John Oncea

PBM short for Probability Based Matching is the blazingly fast Agilent Technologies ChemStation compatible mass spectra library search. In #OpenChrom it is tightly integrated, requiring no extra software to be installed. It is a great alternative for use with old and proven methods that rely on legacy software and EOL operating systems.

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#Webinar #DDI #CellBasedAssays 🔍INDIGO's webinar page is full of helpful resources pertaining to receptors, cell-based assays, and their use in drug discovery or environmental testing! 💡 🧫Environmental Monitoring: Evaluating Cellular Response Pathways in Complex Mixtures In this webinar, Dr. Jack Vanden Heuvel will review recent environmental toxicology research that employs an alternative workflow for evaluating water samples. This method allows researchers to maximize the number of receptors and pathways evaluated while providing better throughput and toxicologic information. 📚How to Better Predict Potential Drug Interactions Early in the Discovery Process Drug-drug interactions (DDI) are a cause of many adverse outcomes clinically, costing the health care system over a billion dollars. Thus, there is increasing interest in understanding the risk posed by certain drug candidates early in the discovery process. Fortunately, many aspects of DDI are predictable based on our increasing understanding of the mechanisms of altered absorption, distribution, metabolism, and excretion (ADME) and improved tools for screening for potential liabilities early in the drug-discovery process. These tools include in vitro assays that look at pharmacokinetic interactions through changing the activity of enzymes involved in the clearance of drugs, such as cytochromes P450 (CYPs). 🌿Save Time and Money When Prioritizing Drug Candidates: Using Cell-Based Reporter Assays for Nuclear Receptor Profiling In preclinical drug discovery, the identification of potential drug candidates requires a thorough evaluation of their pharmacological effects, as well as any potential off-target liabilities. Nuclear receptors play a crucial role in many physiological processes and have emerged as important targets for drug discovery. However, potential drugs often have multiple effects, often within a gene family, leading to potential polypharmacology, where new beneficial effects, as well as off-target liabilities, can be discovered. To triage or prioritize data, dose-response experiments with nuclear receptor assays can be used. In this presentation, we discuss the use of cell-based reporter assays for nuclear receptor profiling and how this strategy can help identify potential drug candidates with desirable pharmacological properties and reduced off-target effects. Check out these webinars and more on our website! https://hubs.la/Q02GKmlS0

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#Webinar #DDI #CellBasedAssays 🔍INDIGO's webinar page is full of helpful resources pertaining to receptors, cell-based assays, and their use in drug discovery or environmental testing! 💡 🧫Environmental Monitoring: Evaluating Cellular Response Pathways in Complex Mixtures In this webinar, Dr. Jack Vanden Heuvel will review recent environmental toxicology research that employs an alternative workflow for evaluating water samples. This method allows researchers to maximize the number of receptors and pathways evaluated while providing better throughput and toxicologic information. 📚How to Better Predict Potential Drug Interactions Early in the Discovery Process Drug-drug interactions (DDI) are a cause of many adverse outcomes clinically, costing the health care system over a billion dollars. Thus, there is increasing interest in understanding the risk posed by certain drug candidates early in the discovery process. Fortunately, many aspects of DDI are predictable based on our increasing understanding of the mechanisms of altered absorption, distribution, metabolism, and excretion (ADME) and improved tools for screening for potential liabilities early in the drug-discovery process. These tools include in vitro assays that look at pharmacokinetic interactions through changing the activity of enzymes involved in the clearance of drugs, such as cytochromes P450 (CYPs). 🌿Save Time and Money When Prioritizing Drug Candidates: Using Cell-Based Reporter Assays for Nuclear Receptor Profiling In preclinical drug discovery, the identification of potential drug candidates requires a thorough evaluation of their pharmacological effects, as well as any potential off-target liabilities. Nuclear receptors play a crucial role in many physiological processes and have emerged as important targets for drug discovery. However, potential drugs often have multiple effects, often within a gene family, leading to potential polypharmacology, where new beneficial effects, as well as off-target liabilities, can be discovered. To triage or prioritize data, dose-response experiments with nuclear receptor assays can be used. In this presentation, we discuss the use of cell-based reporter assays for nuclear receptor profiling and how this strategy can help identify potential drug candidates with desirable pharmacological properties and reduced off-target effects. Check out these webinars and more on our website! https://hubs.ly/Q02V5pCf0

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New Blog Alert! Check out our latest post: "Finding the Correct Mass Spectrometry for Small Molecule Analysis: A Helpful Guide for Laboratories." Discover how to choose the best mass spectrometer for your lab's needs. 🔗 Read more here! https://lnkd.in/eyUZbSuk #MassSpectrometry #LabTech #NewBlog #lcmsms #lcms

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Air bubbles adhering to oxygen sensors in bioreactors cause noisy measurements that complicate process control. See how METTLER TOLEDO DO sensors eliminate signal noise, helping minimize process variability. Learn more. #OxygenMeasurement #CellCulture #Fermentation https://okt.to/GOsuYP

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Optical density can be affected by many factors, including sample conditions, the state of the measuring vessel, and instrument configuration. Discover five key tips for optimizing the accuracy and consistency of these measurements! Learn more in this new issue of the TS Digest: https://lnkd.in/eeyHCSDR

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🔬🔬🔬 How many laboratory instruments are there? SDi covered 273 instrument types for the 84 analytical technologies. Learn the average price, units shipped, units retired, and active systems to help guide you through each market landscape and potential opportunities. Let’s get into the numbers with the 2024 Installed Base DataFile! https://hubs.la/Q02zyVmw0

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🌟 Learn how the T2Bacteria Panel identifies three times more on-panel bacterial pathogens compared to conventional blood culture by watching our video poster presentation with data presented at #SCCM! 📈 #T2BacteriaPanel #InnovativeTechnology https://ow.ly/i1xC50Ria4c

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#AAVmanufacturing is complex requiring innovative approaches. It's a focus at #ASGCT2024 with #biopharma companies offering solutions to improve the efficiency and quality of #AAV production to meet safety/efficacy. https://lnkd.in/gkwbzEED #adenoassociatedviruses #ASGCT24 #ASGCT #AAVs

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Curious about how MRR spectroscopy is transforming pharmaceutical analysis? Check out our article in Spectroscopy Media by Brightspec’s Christopher J. Thompson! Learn how we’re pushing boundaries in applied analysis. https://lnkd.in/gxuC4N4k

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Join ZONTAL on October 22, 2024, for our webinar, "Utilizing FAIR Data to Integrate Across Your Laboratory Ecosystem." This webinar will highlight how ZONTAL’s FAIR data platform can seamlessly integrate all software planning tools (LIMS, ELN, etc.) with all data producers (instruments, robots, equipment, etc). Register today: https://lnkd.in/dYXAKCBa The goal of most informatics projects is to simplify scientists' daily workflows. Our focus is on creating an automated, closed-loop experiment that transfers data seamlessly between systems, eliminating manual file transfers and data copying. #Webinar #DataManagement #FAIRData #DataIntegration #LifeSciences #ZONTAL #Innovation #Compliance #AIinScience #DigitalInnovation #LabAutomation #SciY

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Did you know that Spectrum CE combined with eight-color PowerPlex® STR Systems maximizes your chance of producing searchable profiles from degraded or inhibited casework samples? Read about it in this new Promega Notes Technical Article: https://bit.ly/3yAokm6

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Triple quadrupole mass spectrometers (LC/MS/MS) are key in labs dealing with challenging matrices. They offer very low detection limits with specificity and selectivity leading to increased laboratory operations efficiency and cost-effectiveness. Read our new blog to discover more. https://bit.ly/3vNue22

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Triple quadrupole mass spectrometers (LC/MS/MS) are key in labs dealing with challenging matrices. They offer very low detection limits with specificity and selectivity leading to increased laboratory operations efficiency and cost-effectiveness. Read our new blog to discover more. https://bit.ly/3vNue22

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🔬 Webinar Alert: Optimize Your AAV Vector Production! Join us on May 14, 2024, at 11:00 AM EDT for an enlightening webinar hosted by Revvity Gene Delivery. Discover how Design-of-Experiments (DoE) can transform your AAV manufacturing process, leading to improved yield, consistency, and scalability. Don't miss the chance to learn about practical DoE applications and see real-world results from our latest case study. https://lnkd.in/eYrxZJKQ

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Ensure instrument sensitivity in analytical labs with Brooks' AIM Autosamplers. Our solutions use contamination-minimizing materials to deliver accurate signal measurements, enhancing the precision and reliability of your analytical results. Discover the difference advanced sample handling technology can make. #AnalyticalExcellence #LabTechnology #Precision #Reliability #BrooksAutomation

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On Oct 3rd dive into the future of analytical science with our upcoming webinar on the latest advancements in ion chromatography (IC)! Discover how upgrading to the newest IC system can revolutionize your approach to analyzing ionic and small polar compounds, from drinking water to lithium-ion batteries and beyond.

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Research into the application of WD-40®when utilizing optical-capacitive scanners has shown to greatly increase the efficacy of capturing usable #PostmortemFingerprints. Learn about novel #DVI identification methods. Read more in #JFS article: https://lnkd.in/gyHaH9vX

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