Laura Soucek

NEXT EAI SEMINAR "The Pathway to Prebiotic Chemistry: molecular precursors from space" Víctor M. Rivilla Centro de Astrobiología (CAB, CSIC-INTA), Madrid, Spain Tuesday, 7th May 16:00 CEST (UTC + 02:00) Trailer: https://lnkd.in/du2BnDua Zoom: https://lnkd.in/d-3WufX4 Abstract: One of the main challenges in the study of the origin of life is the lack of direct evidence of the conditions on the early Earth when the first organisms appeared. In particular, we do not have any proof of the molecular material that formed the building blocks of life. In this regard, prebiotic experiments in the laboratory have suggested that the RNA world, which is deemed the most plausible explanation for the origin of life, could have started from relatively simple molecular precursors, species with only a handful of atoms. Since our Solar System was formed from a molecular cloud in the ISM, an obvious question naturally arises: could some of the basic ingredients of the life recipe had an interstellar origin, given that they could have been delivered towards the Earth surface through meteoritic and cometary impacts? In other words, could the chemistry that occurs in space have a fundamental contribution for triggering prebiotic chemistry here on Earth, or elsewhere in the Galaxy? To answer this question we need first to know how complex is the chemistry that happens in the interstellar medium, in the molecular clouds where stars and planets form. And, fortunately, despite outer space being a very hostile environment, we know that it harbours a great variety of molecules. Nowadays, the improved sensitivity of current radiotelescopes and the advances in laboratory molecular spectroscopy are indeed revolutionizing the detection of new molecules in space. In my seminar I will present the most recent results of our query of new species with astrobiological interest in space, combining ultra-sensitive unbiased observational spectral surveys and spectroscopic studies in the lab. In particular, I will show our findings towards the molecular cloud G+0.693-0.027, located in the Galactic Center. This source has been revealed as a true astrochemical mine, since it has provided us the detection of 18 new molecular species in the last 5 years. Among them, we have the first glycine isomer detected in space, glycolamide (NH2COCH2OH); key precursors of RNA nucleotides such as hydroxylamine (NH2OH); or ethenediol ((CHOH)2); precursors of proteins, such as carbonic acid (HOCOOH); of lipids, such as ethanolamine (NH2CH2CH2OH) and propanol (CH3CH2CH2OH); and also new interstellar species with phosphorus, one of the key elements for life, such as the cation PO+. Obviously, besides the detection of these possible molecular precursors of life, we also want to understand how they are synthesised in space, and also equally important, how they can elude destruction.

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🚀🚀🚀 Fantastic team effort to discover the role of ubiquitination and selective autophagy in combatting defective splicing now published in Science: A team around Institute of Biochemistry II (IBC2) Director Ivan Đikić and Cristian Prieto-Garcia reveals how cells deploy ubiquitin-proteasome system and ER-phagy to combat the harmful effects of cryptic splicing, protecting against accumulation of misfolded proteins and preserving cellular health. #Splicing is a precisely regulated process facilitated by the #spliceosome, a large protein complex composed of more than 200 proteins. Defects in this dynamic process cause diseases such as retinitis pigmentosa (#RP), a genetic disorder that leads to progressive retina degeneration due to aberrant splicing in photoreceptor cells. 🔬The team around Đikić now discovered a novel mechanistic link between the deubiquitinase #USP39 and impaired RNA splicing. Using zebrafish and cellular models, they demonstrated that USP39 depletion mimics RP-like phenotypes with retinal degeneration. USP39 deficiency led to activation of cryptic 5’ splice sites, resulting in the production of aberrant protein isoforms that are prone to misfolding and aggregation. The misfolded proteins and protein aggregates disrupt cellular proteostasis and trigger cellular stress responses. 🔬 The team analyzed the repertoire of stress responses following USP39 depletion and found that cells ramped up #ubiquitination and #ERphagy, a specialized form of selective #autophagy targeting the endoplasmic reticulum (ER). By this, misfolded proteins can be removed and ER stress alleviated. If the proteotoxic burden cannot be successfully managed, then this leads to prolongation of ER stress, activation of the unfolded protein response (UPR), and, ultimately, apoptotic cell death. ➡ The result highlights the central role of the ubiquitin and autophagy systems in the pathology of spliceosome-associated diseases such as RP. They also suggest that enhancing protein degradation pathways could serve as a therapeutic approach to mitigate the toxic effects of cryptic splicing which was associated with multiple diseases, such as Alzheimer's.   🙏 🎉 Thanks to the international team for this great collaboration! 🙏 🎉 Goethe-Universität Frankfurt, Senckenberg Nature Research, Institute of Molecular Biology (IMB), SRCSB - Stuttgart Research Center Systems Biology, Max Planck Institute of Biophysics, Max Planck Institute for Heart and Lung Research, Johannes Gutenberg-Universität Mainz, EMBL, 中国科学技术大学, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Kyushu University PROXIDRUGS Zukunftscluster, SFB 1177, ProLOEWE, #ENABLE, DZHK Deutsches Zentrum für Herz-Kreislauf-Forschung e. V., Cardio-Pulmonary Institute, #TRR267, Innovation Center TheraNova Bundesministerium für Bildung und Forschung, Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation, #HMWK, Max Planck Society, Schwiete Stiftung, Fraunhofer Gesundheit, #SCALE

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🔬​ The future of early detection of #Alzheimer's disease lies in the search for stable and easily detectable biomarkers, such as microRNAs, that would help diagnose and treat the disease. 💡​ Recently, a group of researchers from the Institute of Bioengineering of Catalonia (#IBEC) and the University of Barcelona (#UB) discovered a new biomarker that could fulfil these characteristics. This is the molecule miR-519a-3p, a biomarker directly linked to the cellular prion protein (PrPC), whose expression is deregulated in patients with this pathology. 🔎​ However, the authors of the study need to confirm that miR-519a-3p levels are not altered in other neurodegenerative diseases. 📚​ Read the full article for more details on this research. Learn More: 👉​ https://lnkd.in/dGq9zYEf #fisherscientificeu #Alzheimer #biomarkers #microRNAs

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🎙️ Join Dr. Adrian Zambrano, PhD, in 2 weeks to explore the critical aspects of single-cell isolation and gain tips for optimizing #CHO and #HEK cell lines. #Webinar Outline: 1️⃣ Challenges in Developing Stable Producer Cell Lines 2️⃣ Guidance for #CHO and #HEK Suspension Culture and Cloning 3️⃣ Results and Impact of Optimization: Enhancements in single-cell dispensing efficiency, clonal derivation probability, and clonal recovery 4️⃣ Future Directions and Innovations in Cell Line Development (#CLD) Save your spot today 👇 https://lnkd.in/eg7cW8Dn #SingleCell #Cloning #Automation #CellLineDevelopment #UPSIGHT #CloneRecovery

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Nanomedicine preclinical researcher position in Nano4Rare project The Institute of Materials Science of Barcelona (ICMAB-CSIC) is a multidisciplinary research center focused on cutting-edge research in functional advanced materials in the fields of ENERGY, ELECTRONICS, NANOMEDICINE and application fields https://bit.ly/3V4DUiN

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#Horticulturae - Featured #specialissue Recommendations 🎉 📖SI: Advances in #Asparagus #Production, #Genomics and #Breeding 🎓Edited by Dr. Roberto Moreno, Dr. Patricia Castro and Dr. Jose V. Die 👉Find all published papers: https://lnkd.in/gxKHuTs5 Published paper list: - Studies on the Identification of Resistance to Fusarium oxysporum (Schlecht.) in Different Genetic Backgrounds of Asparagus officinalis (L.) and Its Defense Responses https://lnkd.in/gtKMD-_E - Genetic Variability Assessment of a Diploid Pre-Breeding Asparagus Population Developed Using the Tetraploid Landrace ‘Morado de Huétor’ https://lnkd.in/gMs-G4mB - Combining Ability and Heterosis for Market Yield in Green Asparagus https://lnkd.in/gdj9_bmb - Effects of Mulching on Early-Spring Green Asparagus Yield and Quality under Cultivation in Plastic Tunnels https://lnkd.in/gPCBMMzv - Aspects of In Vitro Plant Tissue Culture and Breeding of Asparagus: A Review        https://lnkd.in/gG26VDRC #academic #publishing #MDPI #horticulture #science #scientific

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Annovis Bio will present two posters at the upcoming #CTAD2024 conference, held October 29 - November 1 in Madrid, Spain. Poster 1: Title: Efficacy of Buntanetap in Early AD and APOE4 Phase 2/3 Alzheimer’s Patients. Poster 2: Title: Biomarker Data Showed Buntanetap Reduced Neurotoxic Proteins, Improved Axonal Integrity, Reduced Inflammation, and Neuronal Functions in Alzheimer’s Clinical Studies. Find more information at: https://lnkd.in/edb3eFyJ CTAD Clinical Trials on Alzheimer's Disease #AlzheimersDisease #Alzheimers #AnnovisBio #Dementia #Biotech #Buntanetap

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Exciting discoveries unveiled by Eulalia Marti's team from the University of Barcelona in the Journal of Extracellular Vesicles shed light on the critical role of #Plasma #ExtracellularVesicles -derived sRNAs as potential early biomarkers in the premanifest phase of #HuntingtonsDisease. The identification of key sRNAs, such as miR-21-5p and miR-26a-5p, linked to cognitive changes not only aids in early diagnosis but also presents potential targets for future interventions. This research signifies a significant step towards understanding the disease's progression dynamics. First author: Marina Herrero Lorenzo Read more here: https://lnkd.in/gevEyU34 #neuroscience #research #exosomes #plasma #diagnosis

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New Innovative Solutions to Combat Multidrug-Resistant Bacterial Infections! A review by Marco Pardo-Freire and Pilar Domingo-Calap from the University of Valencia covered the latest phage-based nanotechnology advancing the fight against resistant bacteria, with a focus on synthetic polymers treating cystic fibrosis patients. 📢 Join Marco Pardo-Freire at Targeting Phage Therapy 2024 conference in Malta on June 20-21, where he will show the effects of nebulized phage therapy on two cystic fibrosis patients with multi-drug resistant bacterial lung infections in an oral presentation: "Neutralizing Antibodies After Nebulized Phage Therapy in Cystic Fibrosis Patients". 🔗 More about this study: https://lnkd.in/d4_kePqf. 🌐 Visit conference website: https://lnkd.in/egH62bTR. #PhageTherapy #TargetingPahgeTherapy #antimicrobialresistance #biotechnology #phagecocktails #cysticfibrosis

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📢 A new paper is out! 🔊 Thanks to our collaboration with the Infectios Diseases Unit of the General Hospital of Elche-Fisabio foundation we publised together a paper in the Journal Clinical Infectious Diseases entitled "Virological History Predicts Non-sustained Viral Suppression with Long-Acting Cabotegravir and Rilpivirine Therapy, independent of Pharmacokinetic Parameters". 🔬 This study investigated the factors contributing to non-sustained viral suppression, such as intermittent viremia and persistent low-level viremia, during long-acting (LA) injectable therapy with cabotegravir (CAB) and rilpivirine (RPV), with a specific focus on pharmacokinetics (PK). The findings suggest that non-sustained viral suppression in people with HIV (PWH) transitioning from stable oral ART to CAB+RPV LA was associated with pre-existing factors prior to the transition. Elevated viral loads before ART initiation and incomplete suppression during oral therapy increased the risk, regardless of PK parameters. 🎙 Congrats to Félix Gutiérrez, Marta Fernández González, Christian Ledesma, María Losada Echeberria, Enrique Barrajón-Catalán, Javier García-Abellán, Daria De Stefano, Leandro López, Melissa Belló Pérez, Sergio Padilla and Mar Masiá 📜 More information: https://lnkd.in/dqZ_m5wi #virology #infectiousdiseases #HIV #Pharmacokinetics #longacting #treatment

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🌟 Exciting Kickoff to the Next GynGeneration Symposium! 🌟 🔜 Introducing the first session of «Bridging RNA Biology and Therapy: Exploring the Frontiers of Advanced Medicine» that will take place on the 9th and 10th of October 2024. 🧬 Our initial session is called «Functional ncRNAs and RNA modifications in development and disease» and will be divided into two sections. The first one named Noncoding RNA will explore the significant roles these RNAs play in physiology, development, and disease. The second one, RNA Modifications, will delve into how RNA modifications introduce functional diversity and regulate gene expression, influencing RNA structure, interactions, and metabolism. We will discuss how these modifications enable rapid responses to environmental changes and their implications in disease pathogenesis, including cancer. 🔍 Explore the whole program here and don’t forget to submit your abstracts before September 2nd, 2024: https://lnkd.in/drymNztB #RNABiology #Therapy #RNA #AdvancedMedicine #RNAInsights #ScienceEvent #CIMA #Pamplona #SymposiumProgram #Innovation #Research

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An elusive cell population with extraordinary properties, finally uncovered in a sea anemone 👏 In a new article published in Nature Communications, lead author Paula Miramón-Puértolas and Eudald Pascual Carreras from the group of Patrick Steinmetz have identified and characterized a population of stem cells in the sea anemone Nematostella vectensis. These cells give rise to gametes, but also to other cell types such as neurons 🔬 “Sea anemones can easily replace lost tissues, clone themselves and regenerate after bisection. Identifying their stem cells is important to understand these abilities and [to] shed light on the evolution of stem cells and regeneration.” - Paula Miramón-Puértolas ✨ Take a peek behind the scenes: 🔗 tinyurl.com/3eu556mu ✨ Read the article: 🔗 https://lnkd.in/dA2Mzizr University of Bergen - Realfag UiB - Nature Portfolio - Kathrin Garschall, PhD - Inés Fournon Berodia - Pawel Burkhardt - Aishwarya Ravi - Alexandre Jan - Carine Le Goff - Anna Ferraioli - Ruth Styfhals - Roberto Santoro - Ira M.

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Identifying small RNAs in plasma extracellular vesicles as biomarkers for early changes in Huntington's disease: in their latest work, Marina Herrero Lorenzo, Eulalia Marti at the University of Barcelona and collaborators aimed to identify biomarkers for tracking early changes in pre-symptomatic Huntington's disease by examining plasma sRNA levels. They compared sRNA profiles from EV-enriched and non-EV plasma fractions of pre-manifest and manifest HD mutation carriers to control samples https://lnkd.in/etAdwQWz Their findings revealed that sRNA levels are more stable in EVs compared to non-EV fractions, and most sRNAs were downregulated in EVs from mutation carriers, with many alterations occurring at pre-manifest stages. An article co-authored by Jesus Perez-Perez, Georgia Escaramis, Saul Martinez Horta, Rocío Pérez González, PhD, Elisa Rivas Asensio, Jaime Kulisevsky and Ana Gámez Valero #extracellularvesicles #exosomes #miRNA #biomarkers #Huntingtonsdisease #Vesiculab

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Therapeutic Efficacy of Novel Conjugates Based on Gold and Cerium Oxide Nanoparticles in Rats with Metabolic Dysfunction-Associated Steatohepatitis Guillermo Fernández-Varo from Hospital Clínic de Barcelona-IDIPAPS, Spain, highlighted his innovative research at #RedoxMedicine2024. His study investigates the therapeutic potential of novel conjugates based on gold and cerium oxide nanoparticles in rats with metabolic dysfunction-associated steatohepatitis (MASH), paving the way for new treatment possibilities. #RedoxMedicieSociety #RedoxMedicine #biomarkers #redoxbiology #redox #antioxidants #innovation #oxidativestress #RedoxResearch

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#CICbiomaGUNEseminars 👨‍🏫 Dr. Arkaitz Carracedo from CIC bioGUNE 🗓️ May 15, 2024 ✅ Understanding and predicting prostate #cancer aggressiveness through the #deconstruction of cell signaling and #metabolism #science #ciencia #research #investigacion #seminar #donostia

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Exploring extracellular vesicles in pancreatic cancer, from biomarkers to novel therapies: in this review article, Carolina Torres, Pedro J. Real Luna at the Universidad de Granada and collaborators investigated the diverse roles of extracellular vesicles in cancer progression, while also exploring their potential as diagnostic, prognostic, and therapeutic markers specifically in pancreatic cancer https://lnkd.in/etEhqDNv Their conclusion highlighted how researchers and clinicians were leveraging the distinctive characteristics of EVs, paving the path for more efficient and personalized strategies to tackle this disease. An article also authored by Jose Manuel Sanchez Mañas, Natalia Pérez de Gracia Velázquez, Sonia Perales Romero and Joaquina Martinez-Galan #extracellularvesicles #exosomes #liquidbiopsy #biomarkers #pancreaticcancer #Vesiculab

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From NANBIOSIS we want to rise awareness on cystic fibrosis by highlihgting the efforts that our academic researchers are making towards developing new treatments to fight against this disease. In this new interview, Lucía Enríquez Rodríguez, PhD researcher at NANBIOSIS, discusses her work on gene therapies for cystic fibrosis, a genetic disease that mainly affects the lungs. Her research focuses on using non-viral vectors to deliver gene-editing tools, like Prime Editing, a variation of CRISPR-Cas9, to correct mutations at the genetic level. In addition, she also also explains the advantages of non-viral vectors, such as avoiding immune responses and offering safer, non-invasive treatment options. Finally, Enríquez highlights the importance of interdisciplinary collaboration, particularly in her work at NANBIOSIS, where advanced drug formulation and pulmonary delivery systems are developed; and reflects on the challenges of pursuing a scientific career in Spain, emphasizing the need for better working conditions and societal support for researchers. You can read the entire interview here (English): https://lnkd.in/dU3FKswr In addition, the interview is fully available in our YouTube chanel here: https://lnkd.in/dK4FuQMH #NanbiosisExpertise #CEBiomedS #ICTSnews #CysticFibrosis #CysticFibrosisDay Centro de Investigación Biomédica en Red CIBER Jesús Usón Minimally Invasive Surgery Center - JUMISC IBIMA - Plataforma Bionand

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