John Krystal

Neurobiological Consequences of Childhood Maltreatment: The Implications for Practitioners https://bit.ly/44jGlAQ In this interesting podcast, Assistant Professor Jacqueline Samson and Associate Professor Martin Teicher explore how childhood maltreatment alters threat detection and the impact of childhood maltreatment on the area and integrity of white matter tracts. Listen now to learn more. https://bit.ly/44jGlAQ #Neurobiological #ChildhoodMaltreatment #ACEs #AdverseChildhoodExperiences #CAMH #CAMHS #MentalHealth #MentalHealthMatters #MentalHealthAwareness #Psychiatry #Psychology

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The Footprints of IMD series is an effort to move away from thinking about IMD from the perspective of an established diagnosis, but rather place it where it is normally found, within the differential. In this latest episode, Gabriella Horvath explains when a psychiatric illness might herald a metabolic diagnosis and explains which IMDs frequently have associated psychiatric symptoms. Listen on Spotify: https://lnkd.in/e7mGs5kq Or wherever you get your podcasts. #psychiatry #psychiatricpresentations #raredisease

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Our new work led by Seda Sacu. "Neural mechanisms of disease pathology and cognition in young-onset Alzheimer's Disease variants" https://lnkd.in/gDcFen37 Jonathan Schott Monash Psychological Sciences Turner Institute for Brain and Mental Health UCL Abstract -- Late-onset Alzheimer’s disease is consistently associated with alterations in the default-mode network (DMN)—a large-scale brain network associated with self-related processing and memory. However, the functional organization of DMN is far less clear in young-onset Alzheimer’s disease (YOAD). We assessed resting-state DMN effective connectivity in two common YOAD variants (i.e., amnestic variant (n = 26) and posterior cortical atrophy (n = 13) and healthy participants (n=24) to identify disease- and variant-specific connectivity differences using spectral dynamic causal modelling. Patients with the amnestic variant showed increased connectivity from prefrontal cortex to posterior DMN nodes relative to healthy controls, whereas patients with posterior cortical atrophy exhibited decreased posterior DMN connectivity. Right hippocampus connectivity differentiated the two patient groups. Furthermore, disease-related connectivity alterations were also predictive of group membership and cognitive performance. These findings suggest that resting-state DMN effective connectivity provides a new understanding of neural mechanisms underlying the disease pathology and cognition in YOAD.

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Read full paper in #Med

The Cardiovascular system and associated disorders - The first in a series of articles in the British Journal of Midwifery focusing on specific systems taken from chapters featured in Fundamentals of Maternal Pathophysiology and Maternal Anatomy & Physiology for midwives. An excellent resource for students, midwives and other health professionals caring for childbearing women. #midwifery #cardiovascular #maternity #pregnancy @britishjournalofmidwifery #studentmidwife #midwife #obstetrics #maternalmedicine #pathophysiology

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This study explored how character strength patterns and social support impact psychological distress among adolescents and young adults with cancer (AYAC). Conducted across four hospitals in China, 728 participants were surveyed to identify three distinct character strength patterns: low, moderate, and high. The study found that higher social support was linked to lower psychological distress, with stronger effects observed in males. Interestingly, while character strength patterns did not directly influence the relationship between social support and distress, individuals with higher character strengths experienced significantly lower distress. These findings suggest that enhancing character strengths, especially in males, may improve mental health outcomes in AYAC. Interventions should therefore focus on both social support and building character strengths to effectively reduce psychological distress in this vulnerable population. #cancer #socialsupport #distress #cancercare #intervention

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A new study published in Brain Communications and led by scientists at the Center for Advanced Imaging Innovation and Research at NYU Langone Health finds additional evidence for the potential of sodium MRI as a biomarker of cognitive function in patients with mild traumatic brain injury, also known as concussion. Concussions disrupt the brain's homeostasis, a state of natural equilibrium in which sodium plays an essential role as it helps regulate the transmission of nerve impulses, maintain cell volume and fluid balance, and regulate the flow, volume, and pressure of blood. "Ionic imbalances and sodium channel dysfunction, well-known sequelae of traumatic brain injury, promote functional impairment in affected subjects," write the authors. "Therefore, non-invasive measurement of sodium concentrations using [sodium] MRI has the potential to detect clinically relevant injury and predict persistent symptoms." In the study, scientists scanned participants diagnosed with mild traumatic brain injury approximately three weeks and three months after concussion. From the MRI data, the researchers calculated the "apparent total sodium concentration" in grey and white matter. They also evaluated patients' cognitive outcomes, symptom severity, and overall recovery at the three-week and three-month mark, with a final follow-up about a year later. Healthy volunteers served as a control group. An analysis of the data from all these measures and comparison between the groups has shown that participants who had concussions also had lower apparent total sodium concentration in both grey and white matter shortly after injury. The team has also found that the normalization of sodium levels corresponded with improvement in measures of cognitive function (but not with measures of symptoms). The researchers write that the findings, which are consistent with the team's prior work, lend "further support to [apparent total sodium concentration] as a predictor of cognitive function rather than symptomatology." The study: https://lnkd.in/ej96yc95 The research team was led by NYU Langone Health scientists at the departments of radiology and neurology in collaboration with colleagues at the departments of emergency medicine, rehabilitation medicine, and psychiatry. CC: Teresa Gerhalter, Anna Chen, Seena Dehkharghani, Rosemary Peralta, Mia Gajdosik, Alejandro Zarate, Tamara Bushnik, Jonathan Silver, Stephen Wall, Guillaume Madelin, Ivan Kirov, NYU Grossman School of Medicine #MRI #research on #concussion #radiology research on #mTBI #multinuclearMRI in #neuroscience and #medicine #BrainHealth

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Each week we highlight the latest in #OMM & #OMTResearch! CHECK OUT this article from our colleagues at the School of Rehabilitation Sciences at Ahvaz Jundishapur University of Medical Sciences in Ahvaz, Iran, titled "Effect of Visceral Manipulation on Children with Refractory Chronic Functional Constipation: a Randomized Controlled Trial." This randomized controlled trial concluded that visceral manipulaiton may be considered as a possible treatment method for chronic functional constipation but states that further long-term research in its use is needed. Read the article here - https://loom.ly/1c3V14Y

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Call for Papers: International Nursing Journal 🌟 We are excited to invite submissions for the inaugural issue of the Nursing and Immunology International Journal, an open-access, peer-reviewed journal dedicated to advancing nursing research and practice globally. ✅ Indexed in Google Scholar ✅ DOI for every article ✅ Topics: Clinical Nursing, Community Health, Nursing Education, and more ✅ Fast review process ✅ Complimentary DOI for all International Authors. Let’s shape the future of nursing together! 🩺 Please mail at  [email protected] or DM for any query related to submission. #NursingResearch #CallForPapers #NursingInnovation

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First participant dosed in research study investigating the effects of BPL-003, a novel formulation of 5-MeO-DMT, on the human brain https://lnkd.in/eC5Suisu

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It's Workplace Lactation Week - yes it's such a thing! As a former breastfeeding mom who had to pump 3 x day in the office for two years, I can't emphasize how important it is to recognize the needs of moms to pump in the workplace. And what if we were able to show that pumping actually extends breastfeeding rates AND addresses racial inequities in breastfeeding? This is exactly what the latest exciting results suggest from a new study of over 19,000 mothers in the US, published in the Journal of Pediatrics. It concludes that pumping extends breastfeeding duration by an average of a whopping 5+ months vs those who do not pump. In addition, the greatest positive association of pump use with breastfeeding was found among non-Hispanic Black and Native American mothers, who also have the lowest rates of breastfeeding. This builds on previous studies that looked at the WIC program, a US government-subsidized nutrition program for at-risk families, which showed that when provided an electric breast pump, a mom would request for formula at 8.8 months, vs those who did not receive a pump, would request formula on average at 4.8 months. With 65.5% of all babies in the US under one year, born to a working mom, companies must step forward to ensure their breastfeeding employees have the support they need. So what do breastfeeding parents need in the workplace? 1. Paid Parental Leave (UNICEF supports a min. of 6 months) 2. Adequate time to pump (30 min at least) 3. A Private Place to Pump (not a bathroom) 4. The Tools to Pump (subsidized breast pump and cold milk storage) 5. Lactation education/support regarding pumping Paid leave, along with pumping support when she returns to work, economically empowers women to continue to work without sacrificing the needs of her baby. Would it also be a stretch to say it would also reduce the Maternal Wage Gap of 71 cents on the dollar? Could more investments in pumping, actually make WHO's global goal of 50% 6-months exclusive breastfeeding rates within reach for the US? As we currently stand at less than 25%, we moms need all the help we can get! #breastfeeding #workplacesupport #equity

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🧩 #Autism in Greece: Untangling predictors for better outcomes. What influences the functionality of children with Autism Spectrum Disorders (ASD)? This nationwide study of 517 children aged 4–7 in Greece by Mrs. Katerina Sousamli, Dr. Antigoni Sarantaki, and colleagues reveals some thought-provoking insights: 📌 Key predictors of lower functionality: - Higher maternal age - Delayed ASD diagnosis - Lower family income - Higher birth order The findings underscore the importance of early diagnosis, equitable access to resources, and systematic screening to improve outcomes. https://brnw.ch/21wOPvO University of West Attica #AutismResearch #PublicHealth #ASDCare

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PRESS RELEASE 👉 Mount Sinai Researchers Have Uncovered the Mechanism in the Brain That Constantly Refreshes Memory ➡️ https://lnkd.in/eGusiUGu Mount Sinai researchers have discovered a neural mechanism for memory integration that stretches across both time and personal experience. These findings demonstrate how memories stored in neural ensembles in the brain are constantly being updated and reorganized with salient information, and represent an important step in deciphering how our memories stay current with the most recently available information. This discovery could have important implications for better understanding adaptive memory processes (such as making causal inferences) as well as maladaptive processes (such as #PostTraumaticStressDisorder, or #PTSD). “The long-held view is that memories are formed during initial learning and remain stable in neural ensembles over time, enabling us to recall a particular experience... Our work with mouse models shows the inadequacy of this theory, since it doesn’t account for how the brain can both store memories while flexibly updating them with new and relevant information. This combination of stability and flexibility within neural ensembles is critical for us to make everyday predictions and decisions, and to interact with an ever-changing world.” - Denise Cai, PhD Learn More in Nature | Nature Portfolio https://lnkd.in/et25SnSc Offline ensemble co-reactivation links memories across days - Joseph Zaki (Yosif Zaki), Zach Pennington, Denisse Morales-Rodriguez, Madeline Bacon, BumJin Ko, Taylor Francisco, Alexa LaBanca, Patlapa Sompolpong, Zhe Dong, Sophia Lamsifer, Hung-Tu Chen, Simon Carrillo Segura, PhD; Zoé Christenson Wick, PhD; Alcino Silva, Kanaka Rajan, PhD; Matthijs van der Meer, Andre Fenton, Tristan Shuman, Denise Cai Learn More about the Cai Lab https://lnkd.in/ect5bDp7 #FriedmanBrainInstitute #NashNeuroscience Icahn School of Medicine at Mount Sinai The Mount Sinai Hospital Graduate School of Biomedical Sciences at the Icahn School of Medicine Dartmouth College NYU Tandon School of Engineering New York University NYU Langone Health UCLA Image courtesy of Stellate Communications

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