Angsana Health’s Post

This Medscape Medical News MedBrief discusses recent research that over one third of patients develop exocrine pancreatic insufficiency after acute pancreatitis. In the clinical study, the prevalence of EPI was assessed at 3 and 12 months after a case of acute pancreatitis. The study also identified the predictors of EPI, including the role of etiology and severity of acute pancreatitis and preexisting diabetes. The MedBrief summary can be found at: https://wb.md/3N8AkiI Read the journal article at: https://bit.ly/3N8gtA7 VIVUS is committed to working with gastroenterology professionals and associations in order to build awareness of EPI (Exocrine Pancreatic Insufficiency) and provide treatment options to help patients manage this lifelong condition. Visit VIVUS.com to learn more about our work in this area. #treatingEPI #ExocrinePancreaticInsufficiency #vivusllc

Tremendous key take away message at #EASLCongress where the latest clinical practice guidelines from were presented by Frank Tacke: " Patients with either #obesity or #diabetes + cardiovascular risk or elevated liver enzymes and in the intermediary zone for FIB-4 may have a liver stiffness measurement #LSM for screening and potential referral to #hepatology care." With the ultraportability of #Hepatoscope, E-Scopics intends to offer #pointofcare solutions for both LSM and quantitative steatosis measurements to #democratize the screening of at-risk patients from primary care settings. European Association for the Study of Obesity (EASO) , EASL | The Home of Hepatology , European Association for the Study of Diabetes e.V. (EASD)

🔍 A common issue I often encounter in the clinic and through numerous phone inquiries is the challenge of patients with very high triglycerides. The therapy is still complex, with many unanswered questions. 📞 Last week, I received a call from a general practitioner about a patient with triglycerides over 1000 mg/dL who couldn't tolerate any fibrates. We had to urgently decide on further treatment steps. High triglyceride levels are indeed almost an emergency in the lipid clinic 🙂 A very informative article, learn more about it: https://lnkd.in/eYz-skY3 #Hypertriglyceridemia #Lipidology 💡

Alcohol-associated liver disease (#ALD) is a major global health concern, leading to high rates of liver-related morbidity and mortality. A new Consensus Statement by Mack Mitchell, Laura Nagy & colleagues highlights the urgent need for clinical trials to explore effective treatments that integrate approaches for both ALD and alcohol use disorder (#AUD). The guidelines, published in Nature Reviews Gastroenterology & Hepatology, delve into the complexities of treating ALD alongside AUD, emphasizing the importance of combining methodologies from both fields to enhance the quality and effectiveness of clinical trials. After an extensive literature search and discussion of expert opinion, 28 recommendations for clinical trials of alcohol use and ALD were developed, with recommendations related to definitions of alcohol use, minimum data sets, statistical considerations and more. READ HERE: https://lnkd.in/eBVa_p3M An accompanying News & Views by Juliana Serrazine & Helena Cortez-Pinto puts these new recommendations into context and discuss how the new guidelines offer a structured framework for conducting research in this field, which should hopefully facilitate development of novel therapies. READ HERE: https://rdcu.be/dKNhq #alcoholusedisorder #alcoholrelatedliverdisease #liverdisease #alcoholpolicy #alcoholuse #alcoholassociatedliverdisease #steatoticliverdisease #metALD

What are the Grades of "Fatty Liver"? Grade 1 Fatty Liver: It is also called mild fatty liver or mild hepatic steatosis, where the fat deposition is up to 5% - 33%. Grade 2 Fatty Liver: It is a moderate fatty liver condition where there will be 34% - 66% of fat accumulation. Grade 3 Fatty Liver: It is a severely fatty liver where there will be more than 66% of fat accumulation in the liver. Grade 4: Liver cirrhosis. In this video, the third in an upcoming series on "Fatty Liver Disease", Dr Anusha V, Consultant Physician at Kauvery Hospital, Radial Road, Chennai, provides awareness or information about this very common yet lesser-known chronic condition.

Canada has one of the highest prevalence of irritable bowel syndrome (IBS) in the world – estimated 18% vs. 11% globally [1]. This statistic highlights the significance of understanding the underlying mechanisms contributing to IBS. Recent research has shed light on a crucial aspect of IBS pathogenesis: the lower activity of glutathione reductase in IBS patients. This enzyme plays a vital role in maintaining the balance of reduced and oxidized glutathione (GSH) in colonic cells. In IBS patients, the lower glutathione reductase activity leads to an accumulation of oxidized GSH, contributing to a heightened oxidative stress load within the colon [2]. The increased oxidative stress in IBS patients has far-reaching consequences. Not only does it impact the colonic cells directly, but it also alters the immune response within the bowel. This dysregulation of the immune system further exacerbates the pathogenesis of IBS. As healthcare professionals, it is crucial to recognize the intricate interplay between lower glutathione reductase activity, increased oxidized GSH levels, and the subsequent oxidative stress and immune dysregulation in IBS patients. By understanding these underlying mechanisms, you can develop more targeted and effective treatment strategies for your patients. Let's continue to raise awareness and share knowledge about IBS among our healthcare community. Together, we can advance our understanding of this complex condition and improve the lives of those affected. #IBSResearch #IBSPathogenesis #OxidativeStress #GlutathioneReductase #HealthcareProfessionals #IBSAwareness #DigestiveHealth References: 1. Lovell RM and Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis. Clin Gastroenterol Hepatol. 2012 Jul;10(7):712-21.e4. 2. Lorestani S, Bahari A, Asadi M, Zahedi Avval F. Evaluation of glutathione reductase activity in colon tissue of patients with irritable bowel syndrome. Horm Mol Biol Clin Investig. 2021 Jun 4;42(2):195-198. doi: 10.1515/hmbci-2020-0041. PMID: 34090318.

#Calcinosis of chronic renal failure can manifest as periarticular nodules mimicking crystalline arthropathy such as tophaceous #gout or calcium #pyrophosphate disease, or soft tissue deposits resulting in pain, ischemia, ulceration, or arteriolopathy, commonly termed #calciphylaxis. It is characterized by dystrophic calcium phosphate crystal deposits related to high calcium phosphorus product (Ca×P) commonly >70 mg/dL, and risk factors include end-stage kidney disease, longer time on dialysis (hemodialysis or peritoneal), hyperparathyroidism, diabetes, obesity, glucocorticoid use, chronic inflammatory diseases, warfarin use, female sex, protein C/S deficiency, hypervitaminosis D, and aluminum intoxication. *From: Lin, J. (2024), Clinical Image: Periarticular nodules in a patient with renal failure. ACR Open Rheumatology.  🔗https://lnkd.in/d7ZTJT6M

Treatment of liver cirrhosis encompasses a multidisciplinary approach aimed at managing symptoms, slowing disease progression, and addressing underlying causes. Dr. Vivek Vij, Chairman of Liver Transplant & Hepatobiliary Science at Fortis Hospital, Noida, sheds light on the comprehensive procedures for #WorldLiverDay. From alcohol abstinence and dietary modifications to managing complications and regular monitoring, a personalized treatment plan is crucial. Medications can help manage symptoms and prevent further liver damage. For end-stage cirrhosis, a liver transplant may be the only option, providing a new lease on life for suitable candidates. #AtFortisWeCare #FortisHealthcare

Analysis Finds Bidirectional Association Between Asthma and Psoriasis: The study authors recommend that health care professionals are aware of the connections, notably in adolescent patients and those with moderate to severe psoriasis. #finance #pharmacy #lifesciences

📚 Our latest article, published in Quality of Life Research, investigated the effect of ferric derisomaltose (FDI) and ferric carboxymaltose (FCM) on quality of life in individuals with inflammatory bowel disease (IBD) and iron deficiency anaemia (IDA): https://lnkd.in/eRK-rKiA 📈 The post hoc analysis of the PHOSPHARE-IBD randomized controlled trial showed significant improvements in SF-36v2 scale scores (excluding the Bodily Pain scale) and health state utility values with both FDI and FCM. However, Vitality scores showed a significantly larger improvement with FDI versus FCM (p=0.026) and the overall utility changes were completely explained by the Vitality score improvements. 💡 Patients with the smallest decrease in post-iron phosphate had significantly larger improvements in Vitality scores at each time point (p≤0.05 for all comparisons) and overall (p=0.0006), strongly suggesting that hypophosphataemia brings about fatigue that attenuates improvements in quality of life arising from the correction of anaemia. With many thanks for the expertise provided by our inimitable coauthors Nick Kennedy, Jakob Bjørner, and Prof. Stefan Lindgren, and to Pharmacosmos for their financial support. #InflammatoryBowelDisease #Anaemia #QualityOfLife #HealthOutcomes #MedicalResearch #IronDeficiency