Abdulaziz Asbeutah’s Post

LONDON — Single-pill combinations that include three or four antihypertensive medications are the way forward for the management of patients with elevated blood pressure, according to experts evaluating the new approach. This multidrug strategy — in which ultralow-dose triple combinations can be used as a starting treatment and four full-dose combinations can be used to treat resistant hypertension — has shown an impressive ability to lower blood pressure in several new studies. But will it catch on as a routine treatment recommendation in current practice? Studies of treatment strategies that involve an ultralow quarter dose of three drugs that lower blood pressure and then escalation to a half-dose triple combination and then to a full-dose triple combination, all given as a single pill, were presented at the European Society of Cardiology (ESC) Congress 2024. Another strategy presented involves a four-drug full-dose combination in patients with resistant hypertension.

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https://lnkd.in/gukWq9Em Article title: Resveratrol and Spirulina: Nutraceuticals that Potentially Improving Cardiovascular Disease Author(s): Yifan Wang; Maria Fides Ocampo; Bianca Rodriguez; Jiwang Chen Journal: Journal of Cardiovascular Medicine and Cardiology Journal ISSN: 2455-2976 Abstract: Resveratrol (3,5,4’-trihydroxy-trans-stilbene) is an extensively studied nutraceutical with several proposed health benefits, including cardio protection, antimetabolic syndrome, and antiatherogenic effects. It was brought to popularity through the proposed “French Paradox” and the consumption of red wine. It has been shown to down regulate the activation of numerous inflammatory and oxidative stress markers with therapeutic potentials. Spirulina (Arthrospira platensis), on the other hand, is a highly nutritional nutraceutical that has not been sufficiently studied. However, several in vitro and animal studies point to its hypolipidemic and antihypertensive properties, which are similar to resveratrol. Although resveratrol and Spirulina both constitutes functional foods with potential therapeutic effects on several cardiovascular diseases, there are few compelling clinical evidence to support their applications in human patients. This warrant further evaluation in clinical trials. This article reviews and evaluates the beneficial effects of the two different nutraceuticals in order to demonstrate their potential in clinical application in patients with cardiovascular diseases. #Resveratrol #Spirulina #CardiovascularDiseases #Dietary #Reviews #CoronaryArteryDiseases #ValvularHeartDisease #Electrophysiology #CardiacElectrophysiology #Echocardiography #InterventionalCardiology #ClinicalCardiology #NuclearCardiology #AcuteCoronarySyndromes #ArrhythmiaEP #CVImaging #CVDPrevention #CardiacArrhythmias #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #CardiacPhysiology #CardiacRegeneration #CardiacRehabilitation #Cardiomyopathies #CardiovascularDrugs #CardiovascularTherapy #CardiovascularAnatomy #CongenitalHeartDefects 

Ahead of print Neutrophil-to-lymphocyte ratio and prognostic nutritional index in predicting composite endpoint of early safety following transcatheter aortic valve replacement The incidence of composite endpoint of early safety (CEES) after transcatheter aortic valve replacement (TAVR) has been a topic of focus within the cardiovascular field due to its impact on long-term patient outcomes. Timely prophylactic interventions are crucial for patients identified as high risk for CEES through preoperative risk stratification. This study aimed to explore the connection between inflammatory and nutritional markers, specifically the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI), and CEES occurrence. https://lnkd.in/d4iVWu45

Unmet Needs in the Management of Patients with Hyperlipidemia: Craig Beavers, PharmD, FACC, FAHA, FCCP, BCCP, BCPS-AQ Cardiology, CACP, discusses how maximally tolerated statin therapy often fails to achieve target low-density lipoprotein cholesterol levels in high-risk patients with atherosclerotic cardiovascular disease and share strategies for optimizing adherence, including when to switch therapies to improve patient outcomes. #finance #pharmacy #lifesciences

#Clinical Use and Interaction of Intravenous Noradrenaline and #MethyleneBlue Mechanism of Action #Noradrenaline (Norepinephrine) - Primary vasopressor used in septic shock - Increases systemic vascular resistance and blood pressure #MethyleneBlue - Inhibits soluble guanylyl cyclase. - Reduces nitric oxide production and improves vasoconstriction. Clinical Applications #Refractory #SepticShock - Methylene blue can be used as an adjunctive therapy to noradrenaline in refractory septic shock . - Potential to improve hemodynamics and reduce vasopressor requirements. #Hemodynamic Effects Mean Arterial Pressure (#MAP) - Methylene blue administration can significantly improve MAP in patients with refractory shock. #Vasopressor Requirements - Methylene blue may decrease the need for noradrenaline and other vasopressors. - Patients responding to methylene blue are more likely to have vasopressor-free time within 24 hours. Dosing and Administration Methylene Blue - Typically administered as an intravenous bolus - Recommended dose: 2 mg/kg over 20 minutes. Potential Benefits Improved Hemodynamics - Methylene blue can enhance the vasoconstrictive effects of noradrenaline. - May lead to faster stabilization of blood pressure in septic shock Reduced ICU Stay and Mechanical Ventilation - Methylene blue treatment associated with shorter ICU stays and fewer days on mechanical ventilation. onsiderations and Caveats Patient Selection - Not all patients with septic shock respond to methylene blue. - Careful monitoring required to identify responders. Potential Side Effects - Methylene blue may affect noradrenaline metabolism and storage in sympathetic nerves. - Monitoring for methemoglobinemia is recommended, although significant elevations are rare. Limited Impact on Mortality - While hemodynamics may improve, current evidence does not show a significant reduction in overall mortality. #Conclusion The combination of intravenous noradrenaline and methylene blue shows promise in managing refractory septic shock. Methylene blue can potentially enhance the vasoconstrictive effects of noradrenaline, leading to improved hemodynamics and reduced vasopressor requirements. However, its use should be carefully monitored, and further research is needed to fully establish its impact on long-term outcomes.

Effect of High-Flow Nasal Cannula Flow on Intrapharyngeal Pressure During Fiberoptic Bronchoscopy Under Deep Sedation Abstract BACKGROUND: The flow reaching the vocal folds may be lower than that at the output of high-flow nasal cannula (HFNC) system. This could be due to upper-respiratory obstruction, oxygen leakage, or other factors. The objective of this study was to observe the effect of flow through a nasopharyngeal airway on intrapharyngeal pressure (IPP) in subjects undergoing fiberoptic bronchoscopy (FOB). METHODS: Patients scheduled for FOB were invited to participate. Measurements were performed at flows of 0–60 L/min; the subjects wore WN-N95 folding medical protective masks (N95) and either underwent FOB or not. IPP at each flow was recorded following 15 s of ventilation, and the cross-sectional area (CSA) of the gastric sinus was measured before and after FOB. Hypoxemia, reflux aspiration, and other pertinent events were recorded. RESULTS: Sixty subjects undergoing FOB at the Affiliated Hospital of Jiaxing University participated in this trial from October 2022–September 2023. IPP increased significantly with an increase in flow and also increased after placing the N95 mask with the same flow (P < .001). When results from before to after FOB were compared, the difference in CSA was statistically significant 263.6 (220.7–300.5) mm2 vs 305.5 (275.4–329.5) mm2, P < .001, but the difference in the risk of reflux aspiration was not statistically significant (0% vs 6.7%, P = .13). Complication rates during treatment were 8.3% for hypoxemia, 0% for reflux aspiration, 1.7% for hypertension, 1.7% for hypotension, 6.7% for tachycardia, 5% for bradycardia, and 10% for postoperative nausea and vomiting. CONCLUSIONS: HFNC can provide effective oxygen therapy for people undergoing FOB, and increases in IPP with flow in the range of 0–60 L/min may not increase the risk of reflux aspiration.

Fresh off press - Xylitol [Commonly used sweetner] is associated with incident MACE risk. Moreover, xylitol both enhanced platelet reactivity and thrombosis potential in vivo. Further studies examining the cardiovascular safety of xylitol are warranted. #healthcare #cardiology #fda #drugs #lifescience #Sweetner #Research

Check out these new findings on Semaglutide for liver and muscle health in patients with T2DM and MASLD by katsutoshi sugimoto & Takao Itoi ⬇️ 🩺 Semaglutide treatment for 6 months significantly reduced fat in the liver and muscles, leading to better liver function and improved diabetic status. 📉 Patients saw their HbA1c levels drop from 6.8% to 5.8%, showing much better blood sugar control. ⚖️ While there was a trend towards weight and BMI reduction, liver and muscle fat significantly decreased without losing muscle mass. We're discovering even more benefits of semaglutide. It not only helps with diabetes and weight loss but also significantly improves liver function- which is huge because NAFLD now affects over 25% of the global population. Semaglutide might just be the all-in-one treatment we need for multiple health problems, and combining it with healthy lifestyle choices could lead to even greater health benefits and improved quality of life. Link to the Study: https://lnkd.in/ggKsnqqY #Diabetes #Liver #Health #Healthcare #Muscle #Fat #Semaglutide #PublicHealth #Science #Ozempic #Wegovy #T2DM #MASLD #NAFLD #NASH #Weightloss #Metabolic #Clinical #Research #Endocrinology #Healthcare #Weight #Habits #Management Endocrine Society American Diabetes Association Fatty Liver Alliance