Susan Preston

AI and Med Tech in Focus   AI System Developed to Identify Pathology in Tissues Engineers at Washington State University have developed an AI tool that uses images of human and animal tissue to detect abnormalities faster and more accurately than people. The AI algorithm was trained using images from past studies that involved kidney, testes, ovarian, prostate, breast and lymph node abnormalities. The new model detected disease in minutes—current processes take humans several hours and require specialized teams to check each other’s work. It was also found to be more accurate, sometimes detecting instances that humans had missed. The engineers designed the system to handle the processing load of the high-resolution gigapixel images by breaking them down into smaller tiles but still retaining the overall context of the tissue sample—akin to the zoom feature on a microscope or phone camera. Aside from getting diagnostic results more accurately and quickly, the new system also shows promise in epigenetics (the study of molecular processes that change gene behavior without changing underlying DNA). Epigenetic researchers can perform analyses and get results that used to take a year or more in just a couple of weeks. VC Investors are always adjusting their "Play Book" with a variety of options for investing. Mikal Ventures is one of those alternatives, offering curated solutions to real world problems. Reach out if you have questions on how we can be of assistance and bookmark https://mikalventures.com/ for additional insights and information.

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Climate change often focuses on reducing carbon emissions, but what about methane? Unlike carbon, which is a waste captured for disposal, methane holds untapped potential as energy that can be repurposed. Startup Windfall Bio’s solution intrigued me: Methane-eating microbes that convert emissions into fertilizer. They supply them to industries like agriculture, oil and gas, and landfills, where companies have the option to either use the fertilizer themselves or sell it for additional revenue. This not only offers a low-cost alternative to traditional carbon capture methods but also creates a near-term revenue stream for companies. While carbon reduction has long been the focus, methane's shorter lifespan (10-12 years) and potential for repurposing make it a promising avenue for immediate impact. Founder: Josh Silverman “It was a long road getting here, lots of years of zero traction.. Now that the traction is there and there aren’t very many people working in this area, there aren’t that many competitors. We are the best of the very few options. As I’ve said, ‘in my land of the blind, the one-eyed man is king.’” #Climate #Innovation #Methane

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AI and Med Tech in Focus   AI System Developed to Identify Pathology in Tissues Engineers at Washington State University have developed an AI tool that uses images of human and animal tissue to detect abnormalities faster and more accurately than people. The AI algorithm was trained using images from past studies that involved kidney, testes, ovarian, prostate, breast and lymph node abnormalities. The new model detected disease in minutes—current processes take humans several hours and require specialized teams to check each other’s work. It was also found to be more accurate, sometimes detecting instances that humans had missed. The engineers designed the system to handle the processing load of the high-resolution gigapixel images by breaking them down into smaller tiles but still retaining the overall context of the tissue sample—akin to the zoom feature on a microscope or phone camera. Aside from getting diagnostic results more accurately and quickly, the new system also shows promise in epigenetics (the study of molecular processes that change gene behavior without changing underlying DNA). Epigenetic researchers can perform analyses and get results that used to take a year or more in just a couple of weeks. VC Investors are always adjusting their "Play Book" with a variety of options for investing. Mikal Ventures is one of those alternatives, offering curated solutions to real world problems. Reach out if you have questions on how we can be of assistance and bookmark https://mikalventures.com/ for additional insights and information.

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🌟Innovative VC Firm Overcomes Exits Drought with Secondary Sales🌟 ⛵Navigating a challenging landscape where exits are scarce, Santa Barbara Venture Partners (SBVP) has pioneered a novel approach to sustain its growth and attract investors for its second fund: secondary sales. Instead of waiting for traditional exits like IPOs or acquisitions, SBVP opted to sell shares of its portfolio companies, demonstrating its ability to generate returns for investors and stand out in a competitive market. 🎤According to Dan Engel, founder and managing partner of SBVP, these secondary transactions have been a game-changer, sparking investor interest and bolstering the firm's credibility. By leveraging its recent successes, including a lucrative stake in sports-betting company DraftKings Inc.' acquisition of digital lottery app Jackpocket, SBVP seized the opportunity to return profits to its limited partners (LPs) and pave the way for its second fund. 💡Engel highlighted the challenges faced by young VC firms in raising subsequent funds, particularly amid a downturn in exit activity and heightened investor scrutiny. With traditional exit routes becoming increasingly elusive, the pressure is on for firms to demonstrate tangible returns and establish a track record of success. ✨"For us, secondary sales have been a game-changer. They've helped us return profits to our LPs and attract investors for our second fund," said Dan Engel. 💰For SBVP, the decision to pursue secondary sales was driven by the need to provide liquidity to LPs and validate its investment thesis in the eyes of prospective investors. By strategically offloading portions of its holdings in high-performing portfolio companies like Bark Technologies and Rad AI, SBVP not only generated substantial returns but also bolstered investor confidence in its ability to deliver results. ⚠Despite the complexities and potential stigma associated with early share sales, Engel emphasized the importance of prioritizing investor returns and seizing opportunities to unlock value for stakeholders. With a focus on profitability and transparency, SBVP remains committed to its mission of delivering sustainable growth and maximizing returns for its LPs. 🔍 "Returning profits to our investors is our top priority. By strategically selling shares, we're proving our commitment to delivering results and driving value for our stakeholders," added Engel. As SBVP continues to explore secondary transactions and expand its investor base, the firm stands as a testament to innovation and resilience in the face of market challenges. 🚀 ✅ Looking to raise capital for your #fund and increase the international pool of your LP #investors?   🤝 Need warm #LP introductions?   📝 Selling #secondaries to increase liquidity?   🧐 Looking for co-investments?   ▶ G+QUANT's link for inquiries and fund decks: https://lnkd.in/gjC_EuTE #VCInnovation #SecondarySalesSuccess #InvestorReturns #ValueCreation 

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Last week, I had the pleasure of moderating a discussion on navigating FOAK in climate tech at the Greentown Labs Summit in Boston (which had >600 people!!). Here’s a quick rundown of what was shared by Katherine St. James of Spring Lane Capital, Paris Smalls, PhD of Eden GeoPower, and Hannah Friedman of Planeteer Capital: 🌱 What is the definition of FOAK? We discussed how the term can be controversial - it's almost too general because it doesn't identify what kind of "First" FOAK refers to - first team project? First geography? First of a technology in a sector? First time for the integration of a system? It's also too specific because it has the word "first" in it, which can be anathema to later stage / project finance investors. 💰 Partnerships for Funding FOAK Projects We discussed how important it is to build a blended capital stack & use off-balance sheet capital for a project so you're not using the most expensive equity dollars to fund an infrastructure project with low-ish IRR. We also talked through being creative about using corporate partners to provide in-kind services or ink some agreement (at least an LOI) to attract this funding. 🏛 Role of Government We talked about how government capital is seen by investors & how it can be catalytic for FOAK. Government capital can provide validation that a startup has passed a rigorous diligence process by a third party - and incentives like grants or credits can help improve returns for the first project- but it's important to be doing this in conjunction with getting customer validation and to be able to present line of sight to competitive economics without concessionary capital. 👥 Advice for FOAK startups The panelists offered some very specific pieces of advice for startups going through FOAK: how to get creative with things like revenue sharing agreements or convertible notes, getting smart with project development early on (like with DeveloperU), being careful about using FOAK too liberally with certain investor groups, getting the right commercialization / FOAK talent in and around you early Huge thanks to the panelists and the team at Greentown Labs (Jill Kirkpatrick, Julia Travaglini, Aisling Carlson, etc you rocked it!!) for hosting this discussion on bridging the FOAK gap. Also immensely enjoyed the rest of the agenda. Check out the full recap & videos here: https://lnkd.in/d9ApYe9Y #ClimateTech #FOAK #ClimateFinance #ProjectDevelopment #GreenTech #CleanEnergy

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Congrats to Christopher Robson, Kurtis Broda and Kristen Cote at Wyvern on bringing on fantastic new investors Guy Filippelli, Dan Madden and Isaac Carp, CFA at Squadra Ventures. I'm a broken record at this point, but we're in the early innings of the Earth Observation market, and as we're seeing with Wyvern there is more demand for hyperspectral data than supply. As we will see in the coming years, there will be all kinds of problems that can be addressed by understanding our world beyond what our eyes can see. https://lnkd.in/gEzTjYks

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“Be quick, but don’t hurry.” John Wooden, the great UCLA basketball coach coined that phrase, and this week will offer interesting opportunities to watch pros applying it: the NBA Playoffs, yes, but also SF Climate Week. I’ve been thinking about how to apply the proper balance of patience and urgency to the climate fight. First, what does Wooden’s advice mean? Prolific basketball scorers will often talk about the need to “let the game come to you.” In other words be aggressive, move with purpose, probe for openings… but not to the point where you are hurrying into the teeth of the defense and in so doing making careless mistakes or missing the right play. The notion of patience also applies over time. Joel Embiid of the Philadelphia 76ers famously talked a few seasons ago (in a very impatient sports town) about trusting “The Process” in turning the league’s worst team into one of its enduring best. Back to climate. While hundreds of functional technologies/approaches are being deployed in thousands of ways across all industries to draw down emissions, it will take time we don’t really have — maybe a generation — to scale up these new methods enough to keep us under the warming levels above which really bad things happen. It can be depressing, and I’m certainly not alone in wanting to push harder. But it occurs to me that some of that urgency could qualify as hurrying in Coach Wooden’s sense. This (possibly contrarian?) perspective comes in part from an executive coach who once reflected that I sometimes struck him as having “both the gas and brake pushed down all the way.” He—and my team it turned out—experienced a grinding between my inner drive to quickly usher everything from decisions to workstreams through to conclusion and a desire to gather more information and make the perfect set of moves. Both “pedals” represented an exertion of control; and the solution to this inner tension was actually to practice patience by easing up with *both* feet. Point being this: amidst our ever-increasing incentives to ramp up velocity with decreasing margins for error, I wonder if being a bit more methodical each day could significantly improve the end result. In a realm as complex and fraught as climate, with so many entrenched defenses, could daily 1% improvements to our patience compound our effectiveness over time? Taking the extra breath to be more present in a conversation and learn more about another perspective. Sitting with the discomfort of ambiguity while waiting on more information. Trusting in the flow of things, the skills of colleagues, the angles that will appear and allow us to make outsized impact with more leverage than if we hadn’t allowed the game come to us. Think about it this week. As a hoops fans or climate warrior, a connector or caretaker — where and how could a little more patience help improve your part of the game? #ClimateChange #Sustainability #EarthDay #Improvement https://lnkd.in/gmyV3DYt

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🚀 Calling all adopters of #proptech and #construction tech: real estate developers, builders, and owner-operators, and more! 🌟 Big News! I’m thrilled to announce our partnership with Wells Fargo Innovation Incubator (IN2), co-administered by the U.S. Department of Energy’s National Renewable Energy Laboratory, to accelerate cleantech adoption. This is a first-of-its-kind initiative bringing public and private industry together to drive the digitization and decarbonization of the built environment with a focus on the adoption of startup technologies by end customers. I couldn’t be more excited to collaborate closely with IN² and NREL’s incredible teams to build the industry’s first Adoption Playbook, and the impact this program will have to catalyze more sustainable innovation implementation to our built world. Led by Program Manager Sarah Derdowski, NREL's team is backed by world-class research and a history of running successful incubators. 💡 If you're a forward-thinking organization that is seeking to innovate your real estate footprint, apply today. Adopters can receive up to $250,000 in grant funding to pilot cutting-edge technologies, while startups have the chance to scale and engage with major corporations. This groundbreaking program offers incredible opportunities for both adopters and startups to drive sustainability and innovation—and we're kicking it off this month! 🌍 With our team at Overlay Build, we will design the curriculum in partnership with IN² for corporate adopters through their Adoption Playbook. The playbook will prioritize pain points, identify innovation areas, and form peer groups for implementation strategies. Overlay will also develop due diligence criteria, help to determine the top startups for potential pilots, and form internal innovation working committees that will drive change. Additionally, Overlay will build a change management strategy to ensure practical evaluation and implementation of pilot projects, helping companies with significant real estate ownership reduce construction inefficiencies, costs, and carbon footprints. 🔍This initiative addresses the "missing middle" in technology adoption of built environment solutions—let's bridge that gap together. For more information or to discuss how you can get involved, feel free to reach out to me directly. 👉 Join us in shaping the future of the built environment! Adopters, apply here today: https://lnkd.in/eCRHCXfm #Sustainability #Cleantech #Innovation #BuiltEnvironment #IN2 #OverlayCapital #DigitalTransformation #Decarbonization #ESG #NetZero

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Yesterday, I spoke with a friend who’s doing everything right when it comes to climate action. He and his wife drive EVs, have rooftop solar, and completed a home energy audit. Yet, he’s frustrated. The next logical move - switching from natural gas to a heat pump - would increase his energy costs by 30%, even with rebates. It’s a tough reality: the system isn’t always set up to make the sustainable choice the rational one - especially if you're already on the leading edge. But here’s what stood out: He’s already a leader, and now he’s turning his frustration into action. He’s talking to his neighbors to make their neighborhood a "green space", and working with his schools and community centers to do audits and make upgrades that make economic sense. This reminded me that while individual actions matter, collective action and systemic change are what truly move the needle. I’ve written more about this conversation and the lessons it offers. If you’re navigating similar challenges, I’d love to hear your story. Check out the full post here: https://lnkd.in/eawyPdNd #ClimateAction #Sustainability #CleanEnergy

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Exciting news! We just sent out the inaugural newsletter for Future Frontier Capital, our pre-seed venture fund backing frontier tech startups. As I hit "send," I realized how launching FFC parallels the path of the founders we support. Starting FFC has required the same passion, perseverance, and self-belief that drive entrepreneurs. Just like a startup, getting a VC fund off the ground demands relentless hustle—building the brand, perfecting the pitch, and networking tirelessly. There are constant challenges that test your resolve and endless hours of unglamorous work behind the scenes. And perhaps most daunting - the self-doubt, wondering if you're crazy for attempting something so bold. Pushing through that negative self-talk requires unshakable faith in your mission. Raising this VC fund reminds me of starting our IP strategy and patent analytics firm two decades ago. It’s a powerful reminder of the perseverance, creativity, and resilience needed to turn an ambitious idea into reality. This experience makes us more empathetic partners, ready to support the founders we back. Our work is just beginning, and this inaugural newsletter underscores our commitment to supporting frontier tech startups every step of the way. #startups #VentureCapital #EmergingManagers #Entrepreneurship #InnovationMindSet

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Some VC investors believe that brick and mortar - referring to a physical presence of some kind - should be avoided at all costs. Yet, the track record of clinic and hybrid care businesses in health care indicates otherwise. ==> One Medical (sold for $3.9 billion to Amazon), Oak Street (bought by CVS for $10.6 billion), Lifestance (IPO at $7.5 billion market cap), and PE-backed Premise Health (acquired by OMERS Private Equity for $1.1 billion) If a clinic is indicated as the optimal way to deliver care for that patient population, there are creative ways to build and operate them. Full article below with advice and strategies on how to build and operate hybrid clinics from my teammate Anarghya Vardhana from Maveron, Amir Dan Rubin from OneMedical Group, Steven Eidelman from Modern Animal and more!

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One of our main goals at Novel is to help tech founders access the capital they need to scale their businesses sustainably.    That’s why we’re excited to be teaming up with Husch Blackwell to co-host Venture Connect, an exclusive part of Startland News’s Startup Crawl that brings together VC investors and founders for a night of networking, connections, and drinks on the house!    It’ll all be going down right here in Kansas City on June 14, so RVSP today.    Just click the link in the comments below. Can’t wait!   #VentureConnect #StartupCrawl #Startland #StartlandStartupCrawl #TechFounders #VC #VentureCapital #networking #startups #entrepreneurship #tech #KCTech #KansasCity 

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Having a Cars and Capital event tomorrow in Southern California with Oren Klaff. If you want to join message me. https://lnkd.in/gDQ4D39u Oren Klaff Bridger Pennington #InvestorEvent #FamilyOffice #InvestmentOpportunity #CarlsbadEvent #PrivateEquity #WealthManagement #InvestmentConference #CapitalRaising #NetworkingEvent #IndustryLeaders #FinancialGrowth #InvestorsMeetup #WealthBuilding #BusinessGrowth #InvestmentForum

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🚀 While the world grapples with access to baseload energy for compute, we've been proud to watch 8090 Industries portfolio founders Hannan P. and Jack Abraham of Exowatt quietly build. 🤯 Today, Exowatt unleashes a new dawn for the energy industry with unveiling P3s - with the ability to generate electricity at scale at just a $0.04 LCOE and with entirely baseload renewable tech. That’s lower than the cost of most fossil fuels and doesn’t account for subsidies. The company has already amassed a 1.2 GW backlog, worth $Billions from mega tech hyperscalers, energy giants and data center companies. Renewable energy can power the data centers of the AI era, and Exowatt founders Jack Abraham and Hannan P. are building that future. We're honored to be backing Exowatt alongside Sam Altman, Andreessen Horowitz, Felicis, Atomic, Overmatch Ventures and Climate Capital. Read more about their launch today here: https://lnkd.in/gZDKZdk8 cc Kerem Ozmen Wes Mendenhall Filip Vurdelja Haluk Sabanci Dincer Grant Brown Ishan Meswani Garuth A. Andrew Irwin Shilpa Patel

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Check out my recent post on why President Trump is the forcing function for us to solve the “Missing Middle” and catch the industrial Tsunami of onshoring coming to the US!

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Ever felt like traditional medical approaches just don't quite fit your needs? You're not alone. Just finished reading the latest Nature article on this, which dives deeper into cutting-edge clinical trial designs like basket, umbrella, and platform trials. If you are curious about how these trials are reshaping the medical landscape, offering tailored solutions based on your unique biomarkers, this can be a good read. The link is in the comments section. Together, let's envision a future where healthcare is truly personalized just for you. 🚀 #PrecisionMedicine #YourHealthYourWay #FutureOfHealthcare American Association for Precision Medicine (AAPM) #aspmhealth #aapm_health #news

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I'm so excited to continue supporting Prolific Machines, Inc., and the incredible Deniz Kent, PhD ,Max Huisman, and Declan Jones. Today's cellular biology processes are incredibly expensive, inefficient, imprecise, and sometimes purely ineffective. These processes are used from everything from making antibodies to treat diseases, to fermentation used to make high-value nutritional proteins in baby formula, to whole cuts of cultured meat. Prolific has developed a biology platform that leverages light to guide cell behavior and optimize performance over time using AI. By combining light, bioengineering, hardware, and AI in fundamentally new ways, Prolific can help pharmaceutical, nutritional, and therapeutics companies get to market faster, less expensively, and more efficiently — ultimately in hopes of helping improve outcomes — a mission any of us can get behind. Mark Cuban Peter T. Frederick Blackford Cooper Rinzler David Adelman Darco Capital Breakthrough Energy Michael Schulson Kevin Love Tobias Harris Breyer Capital Charles Besser Brennan Besser Lettuce Entertain You Restaurants https://lnkd.in/ea2TqdQk

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