Biblioteca Vall d'Hebron Barcelona Hospital Campus’ Post

Cell cycle analysis is crucial for investigating cancer therapeutics, especially to understand population heterogeneity and identify outliers with drug resistance. Livecyte combines label-free Quantitative Phase Imaging (QPI) with fluorescence to provide deep insights into cell-cycle changes. Analyse both at the population and single-cell levels to assess dry mass, growth, and time spent in each phase of the cycle. 🧬 Check out the video to see this in action 👇 #CancerResearch #CellBiology #Microscopy #DrugDiscovery #LifeSciences

Exploring the molecular intricacy of CD19: a key player in immunotherapy! 🧬 Delving into the structure of the B-lymphocyte antigen CD19 with its distinctive domains and antibody binding sites. This molecular understanding is paving the way for groundbreaking advancements in targeted cancer treatments. #Immunotherapy #CD19 #CancerResearch #MolecularBiology #Biotech #Science #HealthcareInnovation #CART #shenclinicalservices

Exosomes, nanosized vesicles released from cells, are gaining popularity as drug delivery vehicles due to their ability to escape liver homing and undesired accumulation. Bovine milk/colostrum-derived exosomes, functionalized for cancer therapeutics, show promise, including validation of anti-tumor efficacy. Check out this free webinar by our friends at Spectral Instruments Imaging on June 11, at 10 AM PDT (12 PM CDT / 1 PM EDT), and learn how milk exosomes can be utilized for targeted drug delivery & the latest advancements in RNA & DNA delivery using the Exosome-PEI-Matrix (EPM) technology: https://lnkd.in/dbPmmX-y #Oncology #Exosomes #Milk #Imaging #PreclinicalImaging

𝐄𝐱𝐜𝐢𝐭𝐢𝐧𝐠 𝐧𝐞𝐰𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐟𝐢𝐞𝐥𝐝 𝐨𝐟 𝐜𝐚𝐧𝐜𝐞𝐫 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭! The latest research by Christiane R. Stadler and team introduces BNT142, a groundbreaking lipid nanoparticle-formulated RNA encoding a novel bispecific antibody targeting CD3 and the oncofetal antigen CLDN6. This innovative approach has shown promising results in inhibiting tumor growth in preclinical models without causing adverse effects. This was followed by a phase 1/2 clinical trial to evaluate its safety and efficacy in patients with advanced solid tumors. 🚀🔬 #CancerResearch #InnovativeTherapies #MedicalBreakthroughs

Exploring extracellular vesicles as a drug delivery system for cancer therapy: in this review article, Jiabing Lian at China Medical University and collaborators offered a comprehensive overview of extracellular vesicles, detailing their biogenesis and absorption mechanisms. Additionally, they explored current research efforts aimed at utilizing EVs as drug carriers, covering purification techniques, drug loading, and bioengineering for targeted delivery https://lnkd.in/eTCm_t4Z Their analysis highlighted the potential of EVs as versatile and effective tools for drug delivery, especially in cancer therapy. An article co-authored by Jin Wang and Bohang Yin #extracellularvesicles #exosomes #drugdelivery #cancertherapy #bioengineering #Vesiculab

ACTIVE loading of vesicles with drugs results in an intra-vesicular drug concentration significantly higher than in the loading medium. For example, the remote loading of liposomes with doxorubicin via an ammonium gradient (the prototype of ACTIVE loading) yields liposomes with drug concentrations inside the liposomes >100-fold the drug level in the loading medium. I severely doubt any of the "active drug loading" methods listed in this paper are able to achieve that. Baring a special interaction of the drug with lipid membranes or components already inside EVs, the intra-vesicular drug concentration can never be higher than in the loading medium, neither by electroporation, sonication, detergent treatment, extrusion nor by freeze-thawing cycles. All these 5 methods lack a driving force leading to an ACCUMULUATION of the drug inside the vesicle. The term "active loading" is wrongly used in this paper. I am happy to be challenged on my opinion, I am open for any discussion and if I am wrong, I would be happy to stand corrected.

Identifying extracellular vesicle lncRNAs as circulating cancer biomarkers: in this review article, Panagiotis Papoutsoglou and Antonin Morillon at Institut Curie aimed to advance understanding of the functional roles of extracellular vesicles and their non-coding RNA cargo in cancer progression, emphasising the potential of EV RNA as novel diagnostic and prognostic biomarkers https://lnkd.in/g9mSntnQ The study also addresses recent technological advances and challenges in identifying EV RNA, assessing its integrity, and preserving its functionality for clinical applications. #extracellularvesicles #exosomes #biomarkers #tumorgenesis #Vesiculab

From target discovery to high-throughput screening, single-cell technologies are transforming every stage of cancer drug development. 💊 🔬 Shandong University researchers highlight the critical role of single-cell technologies in advancing cancer drug discovery and development. These tools offer unprecedented insights at the cellular level, which could lead to more effective cancer therapies. Discover More: https://lnkd.in/gWs4m_CG #bioinformatics #cancer #cancerresearch #singlecelltech #drugdevelopment #scRNAseq #transcriptomics #omics #spatialomics #pharmacokinetics #CRISPR #sciencenews

Are you interested in having a quick overview of approved targeted therapies and #CDx assays for non-small cell lung cancer (NSCLC) patients? If the answer is yes, keep reading! Did you know that there are: - 62 CDx approvals (all methodologies included) - based on 16 assays (out of which 4 are tissue- and 2 liquid biopsy NGS-based assays) and - they are manufactured by 9 providers only! On a leading position is #Roche (including Foundation Medicine) which holds 37 CDx approvals, followed by #LifeTechnologies (8 CDx's), #Qiagen (6), #GuardantHealth (4), #Agilent (Dako) (3), #Abbott (2), #PillarBiosciences (1) and #ExactSciences (Resolution Biosciences (1)).  This goes along with 24 molecularly matched therapies, of which, 3 are combo therapies. I also provide you with the list of new approvals/extensions that have occurred during Q1 2024. Let me know if this is useful (and shout if anything is missing!) ! Have a great Friday everyone! #molecularlymatchedtherapies #targetedtherapies #precisiononcology #CDx

📣 New research alert 📣 The ABACUS study showed that neoadjuvant anti-PD-L1 therapy holds great promise in treating muscle-invasive bladder cancer – an aggressive cancer that is prone to metastasis. But while activated CD8+ T cells in baseline were associated with treatment outcome, no treatment related biomarker was discovered. 🤔 In a poster presented at #ASCO2024, our team explored gene expression in different response groups using an unbiased whole transcriptome spatial approach to identify potential response biomarkers. Learn more: 👉 https://bit.ly/3x5JvvZ #Immunotherapy #Biomarkers #PrecisionMedicine #Transcriptomics