Aline Gomez-Acebo Finat’s Post

[#Publication] Very excited to share the new collaborative publication in JAMA Network Open led by Dr. Muralidharan Sargurupremraj and involving RHU SHIVA researchers: "Cerebral Small Vessel Disease, Blood Pressure, and Dementia". ➡ Using mendelian randomization, this study showed: - a putative causal association of larger white matter hyperintensity (WMH) burden with increased #Alzheimer disease risk after accounting for pulse pressure effects, - an association of lower blood pressure with #Alzheimer disease risk with possible confounding by shared genetic instruments. 📈 Longitudinal analyses on individual-level data supported the association of genetically determined larger WMH with incident all-cause dementia and Alzheimer disease, independently of interim stroke. 💡 These findings suggest that white matter hyperintensity is a primary vascular factor associated with dementia risk, emphasizing its significance in preventive strategies for dementia. Future studies are warranted to examine whether this finding can be generalized to non-European populations. The article here: https://lnkd.in/eKZgDfNp Debette Stéphanie Muralidharan Sargurupremraj Sudha Seshadri Lenore Launer Carole Dufouil Christophe Tzourio helene Jacqmin-Gadda Aniket Mishra Geneviève Chêne Université de Bordeaux CHU de Bordeaux Station Santé UT Health San Antonio ANR (Agence nationale de la recherche) #France2030

Neurxstem is advancing on a solid scaffold of innovative technology and rigorous scientific data developed patiently to first find the upstream "drivers" of aging and neurodegenerative diseases. We now have promising drugs that show significant efficacy for normalizing the dysregulated gene networks that are the drivers of these diseases! Stay tuned, the best is yet to come! 🙏 We are all about Integrity, Innovation and Implementation to make the Impossible, Possible for the Patients! 🙌 Science Without Humanity "If science becomes all technique and technology, it quickly degenerates into man against humanity. Technologies come from the paradigms of science. And if there's very little understanding of the higher human purposes that the technology is striving to serve, we become victims of our own technocracy. We see otherwise highly educated people climbing the scientific ladder of success, even though it's often missing the rung called humanity and leaning against the wrong wall." - Mahatma Gandhi #aging #neurodegeneration #alzheimers #parkinsons #longevity #healthspan #cancer #nutrition #environment #microbiome #infectiousdisease #NIH #DARPA #DOD #Investors #Venturecapital #philanthropy #patients

New genetic cause of obesity could help guide treatment Via ScienceDaily: https://bit.ly/3Y2XjCq. "Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese. A team of international researchers, led by the University of Exeter, discovered that people with a genetic variant that disables the SMIM1 gene have higher body weight because they expend less energy when at rest. SMIM1 was only identified 10 years ago, whilst searching for the gene encoding a specific blood group, known as Vel. The study also found that people without both copies of the gene have other measures linked to obesity including high levels of fat in the blood, signs of fat tissue dysfunction, increased liver enzymes as well as lower levels of thyroid hormones. The new research is published in Med and was funded by the National Institute for Health and Care Research and the British Heart Foundation. The collaboration included partners at the University of Cambridge, the Sanger Institute, the Copenhagen University in Denmark, and the Lund University in Sweden. Lead author Mattia Frontini, Associate Professor of Cell Biology at the University of Exeter Medical School, said: ""Obesity rates have nearly tripled in the past 50 years, and by 2030, more than one billion individuals worldwide are projected to be obese. The associated diseases and complications create significant economic burden on healthcare systems. Obesity is due to an imbalance between energy intake and expenditure, often a complex interplay of lifestyle, environmental, and genetic factors. In a small minority of people, obesity is caused by genetic variants." #ObesityGene #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences

Unlocking the Secrets to Longevity: The Role of the FOXO Gene 🤔 Have you ever wondered why some people live longer and healthier lives? The answer might lie within our DNA, specifically in a gene known as FOXO. Research has shown that variations in the FOXO gene are associated with increased lifespan and improved insulin sensitivity, playing a pivotal role in longevity (Kenyon, Cynthia, 2010). The FOXO gene is part of a family of transcription factors that regulate various processes in the body, including apoptosis, cell-cycle control, glucose metabolism, and oxidative stress resistance. It acts as a cornerstone in the delicate balance of cellular health, influencing how well our bodies can fend off diseases and aging-related decline (Lopez-Otin, Carlos, et al., 2013). In light of these discoveries, the relevance of genetic testing and personalized health coaching has never been more apparent. By understanding your genetic makeup, specifically your FOXO gene variations, you can take proactive steps towards a longer, healthier life. 🚀 Take Action Now for a Healthier Tomorrow! Dive into your genetic blueprint with our state-of-the-art DNA testing services. Don't just stop there; let our expert health coaches guide you through personalized strategies to harness your genetic potential for longevity. Embrace the future of health and wellness today! 🧬 Discover your path to longevity. Order your DNA test and schedule your first coaching session now! https://lnkd.in/ete6Tg9q References: Kenyon, Cynthia J. “The genetics of ageing.” Nature vol. 464,7288 (2010): 504-12. doi:10.1038/nature08980 López-Otín, Carlos et al. “The hallmarks of aging.” Cell vol. 153,6 (2013): 1194-217. doi:10.1016/j.cell.2013.05.039 #longevity #wellness #dna #dnatesting #dnacoaching #foxo #genes Genetic Direction (ISSA) International Sports Sciences Association Springer Nature Group Cell Biology

While this is a huge deal, and should be celebrated, it's also worth noting we've known about the genetic relationship between age related illness and specific proteins for years. We've also been able to selectively alter and reactivate genes for a number of years. It shouldn't be taking this long for small step research that could potentially transform health and medicine. https://lnkd.in/guMked8h.com%2Fscience%2Fscientists-can-tweak-one-gene-to-extend-lifespans-by-up-to-30%2F&utm_campaign=aga&utm_source=agsadl1%2Csh%2Fx%2Fgs%2Fm2%2F4

Scientists have unveiled a groundbreaking discovery shedding light on how malfunctioning mitochondria, the powerhouses of our cells, contribute to harmful inflammation associated with diseases like lupus and rheumatoid arthritis. 🔍 What Did They Find? Mitochondria, when not replicating genetic material correctly, trigger a cascade of events leading to the release of mitochondrial DNA (mtDNA) into cells. The excess mtDNA prompts the immune system to launch an inflammatory response, potentially leading to autoimmune and chronic diseases. 💡 Why Does This Matter? Understanding this process opens doors to new treatment avenues for various diseases, potentially revolutionizing healthcare. By targeting the mechanism behind the leaky mitochondria, researchers hope to develop therapies to mitigate harmful inflammation and its associated health impacts. 👩🔬 What's Next? The research team aims to delve deeper into the physiological contexts and disease scenarios where this process becomes activated. They also plan to explore whether viruses targeting mitochondria activate this pathway, potentially informing strategies for fighting infections and preventing chronic diseases. Find the full article here: https://lnkd.in/gfd_556M #science #mitochondria #cellbiology

New genetic cause of obesity could help guide treatment Via ScienceDaily: https://lnkd.in/e2xn57SS. "Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese. A team of international researchers, led by the University of Exeter, discovered that people with a genetic variant that disables the SMIM1 gene have higher body weight because they expend less energy when at rest. SMIM1 was only identified 10 years ago, whilst searching for the gene encoding a specific blood group, known as Vel. The study also found that people without both copies of the gene have other measures linked to obesity including high levels of fat in the blood, signs of fat tissue dysfunction, increased liver enzymes as well as lower levels of thyroid hormones. The new research is published in Med and was funded by the National Institute for Health and Care Research and the British Heart Foundation. The collaboration included partners at the University of Cambridge, the Sanger Institute, the Copenhagen University in Denmark, and the Lund University in Sweden. Lead author Mattia Frontini, Associate Professor of Cell Biology at the University of Exeter Medical School, said: ""Obesity rates have nearly tripled in the past 50 years, and by 2030, more than one billion individuals worldwide are projected to be obese. The associated diseases and complications create significant economic burden on healthcare systems. Obesity is due to an imbalance between energy intake and expenditure, often a complex interplay of lifestyle, environmental, and genetic factors. In a small minority of people, obesity is caused by genetic variants." #ObesityGene #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences

reverse aging gene therapy

Join us tomorrow. We’re hosting a complimentary live webinar with Dr. Stephanie Seneff on Deuterium Depletion & Health, a hot topic gaining significant attention across social media. We want to give you the opportunity to hear directly from Dr. Seneff on how deuterium may be impacting your patients' health. Deuterium, a stable isotope of hydrogen, is now being recognised as potentially having a greater effect on health than previously understood. Dr. Seneff, who has been closely following the latest research, will provide clear insights into why we should be paying attention to deuterium and what practical steps you can take in your clinical practice. Time/Date: AEDT (Sydney) - Tuesday 8 am, 8th October NZDT (Akl) - Tuesday 10 am, 8th October PDT (US/Can) - Monday 2 pm, 7th October EDT (US/Can) - Monday 5 pm, 7th October MDT (US/Can) - Monday 3 pm, 7th October UK (GMT) - Monday 10 pm, 7th October Where: Register using the link below and join us at the time above. There's no software to download, just open the course lesson at the time to attend live. Add it to your calendar now. Deuterium differs from regular hydrogen because its nucleus contains both a proton and a neutron, while hydrogen typically has just a proton. Though naturally present in water at around 150 parts per million, deuterium exists in trillions of atoms within each of our cells. Emerging research shows that high levels of deuterium can negatively affect health by binding more tightly to other molecules, potentially slowing metabolic reactions, causing mitochondrial dysfunction, reducing insulin sensitivity, altering gene expression, and increasing oxidative stress. These effects are linked to a wide range of conditions, and Dr. Seneff will walk you through how these issues arise and how you can help patients lower their deuterium levels for better health outcomes. Register now to attend this LIVE Webinar on the 8th of October 2024 at 8am (Sydney time). Add the time to your calendar now and turn up to the lesson page on the day. Easy! https://lnkd.in/gKVQaV-M