed in phase 3 success rates, leaving clinical efficacy prediction an open challenge. Predicting clinical efficacy remains an unsolved puzzle—and that’s where the #VPE Team, led by Douglas McCloskey, is focusing their efforts at BioMed X Institute. 💡 Join us TONIGHT for our webinar in partnership with Code Ocean: AI Agents for Pharma R&D 📅 When: ❗New Date ❗December 17th, 2024 | 12 pm EST / 9 am PT 📍 Where: https://lnkd.in/eXZs5Gtr Let’s collaborate to shape the future of AI in drug development. Share your insights! 💬 #AIinPharma #DrugDevelopment #ClinicalTrials #PharmaRND #ArtificialIntelligence #LifeSciences #DrugDiscovery #HealthTech #Innovation #MedTech #AIResearch
BioMed X Institute’s Post
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🔬 Exciting News in the World of Artificial Intelligence and Drug Development 🚀 AlphaFold, the groundbreaking software developed by GoogleAI, has been enhanced to propel the study of proteins 🧬 to new heights and accelerate drug development 💊. This upgrade marks a significant milestone in the intersection of technology and healthcare. 🌟 The upgraded AlphaFold software promises to revolutionize how we understand and manipulate proteins, unlocking vast potential in drug discovery and development. 👨🔬 Led by Demis Hassabis, Google’s AI chief, this advancement showcases the power of artificial intelligence in transforming complex scientific processes. 🧪 With enhanced capabilities, researchers and pharmaceutical companies can potentially expedite the discovery of novel drugs for various diseases, providing hope for improved treatments. 🔍 By offering a deeper understanding of protein structures, AlphaFold's upgrade opens doors to more precise drug targeting and design, potentially leading to more effective therapies. In conclusion, the evolution of AlphaFold stands as a testament to the incredible strides being made in AI-powered solutions for scientific innovation 🌐. This advancement not only holds promise for the future of drug development but also underscores the potential of AI to drive impactful change in various fields. Stay tuned for more groundbreaking developments! #ArtificialIntelligence #DrugDevelopment #AlphaFold #Innovation ⚛️🔝
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BIP xTech and Harvard Extension School Capstone Program 🎓 Last week we kicked off the BIP xTech challenge in collaboration with the Harvard Extension School! This innovative initiative focuses on leveraging Generative AI to revolutionise the commercial access of the Pharma industry. Special thanks to Professor Henrik Totterman, D.Sc. for his invaluable support and guidance in shaping this program. We also appreciate the efforts of Antonio Corghi and Silvia Ondategui-Parra, MD, MPH, MSc, PhD, our key stakeholders from BIP Life Science and BIP xTech teams, whose vision and leadership have been instrumental in launching this challenge. As part of this exciting challenge, students from the Harvard Extension School will engage in intensive research and strategic planning to explore how AI can enhance pharmaceutical commercialization, business operations, and the launch of new drugs. The insights and solutions developed during this program aim to empower the pharmaceutical sector with cutting-edge AI capabilities. #HereToDare #TogetherWeGoFurther #BIPxTech #HarvardExtensionSchool #GenerativeAI #PharmaInnovation
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“To help scientists make cost-aware choices, MIT researchers developed an algorithmic framework to automatically identify optimal molecular candidates, which minimizes synthetic cost while maximizing the likelihood candidates have desired properties. The algorithm also identifies the materials and experimental steps needed to synthesize these molecules. Their quantitative framework, known as Synthesis Planning and Rewards-based Route Optimization Workflow (SPARROW), considers the costs of synthesizing a batch of molecules at once, since multiple candidates can often be derived from some of the same chemical compounds. Moreover, this unified approach captures key information on molecular design, property prediction, and synthesis planning from online repositories and widely used AI tools.” #SPARROW #algorithmdevelopment #drugdiscovery #innovation #healthcare #medicine #drugdevelopment #research #science #technology #biotech #techbio #pharma https://lnkd.in/gPaz4wS2
A smarter way to streamline drug discovery
news.mit.edu
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Using an AI algorithm (SPARROW - Synthesis Planning and Rewards-based Route Optimization Workflow) to select which small molecules to make/test in drug discovery projects, taking into account how easy it is to make them. Massachusetts Institute of Technology, Nature Portfolio #smallmolecule #drugdiscovery #medicinalchemistry #syntheticchemistry #artificialintelligence
A smarter way to streamline drug discovery
news.mit.edu
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Today, our Academic Dean, Salavadi Easwaran delivered a guest lecture at The Oxford College of Science on the role of artificial intelligence in the biopharma and pharma sectors, focusing on early-stage drug discovery and diagnosis. The session highlighted how AI speeds up the process of identifying potential drug candidates, refines clinical trials, and increases diagnostic accuracy. Participants were also introduced to the integration of AI at different stages of drug development, its use in predictive analytics, and its transformative effects on healthcare innovation. #ai #biosciences #biotechnology #drugdiscovery #healthcare #growth #innovation #learning #pharma #predictiveanalytics #science #technology
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Welcome to Topic #15 in our CADD series, where we spotlight the 5 Groundbreaking CADD Technologies Transforming Drug Discovery in 2024. In this edition, we’ll explore how these innovative tools are revolutionizing the drug development process, making it faster, more accurate, and more accessible. These five technologies are not just shaping the future—they are already transforming drug discovery today. If you work in the #CADD, #biotech, or #pharma space, these are the innovations to watch as they revolutionize the drug discovery process and push the boundaries of what's possible in molecular design! #CADD #DrugDiscovery #AI #MachineLearning #Biotechnology #QuantumComputing #Innovation
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Advances in #biotechnology and #AI are ushering in a new era in medicine, marked by the rapid discovery of therapeutic targets and innovative treatments. In this article, we explore key trends revolutionising medicine, including biologics growth, transformative curative therapies, AI in drug discovery, and the impact of #multiomics on early detection and personalised care. Read more about this topic: https://bit.ly/3O4K8uI Capital at Risk. #ARKInvest #ETFs #ThematicInvesting #GenomicRevolution
The Transformative Potential of Biotechnology and AI in Healthcare - ARK Invest Europe
https://europe.ark-funds.com
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The future of AI in healthcare and drug development has been transformed by the groundbreaking collaboration between Takeda Pharmaceutical Co. and MIT School of Engineering. This program has resulted in a multitude of research papers, discoveries, and even a patent for a system that improves small-molecule medicine manufacturing. The advantages of this collaboration include the potential for AI to revolutionize the pharmaceutical industry and the opportunity for MIT students and faculty to work on real-world problems. Challenges include the risk of AI becoming uncontrollable and misaligned with human values. These insights and advancements can be applied in various AI-related scenarios, such as using AI to analyze speech for early detection of diseases or improving manufacturing processes. What do you think will be the biggest impact of AI in healthcare and drug development? Hi, 👋🏼 my name is Doug, I love AI, and I post content to keep you up to date with the latest AI news. Follow and ♻️ repost to share the information! #artificialintelligence #healthcare #drugdevelopment
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The fusion of artificial intelligence and drug discovery is revolutionizing healthcare. Recent advancements, such as Google DeepMind's AlphaFold 3, have enhanced our understanding of protein interactions, accelerating research and drug development. Collaborations like Schrödinger's partnership with Novartis, valued at up to $2.5 billion, highlight AI's growing role in pharmaceutical innovation. However, as we embrace AI's potential, we must consider: Could the rapid integration of AI in drug discovery inadvertently overlook the nuanced complexities of human biology, leading to unforeseen challenges? This post was generated by my custom-built personal agent, powered by LLMs and designed to operate my computer. If you're curious about how it works, feel free to ask!
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🧬 Big news, folks! AI at ETH Zurich is designing new drugs based on protein structures, speeding up development and opening new doors in medical research. Check out how AI is revolutionizing healthcare here: https://lnkd.in/dE3das2b. #AI #Biotech #MedicalInnovation
AI designs active pharmaceutical ingredients quickly and easily based on protein structures
phys.org
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