Adrian Mendoza

The New York ecosystem for dual-use technology is small but strong and growing rapidly. Thanks to companies like Decisive Point and @a16z who continue to support the community with networking events for founders, investors, and community members. More and more founders are recognizing the value in partnering with the DOD as a strong way to support the country's national security interests while hopefully decreasing the tax burden on citizens regarding government spend as commercially available technology becomes more available and affordable for government organizations. Not only this, but the DOD serves as a great test bed and sandbox for emerging technologies and talent. #dualuse #emergingtech #defensetech #Kilsar

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Today's post is about our commitment at Bread and Butter Ventures to investing in women's health within our healthcare vertical, which is a big focus of our fund. Our mission in healthtech broadly is to invest in technology that democratizes access to quality care for all. A report this year from Deloitte shared that investment in women’s health rose by 5% between 2022 and 2023 - heading in the right direction, however, women's health represented just 2% of the $41.2 billion in venture funding that went to health companies in 2023, according to Deloitte’s analysis. There is such tremendous opportunity to innovate and invest for half the world's population. This an economic imperative. Spotlighting today 5 outstanding healthcare startups innovation in women's health who are very proud to have in our portfolio: ⭐ Gabbi: is building a comprehensive breast cancer risk assessment and early detection platform, combining cutting-edge technology with personalized care. As a woman's virtual breast specialist, Gabbi ensures every woman knows her risk and has access to early detection via telehealth. https://www.gabbi.com/. Shoutout Kaitlin Christine ⭐ Chiyo: is a personalized & integrative food-as-medicine platform that helps the next generation of mothers looking for guidance as they navigate the acute transitions of fertility, pregnancy and post-partum. https://wearechiyo.com/. Shoutout Irene Liu ⭐ Delfina: is creating an AI-powered pregnancy care platform to solve the global maternal health crisis. Delfina lowers rates of adverse outcomes, hospitalizations, and NICU stays to deliver substantial savings for health plans and risk-sharing providers. https://www.delfina.com/. Shoutout Senan Ebrahim, MD, PhD Priyanka Vaidya Ali Ebrahim ⭐ Nest Collaborative is the first to create a nationwide network of lactation consultants, available to mom 24/7 through virtual consultations. We were also the first to offer mom a no-cost, insurance-paid experience - which means when she has a problem we can connect her with a consultant within hours and we take care of all the payment and paperwork on the back end. We are, in all ways, her BFF - Breast Feeding Friend. https://lnkd.in/gKCVYvtF. Shoutout Judith Nowlin ⭐ Myya: provides breast cancer survivors completely customizable, fully insurance billable post-mastectomy prosthetics with a state-of-the-art fitting experience online and in-person. https://myya.com/ Jasmine Jones #womenshealth #digitalhealth #venturecapital #startups

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āltitude: 𝐑𝐞𝐦𝐨𝐭𝐞-𝐅𝐢𝐫𝐬𝐭 𝐅𝐮𝐧𝐝 We're excited to learn more about remote work from co-founder Matteo Benedetti from our portfolio company Debtist in our SME Tech Leaders webinar "Scaling your Startup Remotely" 𝗥𝗲𝗴𝗶𝘀𝘁𝗲𝗿 𝗵𝗲𝗿𝗲: https://lu.ma/mqgwi5p0 When Marc, Ingo, and I started āltitude last year, we did it remotely from Berlin, London, and Zurich, meeting monthly in person. Our team has since expanded to include Torge, our Chief of Staff, and Fernanda, our visiting analyst, currently based in Luxembourg and Munich. Post-pandemic, we believed against the consensus that building a firm apart was possible—we just had to prove it. Remote work naturally sharpens our focus on priorities, which is crucial for any business but also comes with challenges. Here’s how we’ve approached remote work: 𝗖𝗿𝗲𝗮𝘁𝗲 𝗧𝗿𝗮𝗻𝘀𝗽𝗮𝗿𝗲𝗻𝗰𝘆: We utilise tools like Notion, Asana, Google Docs, Shared Google Calendars and Folk. We also streamline our financial operations by using our own portfolio company cleverlohn for payroll. 𝗙𝗿𝗲𝗾𝘂𝗲𝗻𝘁 𝗖𝗼𝗺𝗺𝘂𝗻𝗶𝗰𝗮𝘁𝗶𝗼𝗻: We hold daily check-ins—morning for strategic decisions and afternoons for operational priorities. If needed, we schedule dedicated calls for deeper discussions on strategic topics. Regular in-person meetings in different cities keep us connected without the overhead of a permanent office. 𝗖𝗹𝗲𝗮𝗿 𝗧𝗮𝘀𝗸𝘀, 𝗥𝗼𝗹𝗲𝘀, 𝗮𝗻𝗱 𝗧𝗿𝘂𝘀𝘁: Remote work demands trust as you cannot see what people are doing, which we build through clearly defined tasks, deadlines and roles. This clarity ensures that everyone is aligned. 𝗗𝗲𝗳𝗶𝗻𝗲𝗱 𝗞𝗣𝗜𝘀: Understanding what outcomes need to be achieved every quarter is key. Especially as we continue fundraising and deploying capital. 𝗔𝗰𝗰𝗼𝘂𝗻𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗮𝗻𝗱 𝗖𝘂𝗹𝘁𝘂𝗿𝗲: Our culture is built on radical candor and transparency, ensuring everyone is working towards the same goals. Open discussions and quick feedback loops allow us to address issues openly. This environment encourages accountability and continuous improvement. 𝗣𝗿𝗼𝗰𝗲𝘀𝘀 𝗗𝗶𝘀𝗰𝗶𝗽𝗹𝗶𝗻𝗲: We meticulously discuss and document our processes via Loom recordings, google docs or notion so everyone understands how things are done. Regular iteration on these processes helps us stay disciplined and efficient. This is particularly important in a remote setup where discipline is key to consistency. 𝗣𝗿𝗼𝗮𝗰𝘁𝗶𝘃𝗲 𝗣𝗹𝗮𝗻𝗻𝗶𝗻𝗴: We anticipate predictable workload:, such as attending events (booking travel/meetings) and LP updates, by planning and working ahead of time. This allows us to be proactive rather than reactive, a necessity in remote work where spontaneous problem-solving isn’t as easy. These strategies have enabled us to build and scale our venture capital firm remotely, proving that it’s possible. #scaleup #venturecapital #remotework

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And my second investment at defy is in 🐶 zeroETL puppies 🐶... I mean PuppyGraph, which is all the beauty of a graph database, none of the data migration or continuous upkeep of a graph database. Sounds like magic? So are puppies 🐶 . Puppygraph is NOT a graph or a database. It is graph analytics engine that answers graph questions on your existing data warehouses, whether that is a Databricks datalake, Google BigQuery or postgres. Compared to SQL, it's faster, handles way more complexity, scales and has almost no upkeep. How did I get to conviction? 1. Tailwinds - 🌊 Lakehouses 🌊 have helped enterprises put all their data in one place, enabling Puppygraph to unlock insights previously unavailable. - 📚 LLMs! 📚AI and RAG cannot easily traverse fragmented data. Puppygraph's Graph RAG unlocks insights with their Knowledge Graph and spoonfeeds to the LLMs. 2. 👯 Team 👯 We have graph experts from Google, LinkedIn, Databricks, Tigergraph, and Instacart who are uniquely able to build this solution. 3. 💸 Customers 💸 . My alma mater Coinbase is a proud user. The feedback from my former colleagues was off the charts! A blockchain is very much a graph database and Puppygraph tracks down fraudulent transactions that go through mixers and helps identify patterns. Huge congrats to Weimo Liu Danfeng Xu Lei Huang Zhenni Wu Gary Hagmueller, defy.vc is proud to be an investor!!

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The (Healthcare) Ground Beneath Our Feet… This year it is likely that over $10 billion will be invested in the digital health sector – a robust amount, no doubt, but inconsequential when compared to the amount of capital tied up in healthcare real estate assets, which is estimated to be $1.2 trillion by Jones Lang Lasalle. Of that amount, approximately $790 billion is in the hospital sector while the remaining $490 billion is in medical office assets. It is estimated that there are 48.6k facilities with 3.4 billion square feet of healthcare real estate, 42% of which are owned by REITs and another 33% held by other private investment vehicles. Much of the digital health investment is meant to make the physical healthcare infrastructure more productive: greater operating efficiencies, greater patient throughput, more relevant personalized care models with better outcomes. As the healthcare system is being pushed to be more distributed to lower cost sites of care, accelerated now by the rapid proliferation of automation and AI capabilities, the potential impact on healthcare infrastructure assets will be profound. Thoughts on what that might look like... https://lnkd.in/eTfAdUbS #digitalhealth Flare Capital Partners

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One of the most important concepts we introduced in our recent Healthcare AI roadmap is the notion of “Modality—Business Model—Market fit.” This concept describes how the delivery method and business model of AI in healthcare directly shape its potential to create value. There are many possible combinations of modalities and business models in healthcare. AI can be delivered as software, copilots, agents, services, diagnostics, or therapeutics, supported by business models ranging from usage-based and volumetric pricing to performance-based and shared savings arrangements. Nailing selection of modality and business model is essential for AI companies seeking large market opportunities and profitable operations. As we describe in an example with computer vision-based diabetic retinopathy screening, modality and business model selection can drive a difference in TAM by upwards of 25x, and has serious implications for overall margin structures. Read more here 👉 https://lnkd.in/eK7rjpJz

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Imagine swallowing the competition whole. That's what many players in tech do via roll-up strategies, gobbling up smaller firms to deliver richer solutions and amass greater market share. Where else are roll-up strategies common? // HEALTHCARE Picture being a patient at a medical practice that’s been part of a roll-up in Healthcare Services. It's an industry ripe for roll-ups due to its fragmented nature and potential for greater efficiency. // CONSUMER SERVICES Or let's say you needed your HVAC serviced, and notice your local repairman is now part of a bigger Consumer Services entity? Centralized management and scale economy turn these localized businesses into roll-up targets. // FINANCIAL SERVICES Think about your insurance agent or wealth management advisor. They're working in complex, highly regulated environments. In the Financial Services sector, roll-ups offer an effective way to consolidate expertise, streamline operations, and enhance customer offerings. // MANUFACTURING Now, imagine driving past factories under a new name — the result of Manufacturing and Industrial Services roll-ups. Bulk purchasing reduces costs, enhances production capabilities, and expands geographical footprints. // REAL ESTATE Lastly, envision your real estate brokerage firm. The industry sees roll-ups as a strategic move to increase market penetration, enhance service offerings, and hike up portfolio value. Roll-ups play a huge role in most industries, rather like a snowball rolling downhill, gaining momentum, and size. Are you seeing roll-ups in your sector or considering M&A?

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How do we design funding mechanisms that are regenerative and built to last? In the latest Rehash episode, Sophia Dew from Celo Foundation joins me to talk about what blockchain enables for public goods funding, frameworks for designing regenerative onchain funding apps, and what it takes to build and maintain a layer 2 blockchain. Tune into our full conversation at the links below:

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Insightful look into bioplatform strategy, and what it takes to raise a Series A from my partner, Omri Amirav-Drory: https://lnkd.in/dFv7GbF6

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🎨 📺 Sharon Roth is a Product & Design leader who’s built her career in the lab, across different modalities, to bring more creative product experiences to life 📺 🎨 It's W3 / Q3 / 2024 and this week in our MGMT Boston up & coming operator series we’ve got Sharon who serves as the Senior Director of Product Management at Quantified.ai, the AI-driven flight simulator for sellers. The app feels as real as your next video call, scales across teams, programs, and companies, and ramps reps 42% faster. Sharon is leading Quantified AI’s Product & Design team after previous roles in Product leadership at Tamr & Honor Education. She’s excited to be back working in an Enterprise focused company, leading Design alongside Product, focused on strategic & execution based discipline. ❓Questions Are Your Roadmap ❓ It’s popular to encourage new hires to ask a lot of questions. But it’s always a good time to ask questions! When a member of your team comes to you and says “we really need to build X feature”, they’re coming to you for good reason. Dig into the why to understand how often the issue comes up, when it happens in a customer conversation, and why they’re asking for it in the first place. Is there an even better way to build a solution? Also, people are always excited about getting to a solution. By delaying the solution discussion to first get everyone to agree on the problem, you can coordinate a better response. Sharon has been in rooms where stakeholders can’t agree on the problem they’re trying to solve, which can sometimes be even more painful! By asking better questions and articulating the underlying issues thoroughly, they can work together as an organization to chart a better path forward. 3 Career Insights / Learnings 🙋‍♀️ Seek New Challenges - “Trying new things is how you learn and grow. At a startup, there are so many opportunities to try new things. As startups evolve, you need to embrace all that’s going to happen and make it a positive thing. Otherwise don’t go to a startup!” 🤝 Act with Integrity - “Do your best, show your work. But also treat others with respect and kindness while doing it. How you treat people and how you show up every day will impact your work environment. You’re responsible for the energy you bring to the room, so be authentic and try to inject some positivity. It will help you build the type of network you want to have too” 🗣 Invest in Communication Skills - “It helps you ask questions well, advocate for yourself, have your ideas be heard. It also helps others understand your impact. It takes continuous practice to do well.” If you’d like to learn more about Sharon’s career, the full post is linked in the comments. Go ahead and sign up for the newsletter to see the operator learnings we bring you in the weeks ahead too, will ya? #bostontech #operators

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Some VC investors believe that brick and mortar - referring to a physical presence of some kind - should be avoided at all costs. Yet, the track record of clinic and hybrid care businesses in health care indicates otherwise. ==> One Medical (sold for $3.9 billion to Amazon), Oak Street (bought by CVS for $10.6 billion), Lifestance (IPO at $7.5 billion market cap), and PE-backed Premise Health (acquired by OMERS Private Equity for $1.1 billion) If a clinic is indicated as the optimal way to deliver care for that patient population, there are creative ways to build and operate them. Full article below with advice and strategies on how to build and operate hybrid clinics from my teammate Anarghya Vardhana from Maveron, Amir Dan Rubin from OneMedical Group, Steven Eidelman from Modern Animal and more!

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The healthcare landscape is rapidly evolving, driven by advancements in technology and a deeper understanding of patient care. I had the pleasure of speaking with Ambar Bhattacharyya, Co-Managing Partner at Maverick Ventures, on the latest episode of The Full Ratchet. Ambar has partnered with numerous billion-dollar companies like hims & hers, Cityblock Health, Devoted Health, and ConcertAI. His unique journey from rural America to becoming a prominent figure in venture capital offers invaluable insights into the future of healthcare and technology. We discuss his investment strategy at Maverick Ventures, the megatrends shaping healthcare, the impact of AI on the industry, and the importance of integrated care. Ambar also shares his thoughts on the challenges and opportunities in healthcare investment, offering a comprehensive view of what lies ahead. Check out TFR Episode 438 to catch our conversation. You'll be glad you listened. Link to the full episode is in the comment section below.

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Incredibly excited to share our updated Healthcare AI thesis. This is not a market map – in 4,000 words, we dive deeply into the research, products, business models, and market entry points that are reimagining healthcare with AI. More specifically, we cover: • Translating AI research into real-world products • Mapping modalities (software, copilots, agents, services, diagnostics, therapeutics) to problems in healthcare • Designing AI business models that unlock billion-dollar markets • Closing current gaps in healthcare AI infrastructure • Distinguishing AI platforms from point solutions Let us know what you think ⤵️

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We gathered dozens of operators from the MGMT Boston Operators Club and local founders alongside the 186 Ventures team this October to discuss the evolution of our dear software markets, the status of some predictions for 2024 (all looking good!), and what’s on deck for next year. General Partner Giuseppe Stuto led us through the following predictions for 2025 to share with you all.. ↕ We will see more vertical AI applications manifest themselves within the Enterprise in a similar ways that SaaS moved from horizontal to vertical use cases 🔔 We will see services business models more common and software budget purchasing models less common - SaaS may even be given away for cheap/free as a “way in” ⚖ Capital efficiency, on a relative basis, will almost be required to create enduring & compounding defensible enterprise value. Details like procurement cycle lengths and creativity with non-dilutive financing, like leveraging revenue based financing tools for example, will all matter 💡 Specific to AI, premiums will be placed on applications that can actually get “reasoning” right. All purpose LLMs still have a ways to go and there are multiple approaches with the “jury still out” on how to get context and reasoning right. Infrastructure solutions that use general purpose or customizable knowledge graphs to help application developers get to 100% (enterprise acceptable accuracy) will emerge OR savvy application developers will fill the gaps themselves. We will likely see both, depending upon the specific case! Thank you Giuseppe, Julian, and Sophie for a great discussion and evening!

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Today, Two Chairs announces $72M of new funding to continue building a world where everyone has access to exceptional mental health care. Since late 2017, when Maveron led the Two Chairs Series A, the need for mental health services has grown considerably as our society has become lonelier and more isolated than ever. At the same time, our culture’s willingness to openly acknowledge these challenges is greater than ever. Sadly, the rapid growth of Two Chairs affirms the fact that our society is in desperate need of better mental health support. Two Chairs has built a business that believes clinical quality is the defining characteristic of success. Alex Katz has always emphasized the paramountcy of measurement-based clinical outcomes, which the team works tirelessly to achieve. In the process, Two Chairs has illustrated that embracing the ‘move fast and break things’ mentality doesn’t always work. Instead, Two Chairs opted for a different approach: they went slow to go fast. They built a proprietary algorithm that matches patients with the perfect therapist at the onset and hired a team of W2 clinicians oriented toward providing the highest quality care available. Even as the Two Chairs team has grown, their culture has remained small. This has enabled more intimate relationships within the team and between clients and clinicians. Reflecting on this milestone brings me back to the founding of Maveron and the values we hold dear. In 1998, my friend Howard Schultz and I founded Maveron to help entrepreneurs build companies that improve the lives of everyday people—their employees and their customers. There is perhaps no better example of this than Two Chairs. *** Thank you to TechCrunch's Marina Temkin, CFA for the great write-up. https://tcrn.ch/4aMt7yG

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I spend a lot of time discussing #VentureStudios — often these are #investors (#angels, #LP's, #VC's, and #FamilyOffices), current and aspiring studio operators, and #startup #founders curious about how being part of a studio might benefit them. This is a relatively new asset class, so many of the questions I get come down to understanding the studio model itself (e.g., what exactly is—and isn’t—a studio). For me, the simplest way to explain it is this: a venture studio is a company that builds companies. They typically serve as founding or cofounding entities. While #incubators and #accelerators can offer similar support, they tend to work with businesses that are already up and running. What sets studios apart is their involvement from the very start.

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Laura Esteves thoughts on the importance of bringing together a team from diverse backgrounds 📄 Perspective diversity is incredibly valuable when setting up a web3 product development team. At Subvisual, we embrace a cross-disciplinary approach to craft user-centric products - essential for widespread adoption. Blending the product designers' creative thinking with the developers' technical rigor, balanced by business-oriented guidance, we strive for excellence beyond optimal technology

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Small investors like family offices and high-net-worth individuals are finding creative ways to get exposure to coveted AI startups, like Anthropic, Groq, OpenAI, and Elon Musk's xAI, by investing through special purpose vehicles (SPVs). SPVs allow investors to pool capital from multiple backers and buy shares being sold by existing VC backers. SPVs often come with high fees and limited transparency, with sponsors typically charging up to 2% upfront fees and 20% carried interest on profits for recent AI startup deals. There are even cases of SPVs being formed on top of other SPVs, with additional fees layered on. The FTX bankruptcy triggered a flood of Anthropic shares that brokers scooped up and resold via SPVs. With buzzy startups like xAI keeping funding rounds open for weeks, more SPV investors piled in as valuations climbed from initial targets. Per a Business Insider report, small investors participating in xAI’s recent $6B funding round had to contend with a 5% upfront fee in addition to management fees and carried interest. xAI initially planned to raise $3B on a pre-money valuation of $15B, but increased the round size to $6B at a pre-money valuation of $18B to account for the higher demand from investors.

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